EWTX Edgewise Therapeutics, Inc. - Common Stock
$46,22
Prix · Aoû 19, 2026
Données fondamentales au Aoû 6, 2026
Fourchette 52 semaines
$14–$48
94% of range
Note des analystes
BUY
19 analysts
Objectif de cours
$51
+11% upside
P/E (TTM)
-28.7
ROE
-30.2%
Marge nette
—
EWTX Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines
Prix
$46.22
Capitalisation Boursière
$4.97B
P/E (TTM)
-28.7
BPA (TTM)
$-1.63
Revenus (TTM)
—
Rendement div.
—
ROE
-30.2%
Dette/Capitaux propres
—
Fourchette 52 semaines
$14 – $48
EWTX Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue
Configure
Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA
Revenus et bénéfice net
—
BPA
$-1.63
2020-12-31
→
2025-12-31
Flux de trésorerie libre
$-144M
2021-12-31
→
2025-12-31
Marges
—
Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?
Métrique
Tendance sur 5 ans
EWTX
Médiane des pairs
P/E (TTM)
-28.7
38.7
P/B
9.5
3.8
Price / FCF (Cours / FCF)
-34.5
—
Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC
Métrique
Tendance sur 5 ans
EWTX
Médiane des pairs
ROA
-32.3%
-6.4%
ROE
-30.2%
-16.8%
ROIC
-36.6%
—
Santé financière Dette, liquidité, solvabilité — solidité du bilan
Métrique
Tendance sur 5 ans
EWTX
Médiane des pairs
Current Ratio (Ratio de liquidité)
19.9
12.8
Quick Ratio (Ratio de liquidité réduite)
2.2
—
Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans
Métrique
Tendance sur 5 ans
EWTX
Médiane des pairs
Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances
Métrique
Tendance sur 5 ans
EWTX
Médiane des pairs
EWTX Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse
ACHAT
19 analystes
- Achat fort 7 36,8%
- Achat 9 47,4%
- Conserver 3 15,8%
- Vente 0 0,0%
- Vente forte 0 0,0%
Objectif de cours à 12 mois
13 analystes · 2026-08-18
Médiane
$52.00
Maintenant
$46.22
Bas
$36.00
Haut
$66.00
Objectif médian
$52.00
+12,5%
Objectif moyen
$51.15
+10,7%
Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats
Surprise Moyenne
0.01%
| Période | EPS Actual | BPA est. | Surprise |
|---|---|---|---|
| 30 juin 2026 | $-0.53 | $-0.48 | -0.05% |
| 31 mars 2026 | $-0.46 | $-0.50 | 0.04% |
| 31 décembre 2025 | $-0.47 | $-0.44 | -0.03% |
| 30 septembre 2025 | $-0.39 | $-0.41 | 0.02% |
| 30 juin 2025 | $-0.34 | $-0.42 | 0.08% |
| 31 mars 2025 | $-0.43 | $-0.44 | 0.01% |
Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur
| Ticker | Capitalisation Boursière | P/E | Revenus Année/Année | Marge Nette | ROE | Marge Brute |
|---|---|---|---|---|---|---|
| EWTX | $2.64B | -15.2 | — | — | -30.2% | — |
| BLTE | — | — | — | — | — | — |
| LGND | $3.74B | 30.8 | 60.4% | 46.4% | 13.5% | — |
| DFTX | $1.32B | -6.5 | 212.0% | — | -71.0% | — |
| AMRX | — | 57.3 | 8.1% | 2.4% | -80.0% | 36.9% |
| INDV | — | 21.9 | 4.3% | 17.0% | -118.3% | 80.2% |
| MANE | — | — | — | — | 82.6% | — |
| ELVN | $915M | -8.4 | — | — | -21.9% | — |
| GPCR | $14.78B | -86.9 | — | — | -12.3% | — |
| OGN | $1.87B | 10.0 | -2.9% | 3.0% | 25.2% | 53.3% |
Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie
Compte de résultat 12
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| R&D Expense | $151M | $127M | $91M | $54M | $32M | $15M | |
| SG&A Expense | $40M | $32M | $23M | $18M | $11M | $2M | |
| Operating Expenses | $191M | $159M | $114M | $72M | $43M | $17M | |
| Operating Income | $-191M | $-159M | $-114M | $-72M | $-43M | $-17M | |
| Pretax Income | $-168M | $-134M | $-100M | · | · | · | |
| Income Tax | $4.0K | $3.0K | $4.0K | $0 | $0 | · | |
| Net Income | $-168M | $-134M | $-100M | $-68M | $-43M | $-17M | |
| EPS (Basic) | $-1.63 | $-1.45 | $-1.57 | $-1.26 | $-1.14 | $-23.17 | |
| EPS (Diluted) | $-1.63 | $-1.45 | $-1.57 | $-1.26 | $-1.14 | $-23.17 | |
| Shares (Basic) | 102,930,744 | 92,414,626 | 63,723,600 | 53,593,753 | 37,526,332 | 739,004 | |
| Shares (Diluted) | 102,930,744 | 92,414,626 | 63,723,600 | 53,593,753 | 37,526,332 | 739,004 | |
| EBITDA | $-191M | $-159M | $-114M | $-72M | $-43M | · |
Bilan 21
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $61M | $42M | $86M | $22M | $16M | $105M | |
| Prepaid Expense | $13M | $5M | $9M | $5M | $3M | $551.0K | |
| Current Assets | $543M | $475M | $327M | $357M | $284M | $130M | |
| PP&E (Net) | $8M | $10M | $10M | $9M | $912.0K | $516.0K | |
| PP&E (Gross) | $15M | $14M | $13M | $10M | $2M | $946.0K | |
| Accum. Depreciation | $7M | $5M | $3M | $1M | $702.0K | $430.0K | |
| Other Non-current Assets | · | $262.0K | $348.0K | $251.0K | $548.0K | $975.0K | |
| Total Assets | $553M | $487M | $340M | $367M | $285M | $131M | |
| Accounts Payable | $6M | $6M | $4M | $6M | $4M | $2M | |
| Accrued Liabilities | $8M | $7M | $6M | $6M | $4M | $2M | |
| Current Liabilities | $27M | $24M | $17M | $17M | $11M | $4M | |
| Capital Leases | $3M | $4M | $4M | $4M | · | · | |
| Other Non-current Liabilities | · | · | · | · | $329.0K | · | |
| Total Liabilities | $30M | $28M | $21M | $20M | $11M | $4M | |
| Common Stock | $10.0K | $9.0K | $7.0K | $6.0K | $5.0K | · | |
| Paid-in Capital | $1.07B | $837M | $563M | $493M | $352M | $727.0K | |
| Retained Earnings | $-546M | $-379M | $-245M | $-145M | $-77M | $-34M | |
| AOCI | $677.0K | $420.0K | $99.0K | $-1M | $-514.0K | · | |
| Stockholders' Equity | $522M | $459M | $319M | $347M | $274M | $-33M | |
| Liabilities + Equity | $553M | $487M | $340M | $367M | $285M | $131M | |
| Shares Outstanding | 106,249,579 | 94,838,466 | 70,453,342 | 63,257,376 | 49,500,308 | 1,009,479 |
Flux de trésorerie 9
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Stock-based Comp | $35M | $25M | $18M | $11M | $4M | $354.0K | |
| Operating Cash Flow | $-144M | $-109M | $-92M | $-53M | $-34M | $-15M | |
| CapEx | $256.0K | $1M | $6M | $6M | $668.0K | $203.0K | |
| Investing Cash Flow | $-33M | $-185M | $103M | $-71M | $-242M | $-24M | |
| Stock Issued | $187M | $239M | $53M | $129M | · | · | |
| Net Stock Activity | $187M | $239M | $53M | $129M | · | · | |
| Financing Cash Flow | $196M | $249M | $53M | $130M | $186M | $120M | |
| Net Change in Cash | $19M | $-44M | $64M | $6M | $-89M | $81M | |
| Free Cash Flow | $-144M | $-110M | $-98M | $-58M | $-34M | · |
Rentabilité 3
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| ROA | -32.3% | -32.4% | -28.3% | -20.7% | -20.6% | · | |
| ROE | -30.2% | -28.2% | -32.9% | -19.1% | -15.3% | · | |
| ROIC | -36.6% | · | · | · | · | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Current Ratio | 19.9 | 19.9 | 19.5 | 21.5 | 27.0 | · | |
| Quick Ratio | 2.2 | 1.7 | 5.1 | 1.3 | 1.5 | · |
Valorisation (TTM) 8
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 |
|---|---|---|---|---|---|---|---|
| Net Income TTM | $-168M | $-134M | $-100M | $-68M | $-43M | · | |
| Market Cap | $2.64B | $2.53B | $771M | $566M | $756M | · | |
| P/E | -15.2 | -18.4 | -7.0 | -7.1 | -13.4 | · | |
| P/B | 5.0 | 5.5 | 2.4 | 1.6 | 2.8 | · | |
| P / Tangible Book | 5.0 | 5.5 | 2.4 | 1.6 | 2.8 | · | |
| P / Cash Flow | -18.3 | -23.2 | -8.4 | -10.7 | -22.6 | · | |
| P / FCF | -18.3 | -22.9 | -7.9 | -9.7 | -22.1 | · | |
| Earnings Yield | -6.6% | -5.4% | -14.3% | -14.1% | -7.5% | · |
Compte de résultat 10
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $48M | $43M | $44M | $37M | $34M | $37M | $36M | $32M | $31M | $28M | $24M | $20M | $20M | $17M | $14M | $12M | |
| SG&A Expense | $14M | $11M | $12M | $9M | $9M | $9M | $9M | $8M | $7M | $7M | $6M | $6M | $6M | $5M | $4M | $4M | |
| Operating Expenses | $62M | $54M | $56M | $47M | $43M | $46M | $46M | $40M | $38M | $35M | $29M | $25M | $26M | $22M | $18M | $16M | |
| Operating Income | $-62M | $-54M | $-56M | $-47M | $-43M | $-46M | $-46M | $-40M | $-38M | $-35M | $-29M | $-25M | $-26M | $-22M | $-18M | $-16M | |
| Net Income | $-57M | $-49M | $-50M | $-41M | $-36M | $-41M | $-40M | $-34M | $-31M | $-29M | $-26M | $-21M | $-23M | $-19M | $-17M | $-16M | |
| EPS (Basic) | $-0.53 | $-0.46 | $-0.47 | $-0.39 | $-0.34 | $-0.43 | $-0.42 | $-0.36 | $-0.34 | $-0.33 | $-0.41 | $-0.34 | $-0.36 | $-0.30 | $-0.34 | $-0.32 | |
| EPS (Diluted) | $-0.53 | $-0.46 | $-0.47 | $-0.39 | $-0.34 | $-0.43 | $-0.42 | $-0.36 | $-0.34 | $-0.33 | $-0.41 | $-0.34 | $-0.36 | $-0.30 | $-0.34 | $-0.32 | |
| Shares (Basic) | 107,669,774 | 107,116,709 | -202,632,581 | 105,492,779 | 104,940,493 | 95,130,053 | -182,481,383 | 93,813,346 | 93,515,356 | 87,567,307 | 63,459,560 | 63,380,430 | 63,265,800 | -97,418,492 | 51,844,904 | 49,622,752 | |
| Shares (Diluted) | 107,669,774 | 107,116,709 | -202,632,581 | 105,492,779 | 104,940,493 | 95,130,053 | -182,481,383 | 93,813,346 | 93,515,356 | 87,567,307 | 63,459,560 | 63,380,430 | 63,265,800 | -97,418,492 | 51,844,904 | 49,622,752 | |
| EBITDA | $-62M | $-54M | · | $-47M | $-43M | $-46M | · | $-40M | $-38M | $-35M | $-29M | $-25M | $-26M | · | $-18M | $-16M |
Bilan 24
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $72M | $33M | $61M | $46M | $43M | $50M | $42M | $45M | $43M | $30M | $33M | $32M | $48M | $22M | $110M | $18M | |
| Prepaid Expense | $6M | $10M | $13M | $11M | $9M | $7M | $5M | $7M | $8M | $9M | $8M | $7M | $5M | $5M | $5M | $5M | |
| Current Assets | $472M | $510M | $543M | $574M | $603M | $443M | $475M | $499M | $519M | $541M | $298M | $317M | $333M | $357M | $370M | $253M | |
| PP&E (Net) | $7M | $7M | $8M | $8M | $9M | $9M | $10M | $10M | $10M | $10M | $11M | $11M | $10M | $9M | $5M | $2M | |
| PP&E (Gross) | $15M | $15M | $15M | $14M | $14M | $14M | $14M | $14M | $13M | $13M | $13M | $13M | $12M | $10M | $6M | $3M | |
| Accum. Depreciation | $8M | $7M | $7M | $6M | $6M | $5M | $5M | $4M | $4M | $3M | $2M | $2M | $1M | $1M | $977.0K | $882.0K | |
| Other Non-current Assets | · | · | · | · | · | $695.0K | $262.0K | $262.0K | $262.0K | · | $467.0K | $419.0K | $251.0K | $251.0K | $264.0K | $447.0K | |
| Total Assets | $480M | $519M | $553M | $583M | $613M | $454M | $487M | $511M | $532M | $554M | $311M | $331M | $346M | $367M | $377M | $257M | |
| Accounts Payable | $5M | $7M | $6M | $6M | $8M | $9M | $6M | $6M | $7M | $5M | $5M | $4M | $4M | $6M | $6M | $3M | |
| Accrued Liabilities | $5M | $9M | $8M | $6M | $6M | $7M | $7M | $6M | $5M | $6M | $6M | $7M | $6M | $6M | $5M | $4M | |
| Short-term Debt | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $7.0K | · | |
| Current Liabilities | $29M | $23M | $27M | $22M | $21M | $21M | $24M | $19M | $17M | $15M | $16M | $14M | $13M | $17M | $13M | $9M | |
| Capital Leases | $3M | $3M | $3M | $3M | $3M | $4M | $4M | $3M | $4M | $4M | $5M | $5M | $5M | $4M | $2M | $2M | |
| Other Non-current Liabilities | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $192.0K | |
| Total Liabilities | $32M | $25M | $30M | $25M | $24M | $25M | $28M | $22M | $21M | $19M | $21M | $19M | $18M | $20M | $16M | $11M | |
| Long-term Debt | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $59.0K | · | |
| Total Debt | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $7.0K | · | |
| Common Stock | $10.0K | $10.0K | $10.0K | $10.0K | $10.0K | $9.0K | $9.0K | $9.0K | $9.0K | $9.0K | $6.0K | $6.0K | $6.0K | $6.0K | $6.0K | $5.0K | |
| Paid-in Capital | $1.10B | $1.09B | $1.07B | $1.05B | $1.04B | $849M | $837M | $827M | $816M | $809M | $505M | $501M | $497M | $493M | $489M | $356M | |
| Retained Earnings | $-653M | $-595M | $-546M | $-496M | $-455M | $-419M | $-379M | $-339M | $-305M | $-273M | $-215M | $-189M | $-167M | $-145M | $-125M | $-108M | |
| AOCI | $-500.0K | $-252.0K | $677.0K | $701.0K | $204.0K | $401.0K | $420.0K | $1M | $-1M | $-861.0K | $-424.0K | $-547.0K | $-251.0K | $-1M | $-2M | $-2M | |
| Stockholders' Equity | $448M | $493M | $522M | $559M | $589M | $430M | $459M | $489M | $510M | $535M | $290M | $311M | $329M | $347M | $361M | $246M | |
| Liabilities + Equity | $480M | $519M | $553M | $583M | $613M | $454M | $487M | $511M | $532M | $554M | $311M | $331M | $346M | $367M | $377M | $257M | |
| Shares Outstanding | 107,776,380 | 107,481,522 | 106,249,579 | 105,761,949 | 105,341,296 | 95,205,683 | 94,838,466 | 94,408,911 | 93,643,341 | 93,284,528 | 63,460,939 | 63,458,932 | 63,274,732 | 63,257,376 | 63,208,828 | 49,780,365 |
Flux de trésorerie 9
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $9M | $9M | $10M | $8M | $8M | $9M | $8M | $7M | $5M | $5M | $5M | $4M | $4M | $4M | $3M | $2M | |
| Operating Cash Flow | $-42M | $-43M | $-39M | $-35M | $-33M | $-38M | $-27M | $-27M | $-26M | $-29M | $-22M | $-20M | $-23M | $-12M | $-12M | $-16M | |
| CapEx | $32.0K | $260.0K | $73.0K | $89.0K | $50.0K | $44.0K | $274.0K | $520.0K | $221.0K | $297.0K | $457.0K | $759.0K | $4M | $3M | $1M | $554.0K | |
| Investing Cash Flow | $78M | $2M | $50M | $36M | $-162M | $44M | $21M | $25M | $37M | $-268M | $23M | $3M | $49M | $-76M | $-26M | $-46.0K | |
| Stock Issued | · | · | $0 | $0 | · | · | $0 | $0 | $0 | $239M | · | · | · | $-555.0K | · | · | |
| Net Stock Activity | · | · | · | · | · | · | · | · | · | $239M | · | · | · | · | · | · | |
| Financing Cash Flow | $3M | $12M | $4M | $2M | $188M | $2M | $3M | $3M | $2M | $241M | $-211.0K | $369.0K | $21.0K | $-303.0K | $130M | $179.0K | |
| Net Change in Cash | $39M | $-28M | $15M | $3M | $-7M | $8M | $-3M | $1M | $13M | $-56M | $1M | $-16M | $26M | $-88M | $91M | $-16M | |
| Free Cash Flow | · | $-43M | · | · | · | · | · | · | · | $-29M | · | · | $-27M | · | · | · |
Rentabilité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -10.5% | -10.1% | · | -7.4% | -6.3% | -8.1% | · | -8.3% | -7.3% | -6.3% | -7.5% | -7.3% | -7.4% | · | -5.2% | -5.7% | |
| ROE | -11.1% | -10.6% | · | -7.8% | -6.6% | -8.5% | · | -8.8% | -7.7% | -6.6% | -7.9% | -7.7% | -7.8% | · | -5.4% | -5.9% |
Liquidité et Solvabilité 3
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 16.2 | 22.6 | · | 26.5 | 28.9 | 21.0 | · | 26.3 | 30.2 | 37.1 | 18.2 | 22.0 | 26.2 | · | 27.8 | 27.5 | |
| Quick Ratio | 2.5 | 1.5 | · | 2.1 | 2.1 | 2.4 | · | 2.4 | 2.5 | 2.1 | 2.0 | 2.2 | 3.8 | · | 8.2 | 2.0 | |
| Debt / Equity | · | · | · | · | · | · | · | · | · | · | · | · | · | · | 0.0 | · |
Valorisation (TTM) 10
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 | Q2 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-183M | $-167M | · | $-152M | $-143M | $-135M | · | $-120M | $-107M | $-99M | $-88M | $-78M | $-71M | · | $-61M | $-54M | |
| Market Cap | $4.38B | $3.39B | · | $1.72B | $1.38B | $2.09B | · | $2.52B | $1.69B | $1.70B | $364M | $492M | $422M | · | $622M | $396M | |
| Enterprise Value | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $512M | · | |
| P/E | -23.6 | -19.4 | · | -10.7 | -8.9 | -15.1 | · | -18.5 | -12.7 | -12.7 | -4.0 | -5.7 | -5.1 | · | -8.1 | -7.3 | |
| P/B | 9.8 | 6.9 | · | 3.1 | 2.3 | 4.9 | · | 5.2 | 3.3 | 3.2 | 1.3 | 1.6 | 1.3 | · | 1.7 | 1.6 | |
| P / Tangible Book | 9.8 | 6.9 | · | 3.1 | 2.3 | 4.9 | · | 5.2 | 3.3 | 3.2 | 1.3 | 1.6 | 1.3 | · | 1.7 | 1.6 | |
| P / Cash Flow | · | -79.6 | · | · | · | -55.3 | · | · | · | -59.5 | · | · | -18.5 | · | · | · | |
| P / FCF | · | -79.1 | · | · | · | · | · | · | · | -58.9 | · | · | -15.5 | · | · | · | |
| EV / EBITDA | · | · | · | · | · | · | · | · | · | · | · | · | · | · | -28.0 | · | |
| Earnings Yield | -4.2% | -5.1% | · | -9.4% | -11.2% | -6.6% | · | -5.4% | -7.9% | -7.9% | -25.3% | -17.5% | -19.8% | · | -12.4% | -13.7% |
États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années
Compte de résultat
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Résultat net | $-168M | $-134M | $-100M | $-68M | $-43M |
| BPA dilué | $-1.63 | $-1.45 | $-1.57 | $-1.26 | $-1.14 |
Bilan
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Ratio de liquidité | 19.9 | 19.9 | 19.5 | 21.5 | 27.0 |
| Ratio de liquidité réduite | 2.2 | 1.7 | 5.1 | 1.3 | 1.5 |
Flux de trésorerie
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flux de trésorerie libre | $-144M | $-110M | $-98M | $-58M | $-34M |
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Détenteurs institutionnels (13F) 249 déclarants · $4.0B total · Au 30 juin 2026
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
Activité institutionnelle — Q2 2026 vs trimestre précédent
| Nouvelles positions | Positions clôturées | Augmenté | Diminué | Variation nette des actions |
|---|---|---|---|---|
| 47 (+1 vs T. préc.) | 24 (+1 vs T. préc.) | 79 (+12 vs T. préc.) | 74 (+9 vs T. préc.) | +3.3M |
Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $630 516 330 | 15 518 492 | 15,63% | Actions |
| Paradigm Biocapital Advisors LP | $415 053 937 | 10 215 455 | 10,29% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $340 996 620 | 8 392 730 | 8,46% | Actions |
| NOVO HOLDINGS A/S | $217 370 500 | 5 350 000 | 5,39% | Actions |
| Driehaus Capital Management LLC | $192 123 952 | 4 728 623 | 4,76% | Actions |
| PERCEPTIVE ADVISORS LLC | $177 714 564 | 4 373 974 | 4,41% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $156 859 022 | 3 860 670 | 3,89% | Actions |
| BAKER BROS. ADVISORS LP | $150 400 843 | 3 701 719 | 3,73% | Actions |
| Siren, L.L.C. | $129 391 476 | 3 184 629 | 3,21% | Actions |
| FMR LLC | $107 911 899 | 2 655 966 | 2,68% | Actions |
| Cormorant Asset Management, LP | $101 981 300 | 2 510 000 | 2,53% | Actions |
| Integral Health Asset Management, LLC | $81 260 000 | 2 000 000 | 2,01% | Actions |
| BRAIDWELL LP | $81 136 688 | 1 996 965 | 2,01% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $77 257 283 | 1 901 081 | 1,92% | Actions |
| STATE STREET CORP | $74 268 674 | 1 827 927 | 1,84% | Actions |
| ALLIANCEBERNSTEIN L.P. | $66 749 256 | 2 119 024 | 1,66% | Actions |
| MPM BIOIMPACT LLC | $65 852 291 | 1 620 780 | 1,63% | Actions |
| MORGAN STANLEY | $65 647 597 | 1 615 742 | 1,63% | Actions |
| BANK OF AMERICA CORP /DE/ | $56 886 145 | 1 400 102 | 1,41% | Actions |
| Qube Research & Technologies Ltd | $50 889 359 | 1 252 507 | 1,26% | Actions |
| AMERICAN CENTURY COMPANIES INC | $45 793 233 | 1 127 078 | 1,14% | Actions |
| First Light Asset Management, LLC | $44 496 798 | 1 095 171 | 1,10% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $43 383 658 | 1 067 774 | 1,08% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $36 683 608 | 902 870 | 0,91% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $31 953 707 | 786 456 | 0,79% | Actions |
| Aberdeen Group plc | $26 325 233 | 647 926 | 0,65% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25 212 215 | 620 532 | 0,63% | Actions |
| Tyro Capital Management LLC | $24 904 768 | 612 965 | 0,62% | Actions |
| Parkman Healthcare Partners LLC | $23 444 973 | 577 036 | 0,58% | Actions |
| Artisan Partners Limited Partnership | $23 359 203 | 574 925 | 0,58% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $22 276 820 | 548 285 | 0,55% | Actions |
| NORGES BANK | $20 726 988 | 510 140 | 0,51% | Actions |
| Opaleye Management Inc. | $20 315 000 | 500 000 | 0,50% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18 771 060 | 462 000 | 0,47% | Actions |
| Soleus Capital Management, L.P. | $18 319 620 | 450 889 | 0,45% | Actions |
| New Leaf Venture Partners, L.L.C. | $16 709 211 | 1 030 161 | 0,41% | Actions |
| GOLDMAN SACHS GROUP INC | $15 838 224 | 389 816 | 0,39% | Actions |
| Sofinnova Investments, Inc. | $15 476 901 | 380 923 | 0,38% | Actions |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $13 570 989 | 334 014 | 0,34% | Actions |
| CITADEL ADVISORS LLC | $13 539 054 | 333 228 | 0,34% | Actions |
| Squadron Capital Management LLC | $11 782 700 | 290 000 | 0,29% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $11 511 820 | 283 333 | 0,29% | Actions |
| DIADEMA PARTNERS LP | $11 060 055 | 272 214 | 0,27% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $10 425 983 | 256 608 | 0,26% | Actions |
| Schonfeld Strategic Advisors LLC | $10 368 855 | 255 202 | 0,26% | Actions |
| DAFNA Capital Management LLC | $9 215 656 | 226 819 | 0,23% | Actions |
| Woodline Partners LP | $9 112 903 | 224 290 | 0,23% | Actions |
| PRUDENTIAL FINANCIAL INC | $9 053 380 | 222 825 | 0,22% | Actions |
| PEREGRINE CAPITAL MANAGEMENT LLC | $8 067 899 | 198 570 | 0,20% | Actions |
| SEB Asset Management AB | $7 884 765 | 194 063 | 0,20% | Actions |
| Granahan Investment Management, LLC | $7 873 200 | 193 778 | 0,20% | Actions |
| BARCLAYS PLC | $7 694 956 | 189 391 | 0,19% | Actions |
| D. E. Shaw & Co., Inc. | $6 616 027 | 162 836 | 0,16% | Actions |
| Caption Management, LLC | $6 480 485 | 159 500 | 0,16% | Option d'achat |
| ADAR1 Capital Management, LLC | $5 818 175 | 143 199 | 0,14% | Actions |
| KVP Capital Advisors, LP | $5 403 790 | 133 000 | 0,13% | Actions |
| NEUBERGER BERMAN GROUP LLC | $5 201 900 | 128 031 | 0,13% | Actions |
| Point72 Asset Management, L.P. | $4 764 355 | 117 262 | 0,12% | Actions |
| Quantum Private Wealth, LLC | $4 606 640 | 113 380 | 0,11% | Actions |
| ALPS ADVISORS INC | $4 420 341 | 108 795 | 0,11% | Actions |
| Moody Aldrich Partners LLC | $4 264 200 | 104 952 | 0,11% | Actions |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | $4 063 000 | 100 000 | 0,10% | Option de vente |
| Artia Global Partners LP | $4 014 244 | 98 800 | 0,10% | Actions |
| Nuveen, LLC | $3 934 203 | 96 830 | 0,10% | Actions |
| Swiss National Bank | $3 932 984 | 96 800 | 0,10% | Actions |
| HighVista Strategies LLC | $3 697 168 | 90 996 | 0,09% | Actions |
| BlackRock, Inc. | $3 668 036 | 90 279 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $3 666 114 | 90 232 | 0,09% | Actions |
| JANUS HENDERSON GROUP PLC | $3 597 171 | 114 215 | 0,09% | Actions |
| Ally Bridge Group (NY) LLC | $3 384 479 | 83 300 | 0,08% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $3 361 482 | 82 734 | 0,08% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $3 258 404 | 80 197 | 0,08% | Actions |
| Centiva Capital, LP | $3 047 250 | 75 000 | 0,08% | Option d'achat |
| Jefferies Financial Group Inc. | $2 900 535 | 71 389 | 0,07% | Actions |
| Persistent Asset Partners Ltd | $2 821 388 | 69 441 | 0,07% | Actions |
| Bank of New York Mellon Corp | $2 805 298 | 69 045 | 0,07% | Actions |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $2 638 000 | 64 918 | 0,07% | Actions |
| TUDOR INVESTMENT CORP ET AL | $2 313 228 | 56 934 | 0,06% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2 312 699 | 73 419 | 0,06% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $2 312 253 | 56 910 | 0,06% | Actions |
| CITADEL ADVISORS LLC | $2 263 091 | 55 700 | 0,06% | Option d'achat |
| CITIGROUP INC | $2 252 324 | 55 435 | 0,06% | Actions |
| HighMark Wealth Management LLC | $2 160 662 | 53 179 | 0,05% | Actions |
| TWO SIGMA INVESTMENTS, LP | $2 013 135 | 49 548 | 0,05% | Actions |
| ALGERT GLOBAL LLC | $1 919 361 | 47 240 | 0,05% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 913 673 | 47 100 | 0,05% | Option de vente |
| XTX Topco Ltd | $1 862 154 | 45 832 | 0,05% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $1 770 940 | 43 587 | 0,04% | Actions |
| MetLife Investment Management, LLC | $1 698 497 | 41 804 | 0,04% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 655 957 | 40 757 | 0,04% | Actions |
| Ensign Peak Advisors, Inc | $1 640 599 | 40 379 | 0,04% | Actions |
| Knights of Columbus Asset Advisors LLC | $1 569 984 | 38 641 | 0,04% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 568 318 | 38 600 | 0,04% | Option d'achat |
| Aquatic Capital Management LLC | $1 499 978 | 36 918 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $1 452 279 | 35 744 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $1 434 361 | 35 303 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1 338 312 | 32 939 | 0,03% | Actions |
| JANE STREET GROUP, LLC | $1 178 676 | 29 010 | 0,03% | Actions |
| Invesco Ltd. | $1 158 077 | 28 503 | 0,03% | Actions |
| Verdad Advisers, LP | $1 106 517 | 27 234 | 0,03% | Actions |
Initiés de la société 15 initiés · 0 dirigeants · 7 administrateurs
| Dirigeant | Rôle | Dernière activité | Actions détenues | Achats 12m | Ventes 12m | Net 12m |
|---|---|---|---|---|---|---|
| Jonathan C Fox | Administrateur | 1 juillet 2026 A | 24 833 | 0 | 0 | $0 |
| Christopher Nathan Martin | Administrateur | 5 juin 2026 A | — | 0 | 0 | $0 |
| Badreddin Edris | Administrateur | 5 juin 2026 A | — | 0 | 0 | $0 |
| Laura Brege | Administrateur | 5 juin 2026 A | — | 0 | 0 | $0 |
| Arlene Morris | Administrateur | 5 juin 2026 A | — | 0 | 0 | $0 |
| Peter A. Thompson | Administrateur | 5 juin 2026 A | 443 792 | 0 | 0 | $0 |
| Jonathan D Root | Administrateur | 5 juin 2026 A | 0 | 0 | 0 | $0 |
| Novo Holdings A/S | Détenteur de 10% | 14 septembre 2022 P | 6 071 703 | 0 | 0 | $0 |
| Wellington Biomedical Innovation Master Investors (Cayman) I L.P. | Détenteur de 10% | 30 mars 2021 C | 681 812 | 0 | 0 | $0 |
| Alan J Russell | — | 12 août 2026 A | 31 466 | 0 | 5 | $-8 140 060 |
| Behrad Derakhshan | — | 12 août 2026 A | 31 826 | 0 | 4 | $-223 420 |
| Michael Nofi | — | 12 août 2026 A | — | 0 | 0 | $0 |
| Joanne M. Donovan | — | 12 août 2026 A | 8 625 | 0 | 5 | $-412 712 |
| John R Moore | — | 12 août 2026 A | 17 697 | 0 | 4 | $-219 831 |
| Kevin Koch | — | 12 août 2026 A | 52 488 | 0 | 3 | $-785 049 |
Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché
Activistes et détenteurs de 5%+ 3 participations
Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.
| Déclarant | Déposé | Participation | Statut | Objectif | Dépôt |
|---|---|---|---|---|---|
| Novo Holdings A/S ×7 dépôts | 27 avril 2026 | 4,90% | Amendement | — | SEC |
| ORBIMED ADVISORS LLC, ORBIMED CAPITAL GP VI LLC, OrbiMed Genesis GP LLC, ORBIMED CAPITAL LLC ×5 dépôts | 12 mai 2025 | 14,50% | Amendement | — | SEC |
| U.S. Venture Partners XI, L.P. (“USVP XI”), Presidio Management Group XI, L.L.C. (“PMG XI”), Casey M. Tansey, Jonathan D. Root ×2 dépôts | 1 février 2023 | — | Dépôt initial | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Détention d'ETF Détenu par 45 ETFs
Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.
| Fonds | Poids | Unités | Au | Source |
|---|---|---|---|---|
| IBRN · iShares Trust | 3,54% | 6 153 SH | 8 août 2026 | Quotidien |
| SBIO · ALPS ETF Trust | 2,33% | 110 576 NS | 31 mai 2026 | N-PORT |
| PILL · Direxion Shares ETF Trust | 1,34% | 5 567 NS | 30 avril 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,97% | 11 685 NS | 30 avril 2026 | N-PORT |
| IHE · iShares Trust | 0,74% | 269 166 SH | 8 août 2026 | Quotidien |
| MMSC · First Trust Exchange-Traded Fund VI… | 0,63% | 9 620 NS | 31 mai 2026 | N-PORT |
| DWAS · Invesco Exchange-Traded Fund Trust … | 0,47% | 48 340 SH | 8 août 2026 | Quotidien |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,32% | 5 857 SH | 8 août 2026 | Quotidien |
| IBB · iShares Trust | 0,27% | 577 144 SH | 8 août 2026 | Quotidien |
| IWO · iShares Trust | 0,20% | 647 964 SH | 8 août 2026 | Quotidien |
| BIB · ProShares Trust | 0,18% | 3 966 NS | 31 mai 2026 | N-PORT |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,17% | 76 681 SH | 8 août 2026 | Quotidien |
| VFMO · VANGUARD WELLINGTON FUND | 0,13% | 65 171 SH | 8 août 2026 | Quotidien |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0,13% | 30 264 NS | 30 avril 2026 | N-PORT |
| IWM · iShares Trust | 0,10% | 1 809 565 SH | 8 août 2026 | Quotidien |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,09% | 411 642 SH | 8 août 2026 | Quotidien |
| ESML · iShares Trust | 0,06% | 42 227 SH | 8 août 2026 | Quotidien |
| RSSL · Global X Funds | 0,06% | 29 238 NS | 30 avril 2026 | N-PORT |
| ISCG · iShares Trust | 0,06% | 13 816 SH | 8 août 2026 | Quotidien |
| ISCB · iShares Trust | 0,06% | 3 892 SH | 8 août 2026 | Quotidien |
| ISCV · iShares Trust | 0,06% | 9 273 SH | 8 août 2026 | Quotidien |
| ITWO · ProShares Trust | 0,06% | 3 175 NS | 31 mai 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,05% | 355 389 NS | 31 mai 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,05% | 30 883 SH | 8 août 2026 | Quotidien |
| DFAS · Dimensional ETF Trust | 0,04% | 167 330 NS | 30 avril 2026 | N-PORT |
| UWM · ProShares Trust | 0,03% | 2 484 NS | 31 mai 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,03% | 864 416 SH | 8 août 2026 | Quotidien |
| VHT · VANGUARD WORLD FUND | 0,03% | 145 298 SH | 8 août 2026 | Quotidien |
| FHLC · FIDELITY COVINGTON TRUST | 0,03% | 24 144 NS | 30 avril 2026 | N-PORT |
| URTY · ProShares Trust | 0,02% | 2 510 NS | 31 mai 2026 | N-PORT |
| WSML · iShares Trust | 0,02% | 3 101 SH | 8 août 2026 | Quotidien |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,01% | 2 733 NS | 31 mai 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0,01% | 33 343 NS | 31 mai 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,01% | 2 902 915 SH | 8 août 2026 | Quotidien |
| HDG · ProShares Trust | 0,01% | 63 NS | 31 mai 2026 | N-PORT |
| TILT · FlexShares Trust | 0,01% | 5 888 NS | 30 avril 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,01% | 7 155 NS | 31 mai 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0,01% | 105 864 NS | 30 avril 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,01% | 6 245 NS | 30 avril 2026 | N-PORT |
| ITOT · iShares Trust | 0,00% | 105 818 SH | 8 août 2026 | Quotidien |
| IWV · iShares Trust | 0,00% | 20 898 SH | 8 août 2026 | Quotidien |
| DFAU · Dimensional ETF Trust | 0,00% | 15 310 NS | 30 avril 2026 | N-PORT |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 44 236 NS | 31 mai 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0,00% | 9 382 NS | 30 avril 2026 | N-PORT |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 5 890 SH | 8 août 2026 | Quotidien |