| Frazier Life Sciences Management, L.P. |
$135261406 |
12466489 |
16.52% |
股份
|
| Medicxi Ventures Management (Jersey) Ltd |
$80990606 |
7464572 |
9.89% |
股份
|
| VANGUARD GROUP INC |
$52709931 |
3177211 |
6.44% |
股份
|
| BlackRock, Inc. |
$49097648 |
4525129 |
6.00% |
股份
|
| Invesco Ltd. |
$43722581 |
4029731 |
5.34% |
股份
|
| Carlyle Group Inc. |
$37940367 |
3496808 |
4.63% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$36627799 |
3375834 |
4.47% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$28827842 |
2656944 |
3.52% |
股份
|
| FRANKLIN RESOURCES INC |
$21383482 |
1970828 |
2.61% |
股份
|
| NEA Management Company, LLC |
$21267834 |
1960169 |
2.60% |
股份
|
| 683 Capital Management, LLC |
$20072501 |
1850000 |
2.45% |
股份
|
| GOLDMAN SACHS GROUP INC |
$19291647 |
1778032 |
2.36% |
股份
|
| STATE STREET CORP |
$17211605 |
1586323 |
2.10% |
股份
|
| Catalys Pacific, LLC |
$16208316 |
1493854 |
1.98% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$15871000 |
1462738 |
1.94% |
股份
|
| WASATCH ADVISORS LP |
$14897577 |
1340916 |
1.82% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$14277589 |
1315687 |
1.74% |
股份
|
| Ensign Peak Advisors, Inc |
$11413256 |
1051913 |
1.39% |
股份
|
| Propel Bio Management, LLC |
$11396384 |
1050358 |
1.39% |
股份
|
| Point72 Asset Management, L.P. |
$11090794 |
1022193 |
1.35% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$8643446 |
796631 |
1.06% |
股份
|
| SummitTX Capital, L.P. |
$8566618 |
789550 |
1.05% |
股份
|
| HSBC HOLDINGS PLC |
$7701936 |
709695 |
0.94% |
股份
|
| MARSHALL WACE, LLP |
$7227078 |
666090 |
0.88% |
股份
|
| EcoR1 Capital, LLC |
$6781250 |
625000 |
0.83% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$5772200 |
532000 |
0.70% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$5631975 |
519076 |
0.69% |
股份
|
| CITADEL ADVISORS LLC |
$5216680 |
480800 |
0.64% |
买入期权
|
| NORTHERN TRUST CORP |
$4972565 |
458301 |
0.61% |
股份
|
| StepStone Group LP |
$4689364 |
422085 |
0.57% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4547170 |
419094 |
0.56% |
股份
|
| Woodline Partners LP |
$4004214 |
369052 |
0.49% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3847117 |
354573 |
0.47% |
股份
|
| AMERIPRISE FINANCIAL INC |
$3189673 |
293979 |
0.39% |
股份
|
| JPMORGAN CHASE & CO |
$2991978 |
275251 |
0.37% |
股份
|
| Simplify Asset Management Inc. |
$2704547 |
249267 |
0.33% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2456440 |
226400 |
0.30% |
股份
|
| JANE STREET GROUP, LLC |
$2307860 |
212706 |
0.28% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2281755 |
210300 |
0.28% |
买入期权
|
| UBS Group AG |
$2219618 |
204573 |
0.27% |
股份
|
| NewEdge Advisors, LLC |
$2212988 |
203962 |
0.27% |
股份
|
| Avidity Partners Management LP |
$2170000 |
200000 |
0.27% |
股份
|
| MORGAN STANLEY |
$2169013 |
199909 |
0.26% |
股份
|
| Jump Financial, LLC |
$2081746 |
191866 |
0.25% |
股份
|
| Opaleye Management Inc. |
$2013641 |
185589 |
0.25% |
股份
|
| CITADEL ADVISORS LLC |
$2006176 |
184901 |
0.25% |
股份
|
| Trexquant Investment LP |
$1886641 |
173884 |
0.23% |
股份
|
| Jones Hill Capital LP |
$1752123 |
161486 |
0.21% |
股份
|
| Bank of New York Mellon Corp |
$1652595 |
152313 |
0.20% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1649221 |
152002 |
0.20% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1638513 |
151015 |
0.20% |
股份
|
| XTX Topco Ltd |
$1473777 |
135832 |
0.18% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1463677 |
134901 |
0.18% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1435281 |
132284 |
0.18% |
股份
|
| DIADEMA PARTNERS LP |
$1409958 |
129950 |
0.17% |
股份
|
| Nuveen, LLC |
$1379328 |
127127 |
0.17% |
股份
|
| SIG BROKERAGE, LP |
$1345400 |
124000 |
0.16% |
买入期权
|
| Engineers Gate Manager LP |
$1283088 |
118257 |
0.16% |
股份
|
| Virtus Investment Advisers, LLC |
$1216708 |
112139 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$1114879 |
102754 |
0.14% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1105968 |
101745 |
0.14% |
股份
|
| Stratos Wealth Partners, LTD. |
$1085000 |
100000 |
0.13% |
股份
|
| Swiss National Bank |
$1071980 |
98800 |
0.13% |
股份
|
| D. E. Shaw & Co., Inc. |
$1037911 |
95660 |
0.13% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$956254 |
88134 |
0.12% |
股份
|
| Stonepine Capital Management, LLC |
$922358 |
85010 |
0.11% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$838879 |
77316 |
0.10% |
股份
|
| JANE STREET GROUP, LLC |
$837620 |
77200 |
0.10% |
买入期权
|
| Campbell & CO Investment Adviser LLC |
$746035 |
68759 |
0.09% |
股份
|
| Penn Mutual Asset Management |
$681402 |
62802 |
0.08% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$675771 |
62283 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$654740 |
60346 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$619804 |
55788 |
0.08% |
股份
|
| Birchview Capital, LP |
$596750 |
55000 |
0.07% |
股份
|
| CITIGROUP INC |
$574453 |
52945 |
0.07% |
股份
|
| STIFEL FINANCIAL CORP |
$573228 |
52832 |
0.07% |
股份
|
| Creative Planning |
$572337 |
52750 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$561889 |
51787 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$547612 |
49290 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$544725 |
50205 |
0.07% |
股份
|
| Pale Fire Capital SE |
$539386 |
49713 |
0.07% |
股份
|
| NOMURA HOLDINGS INC |
$532735 |
49100 |
0.07% |
卖出期权
|
| Man Group plc |
$528167 |
48679 |
0.06% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$521061 |
48024 |
0.06% |
股份
|
| Persistent Asset Partners Ltd |
$517143 |
47663 |
0.06% |
股份
|
| AlphaQuest LLC |
$468668 |
28250 |
0.06% |
股份
|
| ADAR1 Capital Management, LLC |
$465465 |
42900 |
0.06% |
股份
|
| Quantbot Technologies LP |
$463892 |
42755 |
0.06% |
股份
|
| BARCLAYS PLC |
$453280 |
41777 |
0.06% |
股份
|
| NOMURA HOLDINGS INC |
$434000 |
40000 |
0.05% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$432318 |
39845 |
0.05% |
股份
|
| Fiduciary Trust Co |
$387681 |
35731 |
0.05% |
股份
|
| Nebula Research & Development LLC |
$363816 |
37937 |
0.04% |
股份
|
| ALLSTATE CORP |
$356694 |
32875 |
0.04% |
股份
|
| Legal & General Group Plc |
$355207 |
32738 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$342806 |
31595 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$337435 |
31100 |
0.04% |
卖出期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$309290 |
28506 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$304961 |
28107 |
0.04% |
股份
|
| Kera Capital Partners, Inc. |
$291062 |
26826 |
0.04% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$280342 |
25838 |
0.03% |
股份
|
| Caption Management, LLC |
$260400 |
24000 |
0.03% |
买入期权
|
| Caption Management, LLC |
$260400 |
24000 |
0.03% |
卖出期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$245720 |
22647 |
0.03% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$244500 |
22535 |
0.03% |
股份
|
| Summit Financial Wealth Advisors, LLC |
$240252 |
22143 |
0.03% |
股份
|
| JANUS HENDERSON GROUP PLC |
$239403 |
21500 |
0.03% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$236198 |
18731 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$225344 |
20769 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$220255 |
20300 |
0.03% |
卖出期权
|
| INSPIRION WEALTH ADVISORS, LLC |
$209794 |
19914 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$192316 |
17725 |
0.02% |
股份
|
| State of Wyoming |
$191383 |
17639 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$187455 |
17277 |
0.02% |
股份
|
| Jain Global LLC |
$178341 |
16437 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$175206 |
16148 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$172775 |
15924 |
0.02% |
股份
|
| Pathstone Holdings, LLC |
$162750 |
15000 |
0.02% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$159180 |
14671 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$158399 |
14599 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$151900 |
14000 |
0.02% |
股份
|
| GROUP ONE TRADING LLC |
$150609 |
13881 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$147896 |
13631 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$147441 |
13589 |
0.02% |
股份
|
| Rafferty Asset Management, LLC |
$138403 |
12756 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$137719 |
12693 |
0.02% |
股份
|
| TOCQUEVILLE ASSET MANAGEMENT L.P. |
$130200 |
12000 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$123560 |
11388 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$122345 |
11276 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$116855 |
10770 |
0.01% |
股份
|
| Allworth Financial LP |
$113307 |
10443 |
0.01% |
股份
|
| Private Advisor Group, LLC |
$110453 |
10180 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$94308 |
8692 |
0.01% |
股份
|
| FMR LLC |
$89290 |
8230 |
0.01% |
股份
|
| Kera Capital Partners, Inc. |
$54250 |
5000 |
0.01% |
买入期权
|
| Fulcrum Asset Management LLP |
$48458 |
4458 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$48424 |
4463 |
0.01% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$45560 |
4250 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$38702 |
3567 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$28515 |
2628 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$24749 |
2281 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$24000 |
2258 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$23610 |
2176 |
0.00% |
股份
|
| GW&K Investment Management, LLC |
$23510 |
2166838 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$21049 |
1940 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$20799 |
1917 |
0.00% |
股份
|
| CWM, LLC |
$20709 |
1864 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$18109 |
1669 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$15884 |
1464 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$9722 |
896 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$8203 |
756 |
0.00% |
股份
|
| Larson Financial Group LLC |
$7942 |
732 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$5512 |
508 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$4633 |
427 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4340 |
400 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$3711 |
342 |
0.00% |
股份
|
| US BANCORP \DE\ |
$3005 |
277 |
0.00% |
股份
|
| Truvestments Capital LLC |
$2441 |
225 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$2365 |
218 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$1593 |
254 |
0.00% |
股份
|
| Quarry LP |
$1378 |
127 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1085 |
100 |
0.00% |
股份
|
| Optiver Holding B.V. |
$976 |
90 |
0.00% |
股份
|
| True Wealth Design, LLC |
$955 |
88 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$879 |
81 |
0.00% |
股份
|
| KBC Group NV |
$837 |
77139 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$714 |
65722 |
0.00% |
股份
|
| Arax Advisory Partners |
$456 |
42 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$327 |
30138 |
0.00% |
股份
|
| ELEVATION WEALTH PARTNERS, LLC |
$217 |
20 |
0.00% |
股份
|
| HAP Trading, LLC |
$90 |
150000 |
0.00% |
卖出期权
|
| Stone House Investment Management, LLC |
$87 |
8 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$74 |
6818 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$55 |
5 |
0.00% |
股份
|
| Strategic Wealth Advisors LLC |
$16 |
1000 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
29 |
0.00% |
股份
|