| RA CAPITAL MANAGEMENT, L.P. |
$67,304,808 |
12,723,026 |
10.40% |
주식
|
| BML Capital Management, LLC |
$63,347,750 |
11,975,000 |
9.79% |
주식
|
| BlackRock, Inc. |
$53,095,772 |
10,037,008 |
8.21% |
주식
|
| Deep Track Capital, LP |
$49,435,050 |
9,345,000 |
7.64% |
주식
|
| Vivo Capital, LLC |
$35,414,630 |
6,694,637 |
5.47% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$30,776,511 |
5,817,866 |
4.76% |
주식
|
| Frazier Life Sciences Management, L.P. |
$26,055,228 |
4,925,374 |
4.03% |
주식
|
| Rock Springs Capital Management LP |
$22,908,514 |
4,330,532 |
3.54% |
주식
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$21,535,590 |
4,071,000 |
3.33% |
주식
|
| Decheng Capital LLC |
$21,380,783 |
4,041,736 |
3.30% |
주식
|
| VANGUARD GROUP INC |
$19,571,260 |
6,502,080 |
3.02% |
주식
|
| STATE STREET CORP |
$17,220,749 |
3,255,340 |
2.66% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16,879,468 |
3,190,058 |
2.61% |
주식
|
| BRAIDWELL LP |
$11,333,021 |
2,142,348 |
1.75% |
주식
|
| Balyasny Asset Management L.P. |
$10,704,156 |
2,023,470 |
1.65% |
주식
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$10,296,890 |
1,946,482 |
1.59% |
주식
|
| Kalehua Capital Management LLC |
$9,693,211 |
1,832,365 |
1.50% |
주식
|
| CITADEL ADVISORS LLC |
$9,321,408 |
1,762,081 |
1.44% |
주식
|
| Jones Hill Capital LP |
$9,307,713 |
1,759,492 |
1.44% |
주식
|
| Palo Alto Investors LP |
$8,535,045 |
1,613,430 |
1.32% |
주식
|
| Woodline Partners LP |
$8,522,476 |
1,611,054 |
1.32% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7,753,738 |
1,465,735 |
1.20% |
주식
|
| PANAGORA ASSET MANAGEMENT INC |
$7,174,044 |
1,356,152 |
1.11% |
주식
|
| Connor, Clark & Lunn Investment Management Ltd. |
$6,400,297 |
1,209,886 |
0.99% |
주식
|
| MPM BIOIMPACT LLC |
$5,514,650 |
1,042,467 |
0.85% |
주식
|
| DEUTSCHE BANK AG\ |
$5,506,652 |
1,040,955 |
0.85% |
주식
|
| NORTHERN TRUST CORP |
$5,283,456 |
998,763 |
0.82% |
주식
|
| KOTLER KEVIN |
$5,134,846 |
1,705,929 |
0.79% |
주식
|
| Aldebaran Capital, LLC |
$4,955,307 |
936,731 |
0.77% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$4,798,945 |
907,173 |
0.74% |
주식
|
| RENAISSANCE TECHNOLOGIES LLC |
$4,324,739 |
817,531 |
0.67% |
주식
|
| Three Bridge Wealth Advisors, LLC |
$3,781,414 |
714,823 |
0.58% |
주식
|
| GOLDMAN SACHS GROUP INC |
$3,222,447 |
609,158 |
0.50% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$2,771,405 |
523,895 |
0.43% |
주식
|
| CITADEL ADVISORS LLC |
$2,756,090 |
521,000 |
0.43% |
콜 옵션
|
| DIMENSIONAL FUND ADVISORS LP |
$2,714,467 |
513,840 |
0.42% |
주식
|
| JPMORGAN CHASE & CO |
$2,354,200 |
468,964 |
0.36% |
주식
|
| Aisling Capital Management LP |
$2,298,267 |
434,455 |
0.36% |
주식
|
| ORBIMED ADVISORS LLC |
$2,229,735 |
421,500 |
0.34% |
주식
|
| D. E. Shaw & Co., Inc. |
$2,192,700 |
414,499 |
0.34% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2,182,384 |
412,549 |
0.34% |
주식
|
| Tetragon Partners GP Ltd |
$2,116,000 |
400,000 |
0.33% |
주식
|
| Russell Investments Group, Ltd. |
$1,931,139 |
365,055 |
0.30% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1,830,647 |
346,058 |
0.28% |
주식
|
| FMR LLC |
$1,660,267 |
313,850 |
0.26% |
주식
|
| Bank of New York Mellon Corp |
$1,494,949 |
282,599 |
0.23% |
주식
|
| Nuveen, LLC |
$1,472,758 |
278,404 |
0.23% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$1,457,982 |
275,611 |
0.23% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1,415,064 |
267,498 |
0.22% |
주식
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$1,363,101 |
257,675 |
0.21% |
주식
|
| UBS Group AG |
$1,359,536 |
257,001 |
0.21% |
주식
|
| Invesco Ltd. |
$1,285,618 |
243,028 |
0.20% |
주식
|
| HighTower Advisors, LLC |
$1,150,702 |
217,524 |
0.18% |
주식
|
| Creative Planning |
$1,093,163 |
206,647 |
0.17% |
주식
|
| Logos Global Management LP |
$1,058,000 |
200,000 |
0.16% |
주식
|
| Verdad Advisers, LP |
$927,189 |
175,272 |
0.14% |
주식
|
| Informed Momentum Co LLC |
$906,320 |
171,327 |
0.14% |
주식
|
| Assenagon Asset Management S.A. |
$817,591 |
154,554 |
0.13% |
주식
|
| Atom Investors LP |
$787,443 |
148,855 |
0.12% |
주식
|
| TWO SIGMA ADVISERS, LP |
$768,754 |
255,400 |
0.12% |
주식
|
| RHUMBLINE ADVISERS |
$757,603 |
143,216 |
0.12% |
주식
|
| ALPS ADVISORS INC |
$749,852 |
141,749 |
0.12% |
주식
|
| SEI INVESTMENTS CO |
$734,136 |
138,778 |
0.11% |
주식
|
| MORGAN STANLEY |
$709,477 |
134,117 |
0.11% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$703,930 |
133,068 |
0.11% |
주식
|
| Vanguard Global Advisers, LLC |
$682,706 |
129,056 |
0.11% |
주식
|
| Hudson Bay Capital Management LP |
$634,800 |
120,000 |
0.10% |
주식
|
| CenterBook Partners LP |
$625,426 |
118,228 |
0.10% |
주식
|
| CITIGROUP INC |
$623,088 |
117,786 |
0.10% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$584,080 |
110,412 |
0.09% |
주식
|
| WELLS FARGO & COMPANY/MN |
$574,748 |
108,648 |
0.09% |
주식
|
| CITADEL ADVISORS LLC |
$550,160 |
104,000 |
0.09% |
풋 옵션
|
| Verition Fund Management LLC |
$518,420 |
98,000 |
0.08% |
주식
|
| STRS OHIO |
$430,606 |
81,400 |
0.07% |
주식
|
| Voleon Capital Management LP |
$408,219 |
77,168 |
0.06% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$403,468 |
76,270 |
0.06% |
주식
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$396,851 |
75,019 |
0.06% |
주식
|
| BARCLAYS PLC |
$386,223 |
73,010 |
0.06% |
주식
|
| MetLife Investment Management, LLC |
$368,708 |
69,699 |
0.06% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$318,771 |
60,259 |
0.05% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$288,718 |
54,578 |
0.04% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$280,899 |
53,100 |
0.04% |
풋 옵션
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$271,906 |
51,400 |
0.04% |
콜 옵션
|
| MANGROVE PARTNERS IM, LLC |
$266,039 |
50,291 |
0.04% |
주식
|
| DIVERSIFIED TRUST CO |
$240,816 |
45,523 |
0.04% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$213,750 |
57,000 |
0.03% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$205,390 |
38,826 |
0.03% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$187,922 |
35,524 |
0.03% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$171,428 |
32,406 |
0.03% |
주식
|
| PROFUND ADVISORS LLC |
$161,271 |
30,486 |
0.02% |
주식
|
| State of Wyoming |
$145,152 |
27,439 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$144,417 |
27,300 |
0.02% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$130,494 |
24,668 |
0.02% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$122,220 |
23,104 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$117,586 |
22,228 |
0.02% |
주식
|
| Rafferty Asset Management, LLC |
$116,364 |
21,997 |
0.02% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$107,228 |
20,270 |
0.02% |
주식
|
| ProShare Advisors LLC |
$106,302 |
20,095 |
0.02% |
주식
|
| Verition Fund Management LLC |
$105,800 |
20,000 |
0.02% |
콜 옵션
|
| Walleye Capital LLC |
$103,557 |
19,576 |
0.02% |
주식
|
| NEUBERGER BERMAN GROUP LLC |
$102,451 |
19,367 |
0.02% |
주식
|
| Vontobel Holding Ltd. |
$95,220 |
18,000 |
0.01% |
주식
|
| CRA Financial Services, LLC |
$94,067 |
17,782 |
0.01% |
주식
|
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management |
$85,021 |
16,072 |
0.01% |
주식
|
| Vanguard Personalized Indexing Management, LLC |
$83,005 |
15,691 |
0.01% |
주식
|
| Dynamic Technology Lab Private Ltd |
$72,000 |
13,521 |
0.01% |
주식
|
| VICTORY CAPITAL MANAGEMENT INC |
$67,278 |
12,718 |
0.01% |
주식
|
| TWO SIGMA SECURITIES, LLC |
$67,030 |
12,671 |
0.01% |
주식
|
| Legal & General Group Plc |
$60,930 |
11,518 |
0.01% |
주식
|
| XPONANCE LLC |
$59,634 |
11,273 |
0.01% |
주식
|
| Jefferies Financial Group Inc. |
$58,190 |
11,000 |
0.01% |
주식
|
| Quadrature Capital Ltd |
$57,635 |
10,895 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$56,899 |
10,756 |
0.01% |
주식
|
| MERCER GLOBAL ADVISORS INC /ADV |
$56,540 |
10,688 |
0.01% |
주식
|
| M&T Bank Corp |
$55,630 |
10,516 |
0.01% |
주식
|
| JANE STREET GROUP, LLC |
$54,487 |
10,300 |
0.01% |
콜 옵션
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$50,260 |
9,501 |
0.01% |
주식
|
| Tower Research Capital LLC (TRC) |
$39,728 |
7,510 |
0.01% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$33,041 |
6,246 |
0.01% |
주식
|
| Rockefeller Capital Management L.P. |
$32,333 |
6,112 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$30,031 |
5,677 |
0.00% |
주식
|
| SIMPLEX TRADING, LLC |
$29,089 |
5,499 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$23,000 |
4,394 |
0.00% |
주식
|
| Quantbot Technologies LP |
$20,033 |
3,787 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$13,505 |
2,553 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$10,924 |
2,065 |
0.00% |
주식
|
| ACADIAN ASSET MANAGEMENT LLC |
$8,677 |
1,641,472 |
0.00% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$6,798 |
1,285 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$6,216 |
1,175 |
0.00% |
주식
|
| GAMMA Investing LLC |
$5,396 |
1,020 |
0.00% |
주식
|
| CWM, LLC |
$5,093 |
1,358 |
0.00% |
주식
|
| Arax Advisory Partners |
$4,158 |
786 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$3,887 |
735 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$3,629 |
686 |
0.00% |
주식
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$2,645 |
500 |
0.00% |
주식
|
| HUNTINGTON NATIONAL BANK |
$2,423 |
458 |
0.00% |
주식
|
| Bollard Group LLC |
$2,283 |
431,631 |
0.00% |
주식
|
| MassMutual Private Wealth & Trust, FSB |
$2,068 |
391 |
0.00% |
주식
|
| Parallel Advisors, LLC |
$1,889 |
357 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$1,888 |
376 |
0.00% |
주식
|
| Optiver Holding B.V. |
$1,777 |
336 |
0.00% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$1,682 |
318 |
0.00% |
주식
|
| Cornerstone Financial Management LLC |
$1,428 |
270 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1,173 |
221,599 |
0.00% |
주식
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$825 |
156 |
0.00% |
주식
|
| Truvestments Capital LLC |
$794 |
150 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$540 |
102 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$540 |
102 |
0.00% |
주식
|
| Allworth Financial LP |
$461 |
87 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$354 |
67 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$296 |
56 |
0.00% |
주식
|
| Cambridge Investment Research Advisors, Inc. |
$222 |
41,873 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$184 |
34,814 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$101 |
19 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$48 |
9 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$32 |
6 |
0.00% |
주식
|
| Essential Partners LLC |
$26 |
5 |
0.00% |
주식
|
| Motiv8 Investments LLC |
$3 |
1,000 |
0.00% |
주식
|
| Capital Advisors, Ltd. LLC |
$2 |
454 |
0.00% |
주식
|