| Frazier Life Sciences Management, L.P. |
$367,191,118 |
6,652,013 |
11.84% |
주식
|
| FMR LLC |
$293,823,234 |
5,322,885 |
9.47% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$274,759,269 |
4,977,523 |
8.86% |
주식
|
| NEA Management Company, LLC |
$199,519,627 |
3,614,486 |
6.43% |
주식
|
| ORBIMED ADVISORS LLC |
$189,266,227 |
3,428,736 |
6.10% |
주식
|
| BlackRock, Inc. |
$183,466,695 |
3,323,672 |
5.91% |
주식
|
| Paradigm Biocapital Advisors LP |
$138,442,428 |
2,508,015 |
4.46% |
주식
|
| NVP ASSOCIATES, LLC |
$117,925,692 |
2,136,335 |
3.80% |
주식
|
| Deep Track Capital, LP |
$95,637,809 |
1,732,569 |
3.08% |
주식
|
| Polar Capital Holdings Plc |
$88,789,973 |
1,608,514 |
2.86% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$81,551,818 |
1,477,388 |
2.63% |
주식
|
| Aaron Wealth Advisors LLC |
$64,462,505 |
1,167,799 |
2.08% |
주식
|
| Driehaus Capital Management LLC |
$58,323,161 |
1,056,579 |
1.88% |
주식
|
| VANGUARD GROUP INC |
$57,333,759 |
1,817,811 |
1.85% |
주식
|
| Kynam Capital Management, LP |
$51,600,905 |
934,799 |
1.66% |
주식
|
| Woodline Partners LP |
$49,685,078 |
900,092 |
1.60% |
주식
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$48,216,758 |
873,492 |
1.55% |
주식
|
| STATE STREET CORP |
$47,718,523 |
864,466 |
1.54% |
주식
|
| Parkman Healthcare Partners LLC |
$44,169,550 |
800,173 |
1.42% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$42,683,039 |
773,072 |
1.38% |
주식
|
| BRAIDWELL LP |
$39,240,576 |
710,880 |
1.26% |
주식
|
| TCG Crossover Management, LLC |
$35,880,000 |
650,000 |
1.16% |
주식
|
| Cormorant Asset Management, LP |
$30,360,000 |
550,000 |
0.98% |
주식
|
| Soleus Capital Management, L.P. |
$28,443,401 |
515,279 |
0.92% |
주식
|
| GOLDMAN SACHS GROUP INC |
$25,337,076 |
459,005 |
0.82% |
주식
|
| MARSHALL WACE, LLP |
$22,184,052 |
401,885 |
0.72% |
주식
|
| EcoR1 Capital, LLC |
$21,445,200 |
388,500 |
0.69% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$19,138,778 |
346,717 |
0.62% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$16,500,771 |
298,927 |
0.53% |
주식
|
| Rock Springs Capital Management LP |
$16,461,634 |
298,218 |
0.53% |
주식
|
| Candriam S.C.A. |
$15,986,698 |
289,893 |
0.52% |
주식
|
| UBS Group AG |
$15,055,635 |
272,747 |
0.49% |
주식
|
| Opaleye Management Inc. |
$14,352,000 |
260,000 |
0.46% |
주식
|
| FRANKLIN RESOURCES INC |
$13,947,108 |
252,665 |
0.45% |
주식
|
| Schonfeld Strategic Advisors LLC |
$13,726,583 |
248,670 |
0.44% |
주식
|
| MORGAN STANLEY |
$13,720,403 |
248,558 |
0.44% |
주식
|
| NORTHERN TRUST CORP |
$13,616,626 |
246,678 |
0.44% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$12,900,240 |
233,700 |
0.42% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$12,866,844 |
233,095 |
0.41% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$12,483,535 |
226,151 |
0.40% |
주식
|
| Tetragon Partners GP Ltd |
$11,235,574 |
203,543 |
0.36% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$11,118,881 |
201,429 |
0.36% |
주식
|
| Caption Management, LLC |
$11,040,000 |
200,000 |
0.36% |
콜 옵션
|
| Caption Management, LLC |
$11,040,000 |
200,000 |
0.36% |
풋 옵션
|
| Caligan Partners LP |
$11,040,000 |
200,000 |
0.36% |
주식
|
| D. E. Shaw & Co., Inc. |
$10,088,738 |
182,767 |
0.33% |
주식
|
| JPMORGAN CHASE & CO |
$7,518,053 |
139,611 |
0.24% |
주식
|
| KVP Capital Advisors, LP |
$6,708,125 |
121,524 |
0.22% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$6,263,820 |
113,475 |
0.20% |
주식
|
| Burkehill Global Management, LP |
$5,520,000 |
100,000 |
0.18% |
주식
|
| Nuveen, LLC |
$5,450,062 |
98,733 |
0.18% |
주식
|
| TD Asset Management Inc |
$5,277,010 |
95,598 |
0.17% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5,210,880 |
94,400 |
0.17% |
콜 옵션
|
| Elmind Capital, LP |
$5,023,200 |
91,000 |
0.16% |
주식
|
| Bank of New York Mellon Corp |
$4,908,760 |
88,927 |
0.16% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$4,860,084 |
88,045 |
0.16% |
주식
|
| BARCLAYS PLC |
$4,849,540 |
87,854 |
0.16% |
주식
|
| Affinity Asset Advisors, LLC |
$4,140,000 |
75,000 |
0.13% |
주식
|
| PFM Health Sciences, LP |
$3,917,599 |
70,971 |
0.13% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3,883,486 |
70,353 |
0.13% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3,649,382 |
66,112 |
0.12% |
주식
|
| MOORE CAPITAL MANAGEMENT, LP |
$3,582,094 |
64,893 |
0.12% |
주식
|
| Rhenman & Partners Asset Management AB |
$3,422,400 |
62,000 |
0.11% |
주식
|
| Invesco Ltd. |
$2,797,425 |
50,678 |
0.09% |
주식
|
| ALPS ADVISORS INC |
$2,650,262 |
48,012 |
0.09% |
주식
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$2,406,554 |
43,597 |
0.08% |
주식
|
| Swiss National Bank |
$2,368,080 |
42,900 |
0.08% |
주식
|
| Ensign Peak Advisors, Inc |
$2,327,011 |
42,156 |
0.08% |
주식
|
| ALGERT GLOBAL LLC |
$2,322,264 |
42,070 |
0.07% |
주식
|
| Creative Planning |
$2,181,724 |
39,524 |
0.07% |
주식
|
| JANE STREET GROUP, LLC |
$2,075,520 |
37,600 |
0.07% |
콜 옵션
|
| RHUMBLINE ADVISERS |
$2,053,213 |
37,196 |
0.07% |
주식
|
| DEUTSCHE BANK AG\ |
$1,749,454 |
31,693 |
0.06% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,711,200 |
31,000 |
0.06% |
풋 옵션
|
| WELLS FARGO & COMPANY/MN |
$1,562,878 |
28,313 |
0.05% |
주식
|
| EXCHANGE TRADED CONCEPTS, LLC |
$1,513,639 |
27,421 |
0.05% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,472,957 |
26,684 |
0.05% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1,442,486 |
26,132 |
0.05% |
주식
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$1,424,160 |
25,800 |
0.05% |
주식
|
| CITIGROUP INC |
$1,386,734 |
25,122 |
0.04% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1,290,355 |
23,376 |
0.04% |
주식
|
| AMERICAN CENTURY COMPANIES INC |
$1,251,936 |
22,680 |
0.04% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$1,247,023 |
22,591 |
0.04% |
주식
|
| CITADEL ADVISORS LLC |
$1,236,480 |
22,400 |
0.04% |
콜 옵션
|
| Legal & General Group Plc |
$1,191,382 |
21,583 |
0.04% |
주식
|
| Cerity Partners LLC |
$1,159,034 |
20,997 |
0.04% |
주식
|
| Vanguard Global Advisers, LLC |
$1,047,089 |
18,969 |
0.03% |
주식
|
| MetLife Investment Management, LLC |
$1,007,400 |
18,250 |
0.03% |
주식
|
| Russell Investments Group, Ltd. |
$1,002,541 |
18,162 |
0.03% |
주식
|
| Koa Wealth Management, LLC |
$944,638 |
17,113 |
0.03% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$925,350 |
31,000 |
0.03% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$881,599 |
15,971 |
0.03% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$814,310 |
14,752 |
0.03% |
주식
|
| OPTIMIZE FINANCIAL INC. |
$798,082 |
14,458 |
0.03% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$788,918 |
14,292 |
0.03% |
주식
|
| DAFNA Capital Management LLC |
$651,857 |
11,809 |
0.02% |
주식
|
| HighVista Strategies LLC |
$642,197 |
11,634 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$607,200 |
11,000 |
0.02% |
주식
|
| FRED ALGER MANAGEMENT, LLC |
$545,210 |
9,877 |
0.02% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$544,272 |
9,860 |
0.02% |
주식
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$539,690 |
9,777 |
0.02% |
주식
|
| Virtus Investment Advisers, LLC |
$508,668 |
9,215 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$506,460 |
9,175 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$505,301 |
9,154 |
0.02% |
주식
|
| PROFUND ADVISORS LLC |
$486,422 |
8,812 |
0.02% |
주식
|
| Brevan Howard Capital Management LP |
$474,830 |
8,602 |
0.02% |
주식
|
| ACT CAPITAL MANAGEMENT, LLC |
$441,600 |
8,000 |
0.01% |
주식
|
| DNB Asset Management AS |
$430,174 |
7,793 |
0.01% |
주식
|
| AXQ CAPITAL, LP |
$428,186 |
7,757 |
0.01% |
주식
|
| State of New Jersey Common Pension Fund D |
$381,598 |
6,913 |
0.01% |
주식
|
| Quantinno Capital Management LP |
$358,634 |
6,497 |
0.01% |
주식
|
| Rafferty Asset Management, LLC |
$353,832 |
6,410 |
0.01% |
주식
|
| XTX Topco Ltd |
$352,838 |
6,392 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$336,886 |
6,103 |
0.01% |
주식
|
| Seven Fleet Capital Management LP |
$331,200 |
6,000 |
0.01% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$328,495 |
5,951 |
0.01% |
주식
|
| ARIZONA STATE RETIREMENT SYSTEM |
$325,625 |
5,899 |
0.01% |
주식
|
| SEI INVESTMENTS CO |
$323,914 |
5,868 |
0.01% |
주식
|
| ProShare Advisors LLC |
$310,335 |
5,622 |
0.01% |
주식
|
| JANUS HENDERSON GROUP PLC |
$308,176 |
10,300 |
0.01% |
주식
|
| Blackstone Inc. |
$305,422 |
5,533 |
0.01% |
주식
|
| GROUP ONE TRADING LLC |
$288,751 |
5,231 |
0.01% |
주식
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$287,040 |
5,200 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$270,480 |
4,900 |
0.01% |
주식
|
| Verdad Advisers, LP |
$252,485 |
4,574 |
0.01% |
주식
|
| Pictet Asset Management Holding SA |
$226,210 |
4,098 |
0.01% |
주식
|
| Goelzer Investment Management, Inc. |
$220,800 |
4,000 |
0.01% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$216,054 |
7,238 |
0.01% |
주식
|
| Quantbot Technologies LP |
$212,796 |
3,855 |
0.01% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$209,760 |
3,800 |
0.01% |
주식
|
| CITADEL ADVISORS LLC |
$209,760 |
3,800 |
0.01% |
풋 옵션
|
| Tower Research Capital LLC (TRC) |
$201,535 |
3,651 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$155,498 |
2,817 |
0.01% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$117,521 |
2,129 |
0.00% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$115,147 |
2,086 |
0.00% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$111,118 |
2,013 |
0.00% |
주식
|
| STRS OHIO |
$110,400 |
2,000 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$81,000 |
1,464 |
0.00% |
주식
|
| SIMPLEX TRADING, LLC |
$73,250 |
1,327 |
0.00% |
주식
|
| State of Wyoming |
$58,236 |
1,055 |
0.00% |
주식
|
| CWM, LLC |
$52,894 |
1,772 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$52,550 |
952 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$44,978 |
814,807 |
0.00% |
주식
|
| Kemnay Advisory Services Inc. |
$17,719 |
321 |
0.00% |
주식
|
| GAMMA Investing LLC |
$16,781 |
304 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$15,566 |
282 |
0.00% |
주식
|
| Arax Advisory Partners |
$15,401 |
279 |
0.00% |
주식
|
| Rockefeller Capital Management L.P. |
$12,365 |
224 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$11,426 |
207 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$10,552 |
180 |
0.00% |
주식
|
| FIL Ltd |
$9,826 |
178 |
0.00% |
주식
|
| Aster Capital Management (DIFC) Ltd |
$9,494 |
172 |
0.00% |
주식
|
| Physician Wealth Advisors, Inc. |
$6,680 |
121 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$6,017 |
109 |
0.00% |
주식
|
| US BANCORP \DE\ |
$5,962 |
108 |
0.00% |
주식
|
| J.Safra Asset Management Corp |
$4,692 |
85 |
0.00% |
주식
|
| Parallel Advisors, LLC |
$4,361 |
79 |
0.00% |
주식
|
| SIGNATUREFD, LLC |
$4,306 |
78 |
0.00% |
주식
|
| JONES FINANCIAL COMPANIES LLLP |
$4,185 |
80 |
0.00% |
주식
|
| Keating Financial Advisory Services, Inc. |
$2,981 |
54 |
0.00% |
주식
|
| Larson Financial Group LLC |
$2,705 |
49 |
0.00% |
주식
|
| Allworth Financial LP |
$2,650 |
48 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$2,649 |
48 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$2,153 |
39 |
0.00% |
주식
|
| Cornerstone Financial Management LLC |
$1,877 |
34 |
0.00% |
주식
|
| Bare Financial Services, Inc |
$1,877 |
34 |
0.00% |
주식
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$1,401 |
25,377 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$1,049 |
19 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$1,049 |
19 |
0.00% |
주식
|
| Quarry LP |
$994 |
18 |
0.00% |
주식
|
| Essential Partners LLC |
$828 |
15 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$718 |
13 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$607 |
11 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$497 |
9 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$345 |
6,245 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$111 |
2 |
0.00% |
주식
|
| Hughes Financial Services, LLC |
$55 |
1 |
0.00% |
주식
|
| KBC Group NV |
$45 |
810 |
0.00% |
주식
|
| Covestor Ltd |
$1 |
10 |
0.00% |
주식
|