| FMR LLC |
$111450614 |
19518496 |
10.53% |
股份
|
| BlackRock, Inc. |
$77311938 |
13539744 |
7.31% |
股份
|
| Redmile Group, LLC |
$67776998 |
11869877 |
6.41% |
股份
|
| STATE STREET CORP |
$56096873 |
9824321 |
5.30% |
股份
|
| BVF INC/IL |
$49666568 |
8698173 |
4.69% |
股份
|
| Woodline Partners LP |
$39542133 |
6925067 |
3.74% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$39233496 |
6871015 |
3.71% |
股份
|
| VANGUARD GROUP INC |
$38922003 |
7753387 |
3.68% |
股份
|
| MAK CAPITAL ONE LLC |
$33473048 |
5862180 |
3.16% |
股份
|
| GOLDMAN SACHS GROUP INC |
$33264057 |
5825579 |
3.14% |
股份
|
| Siren, L.L.C. |
$25458869 |
4458646 |
2.41% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$25339444 |
4437731 |
2.39% |
股份
|
| Bellevue Group AG |
$23411091 |
4100016 |
2.21% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$23056071 |
4037193 |
2.18% |
股份
|
| MPM BIOIMPACT LLC |
$20238261 |
3544354 |
1.91% |
股份
|
| AMERIPRISE FINANCIAL INC |
$20039948 |
3509623 |
1.89% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$19985000 |
3500000 |
1.89% |
股份
|
| GREAT POINT PARTNERS LLC |
$19985000 |
3500000 |
1.89% |
股份
|
| MORGAN STANLEY |
$17954827 |
3144453 |
1.70% |
股份
|
| Palo Alto Investors LP |
$16833594 |
2948090 |
1.59% |
股份
|
| Balyasny Asset Management L.P. |
$16164873 |
2830976 |
1.53% |
股份
|
| Nuveen, LLC |
$15788607 |
2765080 |
1.49% |
股份
|
| Qube Research & Technologies Ltd |
$15702277 |
2749961 |
1.48% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12829228 |
2246800 |
1.21% |
股份
|
| Opaleye Management Inc. |
$9789515 |
1714451 |
0.93% |
股份
|
| Logos Global Management LP |
$8565000 |
1500000 |
0.81% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$8550585 |
1497756 |
0.81% |
股份
|
| Point72 Asset Management, L.P. |
$7895211 |
1382699 |
0.75% |
股份
|
| NORTHERN TRUST CORP |
$7720182 |
1352046 |
0.73% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7182032 |
1257799 |
0.68% |
股份
|
| Tetragon Partners GP Ltd |
$7094418 |
1242455 |
0.67% |
股份
|
| Candriam S.C.A. |
$6817695 |
1195142 |
0.64% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6765956 |
1184931 |
0.64% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6312120 |
1105450 |
0.60% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$5923360 |
1037366 |
0.56% |
股份
|
| JPMORGAN CHASE & CO |
$5593995 |
1004308 |
0.53% |
股份
|
| WELLS FARGO & COMPANY/MN |
$5584694 |
978055 |
0.53% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$5526857 |
967926 |
0.52% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$5129830 |
898394 |
0.48% |
股份
|
| Ishara Investments LP |
$4682200 |
820000 |
0.44% |
股份
|
| Ensign Peak Advisors, Inc |
$4570946 |
800516 |
0.43% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$4213609 |
737935 |
0.40% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$4194480 |
734585 |
0.40% |
股份
|
| Russell Investments Group, Ltd. |
$4027213 |
705291 |
0.38% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3950245 |
691812 |
0.37% |
股份
|
| Parkman Healthcare Partners LLC |
$3660276 |
641029 |
0.35% |
股份
|
| UBS Group AG |
$3557866 |
623094 |
0.34% |
股份
|
| DEUTSCHE BANK AG\ |
$3520153 |
616489 |
0.33% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3507002 |
614186 |
0.33% |
股份
|
| CITADEL ADVISORS LLC |
$3406483 |
596582 |
0.32% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$3334143 |
583913 |
0.32% |
股份
|
| SIRIOS CAPITAL MANAGEMENT L P |
$3250566 |
569276 |
0.31% |
股份
|
| Schonfeld Strategic Advisors LLC |
$3046666 |
533567 |
0.29% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2928065 |
512796 |
0.28% |
股份
|
| Bank of New York Mellon Corp |
$2863235 |
501442 |
0.27% |
股份
|
| Board of Trustees of The Leland Stanford Junior University |
$2755360 |
482550 |
0.26% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2620890 |
459000 |
0.25% |
股份
|
| Ikarian Capital, LLC |
$2456693 |
430244 |
0.23% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$2428646 |
425332 |
0.23% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2352520 |
412000 |
0.22% |
买入期权
|
| Trexquant Investment LP |
$2339199 |
409667 |
0.22% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2322799 |
406795 |
0.22% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$2256763 |
395230 |
0.21% |
股份
|
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
$2253166 |
394600 |
0.21% |
股份
|
| DIADEMA PARTNERS LP |
$2016772 |
353200 |
0.19% |
买入期权
|
| Invesco Ltd. |
$1888463 |
330729 |
0.18% |
股份
|
| Engineers Gate Manager LP |
$1821815 |
319057 |
0.17% |
股份
|
| DAFNA Capital Management LLC |
$1700507 |
297812 |
0.16% |
股份
|
| Jump Financial, LLC |
$1700438 |
297800 |
0.16% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1635201 |
286375 |
0.15% |
股份
|
| D. E. Shaw & Co., Inc. |
$1514772 |
265284 |
0.14% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$1427643 |
250025 |
0.13% |
股份
|
| Swiss National Bank |
$1396666 |
244600 |
0.13% |
股份
|
| CITIGROUP INC |
$1347502 |
235990 |
0.13% |
股份
|
| CITADEL ADVISORS LLC |
$1340137 |
234700 |
0.13% |
买入期权
|
| Cinctive Capital Management LP |
$1231921 |
215748 |
0.12% |
股份
|
| MARSHALL WACE, LLP |
$1202566 |
210607 |
0.11% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1086042 |
190200 |
0.10% |
卖出期权
|
| RHUMBLINE ADVISERS |
$1082480 |
189578 |
0.10% |
股份
|
| SEI INVESTMENTS CO |
$1049635 |
183817 |
0.10% |
股份
|
| Squarepoint Ops LLC |
$989457 |
173285 |
0.09% |
股份
|
| Rafferty Asset Management, LLC |
$989423 |
173279 |
0.09% |
股份
|
| Point72 Europe (London) LLP |
$923726 |
302861 |
0.09% |
股份
|
| OSAIC HOLDINGS, INC. |
$842933 |
147624 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$815710 |
147240 |
0.08% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$766619 |
134259 |
0.07% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$727100 |
127338 |
0.07% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$723784 |
130647 |
0.07% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$685937 |
120129 |
0.06% |
股份
|
| IEQ CAPITAL, LLC |
$685257 |
120010 |
0.06% |
股份
|
| J. Goldman & Co LP |
$662623 |
116046 |
0.06% |
股份
|
| XTX Topco Ltd |
$640359 |
112147 |
0.06% |
股份
|
| Vanguard Global Advisers, LLC |
$582803 |
102067 |
0.06% |
股份
|
| Quarry LP |
$571000 |
100000 |
0.05% |
股份
|
| SCS Capital Management LLC |
$565290 |
99000 |
0.05% |
股份
|
| Legal & General Group Plc |
$560254 |
98118 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$520567 |
91661 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$519639 |
91005 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$516755 |
90500 |
0.05% |
买入期权
|
| J. Safra Sarasin Holding AG |
$516681 |
90487 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$507619 |
88900 |
0.05% |
卖出期权
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$505438 |
88518 |
0.05% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$501960 |
87909 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$499676 |
87509 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$453865 |
79486 |
0.04% |
股份
|
| DNB Asset Management AS |
$417669 |
73147 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$396662 |
69468 |
0.04% |
股份
|
| Jain Global LLC |
$369545 |
64719 |
0.03% |
股份
|
| China Universal Asset Management Co., Ltd. |
$354454 |
62076 |
0.03% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$354437 |
62073 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$352860 |
61797 |
0.03% |
股份
|
| DLD Asset Management, LP |
$343200 |
60000 |
0.03% |
买入期权
|
| JANUS HENDERSON GROUP PLC |
$327710 |
59100 |
0.03% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$310053 |
54300 |
0.03% |
股份
|
| WINTON GROUP Ltd |
$272938 |
47800 |
0.03% |
股份
|
| JUPITER ASSET MANAGEMENT LTD |
$263083 |
46074 |
0.02% |
股份
|
| Creative Planning |
$262374 |
45950 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$261592 |
45813 |
0.02% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$255272 |
44706 |
0.02% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$254009 |
44485 |
0.02% |
股份
|
| Allegheny Financial Group |
$244959 |
42900 |
0.02% |
股份
|
| BARCLAYS PLC |
$238193 |
41715 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$237062 |
41517 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$225025 |
39409 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$224940 |
39394 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$224146 |
39255 |
0.02% |
股份
|
| FIFTH THIRD BANCORP |
$220634 |
38640 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$220406 |
38600 |
0.02% |
股份
|
| CWM, LLC |
$219672 |
39652 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$208803 |
36568 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$206640 |
897 |
0.02% |
买入期权
|
| Vanguard Investments Australia, Ltd. |
$200044 |
35034 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$192027 |
33630 |
0.02% |
股份
|
| Blueshift Asset Management, LLC |
$190360 |
33338 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$180676 |
31642 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$176268 |
30870 |
0.02% |
股份
|
| Lido Advisors, LLC |
$176114 |
30843 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$175794 |
30787 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$170895 |
29929 |
0.02% |
股份
|
| Bridgefront Capital, LLC |
$162895 |
28528 |
0.02% |
股份
|
| COMERICA BANK |
$162432 |
32357 |
0.02% |
股份
|
| Quadrature Capital Ltd |
$159098 |
27863 |
0.02% |
股份
|
| DIADEMA PARTNERS LP |
$157116 |
27516 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$150173 |
26300 |
0.01% |
股份
|
| ProShare Advisors LLC |
$146810 |
25711 |
0.01% |
股份
|
| Verdad Advisers, LP |
$144463 |
25300 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$144389 |
25287 |
0.01% |
股份
|
| AlphaCentric Advisors LLC |
$142019 |
24872 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$141894 |
24850 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$139512 |
24433 |
0.01% |
股份
|
| Crown Wealth Group, LLC |
$135687 |
23763 |
0.01% |
股份
|
| SBI Securities Co., Ltd. |
$132615 |
23225 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$130582 |
22869 |
0.01% |
股份
|
| STRS OHIO |
$121052 |
21200 |
0.01% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$119967 |
21010 |
0.01% |
股份
|
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
$118843 |
20813 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$117467 |
20253 |
0.01% |
股份
|
| Corient Private Wealth LP |
$112510 |
19704 |
0.01% |
股份
|
| State of Wyoming |
$111225 |
19479 |
0.01% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$97510 |
17077 |
0.01% |
股份
|
| Coastal Bridge Advisors, LLC |
$97070 |
17000 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$95363 |
16701 |
0.01% |
股份
|
| Mariner, LLC |
$94053 |
16469 |
0.01% |
股份
|
| LPL Financial LLC |
$90269 |
15809 |
0.01% |
股份
|
| Balefire, LLC |
$85713 |
15011 |
0.01% |
股份
|
| DLD Asset Management, LP |
$85650 |
15000 |
0.01% |
股份
|
| XPONANCE LLC |
$84879 |
14865 |
0.01% |
股份
|
| Forefront Analytics, LLC |
$81310 |
14240 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$81270 |
14233 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$80494 |
14097 |
0.01% |
股份
|
| Private Advisor Group, LLC |
$80054 |
14020 |
0.01% |
股份
|
| Cerity Partners LLC |
$79182 |
13867 |
0.01% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$73088 |
12800 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$73008 |
12786 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$71306 |
12488 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$70022 |
12263 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$69451 |
22771 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$67812 |
11876 |
0.01% |
股份
|
| Merit Financial Group, LLC |
$63398 |
11103 |
0.01% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$62353 |
10920 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$61548 |
10779 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$57597 |
10087 |
0.01% |
股份
|
| Harbor Advisors LLC |
$57100 |
10000 |
0.01% |
股份
|
| Shay Capital LLC |
$57100 |
10000 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$57100 |
10000 |
0.01% |
卖出期权
|
| Fulcrum Asset Management LLP |
$56090 |
10070 |
0.01% |
股份
|
| Arax Advisory Partners |
$43876 |
7684 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$41843 |
7328 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$38971 |
6825 |
0.00% |
股份
|
| Geneos Wealth Management Inc. |
$34260 |
6000 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$31000 |
5395 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$19536 |
3565 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$17501 |
3065 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$11557 |
2024 |
0.00% |
股份
|
| BARCLAYS PLC |
$11420 |
2000 |
0.00% |
买入期权
|
| Larson Financial Group LLC |
$11420 |
2000 |
0.00% |
股份
|
| Quantbot Technologies LP |
$8919 |
1562 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7114 |
1246 |
0.00% |
股份
|
| Trask Adam Roland |
$5540 |
1000 |
0.00% |
股份
|
| Allworth Financial LP |
$4774 |
836 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$4488 |
786 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4185 |
738 |
0.00% |
股份
|
| Essential Partners LLC |
$3849 |
674 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$3588 |
629127 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3255 |
570 |
0.00% |
股份
|
| IFP Advisors, Inc |
$3249 |
569 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$3191 |
559 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3112 |
545 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2838 |
497 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2758 |
483 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2318 |
406 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$1713 |
300 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1616 |
283 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1536 |
269 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1422 |
249 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$1034 |
181 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$738 |
129243 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$609 |
110 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$596 |
104378 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$383 |
67 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$245 |
42823 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$124 |
21646 |
0.00% |
股份
|
| Cygnus Capital Advisors, LLC |
$123 |
21549 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$115 |
20 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$91 |
16 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$86 |
15 |
0.00% |
股份
|
| MOUNT VERNON ASSOCIATES INC /MD/ |
$60 |
10500 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$58 |
10110 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$17 |
2894 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$6 |
1 |
0.00% |
股份
|