| RA CAPITAL MANAGEMENT, L.P. |
$67,162,061 |
5,049,779 |
9.10% |
주식
|
| BlackRock, Inc. |
$60,462,583 |
4,546,059 |
8.19% |
주식
|
| GOLDMAN SACHS GROUP INC |
$56,640,284 |
4,258,668 |
7.67% |
주식
|
| JANUS HENDERSON GROUP PLC |
$48,868,164 |
5,247,151 |
6.62% |
주식
|
| NOVO HOLDINGS A/S |
$43,214,067 |
3,249,178 |
5.85% |
주식
|
| STATE STREET CORP |
$38,717,750 |
2,911,109 |
5.24% |
주식
|
| BVF INC/IL |
$38,294,544 |
2,879,289 |
5.19% |
주식
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$29,914,400 |
2,249,203 |
4.05% |
주식
|
| Trails Edge Capital Partners, LP |
$29,631,296 |
2,227,917 |
4.01% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$27,917,432 |
2,099,055 |
3.78% |
주식
|
| ARMISTICE CAPITAL, LLC |
$26,600,000 |
2,000,000 |
3.60% |
주식
|
| VANGUARD GROUP INC |
$23,201,453 |
3,093,527 |
3.14% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$15,012,796 |
1,128,466 |
2.03% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$14,904,964 |
1,120,674 |
2.02% |
주식
|
| Evergreen Quality Fund GP, Ltd. |
$12,654,604 |
951,474 |
1.71% |
주식
|
| Parkman Healthcare Partners LLC |
$12,610,847 |
948,184 |
1.71% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$9,717,799 |
730,857 |
1.32% |
주식
|
| DEUTSCHE BANK AG\ |
$9,455,529 |
710,942 |
1.28% |
주식
|
| CITADEL ADVISORS LLC |
$9,145,040 |
687,597 |
1.24% |
주식
|
| RENAISSANCE TECHNOLOGIES LLC |
$8,173,821 |
614,573 |
1.11% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7,712,710 |
579,903 |
1.04% |
주식
|
| DIADEMA PARTNERS LP |
$7,595,723 |
571,107 |
1.03% |
주식
|
| NORTHERN TRUST CORP |
$7,486,956 |
562,929 |
1.01% |
주식
|
| ACUTA CAPITAL PARTNERS, LLC |
$6,753,753 |
507,801 |
0.91% |
주식
|
| Nuveen, LLC |
$6,690,844 |
503,071 |
0.91% |
주식
|
| MORGAN STANLEY |
$6,690,165 |
503,020 |
0.91% |
주식
|
| RTW INVESTMENTS, LP |
$6,327,302 |
475,737 |
0.86% |
주식
|
| Catalio Capital Management, LP |
$6,267,678 |
471,254 |
0.85% |
주식
|
| Schonfeld Strategic Advisors LLC |
$5,419,350 |
407,470 |
0.73% |
주식
|
| JPMORGAN CHASE & CO |
$5,179,524 |
402,137 |
0.70% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4,512,358 |
339,275 |
0.61% |
주식
|
| Opaleye Management Inc. |
$4,448,012 |
334,437 |
0.60% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$3,673,965 |
276,238 |
0.50% |
주식
|
| Burkehill Global Management, LP |
$3,657,500 |
275,000 |
0.50% |
주식
|
| UBS Group AG |
$3,413,751 |
256,673 |
0.46% |
주식
|
| Propel Bio Management, LLC |
$3,360,298 |
252,654 |
0.46% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$3,223,242 |
242,349 |
0.44% |
주식
|
| FEDERATED HERMES, INC. |
$2,958,132 |
222,416 |
0.40% |
주식
|
| ArrowMark Colorado Holdings LLC |
$2,698,091 |
202,864 |
0.37% |
주식
|
| CITADEL ADVISORS LLC |
$2,679,950 |
201,500 |
0.36% |
콜 옵션
|
| Woodline Partners LP |
$2,660,013 |
200,001 |
0.36% |
주식
|
| Brevan Howard Capital Management LP |
$2,352,105 |
176,850 |
0.32% |
주식
|
| TWO SIGMA ADVISERS, LP |
$2,064,750 |
275,300 |
0.28% |
주식
|
| Bank of New York Mellon Corp |
$2,026,079 |
152,337 |
0.27% |
주식
|
| Invesco Ltd. |
$2,000,081 |
150,382 |
0.27% |
주식
|
| Perigon Wealth Management, LLC |
$1,944,261 |
146,185 |
0.26% |
주식
|
| Persistent Asset Partners Ltd |
$1,936,281 |
145,585 |
0.26% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1,864,660 |
140,200 |
0.25% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1,708,571 |
128,464 |
0.23% |
주식
|
| FMR LLC |
$1,706,596 |
128,316 |
0.23% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,627,920 |
122,400 |
0.22% |
콜 옵션
|
| AMERICAN CENTURY COMPANIES INC |
$1,516,200 |
114,000 |
0.21% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$1,422,236 |
106,935 |
0.19% |
주식
|
| Greenland Capital Management LP |
$1,330,000 |
100,000 |
0.18% |
콜 옵션
|
| Privium Fund Management B.V. |
$1,198,463 |
90,110 |
0.16% |
주식
|
| Assenagon Asset Management S.A. |
$1,108,329 |
83,333 |
0.15% |
주식
|
| Greenland Capital Management LP |
$961,018 |
72,257 |
0.13% |
주식
|
| Caption Management, LLC |
$931,000 |
70,000 |
0.13% |
콜 옵션
|
| TWO SIGMA INVESTMENTS, LP |
$924,097 |
69,481 |
0.13% |
주식
|
| CITIGROUP INC |
$920,520 |
69,212 |
0.12% |
주식
|
| Man Group plc |
$909,042 |
68,349 |
0.12% |
주식
|
| Engineers Gate Manager LP |
$907,140 |
68,206 |
0.12% |
주식
|
| XTX Topco Ltd |
$892,723 |
67,122 |
0.12% |
주식
|
| Fisher Asset Management, LLC |
$874,488 |
65,751 |
0.12% |
주식
|
| RHUMBLINE ADVISERS |
$793,180 |
59,638 |
0.11% |
주식
|
| Quantinno Capital Management LP |
$772,491 |
58,082 |
0.10% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$748,152 |
56,252 |
0.10% |
주식
|
| ALPS ADVISORS INC |
$705,645 |
53,056 |
0.10% |
주식
|
| TD Asset Management Inc |
$684,711 |
51,482 |
0.09% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$668,737 |
50,281 |
0.09% |
주식
|
| Birchview Capital, LP |
$645,117 |
48,505 |
0.09% |
주식
|
| PANAGORA ASSET MANAGEMENT INC |
$624,861 |
46,982 |
0.08% |
주식
|
| Rafferty Asset Management, LLC |
$594,696 |
44,714 |
0.08% |
주식
|
| D. E. Shaw & Co., Inc. |
$589,908 |
44,354 |
0.08% |
주식
|
| WELLS FARGO & COMPANY/MN |
$555,036 |
41,732 |
0.08% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$518,939 |
55,740 |
0.07% |
주식
|
| Virtus Investment Advisers, LLC |
$492,832 |
37,055 |
0.07% |
주식
|
| Allspring Global Investments Holdings, LLC |
$472,068 |
37,200 |
0.06% |
주식
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$380,030 |
28,574 |
0.05% |
주식
|
| Creative Planning |
$376,669 |
28,321 |
0.05% |
주식
|
| OMERS ADMINISTRATION Corp |
$369,740 |
27,800 |
0.05% |
주식
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$354,365 |
26,644 |
0.05% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$349,465 |
26,444 |
0.05% |
주식
|
| MetLife Investment Management, LLC |
$346,558 |
26,057 |
0.05% |
주식
|
| Squarepoint Ops LLC |
$340,161 |
25,576 |
0.05% |
주식
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$332,500 |
25,000 |
0.05% |
주식
|
| TRUIST FINANCIAL CORP |
$332,500 |
25,000 |
0.05% |
주식
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$328,510 |
24,700 |
0.04% |
주식
|
| Kera Capital Partners, Inc. |
$320,104 |
24,068 |
0.04% |
주식
|
| BARCLAYS PLC |
$316,873 |
23,825 |
0.04% |
주식
|
| Rockefeller Capital Management L.P. |
$315,596 |
23,729 |
0.04% |
주식
|
| Jain Global LLC |
$313,042 |
23,537 |
0.04% |
주식
|
| Russell Investments Group, Ltd. |
$312,004 |
23,459 |
0.04% |
주식
|
| PROFUND ADVISORS LLC |
$301,897 |
22,699 |
0.04% |
주식
|
| MARSHALL WACE, LLP |
$283,849 |
21,342 |
0.04% |
주식
|
| Rangeley Capital, LLC |
$278,835 |
20,965 |
0.04% |
주식
|
| Headlands Technologies LLC |
$255,865 |
19,238 |
0.03% |
주식
|
| Landing Point Financial Group, LLC |
$246,050 |
18,500 |
0.03% |
주식
|
| Parallel Advisors, LLC |
$237,897 |
17,887 |
0.03% |
주식
|
| SEI INVESTMENTS CO |
$221,633 |
16,664 |
0.03% |
주식
|
| Ballentine Partners, LLC |
$217,575 |
16,359 |
0.03% |
주식
|
| JANE STREET GROUP, LLC |
$207,480 |
15,600 |
0.03% |
콜 옵션
|
| Vanguard Global Advisers, LLC |
$200,617 |
15,084 |
0.03% |
주식
|
| Connor, Clark & Lunn Investment Management Ltd. |
$198,157 |
14,899 |
0.03% |
주식
|
| AXQ CAPITAL, LP |
$185,721 |
13,964 |
0.03% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$183,952 |
13,831 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$166,822 |
12,543 |
0.02% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$166,104 |
12,489 |
0.02% |
주식
|
| LPL Financial LLC |
$165,465 |
12,441 |
0.02% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$161,741 |
12,161 |
0.02% |
주식
|
| CITADEL ADVISORS LLC |
$160,930 |
12,100 |
0.02% |
풋 옵션
|
| Graham Capital Management, L.P. |
$159,640 |
12,003 |
0.02% |
주식
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$148,229 |
11,145 |
0.02% |
주식
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$146,832 |
11,040 |
0.02% |
주식
|
| Inscription Capital, LLC |
$143,414 |
10,783 |
0.02% |
주식
|
| AlphaQuest LLC |
$117,983 |
15,731 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$110,656 |
8,320 |
0.01% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$109,007 |
8,196 |
0.01% |
주식
|
| Tower Research Capital LLC (TRC) |
$81,263 |
6,110 |
0.01% |
주식
|
| Abich Financial Wealth Management LLC |
$80,070 |
9,214 |
0.01% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$73,163 |
5,501 |
0.01% |
주식
|
| STRS OHIO |
$66,500 |
5,000 |
0.01% |
주식
|
| Legal & General Group Plc |
$59,158 |
4,448 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$55,315 |
4,159 |
0.01% |
주식
|
| CWM, LLC |
$44,744 |
4,806 |
0.01% |
주식
|
| Arax Advisory Partners |
$42,920 |
3,227 |
0.01% |
주식
|
| T. Rowe Price Investment Management, Inc. |
$33,409 |
2,511,887 |
0.00% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$31,095 |
2,338 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$26,000 |
1,911 |
0.00% |
주식
|
| Optiver Holding B.V. |
$23,701 |
1,782 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$19,710 |
1,482 |
0.00% |
주식
|
| GAMMA Investing LLC |
$17,742 |
1,334 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$14,391 |
1,082 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$12,289 |
924 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$10,418 |
728 |
0.00% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$8,246 |
620 |
0.00% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$7,581 |
570 |
0.00% |
주식
|
| Steward Partners Investment Advisory, LLC |
$6,650 |
500 |
0.00% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$6,433 |
691 |
0.00% |
주식
|
| SUMMIT SECURITIES GROUP LLC |
$5,746 |
432 |
0.00% |
주식
|
| NewEdge Advisors, LLC |
$2,820 |
212 |
0.00% |
주식
|
| Pacific Center for Financial Services |
$2,754 |
207 |
0.00% |
주식
|
| ACADIAN ASSET MANAGEMENT LLC |
$2,172 |
163,545 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$1,782 |
134 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$1,663 |
125 |
0.00% |
주식
|
| Marshall & Sterling Wealth Advisors Inc. |
$1,330 |
100 |
0.00% |
주식
|
| Pinnacle Wealth Planning Services, Inc. |
$1,330 |
100 |
0.00% |
주식
|
| IFP Advisors, Inc |
$1,037 |
78 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$884 |
66,440 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$785 |
59 |
0.00% |
주식
|
| US BANCORP \DE\ |
$771 |
58 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$730 |
54,869 |
0.00% |
주식
|
| True Wealth Design, LLC |
$719 |
54 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$532 |
40 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$466 |
35 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$466 |
35 |
0.00% |
주식
|
| Quarry LP |
$359 |
27 |
0.00% |
주식
|
| Peloton Wealth Strategists |
$333 |
25,000 |
0.00% |
주식
|
| COMERICA BANK |
$263 |
35 |
0.00% |
주식
|
| DekaBank Deutsche Girozentrale |
$256 |
30,000 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$40 |
3 |
0.00% |
주식
|
| Essential Partners LLC |
$40 |
3 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$13 |
1 |
0.00% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$13 |
1 |
0.00% |
주식
|
| Pacer Advisors, Inc. |
$10 |
747 |
0.00% |
주식
|
| Covestor Ltd |
$0 |
34 |
0.00% |
주식
|