| Artal Group S.A. |
$420374549 |
175156062 |
47.23% |
股份
|
| FMR LLC |
$124276907 |
51782045 |
13.96% |
股份
|
| Siren, L.L.C. |
$106328443 |
44303518 |
11.95% |
股份
|
| Sessa Capital IM, L.P. |
$45506006 |
18960836 |
5.11% |
股份
|
| BlackRock, Inc. |
$41636978 |
17348741 |
4.68% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$23762899 |
9901208 |
2.67% |
股份
|
| Point72 Asset Management, L.P. |
$19803180 |
8251325 |
2.23% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$14989739 |
6244372 |
1.68% |
股份
|
| STATE STREET CORP |
$11802646 |
4917769 |
1.33% |
股份
|
| VANGUARD GROUP INC |
$11047532 |
9606549 |
1.24% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$5658598 |
2357749 |
0.64% |
股份
|
| NORTHERN TRUST CORP |
$4724686 |
1968619 |
0.53% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4696260 |
1956775 |
0.53% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3922970 |
1634571 |
0.44% |
股份
|
| CITADEL ADVISORS LLC |
$3842837 |
1601182 |
0.43% |
股份
|
| CIBC Private Wealth Group LLC |
$3240347 |
2400257 |
0.36% |
股份
|
| Ishara Investments LP |
$3050400 |
1271000 |
0.34% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2722150 |
1134229 |
0.31% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2704800 |
1127000 |
0.30% |
股份
|
| MACKENZIE FINANCIAL CORP |
$2312050 |
963354 |
0.26% |
股份
|
| ADAR1 Capital Management, LLC |
$1800000 |
750000 |
0.20% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1672262 |
696776 |
0.19% |
股份
|
| UBS Group AG |
$1643312 |
684713 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1604400 |
668500 |
0.18% |
买入期权
|
| TWO SIGMA INVESTMENTS, LP |
$1544266 |
643444 |
0.17% |
股份
|
| Nuveen, LLC |
$1407994 |
586664 |
0.16% |
股份
|
| JANE STREET GROUP, LLC |
$1398960 |
582900 |
0.16% |
买入期权
|
| Bank of New York Mellon Corp |
$1364893 |
568706 |
0.15% |
股份
|
| Invesco Ltd. |
$1219370 |
508071 |
0.14% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1165310 |
485546 |
0.13% |
股份
|
| Compagnie Lombard Odier SCmA |
$1152000 |
480000 |
0.13% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1011117 |
421299 |
0.11% |
股份
|
| BARCLAYS PLC |
$929960 |
387483 |
0.10% |
股份
|
| CITADEL ADVISORS LLC |
$886320 |
369300 |
0.10% |
买入期权
|
| XTX Topco Ltd |
$858905 |
357877 |
0.10% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$618960 |
257900 |
0.07% |
股份
|
| RHUMBLINE ADVISERS |
$616523 |
256885 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$594068 |
247528 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$553128 |
230470 |
0.06% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$431280 |
179700 |
0.05% |
股份
|
| CITIGROUP INC |
$420492 |
175205 |
0.05% |
股份
|
| GROUP ONE TRADING LLC |
$420031 |
175013 |
0.05% |
股份
|
| Virtus Investment Advisers, LLC |
$408996 |
170415 |
0.05% |
股份
|
| Headlands Technologies LLC |
$401275 |
167198 |
0.05% |
股份
|
| Ikarian Capital, LLC |
$395218 |
164674 |
0.04% |
股份
|
| Quarry LP |
$374846 |
156186 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$351384 |
146410 |
0.04% |
股份
|
| MORGAN STANLEY |
$318964 |
132902 |
0.04% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$316901 |
132042 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$289975 |
109839 |
0.03% |
股份
|
| State of Wyoming |
$285816 |
119090 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$273874 |
114114 |
0.03% |
股份
|
| Cornerstone Investment Partners, LLC |
$272974 |
113739 |
0.03% |
股份
|
| Cerity Partners LLC |
$236160 |
98400 |
0.03% |
股份
|
| ALGERT GLOBAL LLC |
$221160 |
92150 |
0.02% |
股份
|
| TWO SIGMA ADVISERS, LP |
$208124 |
180977 |
0.02% |
股份
|
| BANK OF NOVA SCOTIA |
$207857 |
86607 |
0.02% |
股份
|
| LPL Financial LLC |
$203799 |
84916 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$187070 |
77946 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$180552 |
75230 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$176165 |
73402 |
0.02% |
股份
|
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
$171426 |
71427 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$171228 |
71345 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$167393 |
69747 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$164160 |
68400 |
0.02% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$159300 |
66375 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$153449 |
63937 |
0.02% |
股份
|
| Straight Path Wealth Management |
$150398 |
62666 |
0.02% |
股份
|
| R Squared Ltd |
$131964 |
54985 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$130402 |
54334 |
0.01% |
股份
|
| Fortis Group Advisors, LLC |
$120000 |
50000 |
0.01% |
股份
|
| Schonfeld Strategic Advisors LLC |
$118642 |
49435 |
0.01% |
股份
|
| SCOTIA CAPITAL INC. |
$117291 |
48871 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$116606 |
48586 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$114650 |
47771 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$109745 |
45727 |
0.01% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$106356 |
44315 |
0.01% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$105768 |
67800 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$103680 |
43200 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$101978 |
42491 |
0.01% |
股份
|
| LMR Partners LLP |
$98618 |
41091 |
0.01% |
股份
|
| BANK OF MONTREAL /CAN/ |
$96000 |
40000 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$90672 |
37780 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$85704 |
63484 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$81816 |
34090 |
0.01% |
股份
|
| ProShare Advisors LLC |
$78212 |
32588 |
0.01% |
股份
|
| Leonteq Securities AG |
$72000 |
30000 |
0.01% |
股份
|
| Pathstone Holdings, LLC |
$71925 |
29969 |
0.01% |
股份
|
| PINNACLE ASSOCIATES LTD |
$69636 |
29015 |
0.01% |
股份
|
| SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ |
$63960 |
26650 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$58135 |
24223 |
0.01% |
股份
|
| Legal & General Group Plc |
$58044 |
24185 |
0.01% |
股份
|
| XPONANCE LLC |
$57031 |
23763 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$56498 |
23541 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$55166 |
22986 |
0.01% |
股份
|
| D. E. Shaw & Co., Inc. |
$53280 |
22200 |
0.01% |
股份
|
| Quadrature Capital Ltd |
$52795 |
21998 |
0.01% |
股份
|
| Invera Wealth Advisors, LLC |
$48000 |
20000 |
0.01% |
股份
|
| DIKER MANAGEMENT LLC |
$48000 |
20000 |
0.01% |
股份
|
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC |
$48000 |
20000 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$47764 |
19902 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$47282 |
35024 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$46766 |
19486 |
0.01% |
股份
|
| KWB Wealth |
$46736 |
40640 |
0.01% |
股份
|
| SBI Securities Co., Ltd. |
$46092 |
19205 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$45682 |
19034 |
0.01% |
股份
|
| CREDIT AGRICOLE S A |
$45540 |
18975 |
0.01% |
股份
|
| WOLVERINE TRADING, LLC |
$43785 |
31500 |
0.00% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$42960 |
17900 |
0.00% |
卖出期权
|
| CITADEL ADVISORS LLC |
$42960 |
17900 |
0.00% |
卖出期权
|
| WOLVERINE TRADING, LLC |
$39615 |
28500 |
0.00% |
买入期权
|
| CAPTRUST FINANCIAL ADVISORS |
$36770 |
15321 |
0.00% |
股份
|
| Callan Family Office, LLC |
$33816 |
14090 |
0.00% |
股份
|
| TRUIST FINANCIAL CORP |
$33600 |
14000 |
0.00% |
股份
|
| CIBC Bancorp USA Inc. |
$32976 |
13740 |
0.00% |
股份
|
| Gotham Asset Management, LLC |
$32705 |
13627 |
0.00% |
股份
|
| CIBC Asset Management Inc |
$31445 |
13102 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$30000 |
12650 |
0.00% |
股份
|
| WOLVERINE TRADING, LLC |
$29455 |
21191 |
0.00% |
股份
|
| HBK Sorce Advisory LLC |
$28876 |
11786 |
0.00% |
股份
|
| Squarepoint Ops LLC |
$28178 |
11741 |
0.00% |
股份
|
| Apollon Wealth Management, LLC |
$27307 |
11378 |
0.00% |
股份
|
| Mariner, LLC |
$26974 |
11239 |
0.00% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$26949 |
12139 |
0.00% |
股份
|
| Perennial Investment Advisors, LLC |
$26376 |
10990 |
0.00% |
股份
|
| Cetera Investment Advisers |
$25258 |
10524 |
0.00% |
股份
|
| Berger Financial Group, Inc |
$24000 |
10000 |
0.00% |
股份
|
| NBT BANK, N.A. |
$24000 |
10000 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$20496 |
8540 |
0.00% |
股份
|
| CWM, LLC |
$16227 |
10402 |
0.00% |
股份
|
| H D Vest Advisory Services |
$11087 |
11724 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$8225 |
3427 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$6221 |
2592 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$3506 |
1461 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3389 |
1412 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$3152 |
1313 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2400 |
1000 |
0.00% |
股份
|
| Cassaday & Co Wealth Management LLC |
$2400 |
1000 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$2297 |
957 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2098 |
874 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$1783 |
743 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1694 |
706 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$1666 |
696617 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$1200 |
500 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$960 |
400 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$953 |
397219 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$908 |
356 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$720 |
300 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$709 |
295548 |
0.00% |
股份
|
| Allworth Financial LP |
$632 |
263 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$593 |
247 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$491 |
204391 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$390 |
163 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$377 |
157 |
0.00% |
股份
|
| SYNTAX RESEARCH, INC. |
$341 |
142 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$240 |
100 |
0.00% |
股份
|
| Larson Financial Group LLC |
$240 |
100 |
0.00% |
股份
|
| COMERICA BANK |
$140 |
122 |
0.00% |
股份
|
| Arax Advisory Partners |
$98 |
41 |
0.00% |
股份
|
| HM PAYSON & CO |
$89 |
37 |
0.00% |
股份
|
| WEDBUSH SECURITIES INC |
$48 |
20000 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$20 |
15 |
0.00% |
股份
|
| Blume Capital Management, Inc. |
$12 |
5 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$5 |
2 |
0.00% |
股份
|
| Avion Wealth |
$2 |
1115 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
81 |
0.00% |
股份
|
| Motiv8 Investments LLC |
$0 |
200 |
0.00% |
股份
|