| Paradigm Biocapital Advisors LP |
$360,767,109 |
13,133,131 |
13.94% |
주식
|
| Orbis Allan Gray Ltd |
$311,366,077 |
11,334,768 |
12.03% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$231,942,050 |
8,644,877 |
8.96% |
주식
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$188,581,550 |
6,865,000 |
7.29% |
주식
|
| Deep Track Capital, LP |
$155,205,500 |
5,650,000 |
6.00% |
주식
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$136,672,150 |
4,975,324 |
5.28% |
주식
|
| Sofinnova Investments, Inc. |
$111,122,056 |
4,045,215 |
4.29% |
주식
|
| RENAISSANCE TECHNOLOGIES LLC |
$96,635,340 |
3,517,850 |
3.73% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$96,332,977 |
3,506,843 |
3.72% |
주식
|
| Harding Loevner LP |
$86,898,395 |
3,086,318 |
3.36% |
주식
|
| Deep Track Capital, LP |
$82,410,000 |
3,000,000 |
3.18% |
콜 옵션
|
| FIRST TRUST ADVISORS LP |
$75,721,659 |
2,756,522 |
2.93% |
주식
|
| CITADEL ADVISORS LLC |
$52,715,562 |
1,919,023 |
2.04% |
주식
|
| Qube Research & Technologies Ltd |
$46,404,631 |
1,689,284 |
1.79% |
주식
|
| FRANKLIN RESOURCES INC |
$32,203,218 |
1,172,305 |
1.24% |
주식
|
| MORGAN STANLEY |
$32,133,656 |
1,169,772 |
1.24% |
주식
|
| Brandywine Global Investment Management, LLC |
$31,769,091 |
1,031,464 |
1.23% |
주식
|
| Pictet Asset Management Holding SA |
$29,281,015 |
1,065,927 |
1.13% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$25,014,292 |
910,604 |
0.97% |
주식
|
| Perpetual Ltd |
$23,937,248 |
871,396 |
0.93% |
주식
|
| ENVESTNET ASSET MANAGEMENT INC |
$22,791,195 |
829,687 |
0.88% |
주식
|
| Alyeska Investment Group, L.P. |
$22,096,154 |
804,374 |
0.85% |
주식
|
| Caption Management, LLC |
$19,174,060 |
698,000 |
0.74% |
콜 옵션
|
| AMERICAN CENTURY COMPANIES INC |
$16,480,709 |
599,953 |
0.64% |
주식
|
| CIBC WORLD MARKET INC. |
$14,140,567 |
514,764 |
0.55% |
주식
|
| GOLDMAN SACHS GROUP INC |
$12,525,386 |
455,966 |
0.48% |
주식
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$11,828,582 |
430,600 |
0.46% |
주식
|
| MOORE CAPITAL MANAGEMENT, LP |
$11,550,778 |
420,487 |
0.45% |
주식
|
| Dixon Mitchell Investment Counsel Inc. |
$11,427,520 |
416,000 |
0.44% |
주식
|
| TWO SIGMA ADVISERS, LP |
$10,472,000 |
340,000 |
0.40% |
주식
|
| Quantinno Capital Management LP |
$9,158,195 |
333,388 |
0.35% |
주식
|
| Hudson Bay Capital Management LP |
$9,065,100 |
330,000 |
0.35% |
주식
|
| SummitTX Capital, L.P. |
$8,746,668 |
318,408 |
0.34% |
주식
|
| CITADEL ADVISORS LLC |
$8,578,881 |
312,300 |
0.33% |
콜 옵션
|
| EAGLE GLOBAL ADVISORS LLC |
$6,722,733 |
244,730 |
0.26% |
주식
|
| ASSETMARK, INC |
$6,559,918 |
238,803 |
0.25% |
주식
|
| JANE STREET GROUP, LLC |
$6,518,631 |
237,300 |
0.25% |
콜 옵션
|
| NORTHERN TRUST CORP |
$6,282,114 |
228,690 |
0.24% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$6,262,885 |
227,990 |
0.24% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6,081,858 |
221,400 |
0.24% |
콜 옵션
|
| Caption Management, LLC |
$5,487,792 |
199,774 |
0.21% |
주식
|
| FOLKETRYGDFONDET |
$4,534,803 |
165,082 |
0.18% |
주식
|
| AIMZ Investment Advisors, LLC |
$4,420,198 |
160,910 |
0.17% |
주식
|
| JANE STREET GROUP, LLC |
$4,229,309 |
153,961 |
0.16% |
주식
|
| LPL Financial LLC |
$3,964,507 |
144,321 |
0.15% |
주식
|
| Schonfeld Strategic Advisors LLC |
$3,882,965 |
141,353 |
0.15% |
주식
|
| Balyasny Asset Management L.P. |
$3,876,017 |
141,100 |
0.15% |
콜 옵션
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3,821,764 |
139,125 |
0.15% |
주식
|
| Point72 Asset Management, L.P. |
$3,726,223 |
135,647 |
0.14% |
주식
|
| Woodline Partners LP |
$3,664,141 |
133,387 |
0.14% |
주식
|
| Point72 Europe (London) LLP |
$3,308,169 |
107,864 |
0.13% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$2,885,822 |
105,054 |
0.11% |
주식
|
| Ishara Investments LP |
$2,815,675 |
102,500 |
0.11% |
주식
|
| Legacy Wealth Asset Management, LLC |
$2,806,445 |
102,164 |
0.11% |
주식
|
| BlackRock, Inc. |
$2,503,698 |
91,143 |
0.10% |
주식
|
| Integrated Quantitative Investments LLC |
$2,492,023 |
90,718 |
0.10% |
주식
|
| Quadrature Capital Ltd |
$2,158,290 |
78,569 |
0.08% |
주식
|
| Cetera Investment Advisers |
$2,100,191 |
76,454 |
0.08% |
주식
|
| US BANCORP \DE\ |
$2,044,400 |
74,423 |
0.08% |
주식
|
| QRG CAPITAL MANAGEMENT, INC. |
$1,995,505 |
72,643 |
0.08% |
주식
|
| OPPENHEIMER ASSET MANAGEMENT INC. |
$1,970,725 |
71,741 |
0.08% |
주식
|
| IMC-Chicago, LLC |
$1,966,742 |
71,596 |
0.08% |
주식
|
| Madison Asset Management, LLC |
$1,944,354 |
70,781 |
0.08% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$1,805,081 |
65,711 |
0.07% |
주식
|
| Terra Nova Asset Management LLC |
$1,764,646 |
64,239 |
0.07% |
주식
|
| AMERIPRISE FINANCIAL INC |
$1,601,227 |
58,290 |
0.06% |
주식
|
| LEVEL FOUR ADVISORY SERVICES, LLC |
$1,593,260 |
58,000 |
0.06% |
주식
|
| MML INVESTORS SERVICES, LLC |
$1,536,892 |
55,948 |
0.06% |
주식
|
| Callan Family Office, LLC |
$1,511,756 |
55,033 |
0.06% |
주식
|
| Mariner, LLC |
$1,500,898 |
54,677 |
0.06% |
주식
|
| H D Vest Advisory Services |
$1,479,979 |
71,635 |
0.06% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$1,397,042 |
50,857 |
0.05% |
주식
|
| Avidity Partners Management LP |
$1,373,500 |
50,000 |
0.05% |
주식
|
| Vanguard Personalized Indexing Management, LLC |
$1,360,067 |
49,511 |
0.05% |
주식
|
| Entropy Technologies, LP |
$1,336,525 |
48,654 |
0.05% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$1,322,264 |
48,135 |
0.05% |
주식
|
| Pinnacle Financial Partners, Inc. |
$1,306,830 |
47,573 |
0.05% |
주식
|
| FIFTH THIRD BANCORP |
$1,296,062 |
47,181 |
0.05% |
주식
|
| RAYMOND JAMES FINANCIAL INC |
$1,258,703 |
45,821 |
0.05% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,249,885 |
45,500 |
0.05% |
풋 옵션
|
| BAROMETER CAPITAL MANAGEMENT INC. |
$1,247,138 |
45,400 |
0.05% |
주식
|
| CITADEL ADVISORS LLC |
$1,244,391 |
45,300 |
0.05% |
풋 옵션
|
| Walleye Capital LLC |
$1,216,921 |
44,300 |
0.05% |
콜 옵션
|
| ExodusPoint Capital Management, LP |
$1,185,935 |
43,172 |
0.05% |
주식
|
| Nuveen, LLC |
$1,179,772 |
42,948 |
0.05% |
주식
|
| DAVENPORT & Co LLC |
$1,168,691 |
42,544 |
0.05% |
주식
|
| LMR Partners LLP |
$1,159,124 |
42,196 |
0.04% |
주식
|
| WINTON GROUP Ltd |
$1,123,523 |
40,900 |
0.04% |
주식
|
| RHUMBLINE ADVISERS |
$1,098,372 |
39,985 |
0.04% |
주식
|
| SYNOVUS FINANCIAL CORP |
$1,069,064 |
34,857 |
0.04% |
주식
|
| GRANDFIELD & DODD, LLC |
$1,033,779 |
37,633 |
0.04% |
주식
|
| FMR LLC |
$1,023,699 |
37,266 |
0.04% |
주식
|
| Madison Investment Advisors, LLC |
$978,886 |
46,904 |
0.04% |
주식
|
| JANE STREET GROUP, LLC |
$961,450 |
35,000 |
0.04% |
풋 옵션
|
| Skopos Labs, Inc. |
$961,122 |
35,823 |
0.04% |
주식
|
| UBS Group AG |
$956,011 |
34,802 |
0.04% |
주식
|
| Cubist Systematic Strategies, LLC |
$895,302 |
29,191 |
0.03% |
주식
|
| GTS SECURITIES LLC |
$882,227 |
32,116 |
0.03% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$875,839 |
32,644 |
0.03% |
주식
|
| CAPITAL FUND MANAGEMENT S.A. |
$861,486 |
31,361 |
0.03% |
주식
|