| MORGAN STANLEY |
$44184173 |
9461279 |
9.54% |
股份
|
| FMR LLC |
$38862138 |
8321657 |
8.39% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$37208011 |
7967454 |
8.03% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$37049403 |
7933491 |
8.00% |
股份
|
| Saturn V Capital Management LP |
$32565512 |
6973343 |
7.03% |
股份
|
| Empery Asset Management, LP |
$32365860 |
6930591 |
6.99% |
股份
|
| Deep Track Capital, LP |
$27453795 |
5878757 |
5.93% |
股份
|
| BlackRock, Inc. |
$25941411 |
5554906 |
5.60% |
股份
|
| Kalehua Capital Management LLC |
$17385663 |
3722840 |
3.75% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$17353062 |
3715859 |
3.75% |
股份
|
| Rosalind Advisors, Inc. |
$15012957 |
3214766 |
3.24% |
股份
|
| VANGUARD GROUP INC |
$13694648 |
3423662 |
2.96% |
股份
|
| BRAIDWELL LP |
$13649261 |
2922754 |
2.95% |
股份
|
| Blackstone Inc. |
$12524576 |
2681922 |
2.70% |
股份
|
| Trails Edge Capital Partners, LP |
$12008803 |
2571478 |
2.59% |
股份
|
| Nantahala Capital Management, LLC |
$11439016 |
2449468 |
2.47% |
股份
|
| BVF INC/IL |
$10431575 |
2233742 |
2.25% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9800562 |
2098047 |
2.12% |
股份
|
| Venrock Adviser, LLC |
$9032962 |
1934253 |
1.95% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$6517391 |
1395587 |
1.41% |
股份
|
| STATE STREET CORP |
$6052399 |
1296017 |
1.31% |
股份
|
| Woodline Partners LP |
$4675114 |
1001095 |
1.01% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4280223 |
916536 |
0.92% |
股份
|
| NORTHERN TRUST CORP |
$3048805 |
652849 |
0.66% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2671417 |
572038 |
0.58% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2531738 |
542128 |
0.55% |
股份
|
| Verdad Advisers, LP |
$1644274 |
352093 |
0.35% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1229443 |
263264 |
0.27% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1168901 |
250300 |
0.25% |
买入期权
|
| Caption Management, LLC |
$1167500 |
250000 |
0.25% |
买入期权
|
| Stonepine Capital Management, LLC |
$1050699 |
224989 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$916908 |
196340 |
0.20% |
股份
|
| Affinity Asset Advisors, LLC |
$677150 |
145000 |
0.15% |
股份
|
| Nuveen, LLC |
$501507 |
107389 |
0.11% |
股份
|
| Invesco Ltd. |
$451926 |
96772 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$447040 |
95726 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$444022 |
95081 |
0.10% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$407607 |
87282 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$368393 |
78885 |
0.08% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$349293 |
74795 |
0.08% |
股份
|
| CITIGROUP INC |
$327423 |
70112 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$316215 |
67712 |
0.07% |
股份
|
| Palumbo Wealth Management LLC |
$313432 |
67116 |
0.07% |
股份
|
| Squarepoint Ops LLC |
$313254 |
67078 |
0.07% |
股份
|
| UBS Group AG |
$271060 |
58043 |
0.06% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$241906 |
51800 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$224015 |
47969 |
0.05% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$218841 |
46861 |
0.05% |
股份
|
| Point72 Asset Management, L.P. |
$191806 |
41072 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$173131 |
37073 |
0.04% |
股份
|
| Jump Financial, LLC |
$159961 |
34253 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$154003 |
32977 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$141925 |
33552 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$111361 |
23846 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$106850 |
22880 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$103128 |
22083 |
0.02% |
股份
|
| BARCLAYS PLC |
$90780 |
19439 |
0.02% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$90719 |
19426 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$86483 |
18519 |
0.02% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$84527 |
18100 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$80744 |
17290 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$77055 |
16500 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$76513 |
16384 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$73963 |
15838 |
0.02% |
股份
|
| CAXTON CORP |
$72650 |
15557 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$67248 |
14400 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$65614 |
14050 |
0.01% |
股份
|
| Creative Planning |
$64782 |
13872 |
0.01% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$60215 |
14580 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$58375 |
12500 |
0.01% |
股份
|
| ProShare Advisors LLC |
$49445 |
10588 |
0.01% |
股份
|
| Indivisible Partners |
$46850 |
10000 |
0.01% |
股份
|
| Pettinga Financial Advisors LLC |
$46700 |
10000 |
0.01% |
股份
|
| Legal & General Group Plc |
$36697 |
7858 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$36169 |
7745 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$34268 |
7338 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$33520 |
7178 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$12000 |
2559 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$9966 |
2914 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$8215 |
1759 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7607 |
1629 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$7408 |
2166 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5198 |
1113 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$3325 |
712 |
0.00% |
股份
|
| Bleichroeder LP |
$2779 |
595 |
0.00% |
股份
|
| Blue Trust, Inc. |
$1326 |
284 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$356 |
76314 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$310 |
66379 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$154 |
33 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$153 |
38 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$140 |
30 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$42 |
9 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$28 |
6 |
0.00% |
股份
|