| RTW INVESTMENTS, LP |
$124906608 |
6574032 |
15.35% |
股份
|
| TCG Crossover Management, LLC |
$116614913 |
6137627 |
14.33% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$109127127 |
5743533 |
13.41% |
股份
|
| ADAR1 Capital Management, LLC |
$64011646 |
3369034 |
7.87% |
股份
|
| FMR LLC |
$53489066 |
2815214 |
6.57% |
股份
|
| GOLDMAN SACHS GROUP INC |
$43994120 |
2315480 |
5.41% |
股份
|
| Woodline Partners LP |
$41938567 |
2207293 |
5.15% |
股份
|
| Frazier Life Sciences Management, L.P. |
$36144080 |
1902320 |
4.44% |
股份
|
| BAMCO INC /NY/ |
$30850186 |
1623694 |
3.79% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$24688486 |
1299394 |
3.03% |
股份
|
| CITADEL ADVISORS LLC |
$24409414 |
1284706 |
3.00% |
股份
|
| Rock Springs Capital Management LP |
$15479433 |
814707 |
1.90% |
股份
|
| BlackRock, Inc. |
$12624778 |
664462 |
1.55% |
股份
|
| JANE STREET GROUP, LLC |
$9054279 |
476541 |
1.11% |
股份
|
| B Group, Inc. |
$8562274 |
450646 |
1.05% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$7238204 |
393167 |
0.89% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$6582854 |
346466 |
0.81% |
股份
|
| Aberdeen Group plc |
$5914586 |
311294 |
0.73% |
股份
|
| CITIGROUP INC |
$5714725 |
300775 |
0.70% |
股份
|
| Spruce Street Capital LP |
$5303090 |
279110 |
0.65% |
股份
|
| AMERIPRISE FINANCIAL INC |
$4810249 |
253171 |
0.59% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$4692658 |
246982 |
0.58% |
股份
|
| Hudson Bay Capital Management LP |
$4085000 |
215000 |
0.50% |
股份
|
| JANE STREET GROUP, LLC |
$3864600 |
203400 |
0.47% |
卖出期权
|
| Nantahala Capital Management, LLC |
$3800000 |
200000 |
0.47% |
股份
|
| NEXTBio Capital Management LP |
$3483878 |
183362 |
0.43% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$2960447 |
155813 |
0.36% |
股份
|
| Seven Fleet Capital Management LP |
$2924756 |
136016 |
0.36% |
股份
|
| MARSHALL WACE, LLP |
$2797123 |
147217 |
0.34% |
股份
|
| D. E. Shaw & Co., Inc. |
$2682002 |
141158 |
0.33% |
股份
|
| Privium Fund Management B.V. |
$2321591 |
122189 |
0.29% |
股份
|
| STATE STREET CORP |
$2296074 |
120846 |
0.28% |
股份
|
| AXA Investment Managers S.A. |
$2230436 |
65814 |
0.27% |
股份
|
| ALPS ADVISORS INC |
$2098189 |
110431 |
0.26% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2086200 |
109800 |
0.26% |
卖出期权
|
| DIMENSIONAL FUND ADVISORS LP |
$1934621 |
101997 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1454735 |
76565 |
0.18% |
股份
|
| Legal & General Group Plc |
$1358116 |
71461 |
0.17% |
股份
|
| UBS Group AG |
$1319626 |
69454 |
0.16% |
股份
|
| Orion Portfolio Solutions, LLC |
$1310400 |
36259 |
0.16% |
股份
|
| Virtus Investment Advisers, LLC |
$1294356 |
68124 |
0.16% |
股份
|
| Headlands Technologies LLC |
$1292190 |
68010 |
0.16% |
股份
|
| MORGAN STANLEY |
$1242619 |
65401 |
0.15% |
股份
|
| DCF Advisers, LLC |
$1206500 |
63500 |
0.15% |
股份
|
| CITADEL ADVISORS LLC |
$953800 |
50200 |
0.12% |
卖出期权
|
| Quadrature Capital Ltd |
$741532 |
39028 |
0.09% |
股份
|
| WOLVERINE TRADING, LLC |
$714581 |
21700 |
0.09% |
卖出期权
|
| WealthPlan Investment Management, LLC |
$698459 |
36761 |
0.09% |
股份
|
| NORTHERN TRUST CORP |
$455601 |
23979 |
0.06% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$453701 |
23879 |
0.06% |
股份
|
| Invesco Ltd. |
$425543 |
22397 |
0.05% |
股份
|
| NJ State Employees Deferred Compensation Plan |
$382957 |
11300 |
0.05% |
股份
|
| XTX Topco Ltd |
$348631 |
18349 |
0.04% |
股份
|
| Schonfeld Strategic Advisors LLC |
$294424 |
15496 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$291004 |
15316 |
0.04% |
股份
|
| Erste Asset Management GmbH |
$277991 |
15100 |
0.03% |
股份
|
| H D Vest Advisory Services |
$275494 |
7878 |
0.03% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$211489 |
11131 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$209760 |
11040 |
0.03% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$192546 |
10134 |
0.02% |
股份
|
| JPMORGAN CHASE & CO |
$127342 |
6917 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$99560 |
5240 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$96729 |
5091 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$74594 |
3926 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$50483 |
2657 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$32000 |
1697 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$19190 |
1010 |
0.00% |
股份
|
| US BANCORP \DE\ |
$18240 |
960 |
0.00% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$14592 |
768 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$13851 |
729 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$13064 |
690 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$11813 |
628 |
0.00% |
股份
|
| C WorldWide Group Holding A/S |
$9690 |
510000 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$5700 |
300 |
0.00% |
股份
|
| BARCLAYS PLC |
$5548 |
292 |
0.00% |
股份
|
| CWM, LLC |
$5436 |
289 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$3895 |
205 |
0.00% |
股份
|
| Arax Advisory Partners |
$3819 |
201 |
0.00% |
股份
|
| ASSETMARK, INC |
$2945 |
155 |
0.00% |
股份
|
| Quent Capital, LLC |
$2850 |
150 |
0.00% |
股份
|
| DEUTSCHE BANK AG\ |
$2793 |
147 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$2660 |
140 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$2430 |
132 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2223 |
117 |
0.00% |
股份
|
| North Star Investment Management Corp. |
$1843 |
97 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$1444 |
76 |
0.00% |
股份
|
| AMERIFLEX GROUP, INC. |
$1178 |
62 |
0.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1140 |
60 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$760 |
40 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$608 |
32 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$494 |
26 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$494 |
26 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$494 |
26 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$418 |
22 |
0.00% |
股份
|
| Blue Trust, Inc. |
$95 |
5 |
0.00% |
股份
|
| Larson Financial Group LLC |
$76 |
4 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$1 |
60 |
0.00% |
股份
|