HOWL Werewolf Therapeutics, Inc. - Common Stock
$0.41
Price · Aug 19, 2026
Fundamentals as of Jul 31, 2026
52W Range
$0–$2
7% of range
Analyst Rating
STRONG BUY
10 analysts
Price Target
$7
+1602% upside
P/E (TTM)
-0.3
ROE
-183.6%
Net Profit Margin
—
HOWL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$0.41
Market Cap
$20M
P/E (TTM)
-0.3
EPS (TTM)
$-1.33
Revenue (TTM)
—
Div Yield
—
ROE
-183.6%
Debt/Equity
1.1
52W Range
$0 – $2
HOWL Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-1.33
2020-12-31
→
2025-12-31
Free Cash Flow
$-60M
2021-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
HOWL
Peer Median
P/E (TTM)
-0.3
—
P/B
0.8
3.3
EV / EBITDA
0.1
—
Price / FCF
-0.3
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
HOWL
Peer Median
ROA
-62.0%
-66.0%
ROE
-183.6%
-128.2%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
HOWL
Peer Median
Debt / Equity
1.1
1.0
Current Ratio
1.6
2.6
Quick Ratio
1.6
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
HOWL
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
HOWL
Peer Median
HOWL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
10 analysts
- Strong Buy 4 40.0%
- Buy 4 40.0%
- Hold 2 20.0%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
1 analysts · 2026-08-18
Low
$7.00
High
$7.00
Median target
$7.00
+1601.5%
Mean target
$7.00
+1601.5%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.09%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $0.08 | $-0.27 | 0.35% |
| March 31, 2026 | $-0.28 | $-0.29 | 0.01% |
| Dec. 31, 2025 | $-0.17 | $-0.35 | 0.18% |
| Sept. 30, 2025 | $-0.36 | $-0.40 | 0.04% |
| June 30, 2025 | $-0.40 | $-0.49 | 0.09% |
| March 31, 2025 | $-0.40 | $-0.40 | 0.00% |
| Dec. 31, 2024 | $-0.46 | $-0.43 | -0.03% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| HOWL | $31M | -0.5 | — | — | -183.6% | — |
| NEUP | $14M | -30.9 | — | -2.4% | -2.3% | — |
| CELU | $32M | -0.3 | -51.0% | -345.4% | 288.6% | — |
| CLRB | — | -0.4 | — | — | — | — |
| MRKR | $25M | -1.9 | -46.2% | -343.0% | -89.1% | — |
| SKYE | $25M | -0.5 | — | — | -175.6% | — |
| KALA | $15M | -0.2 | — | — | -1423.8% | — |
| CYCN | — | -1.1 | 3.7% | — | — | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 14
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| R&D Expense | $45M | $56M | $42M | $54M | $35M | $17M | |
| SG&A Expense | $16M | $19M | $19M | $19M | $15M | $6M | |
| Operating Expenses | $61M | $75M | $60M | $72M | $50M | $22M | |
| Operating Income | $-61M | $-74M | $-41M | $-56M | $-50M | $-22M | |
| Interest Expense | · | · | $3M | $0 | · | · | |
| Interest Income | $3M | $7M | $7M | $2M | · | · | |
| Other Non-op | $2M | $2M | $-1M | $338.0K | $104.0K | $7M | |
| Income Tax | $0 | · | · | · | · | · | |
| Net Income | $-61M | $-71M | $-37M | $-54M | $-50M | $-15M | |
| EPS (Basic) | $-1.32 | $-1.63 | $-1.05 | $-1.86 | $-10.94 | $-28.08 | |
| EPS (Diluted) | $-1.33 | $-1.63 | $-1.05 | $-1.86 | $-10.94 | $-28.08 | |
| Shares (Basic) | 46,018,888 | 43,332,088 | 35,646,572 | 28,863,935 | 18,455,000 | 1,005,000 | |
| Shares (Diluted) | 46,810,252 | 43,859,664 | 35,646,572 | 28,863,935 | 18,455,000 | 1,005,000 | |
| EBITDA | $-61M | $-74M | $-41M | $-56M | $-50M | · |
Balance Sheet 23
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $57M | $111M | $134M | $129M | $158M | $93M | |
| Prepaid Expense | $2M | $2M | $3M | $4M | $4M | $344.0K | |
| Current Assets | $59M | $113M | $138M | $140M | $161M | $93M | |
| PP&E (Net) | $5M | $6M | $8M | $9M | $3M | $651.0K | |
| PP&E (Gross) | $11M | $11M | $11M | $10M | $3M | $826.0K | |
| Accum. Depreciation | · | · | · | · | $391.0K | · | |
| Other Non-current Assets | $5.0K | $320.0K | $594.0K | $1M | $649.0K | $0 | |
| Total Assets | $69M | $127M | $175M | $160M | $179M | $96M | |
| Accounts Payable | $754.0K | $3M | $1M | $1M | $2M | $1M | |
| Accrued Liabilities | $5M | $11M | $9M | $14M | $9M | $4M | |
| Short-term Debt | $28M | $0 | $7M | $0 | · | · | |
| Current Liabilities | $36M | $15M | $19M | $24M | $12M | $5M | |
| Capital Leases | $8M | $9M | $11M | $13M | $15M | $2M | |
| Other Non-current Liabilities | · | · | $0 | $191.0K | $0 | $31.0K | |
| Total Liabilities | $45M | $54M | $63M | $38M | $26M | $7M | |
| Long-term Debt | $32M | $32M | $40M | · | · | · | |
| Total Debt | $28M | $0 | $7M | · | · | · | |
| Common Stock | $5.0K | $5.0K | $4.0K | $3.0K | $2.0K | $2.0K | |
| Paid-in Capital | $500M | $488M | $455M | $429M | $406M | $0 | |
| Retained Earnings | $-475M | $-415M | $-344M | $-307M | $-253M | $-52M | |
| Stockholders' Equity | $25M | $73M | $111M | $122M | $153M | $-52M | |
| Liabilities + Equity | $69M | $127M | $175M | $160M | $179M | $96M | |
| Shares Outstanding | 48,596,817 | 44,827,159 | 39,107,048 | 31,515,074 | 27,313,000 | 1,184,000 |
Cash Flow 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Stock-based Comp | $6M | $9M | $8M | $7M | $4M | $632.0K | |
| Deferred Tax | $0 | $0 | $0 | $0 | $0 | $0 | |
| Operating Cash Flow | $-60M | $-56M | $-33M | $-41M | $-43M | $-19M | |
| CapEx | $0 | $254.0K | $769.0K | $4M | $498.0K | $560.0K | |
| Investing Cash Flow | $0 | $-254.0K | $-769.0K | $-4M | $-498.0K | $-560.0K | |
| Stock Issued | $6M | $24M | $18M | $16M | $0 | · | |
| Net Stock Activity | $6M | $24M | $18M | $16M | · | · | |
| Financing Cash Flow | $6M | $13M | $58M | $16M | $109M | $94M | |
| Net Change in Cash | $-54M | $-43M | $25M | $-28M | $66M | $75M | |
| Free Cash Flow | $-60M | $-56M | $-33M | $-44M | $-43M | · |
Profitability 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| ROA | -62.0% | -46.7% | -22.3% | -31.7% | -36.3% | · | |
| ROE | -183.6% | -86.6% | -33.4% | -42.5% | -31.0% | · |
Liquidity & Solvency 4
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Current Ratio | 1.6 | 7.4 | 7.1 | 5.8 | 13.6 | · | |
| Quick Ratio | 1.6 | 7.3 | 6.9 | 5.4 | 13.3 | · | |
| Debt / Equity | 1.1 | 0.0 | 0.1 | · | · | · | |
| Interest Coverage | · | · | -12.9 | · | · | · |
Valuation (TTM) 11
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Net Income TTM | $-61M | $-71M | $-37M | $-54M | $-50M | · | |
| Market Cap | $31M | $66M | $151M | $64M | $325M | · | |
| Enterprise Value | $2M | $-45M | $23M | · | · | · | |
| P/E | -0.5 | -0.9 | -3.7 | -1.1 | -1.1 | · | |
| P/B | 1.2 | 0.9 | 1.4 | 0.5 | 2.1 | · | |
| P / Tangible Book | 1.2 | 0.9 | 1.4 | 0.5 | 2.1 | · | |
| P / Cash Flow | -0.5 | -1.2 | -4.6 | -1.6 | -7.6 | · | |
| P / FCF | -0.5 | -1.2 | -4.5 | -1.5 | -7.5 | · | |
| EV / EBITDA | -0.0 | 0.6 | -0.6 | · | · | · | |
| EV / FCF | -0.0 | 0.8 | -0.7 | · | · | · | |
| Earnings Yield | -209.8% | -110.1% | -27.2% | -90.7% | -91.9% | · |
Income Statement 13
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $6M | $8M | $7M | $12M | $13M | $13M | $16M | $13M | $15M | $13M | $10M | $11M | $10M | $12M | $16M | $13M | |
| SG&A Expense | $8M | $5M | $2M | $4M | $4M | $5M | $5M | $5M | $5M | $5M | $5M | $4M | $5M | $5M | $5M | $4M | |
| Operating Expenses | $14M | $13M | $9M | $16M | $18M | $18M | $20M | $17M | $20M | $18M | $14M | $15M | $14M | $17M | $20M | $18M | |
| Operating Income | $7M | $-13M | $-9M | $-16M | $-18M | $-18M | $-20M | $-17M | $-19M | $-17M | $-13M | $-9M | $-6M | $-12M | $-13M | $-13M | |
| Interest Expense | · | · | · | · | · | · | · | · | · | $1M | · | · | · | $172.0K | · | · | |
| Interest Income | $277.0K | $433.0K | $564.0K | $697.0K | $850.0K | $997.0K | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | · | · | |
| Other Non-op | $64.0K | $674.0K | $2M | $0 | $11.0K | $168.0K | $-94.0K | $97.0K | $2M | $-1.0K | $-6.0K | $-5.0K | $-25.0K | $-1M | $70.0K | $3.0K | |
| Net Income | $4M | $-14M | $-8M | $-16M | $-18M | $-18M | $-20M | $-17M | $-17M | $-16M | $-12M | $-8M | $-5M | $-12M | $-12M | $-12M | |
| EPS (Basic) | $0.08 | $-0.28 | $-0.16 | $-0.36 | $-0.40 | $-0.40 | $-0.46 | $-0.38 | $-0.40 | $-0.39 | $-0.34 | $-0.23 | $-0.14 | $-0.34 | $-0.37 | $-0.40 | |
| EPS (Diluted) | $0.08 | $-0.28 | $-0.17 | $-0.36 | $-0.40 | $-0.40 | $-0.43 | $-0.38 | $-0.43 | $-0.39 | $-0.34 | $-0.23 | $-0.14 | $-0.34 | $-0.37 | $-0.40 | |
| Shares (Basic) | 48,597,534 | 48,596,817 | -89,594,059 | 45,804,042 | 44,981,746 | 44,827,159 | -85,501,433 | 43,704,836 | 43,521,406 | 41,607,279 | -70,349,735 | 35,653,924 | 35,557,701 | 34,784,682 | -55,810,065 | 29,764,000 | |
| Shares (Diluted) | 48,597,534 | 49,388,181 | -88,802,695 | 45,804,042 | 44,981,746 | 44,827,159 | -85,495,635 | 43,704,836 | 44,043,184 | 41,607,279 | -70,349,735 | 35,653,924 | 35,557,701 | 34,784,682 | -55,810,065 | 29,764,000 | |
| EBITDA | $7M | $-13M | · | $-16M | $-18M | $-18M | · | $-17M | $-19M | $-17M | · | $-9M | $-6M | $-12M | · | $-13M |
Balance Sheet 23
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $22M | $46M | $57M | $66M | $78M | $92M | $111M | $123M | $135M | $139M | $134M | $130M | $137M | $148M | $129M | $140M | |
| Prepaid Expense | $905.0K | $2M | $2M | $2M | $3M | $2M | $2M | $3M | $3M | $2M | $3M | $3M | $3M | $2M | $4M | $7M | |
| Current Assets | $23M | $49M | $59M | $68M | $80M | $94M | $113M | $126M | $139M | $142M | $138M | $139M | $147M | $157M | $140M | $152M | |
| PP&E (Net) | $1M | $4M | $5M | $5M | $5M | $6M | $6M | $7M | $7M | $8M | $8M | $8M | $8M | $9M | $9M | $9M | |
| PP&E (Gross) | · | · | $11M | · | · | · | $11M | · | · | · | $11M | · | · | · | $10M | $10M | |
| Accum. Depreciation | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $992.0K | |
| Other Non-current Assets | $0 | $0 | $5.0K | $46.0K | $122.0K | $179.0K | $320.0K | $42.0K | $265.0K | $248.0K | $594.0K | $516.0K | $652.0K | $670.0K | $1M | $2M | |
| Total Assets | $24M | $58M | $69M | $80M | $93M | $107M | $127M | $140M | $154M | $178M | $175M | $176M | $185M | $195M | $160M | $172M | |
| Accounts Payable | $2M | $4M | $754.0K | $1M | $3M | $986.0K | $3M | $1M | $1M | $2M | $1M | $1M | $1M | $2M | $1M | $1M | |
| Accrued Liabilities | $6M | $5M | $5M | $9M | $9M | $9M | $11M | $10M | $9M | $6M | $9M | $8M | $10M | $13M | $14M | $14M | |
| Short-term Debt | $0 | $29M | $28M | $6M | $2M | · | $0 | $0 | $0 | $12M | $7M | $2M | · | · | $0 | · | |
| Current Liabilities | $8M | $39M | $36M | $18M | $15M | $12M | $15M | $12M | $11M | $21M | $19M | $14M | $15M | $22M | $24M | $28M | |
| Capital Leases | $0 | $7M | $8M | $8M | $9M | $9M | $9M | $10M | $10M | $11M | $11M | $11M | $12M | $12M | $13M | $13M | |
| Other Non-current Liabilities | · | · | · | · | · | · | · | · | · | · | · | $0 | $0 | $0 | $191.0K | $191.0K | |
| Total Liabilities | $8M | $46M | $45M | $50M | $51M | $50M | $54M | $51M | $50M | $60M | $63M | $64M | $67M | $74M | $38M | $41M | |
| Long-term Debt | · | $32M | $32M | $32M | $32M | $32M | · | $32M | $32M | $40M | · | · | · | · | · | · | |
| Total Debt | $0 | $29M | · | $6M | $2M | · | · | $0 | $0 | $12M | · | $2M | · | · | · | · | |
| Common Stock | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $3.0K | $3.0K | $3.0K | $3.0K | $3.0K | |
| Paid-in Capital | $502M | $501M | $500M | $497M | $492M | $490M | $488M | $484M | $482M | $478M | $455M | $445M | $442M | $440M | $429M | $426M | |
| Retained Earnings | $-485M | $-489M | $-475M | $-467M | $-451M | $-433M | $-415M | $-394M | $-378M | $-360M | $-344M | $-332M | $-324M | $-319M | $-307M | $-295M | |
| Stockholders' Equity | $16M | $12M | $25M | $30M | $41M | $57M | $73M | $89M | $104M | $118M | $111M | $112M | $119M | $121M | $122M | $131M | |
| Liabilities + Equity | $24M | $58M | $69M | $80M | $93M | $107M | $127M | $140M | $154M | $178M | $175M | $176M | $185M | $195M | $160M | $172M | |
| Shares Outstanding | 48,599,066 | 48,596,817 | 48,596,817 | 47,273,685 | 45,335,265 | 44,827,159 | 44,827,159 | 43,721,772 | 43,702,147 | 43,282,371 | 39,107,048 | 35,658,000 | 35,642,000 | 35,301,000 | 31,433,731 | 30,611,000 |
Cash Flow 9
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $419.0K | $929.0K | $1M | $1M | $2M | $2M | $2M | $2M | $3M | $2M | $2M | $2M | $2M | $2M | $2M | $2M | |
| Operating Cash Flow | $7M | $-11M | $-11M | $-15M | $-15M | $-19M | $-14M | $-12M | $-14M | $-15M | $-5M | $-7M | $-11M | $-10M | $-12M | $-14M | |
| CapEx | · | · | $0 | $0 | $0 | $0 | $123.0K | $3.0K | $17.0K | $111.0K | $198.0K | $221.0K | $182.0K | $168.0K | $518.0K | $2M | |
| Investing Cash Flow | · | · | $0 | $0 | $0 | $0 | $-123.0K | $-3.0K | $-17.0K | $-111.0K | $-198.0K | $-221.0K | $-182.0K | $-168.0K | $-518.0K | $-2M | |
| Stock Issued | · | · | $2M | $3M | $347.0K | $0 | $2M | $-29.0K | $877.0K | $20M | $9M | $-84.0K | $552.0K | $9M | $979.0K | $11M | |
| Net Stock Activity | · | · | · | · | · | $0 | · | · | · | $20M | · | · | · | $9M | · | · | |
| Financing Cash Flow | · | · | $2M | $3M | $388.0K | $0 | $3M | $-6.0K | $-10M | $20M | $9M | $41.0K | $692.0K | $49M | $1M | $11M | |
| Net Change in Cash | $-25M | $-11M | $-9M | $-12M | $-15M | $-19M | $-12M | $-12M | $-24M | $5M | $4M | $-7M | $-10M | $39M | $-11M | $-5M | |
| Free Cash Flow | · | · | · | · | · | $-19M | · | · | · | $-15M | · | · | · | $-10M | · | · |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | 6.3% | -16.4% | · | -14.9% | -14.6% | -12.7% | · | -10.5% | -10.2% | -8.7% | · | -4.8% | -2.8% | -6.7% | · | -6.8% | |
| ROE | 12.7% | -38.9% | · | -27.5% | -24.7% | -20.7% | · | -16.5% | -15.5% | -13.6% | · | -6.8% | -4.1% | -9.2% | · | -8.0% |
Liquidity & Solvency 4
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.9 | 1.3 | · | 3.9 | 5.3 | 8.1 | · | 10.1 | 12.1 | 6.7 | · | 9.6 | 9.8 | 7.2 | · | 5.5 | |
| Quick Ratio | 2.8 | 1.2 | · | 3.7 | 5.1 | 7.9 | · | 9.9 | 11.8 | 6.6 | · | 9.0 | 9.2 | 6.8 | · | 5.1 | |
| Debt / Equity | 0.0 | 2.4 | · | 0.2 | 0.1 | · | · | 0.0 | 0.0 | 0.1 | · | 0.0 | · | · | · | · | |
| Interest Coverage | · | · | · | · | · | · | · | · | · | -17.1 | · | · | · | · | · | · |
Valuation (TTM) 11
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-44M | $-66M | · | $-69M | $-70M | $-68M | · | $-58M | $-47M | $-42M | · | $-37M | $-44M | $-54M | · | $-56M | |
| Market Cap | $17M | $40M | · | $93M | $49M | $44M | · | $93M | $107M | $280M | · | $76M | $109M | $92M | · | $138M | |
| Enterprise Value | $-4M | $23M | · | $33M | $-26M | · | · | $-30M | $-29M | $153M | · | $-52M | · | · | · | · | |
| P/E | -0.4 | -0.6 | · | -1.3 | -0.7 | -0.6 | · | -1.5 | -2.1 | -5.9 | · | -1.9 | -2.2 | -1.4 | · | -2.3 | |
| P/B | 1.1 | 3.3 | · | 3.1 | 1.2 | 0.8 | · | 1.0 | 1.0 | 2.4 | · | 0.7 | 0.9 | 0.8 | · | 1.1 | |
| P / Tangible Book | 1.1 | 3.3 | · | 3.1 | 1.2 | 0.8 | · | 1.0 | 1.0 | 2.4 | · | 0.7 | 0.9 | 0.8 | · | 1.1 | |
| P / Cash Flow | · | -3.8 | · | · | · | -2.3 | · | · | · | -18.3 | · | · | · | -9.3 | · | · | |
| P / FCF | · | · | · | · | · | -2.3 | · | · | · | -18.2 | · | · | · | -9.1 | · | · | |
| EV / EBITDA | -0.6 | -1.7 | · | -2.1 | 1.5 | · | · | 1.8 | 1.5 | -8.9 | · | 5.6 | · | · | · | · | |
| EV / FCF | · | · | · | · | · | · | · | · | · | -9.9 | · | · | · | · | · | · | |
| Earnings Yield | -266.7% | -172.9% | · | -78.2% | -147.7% | -164.6% | · | -67.5% | -48.8% | -17.0% | · | -51.9% | -46.2% | -70.4% | · | -44.4% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Net Income | $-61M | $-71M | $-37M | $-54M | $-50M |
| Diluted EPS | $-1.33 | $-1.63 | $-1.05 | $-1.86 | $-10.94 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Debt / Equity | 1.1 | 0.0 | 0.1 | — | — |
| Current Ratio | 1.6 | 7.4 | 7.1 | 5.8 | 13.6 |
| Quick Ratio | 1.6 | 7.3 | 6.9 | 5.4 | 13.3 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | $-60M | $-56M | $-33M | $-44M | $-43M |
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Institutional owners (13F) 54 filers · $12.4M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 13 (+6 vs prior Q) | 10 (-1 vs prior Q) | 9 (+2 vs prior Q) | 8 (-3 vs prior Q) | -1.9M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| MPM ASSET MANAGEMENT LLC | $8,490,424 | 4,309,860 | 68.38% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $859,349 | 2,387,744 | 6.92% | Shares |
| Balyasny Asset Management L.P. | $644,253 | 1,790,089 | 5.19% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $438,471 | 1,217,976 | 3.53% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $242,800 | 674,632 | 1.96% | Shares |
| Lynx1 Capital Management LP | $236,737 | 657,786 | 1.91% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $225,589 | 626,810 | 1.82% | Shares |
| DC Funds, LP | $212,018 | 589,102 | 1.71% | Shares |
| Verdad Advisers, LP | $125,500 | 348,709 | 1.01% | Shares |
| VANGUARD GROUP INC | $113,948 | 179,728 | 0.92% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $98,563 | 273,764 | 0.79% | Shares |
| XTX Topco Ltd | $97,705 | 271,478 | 0.79% | Shares |
| Cubist Systematic Strategies, LLC | $92,020 | 46,711 | 0.74% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $56,781 | 157,726 | 0.46% | Shares |
| JANE STREET GROUP, LLC | $52,752 | 146,573 | 0.42% | Shares |
| STATE STREET CORP | $42,889 | 119,168 | 0.35% | Shares |
| Squarepoint Ops LLC | $37,157 | 103,242 | 0.30% | Shares |
| Rangeley Capital, LLC | $35,990 | 100,000 | 0.29% | Shares |
| Nuveen Asset Management, LLC | $31,557 | 21,322 | 0.25% | Shares |
| NORTHERN TRUST CORP | $31,258 | 86,851 | 0.25% | Shares |
| Alyeska Investment Group, L.P. | $31,151 | 86,554 | 0.25% | Shares |
| MPM BIOIMPACT LLC | $28,851 | 80,142 | 0.23% | Shares |
| CITADEL ADVISORS LLC | $26,993 | 75,000 | 0.22% | Call option |
| Point72 Asia (Singapore) Pte. Ltd. | $25,642 | 13,016 | 0.21% | Shares |
| MILLENNIUM MANAGEMENT LLC | $22,334 | 62,055 | 0.18% | Shares |
| H D Vest Advisory Services | $11,118 | 10,200 | 0.09% | Shares |
| BlackRock, Inc. | $10,661 | 29,623 | 0.09% | Shares |
| TWO SIGMA INVESTMENTS, LP | $9,825 | 27,300 | 0.08% | Shares |
| StoneX Group Inc. | $9,000 | 20,000 | 0.07% | Shares |
| BANK OF AMERICA CORP /DE/ | $8,331 | 23,206 | 0.07% | Shares |
| GOLDMAN SACHS GROUP INC | $7,206 | 20,023 | 0.06% | Shares |
| TWO SIGMA ADVISERS, LP | $6,525 | 10,300 | 0.05% | Shares |
| CITADEL ADVISORS LLC | $5,578 | 15,500 | 0.04% | Put option |
| CERTUITY, LLC | $5,399 | 15,000 | 0.04% | Shares |
| HBK Sorce Advisory LLC | $5,317 | 13,227 | 0.04% | Shares |
| BARCLAYS PLC | $4,763 | 13,235 | 0.04% | Shares |
| Larson Financial Group LLC | $4,697 | 13,052 | 0.04% | Shares |
| LPL Financial LLC | $4,244 | 11,791 | 0.03% | Shares |
| Ranch Capital Advisors Inc. | $3,959 | 11,000 | 0.03% | Shares |
| Marest Capital, LLC | $3,912 | 10,870 | 0.03% | Shares |
| Cetera Investment Advisers | $3,671 | 10,200 | 0.03% | Shares |
| Tower Research Capital LLC (TRC) | $3,562 | 9,897 | 0.03% | Shares |
| OSAIC HOLDINGS, INC. | $3,087 | 8,575 | 0.02% | Shares |
| Financial Perspectives, Inc | $2,429 | 6,750 | 0.02% | Shares |
| MORGAN STANLEY | $678 | 1,885 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $673 | 1,871 | 0.01% | Shares |
| JPMORGAN CHASE & CO | $287 | 931 | 0.00% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $284 | 790 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $91 | 255 | 0.00% | Shares |
| UBS Group AG | $37 | 102 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $36 | 100 | 0.00% | Shares |
| Virtu Financial LLC | $16 | 45,467 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $10 | 27,146 | 0.00% | Shares |
| Optiver Holding B.V. | $8 | 22 | 0.00% | Shares |
Company insiders 20 insiders · 6 officers · 10 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Daniel J Hicklin | President and Chief Executive Officer | Jan. 2, 2025 A | — | 0 | 0 | $0 |
| Timothy W. Trost | Chief Financial Officer | Jan. 2, 2025 A | — | 0 | 0 | $0 |
| Chulani Karunatilake | Chief Technology Officer | Jan. 2, 2025 A | — | 0 | 0 | $0 |
| Ellen Lubman | Chief Business Officer | Jan. 2, 2025 A | — | 0 | 0 | $0 |
| Randi Isaacs | Chief Medical Officer | Jan. 2, 2025 A | — | 0 | 0 | $0 |
| Cynthia Seidel-Dugan | Chief Scientific Officer | Jan. 2, 2024 A | 164,888 | 0 | 0 | $0 |
| Luke Evnin | Director | July 7, 2026 S | 0 | 0 | 87 | $-3,255,563 |
| Michael B. Atkins | Director | June 12, 2025 A | — | 0 | 0 | $0 |
| Anil K. Singhal | Director | June 12, 2025 A | — | 0 | 0 | $0 |
| Meeta Chatterjee | Director | June 12, 2025 A | — | 0 | 0 | $0 |
| Alon Lazarus | Director | June 12, 2025 A | 2,046,634 | 0 | 0 | $0 |
| Briggs Morrison | Director | June 12, 2025 A | — | 0 | 0 | $0 |
| Michael A. Sherman | Director | June 12, 2025 A | — | 0 | 0 | $0 |
| Derek Dirocco | Director | May 24, 2024 A | — | 0 | 0 | $0 |
| Sakae Asanuma | Director | May 4, 2021 C | 2,068,909 | 0 | 0 | $0 |
| Taiho Ventures LLC | 10% owner | May 4, 2021 C | 2,068,909 | 0 | 0 | $0 |
| UPMC | 10% owner | May 4, 2021 C | 1,097,756 | 0 | 0 | $0 |
| HBM Healthcare Investments (Cayman) Ltd. | 10% owner | May 4, 2021 C | 625,995 | 0 | 0 | $0 |
| Steven H. Bloom | — | May 1, 2025 A | — | 0 | 0 | $0 |
| Reid Leonard | — | Jan. 3, 2023 A | 14,102 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 4 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×13 filings | July 2, 2026 | 4.10% | Amendment | — | SEC |
| MPM BioVentures 2014, L.P., MPM BioVentures 2014 (B), L.P., MPM Asset Management Investors BV2014 LLC, UBS Oncology Impact Fund L.P., MPM BioVentures 2014 GP LLC, MPM BioVentures 2014 LLC, Oncology Impact Fund (Cayman) Management L.P., MPM BioImpact LLC, ANSBERT GADICKE, LUKE EVNIN, Todd Foley, MPM ASSET MANAGEMENT LLC, MPM ONCOLOGY INNOVATIONS FUND LP, MPM Oncology Innovations Fund GP LLC ×8 filings | May 12, 2026 | 3.80% | Amendment | — | SEC |
| Taiho Ventures LLC | May 13, 2021 | — | Initial filing | Board campaign | SEC |
| Arkin Bio Ventures 2 L.P., Arkin Bio Venture GPGP Ltd., Moshe Arkin, Alon Lazarus | May 10, 2021 | — | Initial filing | Board campaign | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 2 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.