NAMS — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $613 032 889 | 18 088 902 | 15,23% | Actions |
| Capital World Investors | $414 493 577 | 12 230 557 | 10,30% | Actions |
| FMR LLC | $350 411 179 | 10 339 663 | 8,70% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $323 655 973 | 9 550 191 | 8,04% | Actions |
| FCPM III SERVICES B.V. | $287 738 063 | 8 490 353 | 7,15% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $144 533 699 | 4 264 789 | 3,59% | Actions |
| VIKING GLOBAL INVESTORS LP | $142 458 886 | 4 203 567 | 3,54% | Actions |
| Bain Capital Life Sciences Investors, LLC | $129 004 522 | 3 806 566 | 3,20% | Actions |
| MAVERICK CAPITAL LTD | $110 745 810 | 3 267 802 | 2,75% | Actions |
| Medicxi Ventures Management (Jersey) Ltd | $74 850 776 | 2 208 639 | 1,86% | Actions |
| JANUS HENDERSON GROUP PLC | $72 253 603 | 2 258 984 | 1,79% | Actions |
| JENNISON ASSOCIATES LLC | $71 246 471 | 2 102 286 | 1,77% | Actions |
| Orbis Allan Gray Ltd | $59 227 079 | 1 747 627 | 1,47% | Actions |
| Polar Capital Holdings Plc | $58 443 915 | 1 724 518 | 1,45% | Actions |
| Capital International Investors | $58 409 246 | 1 723 495 | 1,45% | Actions |
| GOLDMAN SACHS GROUP INC | $52 357 034 | 1 544 911 | 1,30% | Actions |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $52 071 036 | 1 536 472 | 1,29% | Actions |
| Castle Hook Partners LP | $46 463 359 | 1 371 005 | 1,15% | Actions |
| AMERIPRISE FINANCIAL INC | $42 482 886 | 1 253 549 | 1,06% | Actions |
| ALLIANCEBERNSTEIN L.P. | $40 330 679 | 1 259 940 | 1,00% | Actions |
| JPMORGAN CHASE & CO | $38 373 185 | 1 132 955 | 0,95% | Actions |
| Aberdeen Group plc | $37 373 384 | 1 102 785 | 0,93% | Actions |
| BlackRock, Inc. | $36 050 487 | 1 063 750 | 0,90% | Actions |
| FRANKLIN RESOURCES INC | $33 683 835 | 993 917 | 0,84% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $26 472 835 | 781 140 | 0,66% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $25 564 142 | 754 327 | 0,63% | Actions |
| Woodline Partners LP | $25 501 852 | 752 489 | 0,63% | Actions |
| BANK OF AMERICA CORP /DE/ | $24 925 518 | 735 483 | 0,62% | Actions |
| TimesSquare Capital Management, LLC | $24 071 136 | 751 988 | 0,60% | Actions |
| AMERICAN CENTURY COMPANIES INC | $23 208 343 | 684 813 | 0,58% | Actions |
| CITADEL ADVISORS LLC | $21 886 331 | 645 805 | 0,54% | Actions |
| Jefferies Financial Group Inc. | $20 334 000 | 600 000 | 0,51% | Option de vente |
| Rock Springs Capital Management LP | $19 749 194 | 582 744 | 0,49% | Actions |
| First Turn Management, LLC | $19 740 823 | 582 497 | 0,49% | Actions |
| MORGAN STANLEY | $19 514 724 | 575 825 | 0,48% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $19 269 854 | 568 600 | 0,48% | Option de vente |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18 639 500 | 550 000 | 0,46% | Actions |
| Artia Global Partners LP | $17 078 391 | 503 936 | 0,42% | Actions |
| MILLENNIUM MANAGEMENT LLC | $16 999 698 | 501 614 | 0,42% | Actions |
| PERCEPTIVE ADVISORS LLC | $16 945 000 | 500 000 | 0,42% | Option de vente |
| Cormorant Asset Management, LP | $16 945 000 | 500 000 | 0,42% | Actions |
| JANE STREET GROUP, LLC | $16 071 858 | 474 236 | 0,40% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $14 280 365 | 421 374 | 0,35% | Actions |
| Bank of New York Mellon Corp | $11 973 270 | 353 298 | 0,30% | Actions |
| UBS Group AG | $11 660 363 | 344 065 | 0,29% | Actions |
| Slate Path Capital LP | $10 810 910 | 319 000 | 0,27% | Actions |
| ExodusPoint Capital Management, LP | $10 313 879 | 304 334 | 0,26% | Actions |
| Eversept Partners, LP | $9 335 712 | 275 471 | 0,23% | Actions |
| Affinity Asset Advisors, LLC | $9 319 750 | 275 000 | 0,23% | Actions |
| SEB Asset Management AB | $9 240 226 | 272 654 | 0,23% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $9 131 973 | 285 285 | 0,23% | Actions |
| Atle Fund Management AB | $8 433 458 | 248 848 | 0,21% | Actions |
| GILDER GAGNON HOWE & CO LLC | $7 593 732 | 224 070 | 0,19% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $7 413 404 | 218 749 | 0,18% | Actions |
| LMR Partners LLP | $7 269 405 | 214 500 | 0,18% | Option de vente |
| Ensign Peak Advisors, Inc | $7 199 015 | 212 423 | 0,18% | Actions |
| ArrowMark Colorado Holdings LLC | $7 179 359 | 211 843 | 0,18% | Actions |
| DEUTSCHE BANK AG\ | $6 775 662 | 199 931 | 0,17% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $6 156 932 | 181 674 | 0,15% | Actions |
| VANGUARD GROUP INC | $6 067 297 | 172 956 | 0,15% | Actions |
| Decheng Capital LLC | $5 994 700 | 176 887 | 0,15% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $5 851 549 | 172 663 | 0,15% | Actions |
| PEREGRINE CAPITAL MANAGEMENT LLC | $5 743 948 | 169 488 | 0,14% | Actions |
| Point72 Asset Management, L.P. | $5 724 055 | 168 901 | 0,14% | Actions |
| AXA Investment Managers S.A. | $5 596 480 | 196 782 | 0,14% | Actions |
| Mizuho Markets Cayman LP | $5 101 767 | 150 539 | 0,13% | Actions |
| TD Asset Management Inc | $5 029 276 | 148 400 | 0,12% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5 015 720 | 148 000 | 0,12% | Option d'achat |
| XTX Topco Ltd | $4 914 321 | 145 008 | 0,12% | Actions |
| Jump Financial, LLC | $4 897 512 | 144 512 | 0,12% | Actions |
| DCF Advisers, LLC | $4 778 490 | 141 000 | 0,12% | Actions |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $4 742 329 | 139 933 | 0,12% | Actions |
| Cutter Capital Management, LP | $4 526 981 | 221 152 | 0,11% | Actions |
| Jefferies Financial Group Inc. | $4 159 252 | 122 728 | 0,10% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $4 107 468 | 121 200 | 0,10% | Option de vente |
| Swiss National Bank | $4 104 079 | 121 100 | 0,10% | Actions |
| D. E. Shaw & Co., Inc. | $4 085 812 | 120 561 | 0,10% | Actions |
| ADAR1 Capital Management, LLC | $4 020 133 | 118 623 | 0,10% | Actions |
| ALPS ADVISORS INC | $4 003 934 | 118 145 | 0,10% | Actions |
| STATE STREET CORP | $3 904 636 | 115 215 | 0,10% | Actions |
| Walleye Capital LLC | $3 789 546 | 111 819 | 0,09% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $3 562 287 | 105 169 | 0,09% | Actions |
| Swedbank AB | $3 527 949 | 104 100 | 0,09% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3 261 302 | 96 232 | 0,08% | Actions |
| NORTHERN TRUST CORP | $3 184 677 | 93 971 | 0,08% | Actions |
| Caption Management, LLC | $3 124 658 | 92 200 | 0,08% | Option de vente |
| Squarepoint Ops LLC | $3 118 761 | 92 026 | 0,08% | Actions |
| Moody Aldrich Partners LLC | $3 071 010 | 90 617 | 0,08% | Actions |
| Schonfeld Strategic Advisors LLC | $3 042 135 | 89 765 | 0,08% | Actions |
| Bellevue Group AG | $2 948 227 | 86 994 | 0,07% | Actions |
| ALGERT GLOBAL LLC | $2 756 613 | 81 340 | 0,07% | Actions |
| Man Group plc | $2 739 396 | 80 832 | 0,07% | Actions |
| TUDOR INVESTMENT CORP ET AL | $2 692 899 | 79 460 | 0,07% | Actions |
| Y-Intercept (Hong Kong) Ltd | $2 648 029 | 78 136 | 0,07% | Actions |
| STEMPOINT CAPITAL LP | $2 629 491 | 77 589 | 0,07% | Actions |
| Headlands Technologies LLC | $2 451 433 | 72 335 | 0,06% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2 284 796 | 67 418 | 0,06% | Actions |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $2 145 169 | 63 298 | 0,05% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $2 015 675 | 59 477 | 0,05% | Actions |
| Russell Investments Group, Ltd. | $1 989 578 | 58 707 | 0,05% | Actions |
| China Universal Asset Management Co., Ltd. | $1 647 223 | 48 605 | 0,04% | Actions |
| Qube Research & Technologies Ltd | $1 595 880 | 47 090 | 0,04% | Actions |
| FRED ALGER MANAGEMENT, LLC | $1 528 947 | 45 115 | 0,04% | Actions |
| Palo Alto Investors LP | $1 503 327 | 44 359 | 0,04% | Actions |
| Knights of Columbus Asset Advisors LLC | $1 484 382 | 43 800 | 0,04% | Actions |
| FIRST TRUST ADVISORS LP | $1 460 930 | 43 108 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $1 437 682 | 42 422 | 0,04% | Actions |
| Fieldview Capital Management, LLC | $1 418 025 | 41 842 | 0,04% | Actions |
| SEI INVESTMENTS CO | $1 385 017 | 40 868 | 0,03% | Actions |
| Legal & General Group Plc | $1 333 336 | 39 343 | 0,03% | Actions |
| CITADEL ADVISORS LLC | $1 301 376 | 38 400 | 0,03% | Option d'achat |
| Ishara Investments LP | $1 250 541 | 36 900 | 0,03% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $1 211 771 | 35 756 | 0,03% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $1 210 212 | 35 710 | 0,03% | Actions |
| LMR Partners LLP | $1 155 649 | 34 100 | 0,03% | Option d'achat |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 123 759 | 33 159 | 0,03% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $1 118 336 | 32 999 | 0,03% | Actions |
| STIFEL FINANCIAL CORP | $1 079 432 | 31 851 | 0,03% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $1 062 621 | 31 355 | 0,03% | Actions |
| Quadrature Capital Ltd | $1 036 797 | 30 593 | 0,03% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $916 725 | 27 050 | 0,02% | Actions |
| Eleva Capital SAS | $823 329 | 25 721 | 0,02% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $768 998 | 22 691 | 0,02% | Actions |
| HighVista Strategies LLC | $708 470 | 20 905 | 0,02% | Actions |
| GLENMEDE TRUST CO NA | $692 033 | 20 420 | 0,02% | Actions |
| DNB Asset Management AS | $680 850 | 20 090 | 0,02% | Actions |
| Engineers Gate Manager LP | $661 838 | 19 529 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $661 465 | 19 518 | 0,02% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $647 265 | 19 099 | 0,02% | Actions |
| Caption Management, LLC | $633 743 | 18 700 | 0,02% | Option d'achat |
| Point72 Asset Management, L.P. | $620 187 | 18 300 | 0,02% | Option d'achat |
| Point72 Asset Management, L.P. | $620 187 | 18 300 | 0,02% | Option de vente |
| WELLS FARGO & COMPANY/MN | $611 308 | 18 038 | 0,02% | Actions |
| GOLDMAN SACHS GROUP INC | $576 130 | 17 000 | 0,01% | Option d'achat |
| ARIZONA STATE RETIREMENT SYSTEM | $564 472 | 16 656 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $534 581 | 15 774 | 0,01% | Actions |
| ENVESTNET ASSET MANAGEMENT INC | $525 973 | 15 520 | 0,01% | Actions |
| SBI Okasan Asset Management Co.Ltd. | $504 663 | 14 900 | 0,01% | Actions |
| AlphaCentric Advisors LLC | $503 877 | 14 868 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $487 000 | 14 362 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $464 293 | 13 700 | 0,01% | Actions |
| KEYBANK NATIONAL ASSOCIATION/OH | $422 947 | 12 480 | 0,01% | Actions |
| TWO SIGMA INVESTMENTS, LP | $406 714 | 12 001 | 0,01% | Actions |
| PSP Research LLC | $406 680 | 12 000 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $406 680 | 12 000 | 0,01% | Option d'achat |
| PTM WEALTH MANAGEMENT, LLC | $382 356 | 12 900 | 0,01% | Actions |
| Virtus Investment Advisers, LLC | $364 758 | 10 763 | 0,01% | Actions |
| Financiere des Professionnels - Fonds d'investissement inc. | $364 114 | 10 744 | 0,01% | Actions |
| Cerity Partners LLC | $340 967 | 10 061 | 0,01% | Actions |
| Caitong International Asset Management Co., Ltd | $328 123 | 9 682 | 0,01% | Actions |
| Brevan Howard Capital Management LP | $323 582 | 9 548 | 0,01% | Actions |
| LETKO, BROSSEAU & ASSOCIATES INC | $321 108 | 9 475 | 0,01% | Actions |
| BAMCO INC /NY/ | $305 010 | 9 000 | 0,01% | Actions |
| AdvisorNet Financial, Inc | $283 829 | 8 375 | 0,01% | Actions |
| Pictet Asset Management Holding SA | $277 051 | 8 175 | 0,01% | Actions |
| Creative Planning | $275 695 | 8 135 | 0,01% | Actions |
| BARCLAYS PLC | $273 560 | 8 072 | 0,01% | Actions |
| CITIGROUP INC | $272 001 | 8 026 | 0,01% | Actions |
| Mesirow Financial Investment Management, Inc. | $252 989 | 7 465 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $247 397 | 7 300 | 0,01% | Option de vente |
| PNC Financial Services Group, Inc. | $247 091 | 7 291 | 0,01% | Actions |
| US BANCORP \DE\ | $246 922 | 7 286 | 0,01% | Actions |
| Persistent Asset Partners Ltd | $246 855 | 7 284 | 0,01% | Actions |
| Wealth Management Associates, Inc. | $239 094 | 7 055 | 0,01% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $237 501 | 7 008 | 0,01% | Actions |
| Centiva Capital, LP | $237 230 | 7 000 | 0,01% | Actions |
| Invesco Ltd. | $224 250 | 6 617 | 0,01% | Actions |
| Allianz Asset Management GmbH | $223 674 | 6 600 | 0,01% | Actions |
| CIBC Private Wealth Group LLC | $217 282 | 7 640 | 0,01% | Actions |
| GUGGENHEIM CAPITAL LLC | $216 896 | 6 400 | 0,01% | Actions |
| MARSHALL FINANCIAL GROUP INC /ADV | $213 300 | 7 500 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $177 177 | 5 228 | 0,00% | Actions |
| Quarry LP | $153 996 | 4 544 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $152 505 | 4 500 | 0,00% | Actions |
| Mitsubishi UFJ Trust & Banking Corp | $146 744 | 4 330 | 0,00% | Actions |
| WELLS FARGO & COMPANY/MN | $128 782 | 3 800 | 0,00% | Option de vente |
| Duquesne Family Office LLC | $104 047 | 3 070 146 | 0,00% | Actions |
| Quantbot Technologies LP | $91 300 | 2 694 | 0,00% | Actions |
| Toroso Investments, LLC | $84 192 | 2 400 | 0,00% | Option d'achat |
| GF FUND MANAGEMENT CO. LTD. | $82 488 | 2 434 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $61 431 | 1 813 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $60 494 | 1 785 | 0,00% | Actions |
| Parallel Advisors, LLC | $47 446 | 1 400 | 0,00% | Actions |
| Bayforest Capital Ltd | $43 278 | 1 277 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $39 562 | 1 167 357 | 0,00% | Actions |
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. | $36 160 | 1 067 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $34 093 | 1 006 | 0,00% | Actions |
| CWM, LLC | $32 586 | 1 018 | 0,00% | Actions |
| Cheviot Value Management, LLC | $26 976 | 796 | 0,00% | Actions |
| NWI MANAGEMENT LP | $23 791 | 702 000 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $20 842 | 615 | 0,00% | Actions |
| Handelsbanken Fonder AB | $13 409 | 418 900 | 0,00% | Actions |
| HRT FINANCIAL LP | $11 856 | 349 843 | 0,00% | Actions |
| Stone House Investment Management, LLC | $11 014 | 325 | 0,00% | Actions |
| LORD, ABBETT & CO. LLC | $10 389 | 306 560 | 0,00% | Actions |
| Global Retirement Partners, LLC | $9 150 | 270 | 0,00% | Actions |
| FIL Ltd | $7 354 | 217 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $7 083 | 209 | 0,00% | Actions |
| Arax Advisory Partners | $6 032 | 178 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $5 584 | 168 | 0,00% | Actions |
| Continuum Advisory, LLC | $5 219 | 154 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $4 710 | 139 | 0,00% | Actions |
| Clearstead Advisors, LLC | $2 576 | 76 | 0,00% | Actions |
| ORG Partners LLC | $2 104 | 60 | 0,00% | Actions |
| Essential Partners LLC | $1 796 | 53 | 0,00% | Actions |
| Lindbrook Capital, LLC | $921 | 45 | 0,00% | Actions |
| Allworth Financial LP | $848 | 25 | 0,00% | Actions |
| True Wealth Design, LLC | $712 | 21 | 0,00% | Actions |
| FIDUCIARY FINANCIAL ADVISORS | $441 | 13 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $373 | 11 | 0,00% | Actions |
| GAMMA Investing LLC | $305 | 9 | 0,00% | Actions |
| Sunbelt Securities, Inc. | $256 | 8 | 0,00% | Actions |
| SG Americas Securities, LLC | $115 | 3 384 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $102 | 3 | 0,00% | Actions |
| IFP Advisors, Inc | $102 | 3 | 0,00% | Actions |
| KBC Group NV | $84 | 2 483 | 0,00% | Actions |
| DUPONT CAPITAL MANAGEMENT CORP | $34 | 1 | 0,00% | Actions |