APGE Apogee Therapeutics, Inc. - Common Stock
$134.58
价格 · 八月 18, 2026
截至...的财报数据 八月 10, 2026
52周区间
$35–$135
100% of range
分析师评级
HOLD
21 analysts
目标价
$135
+0% upside
P/E (TTM)
-31.9
ROE
—
净利润率
—
APGE 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围
价格
$134.58
市值
$9.21B
P/E (TTM)
-31.9
每股收益 (TTM)
$-4.22
营收 (TTM)
—
股息收益率
—
ROE
—
负债/权益
—
52周区间
$35 – $135
APGE 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图
Configure
10年表现 收入、净利润、利润率和每股收益趋势
营收与净利润
—
EPS
$-4.22
2022-12-31
→
2025-12-31
自由现金流
$-233M
2023-12-31
→
2025-12-31
利润率
—
估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜？
指标
5年趋势
APGE
同行中位数
P/E (TTM)
-31.9
28.5
Price / FCF (股价/自由现金流)
-39.6
—
盈利能力 毛利率、营业利润率和净利率；股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)
指标
5年趋势
APGE
同行中位数
ROA
-30.3%
-28.4%
财务健康 债务、流动性、偿付能力 — 资产负债表强度
指标
5年趋势
APGE
同行中位数
Current Ratio (流动比率)
26.6
5.0
Quick Ratio (速动比率)
26.2
—
成长 营收、每股收益 (EPS) 和净利润增长：同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)
指标
5年趋势
APGE
同行中位数
资本效率 资产周转率、库存周转率、应收账款周转率
指标
5年趋势
APGE
同行中位数
APGE 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间
持有
21 位分析师
- 强烈买入 3 14.3%
- 买入 4 19.0%
- 持有 14 66.7%
- 卖出 0 0.0%
- 强烈卖出 0 0.0%
12个月价格目标
11 位分析师 · 2026-08-14
中位数
$135.00
现在
$134.58
最低
$133.00
最高
$135.11
中位数目标
$135.00
+0.3%
平均目标
$134.85
+0.2%
收益历史 每股收益实际值 vs 预估值，惊喜%，达标率，下次财报日期
平均惊喜
0.08%
| 期间 | EPS Actual | EPS 预期 | 惊喜 |
|---|---|---|---|
| 2026年6月30日 | $-1.14 | $-1.09 | -0.05% |
| 2026年3月31日 | $-1.06 | $-1.12 | 0.06% |
| 2025年12月31日 | $-1.03 | $-1.08 | 0.05% |
| 2025年9月30日 | $-1.11 | $-1.21 | 0.10% |
| 2025年6月30日 | $-1.13 | $-1.10 | -0.03% |
| 2025年3月31日 | $-0.95 | $-1.27 | 0.32% |
同行比较（GICS 子行业） 关键指标与行业同行对比
| 股票代码 | 市值 | P/E | 营收同比增长 | 净利润率 | ROE | 毛利率 |
|---|---|---|---|---|---|---|
| APGE | $5.16B | -17.9 | — | — | — | — |
| MDGL | $13.30B | -45.3 | 432.1% | -30.1% | -44.4% | — |
| HALO | $7.93B | 26.3 | 37.5% | 22.7% | 166.1% | — |
| PRAX | $7.43B | -21.9 | 249.5% | — | -47.3% | — |
| CYTK | $7.81B | -9.7 | 376.6% | -891.6% | 152.7% | — |
| PTGX | $5.47B | -42.6 | -89.4% | -282.8% | -20.3% | — |
| KRYS | $7.20B | 36.0 | 33.9% | 52.6% | 18.1% | — |
| KYMR | $6.33B | -21.1 | -16.7% | -794.0% | -24.4% | — |
| SMMT | $13.56B | -12.1 | — | — | -235.1% | — |
| IONS | $12.92B | -33.2 | — | — | -68.1% | — |
完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表
损益表 14
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| R&D Expense | $215M | $168M | $68M | $28M | |
| SG&A Expense | $71M | $49M | $25M | $3M | |
| Operating Expenses | $286M | $217M | $93M | $31M | |
| Operating Income | $-286M | $-217M | $-93M | $-31M | |
| Interest Income | $30M | $35M | $9M | $92.0K | |
| Other Non-op | $30M | $35M | $9M | $-9M | |
| Pretax Income | $-256M | $-182M | $-84M | · | |
| Income Tax | $278.0K | $18.0K | $0 | · | |
| Net Income | $-256M | $-182M | $-84M | $-40M | |
| EPS (Basic) | $-4.22 | $-3.30 | $-3.36 | $-16.16 | |
| EPS (Diluted) | $-4.22 | $-3.30 | $-3.36 | $-16.16 | |
| Shares (Basic) | 60,690,820 | 55,193,971 | 25,005,774 | 2,462,236 | |
| Shares (Diluted) | 60,690,820 | 55,193,971 | 25,005,774 | 2,462,236 | |
| EBITDA | $-286M | $-217M | $-93M | · |
资产负债表 20
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $132M | $142M | $118M | $152M | |
| Short-term Investments | $599M | $379M | $277M | · | |
| Prepaid Expense | $11M | $9M | $3M | $165.0K | |
| Other Current Assets | $605.0K | $2M | $1M | $57.0K | |
| Current Assets | $741M | $530M | $398M | $152M | |
| PP&E (Net) | $6M | $2M | $377.0K | · | |
| Accum. Depreciation | $2M | $189.0K | · | · | |
| Other Non-current Assets | $9M | $498.0K | $401.0K | · | |
| Total Assets | $937M | $754M | $401M | $152M | |
| Accounts Payable | $1M | $1M | $2M | $418.0K | |
| Accrued Liabilities | $23M | $24M | $17M | $10M | |
| Current Liabilities | $28M | $29M | $21M | $10M | |
| Capital Leases | $5M | $9M | $933.0K | · | |
| Total Liabilities | $33M | $37M | $21M | $10M | |
| Common Stock | $1.0K | $1.0K | · | · | |
| Paid-in Capital | $1.46B | $1.02B | $503M | · | |
| Retained Earnings | $-562M | $-306M | $-124M | $-40M | |
| AOCI | $1M | $915.0K | $329.0K | · | |
| Liabilities + Equity | $937M | $754M | $401M | $152M | |
| Shares Outstanding | 68,401,349 | 58,062,898 | 48,338,769 | 0 |
现金流 10
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Stock-based Comp | $46M | $23M | $6M | $2M | |
| Operating Cash Flow | $-227M | $-171M | $-75M | $-16M | |
| CapEx | $5M | $1M | $167.0K | · | |
| Investing Cash Flow | $-180M | $-300M | $-274M | · | |
| Stock Issued | · | $450M | $315M | · | |
| Net Stock Activity | · | $450M | $315M | · | |
| Financing Cash Flow | $396M | $495M | $315M | $168M | |
| Net Change in Cash | $-11M | $23M | $-33M | $152M | |
| Taxes Paid | · | $360.0K | · | · | |
| Free Cash Flow | $-233M | $-172M | $-75M | · |
盈利能力 1
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| ROA | -30.3% | -31.5% | -30.3% | · |
流动性与偿付能力 2
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 26.6 | 18.5 | 19.4 | · | |
| Quick Ratio | 26.2 | 18.2 | 19.2 | · |
估值 (TTM) 6
| 指标 | 趋势 | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Net Income TTM | $-256M | $-182M | $-84M | · | |
| Market Cap | $5.16B | $2.63B | $1.35B | · | |
| P/E | -17.9 | -13.7 | -8.3 | · | |
| P / Cash Flow | -22.7 | -15.4 | -18.1 | · | |
| P / FCF | -22.2 | -15.3 | -18.0 | · | |
| Earnings Yield | -5.6% | -7.3% | -12.0% | · |
损益表 14
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $67M | $61M | $58M | $54M | $56M | $46M | $60M | $46M | $33M | $29M | $17M | $14M | $8M | |
| SG&A Expense | $24M | $22M | $20M | $17M | $17M | $17M | $16M | $13M | $11M | $9M | $7M | $5M | $4M | |
| Operating Expenses | $96M | $83M | $78M | $71M | $73M | $63M | $76M | $59M | $44M | $38M | $24M | $19M | $13M | |
| Operating Income | $-96M | $-83M | $-78M | $-71M | $-73M | $-63M | $-76M | $-59M | $-44M | $-38M | $-24M | $-19M | $-13M | |
| Interest Income | $12M | $9M | $9M | $6M | $7M | $8M | $9M | $10M | $10M | $6M | $3M | $0 | $133.0K | |
| Other Non-op | $10M | $9M | $9M | $6M | $7M | $8M | $9M | $10M | $10M | $6M | $3M | $0 | $133.0K | |
| Pretax Income | $-86M | $-74M | $-69M | $-65M | $-66M | $-55M | $-67M | $-49M | $-34M | $-32M | · | · | · | |
| Income Tax | $78.0K | $79.0K | $62.0K | $61.0K | $72.0K | $83.0K | $18.0K | $0 | $0 | $0 | · | · | · | |
| Net Income | $-86M | $-74M | $-69M | $-65M | $-66M | $-55M | $-67M | $-49M | $-34M | $-32M | $-21M | $-19M | $-13M | |
| EPS (Basic) | $-1.14 | $-1.06 | $-1.03 | $-1.11 | $-1.13 | $-0.95 | $-1.20 | $-0.86 | $-0.60 | $-0.64 | $-0.51 | $-3.78 | $-2.51 | |
| EPS (Diluted) | $-1.14 | $-1.06 | $-1.03 | $-1.11 | $-1.13 | $-0.95 | $-1.20 | $-0.86 | $-0.60 | $-0.64 | $-0.51 | $-3.78 | $-2.51 | |
| Shares (Basic) | 75,443,496 | 69,668,439 | -114,706,527 | 58,773,731 | 58,428,344 | 58,195,272 | -108,306,384 | 56,795,544 | 56,515,003 | 50,189,808 | 41,231,379 | 5,000,000 | 5,000,000 | |
| Shares (Diluted) | 75,443,496 | 69,668,439 | -114,706,527 | 58,773,731 | 58,428,344 | 58,195,272 | -108,306,384 | 56,795,544 | 56,515,003 | 50,189,808 | 41,231,379 | 5,000,000 | 5,000,000 | |
| EBITDA | $-96M | $-83M | · | $-71M | $-73M | $-63M | · | $-59M | $-44M | $-38M | $-24M | $-19M | · |
资产负债表 20
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $106M | $452M | $132M | $108M | $124M | $107M | $142M | $119M | $307M | $485M | · | $125M | · | |
| Short-term Investments | $866M | $608M | $599M | $419M | $381M | $406M | $379M | $407M | $369M | $331M | $235M | · | · | |
| Prepaid Expense | $20M | $14M | $11M | $13M | $11M | $8M | $9M | $8M | $6M | $4M | $4M | $6M | · | |
| Other Current Assets | $1M | $1M | $605.0K | $919.0K | $963.0K | $586.0K | $2M | $396.0K | $3M | $3M | $1M | $887.0K | · | |
| Current Assets | $992M | $1.07B | $741M | $540M | $516M | $522M | $530M | $534M | $682M | $821M | $426M | $131M | · | |
| PP&E (Net) | $5M | $5M | $6M | $6M | $6M | $6M | $2M | $1M | $714.0K | $699.0K | · | · | · | |
| Accum. Depreciation | $2M | $2M | $2M | $1M | $796.0K | $396.0K | $189.0K | $113.0K | · | · | · | · | · | |
| Other Non-current Assets | $11M | $9M | $9M | $9M | $9M | $7M | $498.0K | $514.0K | $468.0K | $401.0K | · | · | · | |
| Total Assets | $1.34B | $1.29B | $937M | $626M | $658M | $714M | $754M | $776M | $801M | $824M | $426M | $131M | · | |
| Accounts Payable | $3M | $1M | $1M | $376.0K | $6M | $2M | $1M | $2M | $6M | $4M | $1M | $11M | · | |
| Accrued Liabilities | $32M | $29M | $23M | $30M | $22M | $27M | $24M | $28M | $17M | $16M | $16M | $6M | · | |
| Current Liabilities | $38M | $33M | $28M | $34M | $32M | $33M | $29M | $33M | $25M | $22M | $17M | $18M | · | |
| Capital Leases | $4M | $5M | $5M | $6M | $7M | $8M | $9M | $9M | $2M | $630.0K | · | · | · | |
| Total Liabilities | $141M | $38M | $33M | $40M | $38M | $41M | $37M | $42M | $27M | $22M | $17M | $18M | · | |
| Common Stock | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | $1.0K | · | · | · | |
| Paid-in Capital | $1.92B | $1.89B | $1.46B | $1.08B | $1.05B | $1.03B | $1.02B | $970M | $964M | $958M | $501M | · | · | |
| Retained Earnings | $-722M | $-636M | $-562M | $-492M | $-427M | $-361M | $-306M | $-239M | $-190M | $-156M | $-92M | $-71M | · | |
| AOCI | $-3M | $-749.0K | $1M | $1M | $685.0K | $1M | $915.0K | $3M | $-289.0K | $-177.0K | $135.0K | · | · | |
| Liabilities + Equity | $1.34B | $1.29B | $937M | $626M | $658M | $714M | $754M | $776M | $801M | $824M | $426M | $131M | · | |
| Shares Outstanding | 75,339,499 | 74,882,396 | 68,401,349 | 59,315,738 | 58,560,525 | 58,304,801 | 58,062,898 | 56,899,295 | 56,676,465 | 56,367,802 | 48,017,621 | · | · |
现金流 9
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $17M | $17M | $12M | $12M | $11M | $11M | $8M | $6M | $6M | $4M | $2M | $1M | $1M | |
| Operating Cash Flow | $-71M | $-56M | $-63M | $-54M | $-62M | $-48M | $-68M | $-43M | $-29M | $-32M | $-20M | $-15M | $-11M | |
| CapEx | · | · | $62.0K | $0 | $768.0K | $4M | $-1.0K | $751.0K | $51.0K | $351.0K | · | · | · | |
| Investing Cash Flow | $-382M | $-35M | $-289M | $18M | $78M | $13M | $46M | $-146M | $-149M | $-52M | · | · | · | |
| Stock Issued | $-728.0K | $378M | · | $0 | $0 | $0 | · | $0 | $-541.0K | $450M | · | · | · | |
| Net Stock Activity | · | $378M | · | · | · | $0 | · | · | · | $450M | · | · | · | |
| Financing Cash Flow | $107M | $411M | $375M | $20M | $1M | $622.0K | $44M | $383.0K | $-150.0K | $451M | $317M | · | · | |
| Net Change in Cash | $-346M | $320M | $24M | $-17M | $17M | $-35M | $23M | $-189M | $-178M | $367M | $63M | $-16M | $-11M | |
| Free Cash Flow | · | · | · | · | · | $-53M | · | · | · | $-32M | · | · | · |
盈利能力 1
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -8.6% | -7.4% | · | -9.3% | -9.1% | -7.2% | · | -8.2% | -7.3% | -7.8% | -9.8% | -28.9% | · |
流动性与偿付能力 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 26.4 | 32.6 | · | 15.9 | 16.4 | 15.8 | · | 16.4 | 27.7 | 38.1 | 24.8 | 7.4 | · | |
| Quick Ratio | 25.9 | 32.2 | · | 15.5 | 16.0 | 15.6 | · | 16.1 | 27.5 | 37.9 | 13.7 | 7.1 | · |
估值 (TTM) 6
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-291M | $-261M | · | $-235M | $-204M | $-170M | · | $-136M | $-106M | $-84M | $-72M | $-53M | · | |
| Market Cap | $10.00B | $6.30B | · | $2.36B | $2.54B | $2.18B | · | $3.34B | $2.23B | $3.75B | $1.02B | · | · | |
| P/E | -29.9 | -19.8 | · | -9.8 | -12.3 | -12.2 | · | -22.5 | -7.1 | -8.9 | -1.3 | · | · | |
| P / Cash Flow | · | -113.4 | · | · | · | -44.9 | · | · | · | -118.4 | · | · | · | |
| P / FCF | · | · | · | · | · | -41.3 | · | · | · | -117.1 | · | · | · | |
| Earnings Yield | -3.4% | -5.1% | · | -10.2% | -8.2% | -8.2% | · | -4.4% | -14.1% | -11.2% | -76.3% | · | · |
财务报表 损益表、资产负债表、现金流量表 — 年度，近5年
损益表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| 净收入 | $-256M | $-182M | $-84M | $-40M |
| 稀释后每股收益 (EPS) | $-4.22 | $-3.30 | $-3.36 | $-16.16 |
资产负债表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| 流动比率 | 26.6 | 18.5 | 19.4 | — |
| 速动比率 | 26.2 | 18.2 | 19.2 | — |
现金流
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| 自由现金流 | $-233M | $-172M | $-75M | — |
最新新闻 提及该公司的近期头条新闻
- Is AbbVie a Buy After Its Purchase of Apogee?
- AbbVie Just Sparked a 46% Rally in Apogee. Here’s Why This $10.9 Billion Deal Could Be a Win for AbbVie Investors.
- Apogee Therapeutics (APGE) Hits Fresh High on AbbVie $10.9B Merger
- The $11 Billion Reason Abbvie Stock Is Up Today
- Stock Market Today, June 22: Apogee Therapeutics Soars on AbbVie Cash Buyout Offer
- AbbVie to acquire Apogee Therapeutics in $10.9B deal
- VR Adviser Adds Over 1 Million Savara Shares
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机构持有人 (13F) 315 家申报者 · $7.1B 总计 · 截至 2026年6月30日
在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸；单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存，而非方向性判断。
机构活动 — Q2 2026 与上一季度对比
| 新仓位 | 已退出持仓 | 增加 | 减少 | 净股数变动 |
|---|---|---|---|---|
| 130 (+75 与上一季度对比) | 47 (+20 与上一季度对比) | 81 (-23 与上一季度对比) | 67 (+17 与上一季度对比) | -4.7M |
与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天，外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过，优先显示最近一个已完整报告的季度对。
| 机构 | 价值 | 股份 | % 已追踪的13F | 类型 |
|---|---|---|---|---|
| Venrock Adviser, LLC | $1127318496 | 8493321 | 15.92% | 股份 |
| HBK INVESTMENTS L P | $378280500 | 2850000 | 5.34% | 股份 |
| VANGUARD CAPITAL MANAGEMENT LLC | $341397355 | 2572119 | 4.82% | 股份 |
| STATE STREET CORP | $304979428 | 2297743 | 4.31% | 股份 |
| FMR LLC | $241465867 | 1819226 | 3.41% | 股份 |
| Driehaus Capital Management LLC | $230963606 | 1740101 | 3.26% | 股份 |
| Balyasny Asset Management L.P. | $221006068 | 1665080 | 3.12% | 股份 |
| Paradigm Biocapital Advisors LP | $209233581 | 1576385 | 2.95% | 股份 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $202910988 | 1528750 | 2.86% | 股份 |
| GOLDMAN SACHS GROUP INC | $201319157 | 1516757 | 2.84% | 股份 |
| MILLENNIUM MANAGEMENT LLC | $197954053 | 1491404 | 2.79% | 股份 |
| Pentwater Capital Management LP | $189140250 | 1425000 | 2.67% | 股份 |
| PERCEPTIVE ADVISORS LLC | $173625838 | 1308113 | 2.45% | 股份 |
| GEODE CAPITAL MANAGEMENT, LLC | $149266292 | 1124299 | 2.11% | 股份 |
| Affinity Asset Advisors, LLC | $131004510 | 987000 | 1.85% | 股份 |
| MERCER GLOBAL ADVISORS INC /ADV | $124936493 | 941283 | 1.76% | 股份 |
| First Light Asset Management, LLC | $123477259 | 930289 | 1.74% | 股份 |
| Kryger Capital LLC | $98559325 | 742555 | 1.39% | 股份 |
| Qube Research & Technologies Ltd | $87559061 | 659678 | 1.24% | 股份 |
| First Trust Capital Management L.P. | $82980407 | 625182 | 1.17% | 股份 |
| Remedium Capital Partners, LLC | $77871496 | 586691 | 1.10% | 股份 |
| BANK OF AMERICA CORP /DE/ | $76695907 | 577834 | 1.08% | 股份 |
| SOROS FUND MANAGEMENT LLC | $74926085 | 564500 | 1.06% | 股份 |
| Balyasny Asset Management L.P. | $66365000 | 500000 | 0.94% | 卖出期权 |
| ALLIANCEBERNSTEIN L.P. | $65236632 | 775058 | 0.92% | 股份 |
| Woodline Partners LP | $61669278 | 464622 | 0.87% | 股份 |
| WHITEBOX ADVISORS LLC | $59728633 | 450001 | 0.84% | 股份 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $58886726 | 443658 | 0.83% | 股份 |
| AQR Arbitrage LLC | $57060627 | 429900 | 0.81% | 股份 |
| VANGUARD FIDUCIARY TRUST CO | $52186781 | 393180 | 0.74% | 股份 |
| Opaleye Management Inc. | $51764700 | 390000 | 0.73% | 股份 |
| TIG Advisors, LLC | $48346902 | 364250 | 0.68% | 股份 |
| WELLINGTON MANAGEMENT GROUP LLP | $48264344 | 363628 | 0.68% | 股份 |
| Cinctive Capital Management LP | $46477400 | 350165 | 0.66% | 股份 |
| Polar Asset Management Partners Inc. | $42801045 | 322467 | 0.60% | 股份 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $40315285 | 303739 | 0.57% | 股份 |
| Fairmount Funds Management LLC | $39639416 | 298647 | 0.56% | 股份 |
| NEXPOINT ASSET MANAGEMENT, L.P. | $38814234 | 292430 | 0.55% | 股份 |
| Squarepoint Ops LLC | $38586336 | 290713 | 0.54% | 股份 |
| CITIGROUP INC | $38075061 | 286861 | 0.54% | 股份 |
| LOOMIS SAYLES & CO L P | $37377830 | 281608 | 0.53% | 股份 |
| Magnetar Financial LLC | $36502741 | 275015 | 0.52% | 股份 |
| Slotnik Capital, LLC | $34608020 | 260740 | 0.49% | 股份 |
| Man Group plc | $34552274 | 260320 | 0.49% | 股份 |
| EVENTIDE ASSET MANAGEMENT, LLC | $34509800 | 260000 | 0.49% | 股份 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $33182500 | 250000 | 0.47% | 股份 |
| D. E. Shaw & Co., Inc. | $32107785 | 241903 | 0.45% | 股份 |
| BNP PARIBAS FINANCIAL MARKETS | $27901439 | 210212 | 0.39% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $26917644 | 202800 | 0.38% | 卖出期权 |
| PICTON MAHONEY ASSET MANAGEMENT | $26546000 | 200000 | 0.37% | 卖出期权 |
| VANGUARD GROUP INC | $24556890 | 325343 | 0.35% | 股份 |
| MUFG Securities EMEA plc | $23957765 | 180500 | 0.34% | 股份 |
| Allianz Asset Management GmbH | $23493210 | 177000 | 0.33% | 股份 |
| PICTON MAHONEY ASSET MANAGEMENT | $21900456 | 165000 | 0.31% | 股份 |
| Verition Fund Management LLC | $21138049 | 159256 | 0.30% | 股份 |
| BlackRock, Inc. | $20914133 | 157569 | 0.30% | 股份 |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | $20668197 | 155857 | 0.29% | 股份 |
| RENAISSANCE TECHNOLOGIES LLC | $19484764 | 146800 | 0.28% | 股份 |
| First Turn Management, LLC | $18425844 | 138822 | 0.26% | 股份 |
| Grantham, Mayo, Van Otterloo & Co. LLC | $18236438 | 137395 | 0.26% | 股份 |
| Sagefield Capital LP | $17970846 | 135394 | 0.25% | 股份 |
| GABELLI FUNDS LLC | $16894007 | 127281 | 0.24% | 股份 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $16094574 | 121258 | 0.23% | 股份 |
| CAPSTONE INVESTMENT ADVISORS, LLC | $15927600 | 120000 | 0.22% | 股份 |
| Twin Securities, Inc. | $15927600 | 120000 | 0.22% | 股份 |
| Melqart Asset Management (UK) Ltd | $15562460 | 117249 | 0.22% | 股份 |
| Caption Management, LLC | $15356861 | 115700 | 0.22% | 卖出期权 |
| TUDOR INVESTMENT CORP ET AL | $13352638 | 100600 | 0.19% | 卖出期权 |
| SEVEN GRAND MANAGERS, LLC | $13273000 | 100000 | 0.19% | 股份 |
| WATER ISLAND CAPITAL LLC | $12596077 | 94900 | 0.18% | 股份 |
| TWO SIGMA INVESTMENTS, LP | $12577362 | 94759 | 0.18% | 股份 |
| Maven Securities LTD | $12080819 | 91018 | 0.17% | 股份 |
| VICTORY CAPITAL MANAGEMENT INC | $11674002 | 87953 | 0.16% | 股份 |
| ExodusPoint Capital Management, LP | $11608625 | 87500 | 0.16% | 买入期权 |
| GABELLI & Co INVESTMENT ADVISERS, INC. | $10836741 | 81645 | 0.15% | 股份 |
| GARDNER LEWIS ASSET MANAGEMENT L P | $10618400 | 80000 | 0.15% | 股份 |
| Candriam S.C.A. | $10566281 | 79684 | 0.15% | 股份 |
| HARVEST MANAGEMENT LLC | $10485670 | 79000 | 0.15% | 股份 |
| Swiss National Bank | $10180391 | 76700 | 0.14% | 股份 |
| WCM INVESTMENT MANAGEMENT, LLC | $10074912 | 75974 | 0.14% | 股份 |
| Alberta Investment Management Corp | $9954750 | 75000 | 0.14% | 股份 |
| Chicago Capital Management, LLC | $9807420 | 97100 | 0.14% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9768928 | 73600 | 0.14% | 买入期权 |
| Boxer Capital Management, LLC | $9291100 | 70000 | 0.13% | 股份 |
| PRUDENTIAL FINANCIAL INC | $8510648 | 64120 | 0.12% | 股份 |
| KENNEDY CAPITAL MANAGEMENT LLC | $8492198 | 63981 | 0.12% | 股份 |
| CREDIT INDUSTRIEL ET COMMERCIAL | $8418268 | 63424 | 0.12% | 股份 |
| ALPS ADVISORS INC | $8298678 | 62523 | 0.12% | 股份 |
| Westchester Capital Management, LLC | $8253417 | 62182 | 0.12% | 股份 |
| Beryl Capital Management LLC | $7788065 | 58676 | 0.11% | 股份 |
| PRELUDE CAPITAL MANAGEMENT, LLC | $7776651 | 58590 | 0.11% | 股份 |
| PLATINUM INVESTMENT MANAGEMENT LTD | $7740017 | 58314 | 0.11% | 股份 |
| ALPINE ASSOCIATES MANAGEMENT INC. | $7685067 | 57900 | 0.11% | 股份 |
| RHUMBLINE ADVISERS | $7514630 | 56616 | 0.11% | 股份 |
| Point72 Asset Management, L.P. | $7241616 | 54559 | 0.10% | 股份 |
| FIRST TRUST ADVISORS LP | $7073447 | 53292 | 0.10% | 股份 |
| ABC ARBITRAGE SA | $7023806 | 52918 | 0.10% | 股份 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $6755957 | 50900 | 0.10% | 股份 |
| Centiva Capital, LP | $6650038 | 50102 | 0.09% | 股份 |
| Symmetry Investments LP | $6636500 | 50000 | 0.09% | 买入期权 |
公司内部人士 9 位内幕人士 · 2 位高管 · 7 位董事
| 内部人士 | 角色 | 上次活动 | 持股数量 | 买入 12个月 | 卖出 12个月 | 净额 12个月 |
|---|---|---|---|---|---|---|
| Michael Thomas Henderson | Chief Executive Officer | 2026年7月10日 G | 920941 | 0 | 33 | $-28389804 |
| Jane Henderson | Chief Financial Officer | 2026年7月24日 G | 158371 | 0 | 22 | $-2092806 |
| Lisa Bollinger | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Jennifer A. Fox | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Mark C. Mckenna | 董事 | 2026年6月9日 A | 20000 | 0 | 0 | $0 |
| Nimish P Shah | 董事 | 2026年6月9日 A | 1750000 | 0 | 0 | $0 |
| William A Jones JR | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Andrew Gottesdiener | 董事 | 2025年6月17日 A | — | 0 | 0 | $0 |
| Carl Dambkowski | — | 2026年8月5日 M | 168498 | 0 | 29 | $-10257229 |
来自SEC表格3/4/5申报的内部人士；净额=仅公开市场买卖
激进投资者及 5%+ 股东 2 持仓
提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权，意图影响发行人（激进股东持股、董事会活动、并购）。每一行显示该申报人持仓的最新已知状态。
| 申报人 | 已申报 | 持股 | 状态 | 目的 | 申报 |
|---|---|---|---|---|---|
| Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Peter Evan Harwin, Tomas Kiselak ×7 申报 | 2026年6月23日 | 9.99% | 修订 | 并购/出售 | SEC |
| Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Shah, Nimish, Koh, Bong | 2023年7月28日 | — | 初始申报 | 被动投资 | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF持仓 由 49 只交易所交易基金持有
权重仅反映直接股权持仓（N-PORT）；杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。
| 基金 | 权重 | 单位 | 截至 | 来源 |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 2.93% | 57722 NS | 2026年5月31日 | N-PORT |
| GDOC · Goldman Sachs ETF Trust | 1.97% | 4823 NS | 2026年5月31日 | N-PORT |
| GURU · Global X Funds | 1.29% | 9059 NS | 2026年4月30日 | N-PORT |
| LABU · Direxion Shares ETF Trust | 1.04% | 65006 NS | 2026年4月30日 | N-PORT |
| JDOC · J.P. Morgan Exchange-Traded Fund ... | 0.86% | 1152 NS | 2026年4月30日 | N-PORT |
| BBC · ETFis Series Trust I | 0.79% | 3580 NS | 2026年4月30日 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund ... | 0.64% | 4048 NS | 2026年5月31日 | N-PORT |
| IBB · iShares Trust | 0.59% | 418176 SH | 2026年8月8日 | 每日 |
| IBBQ · Invesco Exchange-Traded Fund Trus... | 0.57% | 3368 SH | 2026年8月8日 | 每日 |
| FSCC · Federated Hermes ETF Trust | 0.50% | 16880 NS | 2026年5月31日 | N-PORT |
| IWO · iShares Trust | 0.37% | 408942 SH | 2026年8月8日 | 每日 |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.35% | 48245 SH | 2026年8月8日 | 每日 |
| BIB · ProShares Trust | 0.23% | 2028 NS | 2026年5月31日 | N-PORT |
| IWM · iShares Trust | 0.19% | 1143929 SH | 2026年8月8日 | 每日 |
| BKSE · BNY Mellon ETF Trust | 0.19% | 1817 NS | 2026年4月30日 | N-PORT |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.18% | 259546 SH | 2026年8月8日 | 每日 |
| BBSC · J.P. Morgan Exchange-Traded Fund ... | 0.17% | 15226 NS | 2026年4月30日 | N-PORT |
| ISCG · iShares Trust | 0.17% | 12662 SH | 2026年8月8日 | 每日 |
| RSSL · Global X Funds | 0.11% | 19243 NS | 2026年4月30日 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.09% | 258020 NS | 2026年5月31日 | N-PORT |
| ITWO · ProShares Trust | 0.09% | 2095 NS | 2026年5月31日 | N-PORT |
| ISCB · iShares Trust | 0.08% | 1801 SH | 2026年8月8日 | 每日 |
| VXF · VANGUARD INDEX FUNDS | 0.08% | 641337 SH | 2026年8月8日 | 每日 |
| VBR · VANGUARD INDEX FUNDS | 0.08% | 428167 SH | 2026年8月8日 | 每日 |
| ESML · iShares Trust | 0.08% | 17140 SH | 2026年8月8日 | 每日 |
| VHT · VANGUARD WORLD FUND | 0.07% | 114655 SH | 2026年8月8日 | 每日 |
| UWM · ProShares Trust | 0.05% | 1637 NS | 2026年5月31日 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.05% | 11341 SH | 2026年8月8日 | 每日 |
| FHLC · FIDELITY COVINGTON TRUST | 0.05% | 17612 NS | 2026年4月30日 | N-PORT |
| VB · VANGUARD INDEX FUNDS | 0.05% | 674464 SH | 2026年8月8日 | 每日 |
| WSML · iShares Trust | 0.05% | 2338 SH | 2026年8月8日 | 每日 |
| AVIE · AMERICAN CENTURY ETF TRUST | 0.05% | 58 NS | 2026年5月31日 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0.04% | 4882 NS | 2026年5月31日 | N-PORT |
| URTY · ProShares Trust | 0.04% | 1660 NS | 2026年5月31日 | N-PORT |
| SMLF · iShares Trust | 0.03% | 10566 SH | 2026年8月8日 | 每日 |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.02% | 1535 NS | 2026年5月31日 | N-PORT |
| HDG · ProShares Trust | 0.02% | 42 NS | 2026年5月31日 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 15716 NS | 2026年5月31日 | N-PORT |
| FBCG · FIDELITY COVINGTON TRUST | 0.01% | 8874 NS | 2026年4月30日 | N-PORT |
| ITOT · iShares Trust | 0.01% | 75741 SH | 2026年8月8日 | 每日 |
| VTI · VANGUARD INDEX FUNDS | 0.01% | 1871044 SH | 2026年8月8日 | 每日 |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.01% | 3673 SH | 2026年8月8日 | 每日 |
| IWV · iShares Trust | 0.01% | 11143 SH | 2026年8月8日 | 每日 |
| SCHB · SCHWAB STRATEGIC TRUST | 0.01% | 31667 NS | 2026年5月31日 | N-PORT |
| TILT · FlexShares Trust | 0.00% | 924 NS | 2026年4月30日 | N-PORT |
| AVLC · AMERICAN CENTURY ETF TRUST | 0.00% | 106 NS | 2026年5月31日 | N-PORT |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.00% | 17 NS | 2026年5月31日 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0.00% | 52 NS | 2026年5月31日 | N-PORT |
| FTLS · First Trust Exchange-Traded Fund III | -0.06% | -17470 NS | 2026年4月30日 | N-PORT |