| Bain Capital Life Sciences Investors, LLC |
$247868956 |
8448158 |
11.27% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$230736390 |
7864226 |
10.49% |
股份
|
| BlackRock, Inc. |
$152501905 |
5197747 |
6.94% |
股份
|
| FMR LLC |
$141446490 |
4820944 |
6.43% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$105167118 |
3584428 |
4.78% |
股份
|
| BAMCO INC /NY/ |
$94625402 |
3225133 |
4.30% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$80779064 |
2753206 |
3.67% |
股份
|
| Invesco Ltd. |
$67444387 |
2298718 |
3.07% |
股份
|
| JANUS HENDERSON GROUP PLC |
$53063035 |
2180976 |
2.41% |
股份
|
| Point72 Asset Management, L.P. |
$50502326 |
1721279 |
2.30% |
股份
|
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
$49721060 |
1694651 |
2.26% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$46817440 |
1924268 |
2.13% |
股份
|
| VANGUARD GROUP INC |
$46066124 |
1580313 |
2.10% |
股份
|
| STATE STREET CORP |
$43271525 |
1465895 |
1.97% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$39917601 |
1360391 |
1.82% |
股份
|
| Nuveen, LLC |
$39701949 |
1353168 |
1.81% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$34422765 |
1414828 |
1.57% |
股份
|
| MORGAN STANLEY |
$30950483 |
1054889 |
1.41% |
股份
|
| UBS Group AG |
$28621464 |
975510 |
1.30% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$27320235 |
931160 |
1.24% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$27077681 |
922893 |
1.23% |
股份
|
| 12 West Capital Management LP |
$26479350 |
902500 |
1.20% |
股份
|
| FRANKLIN RESOURCES INC |
$23991347 |
817701 |
1.09% |
股份
|
| CITADEL ADVISORS LLC |
$23468568 |
799883 |
1.07% |
股份
|
| Champlain Investment Partners, LLC |
$21524029 |
733607 |
0.98% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$21511589 |
733183 |
0.98% |
股份
|
| NEXT CENTURY GROWTH INVESTORS LLC |
$19698993 |
671404 |
0.90% |
股份
|
| NZS Capital, LLC |
$19247451 |
656014 |
0.88% |
股份
|
| Bank of New York Mellon Corp |
$19095922 |
650849 |
0.87% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$18688110 |
636942 |
0.85% |
股份
|
| XXEC, Inc. |
$18363954 |
599194 |
0.84% |
股份
|
| GOLDMAN SACHS GROUP INC |
$17820735 |
607387 |
0.81% |
股份
|
| Catalio Capital Management, LP |
$17106834 |
583055 |
0.78% |
股份
|
| Rock Springs Capital Management LP |
$16826490 |
573500 |
0.77% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$16636660 |
567030 |
0.76% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$15818954 |
539160 |
0.72% |
股份
|
| NORTHERN TRUST CORP |
$15782045 |
537902 |
0.72% |
股份
|
| JPMORGAN CHASE & CO |
$15497028 |
441237 |
0.70% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$15008085 |
511523 |
0.68% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$14635144 |
498812 |
0.67% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$11228418 |
382700 |
0.51% |
股份
|
| Alyeska Investment Group, L.P. |
$10269000 |
350000 |
0.47% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$8896483 |
303220 |
0.40% |
股份
|
| Walleye Capital LLC |
$8759985 |
298568 |
0.40% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$8721432 |
297254 |
0.40% |
股份
|
| RTW INVESTMENTS, LP |
$8655300 |
295000 |
0.39% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6918636 |
235809 |
0.31% |
股份
|
| Lisanti Capital Growth, LLC |
$5565065 |
189675 |
0.25% |
股份
|
| SEI INVESTMENTS CO |
$4782684 |
163009 |
0.22% |
股份
|
| Temasek Holdings (Private) Ltd |
$4625275 |
157644 |
0.21% |
股份
|
| EMERALD ADVISERS, LLC |
$4524111 |
154196 |
0.21% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$4467749 |
167206 |
0.20% |
股份
|
| ROYAL BANK OF CANADA |
$4277000 |
145773 |
0.19% |
股份
|
| Brevan Howard Capital Management LP |
$4007375 |
136584 |
0.18% |
股份
|
| WELLS FARGO & COMPANY/MN |
$3471803 |
118330 |
0.16% |
股份
|
| INTREPID FAMILY OFFICE LLC |
$3227400 |
110000 |
0.15% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$3113413 |
106115 |
0.14% |
股份
|
| AMERIPRISE FINANCIAL INC |
$3051859 |
104017 |
0.14% |
股份
|
| BLAIR WILLIAM & CO/IL |
$3006822 |
102482 |
0.14% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$2760865 |
94099 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$2752670 |
93820 |
0.13% |
股份
|
| CITIGROUP INC |
$2734840 |
93212 |
0.12% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$2599964 |
88615 |
0.12% |
股份
|
| Squarepoint Ops LLC |
$2554106 |
87052 |
0.12% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$2414535 |
82295 |
0.11% |
股份
|
| BROWN CAPITAL MANAGEMENT LLC |
$2408550 |
82091 |
0.11% |
股份
|
| DEUTSCHE BANK AG\ |
$2320207 |
79080 |
0.11% |
股份
|
| Swiss National Bank |
$2270916 |
77400 |
0.10% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$2270000 |
77366 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2241576 |
76400 |
0.10% |
买入期权
|
| Quantinno Capital Management LP |
$2217728 |
75587 |
0.10% |
股份
|
| IEQ CAPITAL, LLC |
$2047287 |
69778 |
0.09% |
股份
|
| Russell Investments Group, Ltd. |
$1989279 |
67801 |
0.09% |
股份
|
| Burkehill Global Management, LP |
$1907100 |
65000 |
0.09% |
股份
|
| Ensign Peak Advisors, Inc |
$1895423 |
64602 |
0.09% |
股份
|
| TFC Financial Management, Inc. |
$1631246 |
55598 |
0.07% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$1618600 |
55167 |
0.07% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1607744 |
54797 |
0.07% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$1606658 |
54760 |
0.07% |
股份
|
| Allianz Asset Management GmbH |
$1556810 |
53061 |
0.07% |
股份
|
| Corient Private Wealth LP |
$1546924 |
52724 |
0.07% |
股份
|
| XTX Topco Ltd |
$1491235 |
50826 |
0.07% |
股份
|
| Jump Financial, LLC |
$1467646 |
50022 |
0.07% |
股份
|
| Ghisallo Capital Management LLC |
$1467000 |
50000 |
0.07% |
股份
|
| MetLife Investment Management, LLC |
$1379303 |
47011 |
0.06% |
股份
|
| Balyasny Asset Management L.P. |
$1370823 |
46722 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1290403 |
43981 |
0.06% |
股份
|
| Intellectus Partners, LLC |
$1207605 |
41159 |
0.05% |
股份
|
| Quantbot Technologies LP |
$1206696 |
41128 |
0.05% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1142030 |
38924 |
0.05% |
股份
|
| AlpInvest Partners B.V. |
$1071027 |
36504 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1070910 |
36500 |
0.05% |
卖出期权
|
| CITADEL ADVISORS LLC |
$1056240 |
36000 |
0.05% |
买入期权
|
| LAZARD ASSET MANAGEMENT LLC |
$1008181 |
34362 |
0.05% |
股份
|
| Legal & General Group Plc |
$998148 |
34020 |
0.05% |
股份
|
| BCWM, LLC |
$935301 |
31878 |
0.04% |
股份
|
| ALLSTATE CORP |
$853149 |
29078 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$838655 |
28584 |
0.04% |
股份
|
| BANK OF MONTREAL /CAN/ |
$805060 |
27439 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$798576 |
27218 |
0.04% |
股份
|
| Trexquant Investment LP |
$785667 |
26778 |
0.04% |
股份
|
| OCCUDO QUANTITATIVE STRATEGIES LP |
$785080 |
26758 |
0.04% |
股份
|
| BARCLAYS PLC |
$727955 |
24811 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$727632 |
24800 |
0.03% |
买入期权
|
| DIVERSIFIED TRUST CO |
$719563 |
24525 |
0.03% |
股份
|
| BRIDGES INVESTMENT MANAGEMENT INC |
$700316 |
23869 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$695739 |
23713 |
0.03% |
股份
|
| Mariner, LLC |
$683538 |
23307 |
0.03% |
股份
|
| Voleon Capital Management LP |
$680072 |
23179 |
0.03% |
股份
|
| Jain Global LLC |
$615465 |
20977 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$589910 |
20106 |
0.03% |
股份
|
| Quent Capital, LLC |
$586800 |
20000 |
0.03% |
股份
|
| FORA Capital, LLC |
$552753 |
18846 |
0.03% |
股份
|
| WEXFORD CAPITAL LP |
$548599 |
18698 |
0.02% |
股份
|
| TWINBEECH CAPITAL LP |
$528237 |
18004 |
0.02% |
股份
|
| HB Wealth Management, LLC |
$519025 |
17690 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$480707 |
16384 |
0.02% |
股份
|
| Sandia Investment Management LP |
$463981 |
15917 |
0.02% |
股份
|
| Perpetual Ltd |
$461841 |
15741 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$433205 |
14765 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$418359 |
14259 |
0.02% |
股份
|
| STALEY CAPITAL ADVISERS INC |
$410760 |
14000 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$387788 |
13217 |
0.02% |
股份
|
| CWM, LLC |
$378113 |
15541 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$376286 |
12825 |
0.02% |
股份
|
| Numerai GP LLC |
$373792 |
12740 |
0.02% |
股份
|
| Avior Wealth Management, LLC |
$367630 |
12530 |
0.02% |
股份
|
| Amundi |
$360237 |
12278 |
0.02% |
股份
|
| MAYPORT, LLC |
$352080 |
12000 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$345361 |
11771 |
0.02% |
股份
|
| Accretive Wealth Partners, LLC |
$328608 |
11200 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$316373 |
10783 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$312412 |
10648 |
0.01% |
股份
|
| ProShare Advisors LLC |
$308892 |
10528 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$299268 |
10200 |
0.01% |
卖出期权
|
| BRANDYWINE MANAGERS, LLC |
$294104 |
10024 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$291376 |
9931 |
0.01% |
股份
|
| Focus Partners Wealth |
$287297 |
9792 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$282762 |
8401 |
0.01% |
股份
|
| Entropy Technologies, LP |
$278261 |
9484 |
0.01% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$270192 |
9209 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$255258 |
8700 |
0.01% |
股份
|
| D. E. Shaw & Co., Inc. |
$254701 |
8681 |
0.01% |
股份
|
| Cornerstone Investment Partners, LLC |
$247248 |
8427 |
0.01% |
股份
|
| Cerity Partners LLC |
$243904 |
8313 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$240910 |
8211 |
0.01% |
股份
|
| nVerses Capital, LLC |
$235336 |
8021 |
0.01% |
股份
|
| DONALDSON CAPITAL MANAGEMENT, LLC |
$234456 |
7991 |
0.01% |
股份
|
| XPONANCE LLC |
$230847 |
7868 |
0.01% |
股份
|
| Blackstone Inc. |
$224715 |
7659 |
0.01% |
股份
|
| CONNABLE OFFICE INC |
$221576 |
7552 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$215590 |
7348 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$214065 |
7296 |
0.01% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$209077 |
7126 |
0.01% |
股份
|
| Arax Advisory Partners |
$194377 |
6625 |
0.01% |
股份
|
| Vanguard Global Advisers, LLC |
$188510 |
6425 |
0.01% |
股份
|
| Sofinnova Investments, Inc. |
$149018 |
5079 |
0.01% |
股份
|
| RiverPark Advisors, LLC |
$140069 |
4774 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$67071 |
2286 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$55277 |
1884 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$34726 |
698 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$33565 |
1144 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$33243 |
988 |
0.00% |
股份
|
| MCF Advisors LLC |
$23942 |
816 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$21390 |
600 |
0.00% |
股份
|
| State of Wyoming |
$21360 |
728 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$18935 |
645 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$15668 |
534 |
0.00% |
股份
|
| Allworth Financial LP |
$15521 |
529 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$14758 |
503 |
0.00% |
股份
|
| Essential Partners LLC |
$11736 |
400 |
0.00% |
股份
|
| GAMMA Investing LLC |
$10738 |
366 |
0.00% |
股份
|
| COMERICA BANK |
$10232 |
351 |
0.00% |
股份
|
| Larson Financial Group LLC |
$9242 |
315 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$8274 |
282 |
0.00% |
股份
|
| Center for Financial Planning, Inc. |
$7864 |
268 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$6992 |
238268 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$6513 |
222 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$6161 |
210 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$5884 |
200536 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$5135 |
172 |
0.00% |
股份
|
| True Wealth Design, LLC |
$5076 |
173 |
0.00% |
股份
|
| Quarry LP |
$3579 |
122 |
0.00% |
股份
|
| FLAGSHIP WEALTH ADVISORS, LLC |
$2934 |
100 |
0.00% |
股份
|
| Leo H. Evart, Inc. |
$2934 |
100 |
0.00% |
股份
|
| IFP Advisors, Inc |
$2494 |
85 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$1819 |
62 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1672 |
57 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1614 |
55 |
0.00% |
股份
|
| Nemes Rush Group LLC |
$792 |
27 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$617 |
21 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$557 |
19 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$470 |
16 |
0.00% |
股份
|
| Thrivent Financial for Lutherans |
$465 |
15860 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$440 |
15 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$381 |
13 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$264 |
9 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$218 |
7420 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$205 |
7 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$170 |
7 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$30 |
1 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$3 |
130 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
17 |
0.00% |
股份
|