RARE Ultragenyx Pharmaceutical Inc. - Common Stock
$26.02
价格 · 八月 24, 2026
截至...的财报数据 八月 5, 2026
52周区间
$18–$40
36% of range
分析师评级
BUY
25 analysts
目标价
$54
+108% upside
P/E (TTM)
-4.5
ROE
-1613.2%
净利润率
-85.4%
RARE 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围
价格
$26.02
市值
$2.56B
P/E (TTM)
-4.5
每股收益 (TTM)
$-5.83
营收 (TTM)
$673M
股息收益率
—
ROE
-1613.2%
负债/权益
—
52周区间
$18 – $40
RARE 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图
Configure
10年表现 收入、净利润、利润率和每股收益趋势
营收与净利润
$673M
2016-12-31
→
2025-12-31
EPS
$-5.83
2020-12-31
→
2025-12-31
自由现金流
$-472M
2016-12-31
→
2025-12-31
利润率
-85.4%
估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜？
指标
5年趋势
RARE
同行中位数
P/E (TTM)
-4.5
97.6
P/S (TTM) (市销率 (TTM))
3.8
7.7
P/B (市净率)
-32.0
8.0
Price / FCF (股价/自由现金流)
-5.4
—
盈利能力 毛利率、营业利润率和净利率；股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)
指标
5年趋势
RARE
同行中位数
Operating Margin (营业利润率)
-79.5%
—
Net Profit Margin (净利润率)
-85.4%
-51.7%
ROA
-37.9%
-44.2%
ROE
-1613.2%
-63.5%
ROIC
673.4%
—
财务健康 债务、流动性、偿付能力 — 资产负债表强度
指标
5年趋势
RARE
同行中位数
Current Ratio (流动比率)
2.5
4.9
Quick Ratio (速动比率)
1.5
—
成长 营收、每股收益 (EPS) 和净利润增长：同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)
指标
5年趋势
RARE
同行中位数
Revenue YoY (营收同比增长)
20.2%
—
Revenue CAGR 3Y (营收3年复合年增长率)
22.8%
—
Revenue CAGR 5Y (营收5年复合年增长率)
20.0%
—
资本效率 资产周转率、库存周转率、应收账款周转率
指标
5年趋势
RARE
同行中位数
RARE 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间
买入
25 位分析师
- 强烈买入 8 32.0%
- 买入 14 56.0%
- 持有 3 12.0%
- 卖出 0 0.0%
- 强烈卖出 0 0.0%
12个月价格目标
19 位分析师 · 2026-08-22
中位数
$49.00
← 低于所有目标
$26.02
最低
$28.00
最高
$103.00
中位数目标
$49.00
+88.3%
平均目标
$54.21
+108.3%
收益历史 每股收益实际值 vs 预估值，惊喜%，达标率，下次财报日期
平均惊喜
-0.08%
| 期间 | EPS Actual | EPS 预期 | 惊喜 |
|---|---|---|---|
| 2026年6月30日 | $-0.90 | $-1.24 | 0.34% |
| 2026年3月31日 | $-1.84 | $-1.54 | -0.30% |
| 2025年12月31日 | $-1.29 | $-1.11 | -0.18% |
| 2025年9月30日 | $-1.81 | $-1.26 | -0.55% |
| 2025年6月30日 | $-1.17 | $-1.32 | 0.15% |
| 2025年3月31日 | $-1.57 | $-1.65 | 0.08% |
同行比较（GICS 子行业） 关键指标与行业同行对比
| 股票代码 | 市值 | P/E | 营收同比增长 | 净利润率 | ROE | 毛利率 |
|---|---|---|---|---|---|---|
| RARE | $2.22B | -3.9 | 20.2% | -85.4% | -1613.2% | — |
| IRON | $3.01B | -13.2 | — | — | -31.3% | — |
| SLS | $577M | -15.1 | — | — | -55.4% | — |
| NRIX | $1.80B | -5.8 | 53.9% | -314.9% | -53.6% | — |
| PGEN | $1.48B | -3.1 | 146.7% | -2588.2% | 3159.1% | — |
| BCRX | $1.66B | 6.4 | 94.1% | 30.2% | -97.6% | — |
| KOD | $1.73B | -6.5 | — | — | -202.0% | — |
| CDNA | $959M | -47.1 | 13.8% | -5.6% | -6.8% | — |
| COAG | — | — | — | — | — | — |
| VERA | — | -10.9 | — | — | -55.9% | — |
完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表
损益表 16
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $673M | $560M | $434M | $363M | $351M | $271M | $104M | $51M | $3M | $133.0K | |
| Cost of Revenue | · | · | · | · | · | · | · | $1M | $1.0K | · | |
| R&D Expense | $750M | $698M | $648M | $706M | $497M | $412M | $357M | $294M | $232M | $183M | |
| SG&A Expense | $349M | $321M | $310M | $278M | $220M | $183M | $162M | $128M | $100M | $65M | |
| Operating Expenses | · | · | · | · | · | $601M | $528M | $423M | $332M | $248M | |
| Operating Income | $-535M | $-536M | $-569M | $-649M | $-382M | $-330M | $-424M | $-371M | $-329M | $-248M | |
| Interest Income | $25M | $37M | $27M | $11M | $2M | $7M | $13M | $10M | $4M | $4M | |
| Other Non-op | $1M | $-5M | $-1M | $-2M | $-2M | $607.0K | $-787.0K | $-6M | $7M | $-2M | |
| Pretax Income | $-571M | $-567M | $-609M | $-702M | $-453M | $-185M | $-399M | $-197M | $-318M | $-246M | |
| Income Tax | $4M | $2M | $-2M | $6M | $1M | $1M | $3M | $514.0K | $-16M | $35.0K | |
| Net Income | $-575M | $-569M | $-607M | $-707M | $-454M | $-187M | $-403M | $-198M | $-302M | $-246M | |
| EPS (Basic) | $-5.83 | $-6.29 | $-8.25 | $-10.12 | $-6.70 | $-3.07 | · | · | · | · | |
| EPS (Diluted) | $-5.83 | $-6.29 | $-8.25 | $-10.12 | $-6.70 | $-3.07 | · | · | · | · | |
| Shares (Basic) | 98,600,000 | 90,500,000 | 73,500,000 | 69,914,225 | 67,795,540 | 60,845,550 | · | · | · | · | |
| Shares (Diluted) | 98,600,000 | 90,500,000 | 73,500,000 | 69,914,225 | 67,795,540 | 60,845,550 | · | · | · | · | |
| EBITDA | $-500M | $-500M | $-543M | $-631M | $-368M | $-318M | $-416M | $-352M | $-323M | $-245M |
资产负债表 29
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $421M | $174M | $214M | $133M | $308M | $714M | $434M | $113M | $100M | $161M | |
| Short-term Investments | · | · | · | · | · | · | $322M | $346M | $134M | $219M | |
| Receivables | $158M | $122M | $73M | $40M | $28M | $23M | $33M | $13M | $5M | · | |
| Inventory | $52M | $45M | $34M | $27M | $16M | $13M | $12M | $7M | $757.0K | · | |
| Prepaid Expense | $61M | $40M | $48M | $69M | $72M | $58M | $51M | $43M | $29M | $20M | |
| Other Current Assets | · | · | $48M | $69M | · | · | · | · | · | · | |
| Current Assets | $951M | $817M | $732M | $884M | $857M | $1.30B | $851M | $522M | $270M | $402M | |
| PP&E (Net) | $244M | $266M | $291M | $260M | $141M | $74M | $44M | $20M | $22M | $17M | |
| PP&E (Gross) | $380M | $378M | $374M | $323M | $191M | $111M | $70M | $38M | $33M | $23M | |
| Accum. Depreciation | $136M | $112M | $83M | $63M | $50M | $37M | $26M | $18M | $11M | $6M | |
| Goodwill | $44M | $44M | $44M | $44M | $44M | $44M | $44M | $44M | $44M | · | |
| Intangibles | $176M | $178M | $166M | $160M | $131M | $131M | $129M | $129M | $142M | · | |
| Other Non-current Assets | $60M | $63M | $58M | $48M | $21M | $9M | $3M | $4M | $3M | $2M | |
| Total Assets | $1.53B | $1.50B | $1.49B | $1.55B | $1.52B | $1.76B | $1.14B | $720M | $491M | $541M | |
| Accounts Payable | $31M | $39M | $42M | $43M | $17M | $13M | $13M | $12M | $9M | $5M | |
| Accrued Liabilities | $265M | $241M | $196M | $205M | $146M | $108M | $83M | $62M | $62M | $55M | |
| Current Liabilities | $384M | $344M | $280M | $261M | $181M | $190M | $103M | $75M | $71M | $60M | |
| Capital Leases | $24M | $30M | $31M | $20M | $30M | $39M | $30M | · | · | · | |
| Deferred Tax | $30M | $30M | $30M | $32M | $33M | $33M | $33M | $31M | $31M | · | |
| Other Non-current Liabilities | $44M | $17M | $12M | $5M | $1M | $7M | · | $5M | $5M | $6M | |
| Total Liabilities | $1.60B | $1.24B | $1.22B | $1.19B | $600M | $605M | $482M | $111M | $107M | $67M | |
| Common Stock | $0 | $0 | $82.0K | $70.0K | $69.0K | $67.0K | $58.0K | $51.0K | $44.0K | $41.0K | |
| Paid-in Capital | $4.45B | $4.21B | $3.66B | $3.14B | $3.00B | $2.77B | $2.09B | $1.64B | $1.22B | $1.00B | |
| Retained Earnings | $-4.53B | $-3.96B | $-3.39B | $-2.78B | $-2.07B | $-1.62B | $-1.43B | $-1.03B | $-833M | $-531M | |
| Treasury Stock | $8M | $4M | $432.0K | $0 | · | · | · | · | · | · | |
| AOCI | $1M | $-1M | $647.0K | $-7M | $-1M | $689.0K | $-147.0K | $-633.0K | $-6M | $905.0K | |
| Stockholders' Equity | $-80M | $255M | $275M | $352M | $923M | $1.15B | $654M | $609M | $383M | $474M | |
| Liabilities + Equity | $1.53B | $1.50B | $1.49B | $1.55B | $1.52B | $1.76B | $1.14B | $720M | $491M | $541M | |
| Shares Outstanding | 96,600,000 | 92,500,000 | 82,300,000 | 70,200,000 | 69,344,998 | 66,818,520 | 57,838,220 | 50,860,588 | 44,167,071 | 41,240,230 |
现金流 13
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $35M | $36M | $26M | $18M | $13M | $12M | $9M | $20M | $6M | $3M | |
| Stock-based Comp | · | · | · | · | · | · | · | · | $68M | $48M | |
| Deferred Tax | · | $-1M | $-2M | $2M | · | · | $2M | · | $-16M | · | |
| Other Non-cash | $74M | $118M | $104M | $310M | $102M | $42M | $47M | $-112M | $-9M | $33M | |
| Operating Cash Flow | $-466M | $-414M | $-475M | $-380M | $-339M | $-132M | $-345M | $-291M | $-254M | $-161M | |
| CapEx | $6M | $7M | $44M | $116M | $73M | $44M | $25M | $4M | $3M | $10M | |
| Investing Cash Flow | $236M | $-18M | $168M | $-292M | $-195M | $-179M | $-13M | $-33M | $55M | $91M | |
| Stock Issued | · | · | · | $0 | $0 | $436M | $330M | $271M | · | · | |
| Net Stock Activity | · | · | · | $0 | · | $436M | $330M | $271M | · | · | |
| Financing Cash Flow | $478M | $399M | $388M | $501M | $119M | $600M | $679M | $337M | $136M | $139M | |
| Net Change in Cash | $252M | $-35M | $81M | $-172M | $-417M | $290M | $321M | $12M | $-62M | $69M | |
| Taxes Paid | $4M | · | · | · | · | · | · | · | · | · | |
| Free Cash Flow | $-472M | $-422M | $-519M | $-497M | $-412M | $-176M | $-370M | $-295M | $-257M | $-171M |
盈利能力 7
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -79.5% | -95.7% | -131.1% | -178.6% | -108.6% | -121.8% | -409.0% | -721.2% | -12593.5% | -186471.4% | |
| Net Margin | -85.4% | -101.6% | -139.7% | -194.7% | -129.2% | -68.8% | -388.3% | -383.8% | -11567.3% | -184867.7% | |
| Pretax Margin | -84.8% | -101.3% | -140.1% | -193.1% | -128.9% | -68.4% | -385.1% | -382.8% | -12187.5% | -184841.4% | |
| EBITDA Margin | -74.3% | -89.3% | -125.1% | -173.6% | -104.9% | -117.3% | -400.8% | -683.2% | -12370.5% | -183897.0% | |
| ROA | -37.9% | -38.0% | -40.0% | -46.1% | -27.7% | -12.9% | -43.4% | -32.6% | -58.6% | -44.7% | |
| ROE | -1613.2% | -189.1% | -395.0% | -172.3% | -48.9% | -20.5% | -58.3% | -31.1% | -70.5% | -48.9% | |
| ROIC | 673.4% | -210.5% | -206.1% | -185.6% | -41.5% | -28.8% | -65.4% | -61.2% | -81.4% | -52.3% |
流动性与偿付能力 2
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.5 | 2.4 | 2.6 | 3.4 | 4.7 | 6.8 | 8.2 | 7.0 | 3.8 | 6.7 | |
| Quick Ratio | 1.5 | 0.9 | 1.0 | 0.7 | 1.9 | 3.9 | 7.6 | 6.3 | 3.4 | 6.3 |
效率 3
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.4 | 0.4 | 0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.1 | 0.0 | 0.0 | |
| Inventory Turnover | · | · | · | · | · | · | · | 0.3 | 0.0 | · | |
| Receivables Turnover | 4.8 | 5.7 | 7.6 | 10.6 | 13.6 | 9.7 | 4.6 | 5.7 | 1.0 | · |
增长率 3
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue YoY | 20.2% | 29.0% | 19.4% | 3.4% | 29.7% | · | · | · | · | · | |
| Revenue CAGR 3Y | 22.8% | 16.8% | 17.0% | · | · | · | · | · | · | · | |
| Revenue CAGR 5Y | 20.0% | · | · | · | · | · | · | · | · | · |
估值 (TTM) 10
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $673M | $560M | $434M | $363M | $351M | $271M | $104M | $51M | $3M | $133.0K | |
| Net Income TTM | $-575M | $-569M | $-607M | $-707M | $-454M | $-187M | $-403M | $-198M | $-302M | $-246M | |
| Market Cap | $2.22B | $3.89B | $3.94B | $3.25B | $5.83B | $9.25B | $2.47B | $2.21B | $2.05B | $2.90B | |
| P/E | -3.9 | -6.7 | -5.8 | -4.6 | -12.6 | -45.1 | -6.1 | -11.1 | · | · | |
| P/S | 3.3 | 6.9 | 9.1 | 9.0 | 16.6 | 34.1 | 23.8 | 42.9 | 784.3 | 21801.5 | |
| P/B | -27.8 | 15.2 | 14.3 | 9.2 | 6.3 | 8.0 | 3.8 | 3.6 | 5.3 | 6.1 | |
| P / Tangible Book | · | 117.9 | 61.2 | 22.1 | 7.8 | 9.4 | · | · | · | · | |
| P / Cash Flow | -4.8 | -9.4 | -8.3 | -8.5 | -17.2 | -70.0 | -7.2 | -7.6 | -8.1 | -18.0 | |
| P / FCF | -4.7 | -9.2 | -7.6 | -6.5 | -14.2 | -52.5 | -6.7 | -7.5 | -8.0 | -16.9 | |
| Earnings Yield | -25.4% | -14.9% | -17.2% | -21.8% | -8.0% | -2.2% | -16.4% | -9.0% | · | · |
损益表 14
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $214M | $136M | $207M | $160M | $167M | $139M | $165M | $139M | $147M | $109M | $127M | $98M | $108M | $100M | $103M | $91M | |
| R&D Expense | $167M | $187M | $203M | $216M | $165M | $166M | $188M | $170M | $162M | $178M | $160M | $157M | $165M | $166M | $171M | $237M | |
| SG&A Expense | $88M | $88M | $88M | $87M | $87M | $87M | $82M | $80M | $81M | $78M | $77M | $75M | $81M | $77M | $73M | $70M | |
| Operating Income | $-75M | $-169M | $-113M | $-171M | $-108M | $-143M | $-122M | $-132M | $-116M | $-165M | $-122M | $-145M | $-148M | $-154M | $-146M | $-225M | |
| Interest Income | $5M | $6M | $7M | $6M | $6M | $7M | $10M | $11M | $7M | $9M | $9M | $6M | $6M | $6M | $6M | $3M | |
| Other Non-op | $1M | · | $-934.0K | $-1M | $2M | $837.0K | $-5M | $3M | $-2M | $-2M | $1M | $-699.0K | $-2M | $308.0K | $180.0K | $-1M | |
| Pretax Income | $-91M | $-184M | $-128M | $-180M | $-114M | $-150M | $-133M | $-133M | $-131M | $-170M | $-127M | $-159M | $-159M | $-163M | $-153M | $-239M | |
| Income Tax | $1M | $1M | $870.0K | $873.0K | $1M | $1M | $384.0K | $303.0K | $858.0K | $455.0K | $-4M | $650.0K | $732.0K | $495.0K | $-1M | $6M | |
| Net Income | $-92M | $-185M | $-129M | $-180M | $-115M | $-151M | $-133M | $-134M | $-132M | $-171M | $-124M | $-160M | $-160M | $-164M | $-152M | $-245M | |
| EPS (Basic) | $-0.90 | $-1.84 | $-1.28 | $-1.81 | $-1.17 | $-1.57 | $-1.34 | $-1.40 | $-1.52 | $-2.03 | $-1.44 | $-2.23 | $-2.25 | $-2.33 | $-2.17 | $-3.50 | |
| EPS (Diluted) | $-0.90 | $-1.84 | $-1.28 | $-1.81 | $-1.17 | $-1.57 | $-1.34 | $-1.40 | $-1.52 | $-2.03 | $-1.44 | $-2.23 | $-2.25 | $-2.33 | $-2.17 | $-3.50 | |
| Shares (Basic) | 101,900,000 | 100,600,000 | -195,920,392 | 99,771,297 | 98,500,000 | 96,300,000 | -175,860,804 | 95,493,996 | 86,580,516 | 84,286,292 | -139,430,962 | 71,664,493 | 70,897,991 | 70,368,478 | -139,581,974 | 70,054,173 | |
| Shares (Diluted) | 101,900,000 | 100,600,000 | -195,920,392 | 99,771,297 | 98,500,000 | 96,300,000 | -175,860,804 | 95,493,996 | 86,580,516 | 84,286,292 | -139,430,962 | 71,664,493 | 70,897,991 | 70,368,478 | -139,581,974 | 70,054,173 | |
| EBITDA | $-75M | $-161M | · | $-171M | $-108M | $-134M | · | $-132M | $-116M | $-157M | · | $-145M | $-148M | $-149M | · | $-225M |
资产负债表 28
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $125M | $175M | $421M | $203M | $176M | $127M | $174M | $151M | $481M | $112M | $214M | $73M | $102M | $86M | $133M | $392M | |
| Receivables | $200M | $121M | $158M | $113M | $124M | $99M | $122M | $93M | $106M | $100M | · | $79M | $71M | $43M | · | $31M | |
| Inventory | $59M | $55M | $52M | $52M | $46M | $46M | $45M | $43M | $40M | $36M | · | $32M | $28M | $27M | · | $22M | |
| Prepaid Expense | $55M | $68M | $61M | $53M | $61M | $60M | $40M | · | · | · | · | $46M | $51M | $67M | · | $71M | |
| Other Current Assets | · | · | · | · | · | · | · | $41M | $55M | $48M | · | · | · | · | · | · | |
| Current Assets | $606M | $657M | $951M | $643M | $720M | $699M | $817M | $800M | $965M | $596M | · | $599M | $702M | $766M | · | $1.01B | |
| PP&E (Net) | $235M | $239M | $244M | $250M | $256M | $261M | $266M | $272M | $279M | $285M | · | $297M | $289M | $278M | · | $235M | |
| PP&E (Gross) | · | · | $380M | · | · | · | $378M | · | · | · | · | · | · | · | · | · | |
| Accum. Depreciation | · | · | $136M | · | · | · | $112M | · | · | · | · | · | · | · | · | · | |
| Goodwill | $44M | $44M | $44M | $44M | $44M | $44M | $44M | $44M | $44M | $44M | · | $44M | $44M | $44M | · | $44M | |
| Intangibles | $172M | $174M | $176M | $173M | $175M | $177M | $178M | $165M | $166M | $165M | · | $157M | $158M | $159M | · | $158M | |
| Other Non-current Assets | $63M | $61M | $60M | $58M | $60M | $62M | $63M | $54M | $54M | $60M | · | $28M | $26M | $22M | · | $18M | |
| Total Assets | $1.26B | $1.30B | $1.53B | $1.19B | $1.31B | $1.31B | $1.50B | $1.54B | $1.62B | $1.31B | · | $1.24B | $1.31B | $1.38B | · | $1.62B | |
| Accounts Payable | $39M | $42M | $31M | $41M | $34M | $47M | $39M | $36M | $60M | $41M | · | $33M | $42M | $59M | · | $24M | |
| Accrued Liabilities | $221M | $194M | $265M | $221M | $181M | $173M | $241M | $185M | $154M | $149M | · | $179M | $168M | $144M | · | $189M | |
| Current Liabilities | $351M | $325M | $384M | $340M | $293M | $292M | $344M | $285M | $273M | $246M | · | $254M | $244M | $218M | · | $227M | |
| Capital Leases | · | · | $24M | $22M | $25M | $28M | $30M | · | · | · | · | · | · | · | · | · | |
| Deferred Tax | $30M | $30M | $30M | $30M | $30M | $30M | $30M | $30M | $30M | $30M | · | $32M | $32M | $32M | · | $33M | |
| Other Non-current Liabilities | $41M | $42M | $20M | $19M | $17M | $17M | $17M | $16M | $15M | $14M | · | $10M | $10M | $9M | · | $4M | |
| Total Liabilities | $1.55B | $1.52B | $1.60B | $1.17B | $1.15B | $1.16B | $1.24B | $1.18B | $1.19B | $1.17B | · | $1.21B | $1.18B | $1.16B | · | $1.15B | |
| Common Stock | $0 | $0 | $0 | $96.0K | $96.0K | $94.0K | $0 | $92.0K | $92.0K | $83.0K | · | $72.0K | $71.0K | $71.0K | · | $70.0K | |
| Paid-in Capital | $4.52B | $4.48B | $4.45B | $4.41B | $4.37B | $4.25B | $4.21B | $4.17B | $4.12B | $3.70B | · | $3.30B | $3.24B | $3.17B | · | $3.11B | |
| Retained Earnings | $-4.81B | $-4.72B | $-4.53B | $-4.40B | $-4.22B | $-4.11B | $-3.96B | $-3.82B | $-3.69B | $-3.56B | · | $-3.26B | $-3.10B | $-2.94B | · | $-2.63B | |
| Treasury Stock | $10M | $10M | $8M | $8M | $8M | $8M | $4M | $4M | $3M | $3M | · | $381.0K | $381.0K | $356.0K | · | · | |
| AOCI | $0 | $0 | $1M | $820.0K | $-268.0K | $-341.0K | $-1M | $896.0K | $-1M | $-431.0K | · | $-2M | $-3M | $-4M | · | $-10M | |
| Stockholders' Equity | $-291M | $-236M | $-80M | $9M | $151M | $144M | $255M | $347M | $432M | $140M | $275M | $32M | $129M | $220M | $352M | $469M | |
| Liabilities + Equity | $1.26B | $1.30B | $1.53B | $1.19B | $1.31B | $1.31B | $1.50B | $1.54B | $1.62B | $1.31B | · | $1.24B | $1.31B | $1.38B | · | $1.62B | |
| Shares Outstanding | 98,600,000 | 98,300,000 | 96,600,000 | 96,442,027 | 96,353,634 | 93,903,785 | 92,500,000 | 92,304,317 | 92,135,384 | 83,094,037 | 82,300,000 | 72,174,307 | 71,465,424 | 70,660,249 | 70,197,297 | 70,079,777 |
现金流 8
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $8M | $8M | $9M | $9M | $9M | $9M | $10M | $9M | $9M | $9M | $8M | $7M | $5M | $5M | $5M | $5M | |
| Other Non-cash | · | $-20M | · | · | · | $-24M | · | · | · | $-29M | · | · | · | $2M | · | · | |
| Operating Cash Flow | $-97M | $-197M | $-100M | $-91M | $-108M | $-166M | $-79M | $-67M | $-77M | $-191M | $-84M | $-118M | $-116M | $-157M | $-90M | $-95M | |
| CapEx | $1M | $1M | $938.0K | $1M | $2M | $1M | $163.0K | $2M | $2M | $3M | $1M | $4M | $14M | $25M | $27M | $26M | |
| Investing Cash Flow | $44M | $-49M | $-72M | $117M | $71M | $120M | $103M | $-276M | $61M | $94M | $-107M | $64M | $99M | $111M | $-172M | $-162M | |
| Financing Cash Flow | · | · | $394M | $2.0K | $84M | $157.0K | $3M | $11M | $385M | $-58.0K | $330M | $25M | $33M | $-722.0K | $2M | $492M | |
| Net Change in Cash | $-49M | $-247M | $221M | $26M | $49M | $-45M | $24M | $-330M | $368M | $-97M | $140M | $-29M | $16M | $-46M | $-259M | $234M | |
| Free Cash Flow | · | $-198M | · | · | · | $-168M | · | · | · | $-194M | · | · | · | $-182M | · | · |
盈利能力 7
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -35.0% | -124.3% | · | -106.8% | -64.8% | -102.6% | · | -94.6% | -79.1% | -151.9% | · | -148.0% | -136.6% | -153.3% | · | -248.1% | |
| Net Margin | -43.0% | -136.0% | · | -112.8% | -69.0% | -108.5% | · | -95.7% | -89.5% | -156.8% | · | -162.8% | -147.6% | -163.2% | · | -270.2% | |
| Pretax Margin | -42.5% | -135.3% | · | -112.3% | -68.5% | -107.5% | · | -95.5% | -88.9% | -156.4% | · | -162.2% | -146.9% | -162.7% | · | -263.3% | |
| EBITDA Margin | -35.0% | -118.4% | · | -106.8% | -64.8% | -96.2% | · | -94.6% | -79.1% | -143.8% | · | -148.0% | -136.6% | -148.1% | · | -248.1% | |
| ROA | -7.2% | -14.2% | · | -13.2% | -7.9% | -11.5% | · | -9.6% | -9.0% | -12.7% | · | -11.2% | -12.2% | -11.8% | · | -15.8% | |
| ROE | 131.7% | 403.2% | · | -101.4% | -39.4% | -106.2% | · | -70.5% | -46.9% | -94.6% | · | -63.8% | -39.6% | -32.2% | · | -34.9% | |
| ROIC | 26.1% | 72.0% | · | -1874.9% | -71.9% | -100.0% | · | -38.1% | -27.1% | -118.2% | · | -459.4% | -115.2% | -70.1% | · | -49.3% |
流动性与偿付能力 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 1.7 | 2.0 | · | 1.9 | 2.5 | 2.4 | · | 2.8 | 3.5 | 2.4 | · | 2.4 | 2.9 | 3.5 | · | 4.5 | |
| Quick Ratio | 0.9 | 0.9 | · | 0.9 | 1.0 | 0.8 | · | 0.9 | 2.1 | 0.9 | · | 0.6 | 0.7 | 0.6 | · | 1.9 |
效率 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.2 | 0.1 | · | 0.1 | 0.1 | 0.1 | · | 0.1 | 0.1 | 0.1 | · | 0.1 | 0.1 | 0.1 | · | 0.1 | |
| Receivables Turnover | 1.3 | 1.2 | · | 1.6 | 1.4 | 1.4 | · | 1.6 | 1.7 | 1.5 | · | 1.8 | 2.0 | 2.8 | · | 3.2 |
估值 (TTM) 10
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $677M | $601M | · | $605M | $592M | $535M | · | $493M | $462M | $416M | · | $398M | $389M | $360M | · | $342M | |
| Net Income TTM | $-572M | $-631M | · | $-580M | $-531M | $-587M | · | $-595M | $-622M | $-654M | · | $-729M | $-727M | $-720M | · | $-629M | |
| Market Cap | $3.29B | $2.06B | · | $2.90B | $3.50B | $3.40B | · | $5.13B | $3.79B | $3.88B | · | $2.57B | $3.30B | $2.83B | · | $2.90B | |
| P/E | -5.8 | -3.3 | · | -5.1 | -6.4 | -5.6 | · | -7.7 | -5.1 | -5.3 | · | -3.5 | -4.5 | -3.9 | · | -4.6 | |
| P/S | 4.9 | 3.4 | · | 4.8 | 5.9 | 6.4 | · | 10.4 | 8.2 | 9.3 | · | 6.5 | 8.5 | 7.9 | · | 8.5 | |
| P/B | -11.3 | -8.7 | · | 316.7 | 23.2 | 23.6 | · | 14.8 | 8.8 | 27.7 | · | 81.1 | 25.5 | 12.9 | · | 6.2 | |
| P / Tangible Book | · | · | · | · | · | · | · | 37.3 | 17.1 | · | · | · | · | 167.6 | · | 10.9 | |
| P / Cash Flow | · | -10.5 | · | · | · | -20.4 | · | · | · | -20.3 | · | · | · | -18.1 | · | · | |
| P / FCF | · | -10.4 | · | · | · | -20.3 | · | · | · | -20.0 | · | · | · | -15.6 | · | · | |
| Earnings Yield | -17.1% | -30.5% | · | -19.8% | -15.6% | -18.0% | · | -12.9% | -19.5% | -18.9% | · | -28.9% | -22.4% | -25.6% | · | -21.8% |
财务报表 损益表、资产负债表、现金流量表 — 年度，近5年
损益表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| 收入 | $673M | $560M | $434M | $363M | $351M |
| 营业利润率 % | -79.5% | -95.7% | -131.1% | -178.6% | -108.6% |
| 净收入 | $-575M | $-569M | $-607M | $-707M | $-454M |
| 稀释后每股收益 (EPS) | $-5.83 | $-6.29 | $-8.25 | $-10.12 | $-6.70 |
资产负债表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| 流动比率 | 2.5 | 2.4 | 2.6 | 3.4 | 4.7 |
| 速动比率 | 1.5 | 0.9 | 1.0 | 0.7 | 1.9 |
现金流
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| 自由现金流 | $-472M | $-422M | $-519M | $-497M | $-412M |
最新新闻 提及该公司的近期头条新闻
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机构持有人 (13F) 347 家申报者 · $2.7B 总计 · 截至 2026年6月30日
在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸；单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存，而非方向性判断。
机构活动 — Q2 2026 与上一季度对比
| 新仓位 | 已退出持仓 | 增加 | 减少 | 净股数变动 |
|---|---|---|---|---|
| 63 (-1 与上一季度对比) | 37 (-8 与上一季度对比) | 118 (-8 与上一季度对比) | 98 (+11 与上一季度对比) | -486K |
与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天，外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过，优先显示最近一个已完整报告的季度对。
| 机构 | 价值 | 股份 | % 已追踪的13F | 类型 |
|---|---|---|---|---|
| RTW INVESTMENTS, LP | $260338324 | 7796895 | 9.48% | 股份 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $226722608 | 6790135 | 8.26% | 股份 |
| STATE STREET CORP | $205641197 | 6158766 | 7.49% | 股份 |
| VANGUARD CAPITAL MANAGEMENT LLC | $143459834 | 4296491 | 5.22% | 股份 |
| TWO SIGMA INVESTMENTS, LP | $120911868 | 3621200 | 4.40% | 股份 |
| SANDS CAPITAL MANAGEMENT, LLC | $105457908 | 3158368 | 3.84% | 股份 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $98157217 | 2939719 | 3.57% | 股份 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $95092590 | 2847936 | 3.46% | 股份 |
| GEODE CAPITAL MANAGEMENT, LLC | $73869758 | 2211828 | 2.69% | 股份 |
| Bellevue Group AG | $66204857 | 1982775 | 2.41% | 股份 |
| Sofinnova Investments, Inc. | $57347492 | 1717505 | 2.09% | 股份 |
| D. E. Shaw & Co., Inc. | $54716761 | 1638717 | 1.99% | 股份 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $52756200 | 1580000 | 1.92% | 股份 |
| MPM BIOIMPACT LLC | $47354199 | 1418215 | 1.72% | 股份 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $41455555 | 1241556 | 1.51% | 股份 |
| Candriam S.C.A. | $33419286 | 1001841 | 1.22% | 股份 |
| Rock Springs Capital Management LP | $32316678 | 967855 | 1.18% | 股份 |
| Jefferies Financial Group Inc. | $31040212 | 929626 | 1.13% | 股份 |
| Eagle Health Investments LP | $29520800 | 884121 | 1.07% | 股份 |
| Qube Research & Technologies Ltd | $29457292 | 882219 | 1.07% | 股份 |
| WELLINGTON MANAGEMENT GROUP LLP | $27926528 | 836374 | 1.02% | 股份 |
| MILLENNIUM MANAGEMENT LLC | $25403947 | 760825 | 0.92% | 股份 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25377702 | 760039 | 0.92% | 股份 |
| Caption Management, LLC | $24000732 | 718800 | 0.87% | 卖出期权 |
| BANK OF AMERICA CORP /DE/ | $23505893 | 703980 | 0.86% | 股份 |
| Pictet Asset Management Holding SA | $23159948 | 753695 | 0.84% | 股份 |
| VANGUARD FIDUCIARY TRUST CO | $22418413 | 671411 | 0.82% | 股份 |
| GREAT POINT PARTNERS LLC | $20034000 | 600000 | 0.73% | 卖出期权 |
| Palo Alto Investors LP | $19916968 | 596495 | 0.73% | 股份 |
| SPHERA FUNDS MANAGEMENT LTD. | $19649815 | 588494 | 0.72% | 股份 |
| PANAGORA ASSET MANAGEMENT INC | $19574220 | 586230 | 0.71% | 股份 |
| Trexquant Investment LP | $18577695 | 556385 | 0.68% | 股份 |
| BlackRock, Inc. | $18510448 | 554371 | 0.67% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $16995510 | 509000 | 0.62% | 卖出期权 |
| Sofinnova Investments, Inc. | $16695000 | 500000 | 0.61% | 买入期权 |
| BNP PARIBAS FINANCIAL MARKETS | $16633796 | 498167 | 0.61% | 股份 |
| TORONTO DOMINION BANK | $13856850 | 415000 | 0.50% | 股份 |
| VANGUARD GROUP INC | $13818814 | 600818 | 0.50% | 股份 |
| RENAISSANCE TECHNOLOGIES LLC | $13813443 | 413700 | 0.50% | 股份 |
| Caption Management, LLC | $13753341 | 411900 | 0.50% | 买入期权 |
| Cutter Capital Management, LP | $13734562 | 379303 | 0.50% | 股份 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $13624489 | 408041 | 0.50% | 股份 |
| ALGERT GLOBAL LLC | $13020898 | 389964 | 0.47% | 股份 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $12735614 | 381420 | 0.46% | 股份 |
| AXA Investment Managers S.A. | $12549316 | 417198 | 0.46% | 股份 |
| SummitTX Capital, L.P. | $12496875 | 374270 | 0.46% | 股份 |
| GOLDMAN SACHS GROUP INC | $12394401 | 371201 | 0.45% | 股份 |
| Privium Fund Management B.V. | $11312532 | 338800 | 0.41% | 股份 |
| Squarepoint Ops LLC | $11298108 | 338368 | 0.41% | 股份 |
| Walleye Capital LLC | $11180775 | 334854 | 0.41% | 股份 |
| TWO SIGMA ADVISERS, LP | $11076800 | 481600 | 0.40% | 股份 |
| Catalio Capital Management, LP | $10559654 | 316252 | 0.38% | 股份 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $9944000 | 297819 | 0.36% | 股份 |
| Ensign Peak Advisors, Inc | $9710413 | 290818 | 0.35% | 股份 |
| GordonMD Global Investments LP | $9653082 | 289101 | 0.35% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9215640 | 276000 | 0.34% | 买入期权 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $8929454 | 267429 | 0.33% | 股份 |
| FMR LLC | $8597725 | 257494 | 0.31% | 股份 |
| Quantinno Capital Management LP | $8363060 | 250466 | 0.30% | 股份 |
| JPMORGAN CHASE & CO | $7279842 | 232755 | 0.27% | 股份 |
| KENNEDY CAPITAL MANAGEMENT LLC | $7212140 | 215997 | 0.26% | 股份 |
| WORLDQUANT MILLENNIUM ADVISORS LLC | $7157948 | 214374 | 0.26% | 股份 |
| CITADEL ADVISORS LLC | $7029630 | 210531 | 0.26% | 股份 |
| Ishara Investments LP | $6844950 | 205000 | 0.25% | 股份 |
| Man Group plc | $6508245 | 194916 | 0.24% | 股份 |
| FIFTH THIRD BANCORP | $6452150 | 193236 | 0.23% | 股份 |
| Connor, Clark & Lunn Investment Management Ltd. | $6396789 | 191578 | 0.23% | 股份 |
| Blue Owl Capital Holdings LP | $6098283 | 182638 | 0.22% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6039283 | 180871 | 0.22% | 股份 |
| Woodline Partners LP | $5736569 | 171805 | 0.21% | 股份 |
| Atom Investors LP | $5735434 | 171771 | 0.21% | 股份 |
| Swiss National Bank | $5597900 | 167652 | 0.20% | 股份 |
| Ikarian Capital, LLC | $5529952 | 165617 | 0.20% | 股份 |
| Stonepine Capital Management, LLC | $5500000 | 200000 | 0.20% | 买入期权 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $5260270 | 171456 | 0.19% | 股份 |
| BOOTHBAY FUND MANAGEMENT, LLC | $5229275 | 156612 | 0.19% | 股份 |
| Cubist Systematic Strategies, LLC | $5194035 | 172674 | 0.19% | 股份 |
| Eversept Partners, LP | $5146401 | 154130 | 0.19% | 股份 |
| MARSHALL WACE, LLP | $5053810 | 151357 | 0.18% | 股份 |
| Ghisallo Capital Management LLC | $5008500 | 150000 | 0.18% | 股份 |
| Mariner, LLC | $4887301 | 146400 | 0.18% | 股份 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $4841550 | 145000 | 0.18% | 股份 |
| FRED ALGER MANAGEMENT, LLC | $4779945 | 143155 | 0.17% | 股份 |
| Corient Private Wealth LP | $4644350 | 139094 | 0.17% | 股份 |
| SR One Capital Management, LP | $4599573 | 137753 | 0.17% | 股份 |
| B Group, Inc. | $4507650 | 135000 | 0.16% | 股份 |
| PINNACLE ASSOCIATES LTD | $4377563 | 131104 | 0.16% | 股份 |
| Caption Management, LLC | $4340700 | 130000 | 0.16% | 股份 |
| MOORE CAPITAL MANAGEMENT, LP | $4275089 | 128035 | 0.16% | 股份 |
| RHUMBLINE ADVISERS | $4144518 | 124125 | 0.15% | 股份 |
| Apollon Wealth Management, LLC | $4121962 | 123449 | 0.15% | 股份 |
| Odyssean, LLC | $4076485 | 122087 | 0.15% | 股份 |
| Assenagon Asset Management S.A. | $4035649 | 120864 | 0.15% | 股份 |
| EFG Asset Management (North America) Corp. | $3848509 | 127985 | 0.14% | 股份 |
| BARCLAYS PLC | $3742919 | 112097 | 0.14% | 股份 |
| IEQ CAPITAL, LLC | $3540194 | 106026 | 0.13% | 股份 |
| Rafferty Asset Management, LLC | $3394260 | 101655 | 0.12% | 股份 |
| Crestwood Advisors Group, LLC | $3348149 | 100274 | 0.12% | 股份 |
| Tetragon Partners GP Ltd | $3339000 | 100000 | 0.12% | 买入期权 |
| CITADEL ADVISORS LLC | $3308949 | 99100 | 0.12% | 卖出期权 |
公司内部人士 28 位内幕人士 · 15 位高管 · 11 位董事
| 内部人士 | 角色 | 上次活动 | 持股数量 | 买入 12个月 | 卖出 12个月 | 净额 12个月 |
|---|---|---|---|---|---|---|
| Emil D Kakkis | President & CEO | 2026年4月16日 A | 735739 | 0 | 1 | $-1240411 |
| Howard Horn | Chief Financial Officer | 2026年8月3日 S | 96295 | 0 | 12 | $-1332021 |
| Mardi Dier | CFO & Executive Vice President | 2022年10月14日 S | 66695 | 0 | 0 | $0 |
| Wladimir Hogenhuis | Chief Operating Officer | 2019年10月4日 F | 18703 | 0 | 0 | $0 |
| Karah Herdman Parschauer | EVP and Chief Legal Officer | 2026年8月3日 S | 92562 | 0 | 5 | $-487890 |
| Eric Crombez | EVP and Chief Medical Officer | 2026年5月5日 S | 111189 | 0 | 2 | $-168847 |
| Theodore Alan Huizenga | SVP, Chief Accounting Officer | 2026年4月22日 A | 68911 | 0 | 4 | $-44636 |
| Erik Harris | EVP & Chief Commercial Officer | 2026年4月16日 A | 118410 | 0 | 1 | $-240289 |
| John Richard Pinion | EVP, Chief Quality Operations Officer | 2026年4月16日 A | 133142 | 0 | 1 | $-228661 |
| Dennis Karl Huang | EVP, Chief Technical Operations Officer | 2026年4月16日 A | 147845 | 0 | 0 | $0 |
| Thomas Richard Kassberg | CBO & EVP | 2025年3月3日 F | 264730 | 0 | 0 | $0 |
| Camille L Bedrosian | EVP and Chief Medical Officer | 2023年3月1日 S | 46720 | 0 | 0 | $0 |
| Shalini Sharp | EVP, Finance | 2020年10月14日 S | 97812 | 0 | 0 | $0 |
| Jayson Donald Alexander Dallas | EVP & Chief Commercial Officer | 2018年6月1日 F | 23830 | 0 | 0 | $0 |
| Sunil Agarwal | Chief Medical Officer | 2015年5月21日 A | 29400 | 0 | 0 | $0 |
| Corazon (Corsee) D. Sanders | 董事 | 2026年6月15日 S | 21095 | 0 | 1 | $-50100 |
| Deborah Dunsire | 董事 | 2026年5月14日 A | 38566 | 0 | 0 | $0 |
| Daniel G Welch | 董事 | 2026年5月14日 A | 40441 | 0 | 0 | $0 |
| Amrit Ray | 董事 | 2025年5月15日 A | 23365 | 0 | 0 | $0 |
| Shehnaaz Suliman | 董事 | 2025年5月15日 A | 25940 | 0 | 0 | $0 |
| Lars Ekman | 董事 | 2022年6月24日 A | 17745 | 0 | 0 | $0 |
| William Aliski | 董事 | 2021年6月24日 A | 66849 | 0 | 0 | $0 |
| Clay B Siegall | 董事 | 2020年8月10日 M | 2550 | 0 | 0 | $0 |
| Eran Nadav | 董事 | 2014年7月10日 A | — | 0 | 0 | $0 |
| Marten Steen | 董事 | 2014年1月30日 A | — | 0 | 0 | $0 |
| Matthew K Fust | — | 2026年5月14日 A | 33696 | 0 | 0 | $0 |
| Michael Narachi | — | 2026年5月14日 A | 40441 | 0 | 0 | $0 |
| FMR LLC | — | 2014年8月1日 J | 1457994 | 0 | 0 | $0 |
来自SEC表格3/4/5申报的内部人士；净额=仅公开市场买卖
激进投资者及 5%+ 股东 1 持仓
提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权，意图影响发行人（激进股东持股、董事会活动、并购）。每一行显示该申报人持仓的最新已知状态。
| 申报人 | 已申报 | 持股 | 状态 | 目的 | 申报 |
|---|---|---|---|---|---|
| Ultragenyx Pharmaceutical Inc. | 2020年11月6日 | — | 初始申报 | 被动投资 | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF持仓 由 48 只交易所交易基金持有
权重仅反映直接股权持仓（N-PORT）；杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。
| 基金 | 权重 | 单位 | 截至 | 来源 |
|---|---|---|---|---|
| TMFS · RBB Fund, Inc. | 3.03% | 74931 NS | 2026年5月31日 | N-PORT |
| GNOM · Global X Funds | 2.25% | 52426 NS | 2026年5月31日 | N-PORT |
| HAPS · Harbor ETF Trust | 1.31% | 83707 NS | 2026年4月30日 | N-PORT |
| BBP · ETFis Series Trust I | 1.09% | 26120 NS | 2026年4月30日 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.85% | 178057 NS | 2026年4月30日 | N-PORT |
| MMLG · First Trust Exchange-Traded Fund ... | 0.36% | 13877 NS | 2026年5月31日 | N-PORT |
| ESSC · Strategy Shares | 0.31% | 3204 NS | 2026年4月30日 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.17% | 194551 SH | 2026年8月21日 | 每日 |
| IBBQ · Invesco Exchange-Traded Fund Trus... | 0.16% | 5799 SH | 2026年8月21日 | 每日 |
| IBB · iShares Trust | 0.16% | 671711 SH | 2026年8月21日 | 每日 |
| FYC · First Trust Exchange-Traded Alpha... | 0.13% | 54688 NS | 2026年4月30日 | N-PORT |
| BIB · ProShares Trust | 0.12% | 3571 NS | 2026年5月31日 | N-PORT |
| BBSC · J.P. Morgan Exchange-Traded Fund ... | 0.12% | 34325 NS | 2026年4月30日 | N-PORT |
| GINN · Goldman Sachs ETF Trust | 0.11% | 9780 NS | 2026年5月31日 | N-PORT |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.11% | 46526 SH | 2026年8月19日 | 每日 |
| BKSE · BNY Mellon ETF Trust | 0.10% | 3381 NS | 2026年4月30日 | N-PORT |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.10% | 556246 SH | 2026年8月19日 | 每日 |
| VBK · VANGUARD INDEX FUNDS | 0.09% | 1238640 SH | 2026年8月19日 | 每日 |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.09% | 46723 SH | 2026年8月19日 | 每日 |
| IWN · iShares Trust | 0.09% | 493218 SH | 2026年8月21日 | 每日 |
| IWM · iShares Trust | 0.08% | 2463491 SH | 2026年8月21日 | 每日 |
| IWO · iShares Trust | 0.07% | 405050 SH | 2026年8月21日 | 每日 |
| ESML · iShares Trust | 0.05% | 59240 SH | 2026年8月21日 | 每日 |
| ISCV · iShares Trust | 0.05% | 14131 SH | 2026年8月21日 | 每日 |
| SCHA · SCHWAB STRATEGIC TRUST | 0.05% | 463045 NS | 2026年5月31日 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.04% | 1127405 SH | 2026年8月19日 | 每日 |
| VB · VANGUARD INDEX FUNDS | 0.04% | 2146622 SH | 2026年8月19日 | 每日 |
| VHT · VANGUARD WORLD FUND | 0.04% | 251571 SH | 2026年8月19日 | 每日 |
| ISCB · iShares Trust | 0.04% | 4391 SH | 2026年8月21日 | 每日 |
| FHLC · FIDELITY COVINGTON TRUST | 0.03% | 39736 NS | 2026年4月30日 | N-PORT |
| FAD · First Trust Exchange-Traded Alpha... | 0.03% | 5097 NS | 2026年4月30日 | N-PORT |
| ISCG · iShares Trust | 0.03% | 10374 SH | 2026年8月21日 | 每日 |
| WSML · iShares Trust | 0.02% | 4961 SH | 2026年8月21日 | 每日 |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.01% | 3648 NS | 2026年5月31日 | N-PORT |
| ESGV · VANGUARD WORLD FUND | 0.01% | 21519 SH | 2026年8月19日 | 每日 |
| GGUS · Goldman Sachs ETF Trust | 0.01% | 1628 NS | 2026年5月31日 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 32531 NS | 2026年5月31日 | N-PORT |
| ITOT · iShares Trust | 0.00% | 141009 SH | 2026年8月21日 | 每日 |
| TILT · FlexShares Trust | 0.00% | 3080 NS | 2026年4月30日 | N-PORT |
| JUST · Goldman Sachs ETF Trust | 0.00% | 859 NS | 2026年5月31日 | N-PORT |
| RECS · Columbia ETF Trust I | 0.00% | 7427 NS | 2026年4月30日 | N-PORT |
| IWV · iShares Trust | 0.00% | 25558 SH | 2026年8月21日 | 每日 |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 56898 NS | 2026年5月31日 | N-PORT |
| MSLC · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 3007 NS | 2026年5月31日 | N-PORT |
| AVUQ · AMERICAN CENTURY ETF TRUST | 0.00% | 129 NS | 2026年5月31日 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 2987783 SH | 2026年8月19日 | 每日 |
| VT · VANGUARD INTERNATIONAL EQUITY IND... | 0.00% | 76072 SH | 2026年8月19日 | 每日 |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 8035 SH | 2026年8月19日 | 每日 |