| BAKER BROS. ADVISORS LP |
$46153914 |
10885357 |
30.67% |
股份
|
| FCPM III SERVICES B.V. |
$14706143 |
3468430 |
9.77% |
股份
|
| ARMISTICE CAPITAL, LLC |
$14407520 |
3398000 |
9.57% |
股份
|
| Long Focus Capital Management, LLC |
$14037313 |
3310687 |
9.33% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$6501616 |
1533400 |
4.32% |
股份
|
| GSK plc |
$6485339 |
1529561 |
4.31% |
股份
|
| MARSHALL WACE, LLP |
$3383266 |
797940 |
2.25% |
股份
|
| Qube Research & Technologies Ltd |
$3288404 |
775567 |
2.19% |
股份
|
| MORGAN STANLEY |
$2829221 |
667269 |
1.88% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$2555707 |
615833 |
1.70% |
股份
|
| CITADEL ADVISORS LLC |
$2349914 |
554225 |
1.56% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2348820 |
553967 |
1.56% |
股份
|
| Peapod Lane Capital LLC |
$2281027 |
537978 |
1.52% |
股份
|
| DIADEMA PARTNERS LP |
$1961950 |
462724 |
1.30% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1842606 |
434577 |
1.22% |
股份
|
| JANE STREET GROUP, LLC |
$1662771 |
392163 |
1.10% |
股份
|
| Aquilo Capital Management, LLC |
$1457691 |
171695 |
0.97% |
股份
|
| Birchview Capital, LP |
$1329732 |
313616 |
0.88% |
股份
|
| BlackRock, Inc. |
$1188837 |
280386 |
0.79% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$1166000 |
275000 |
0.77% |
股份
|
| Rangeley Capital, LLC |
$1074840 |
253500 |
0.71% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1042616 |
245900 |
0.69% |
卖出期权
|
| TWO SIGMA ADVISERS, LP |
$1034388 |
146100 |
0.69% |
股份
|
| Palo Alto Investors LP |
$856014 |
201890 |
0.57% |
股份
|
| Sculptor Capital LP |
$839113 |
197904 |
0.56% |
股份
|
| Eversept Partners, LP |
$808632 |
190715 |
0.54% |
股份
|
| PINNACLE ASSOCIATES LTD |
$805558 |
189990 |
0.54% |
股份
|
| Cubist Systematic Strategies, LLC |
$800393 |
103410 |
0.53% |
股份
|
| FLAX POND CAPITAL, LLC |
$763565 |
180086 |
0.51% |
股份
|
| Jump Financial, LLC |
$708504 |
167100 |
0.47% |
股份
|
| Point72 Asset Management, L.P. |
$635729 |
149936 |
0.42% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$542139 |
127863 |
0.36% |
股份
|
| GOLDMAN SACHS GROUP INC |
$514231 |
121281 |
0.34% |
股份
|
| Persistent Asset Partners Ltd |
$497157 |
117254 |
0.33% |
股份
|
| XTX Topco Ltd |
$465556 |
109801 |
0.31% |
股份
|
| Quadrature Capital Ltd |
$441350 |
104092 |
0.29% |
股份
|
| TD Asset Management Inc |
$390046 |
91992 |
0.26% |
股份
|
| Virtus Investment Advisers, LLC |
$342545 |
80789 |
0.23% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$339200 |
80000 |
0.23% |
股份
|
| EntryPoint Capital, LLC |
$329630 |
77743 |
0.22% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$315880 |
74500 |
0.21% |
买入期权
|
| Marquette Asset Management, LLC |
$308901 |
72854 |
0.21% |
股份
|
| DAFNA Capital Management LLC |
$273446 |
64492 |
0.18% |
股份
|
| State of Tennessee, Department of Treasury |
$259289 |
61153 |
0.17% |
股份
|
| CITADEL ADVISORS LLC |
$238288 |
56200 |
0.16% |
卖出期权
|
| SEI INVESTMENTS CO |
$223804 |
52784 |
0.15% |
股份
|
| ALPS ADVISORS INC |
$216757 |
51122 |
0.14% |
股份
|
| Verdad Advisers, LP |
$216664 |
51100 |
0.14% |
股份
|
| ADAR1 Capital Management, LLC |
$214705 |
50638 |
0.14% |
股份
|
| JANE STREET GROUP, LLC |
$151792 |
35800 |
0.10% |
买入期权
|
| SIMPLEX TRADING, LLC |
$149383 |
35232 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$135498 |
31957 |
0.09% |
股份
|
| Trexquant Investment LP |
$131627 |
31044 |
0.09% |
股份
|
| STATE STREET CORP |
$130715 |
30829 |
0.09% |
股份
|
| WOODSTOCK CORP |
$123579 |
29146 |
0.08% |
股份
|
| AXQ CAPITAL, LP |
$116040 |
27368 |
0.08% |
股份
|
| JANE STREET GROUP, LLC |
$113632 |
26800 |
0.08% |
卖出期权
|
| D. E. Shaw & Co., Inc. |
$107938 |
25457 |
0.07% |
股份
|
| Invesco Ltd. |
$105160 |
24802 |
0.07% |
股份
|
| National Philanthropic Trust |
$104826 |
24723 |
0.07% |
股份
|
| Forefront Analytics, LLC |
$92525 |
21822 |
0.06% |
股份
|
| STIFEL FINANCIAL CORP |
$86829 |
20479 |
0.06% |
股份
|
| State of New Jersey Common Pension Fund D |
$85245 |
20105 |
0.06% |
股份
|
| Vontobel Holding Ltd. |
$84800 |
20000 |
0.06% |
股份
|
| Aigen Investment Management, LP |
$81913 |
19319 |
0.05% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$80708 |
19035 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$73352 |
17300 |
0.05% |
买入期权
|
| RHUMBLINE ADVISERS |
$67690 |
15967 |
0.04% |
股份
|
| UBS Group AG |
$65546 |
15459 |
0.04% |
股份
|
| PORTLAND INVESTMENT COUNSEL INC. |
$63600 |
15000 |
0.04% |
股份
|
| Federation des caisses Desjardins du Quebec |
$60603 |
14302 |
0.04% |
股份
|
| Erste Asset Management GmbH |
$58100 |
14000 |
0.04% |
股份
|
| Cerity Partners LLC |
$57537 |
13570 |
0.04% |
股份
|
| Schonfeld Strategic Advisors LLC |
$56810 |
13399 |
0.04% |
股份
|
| Walleye Capital LLC |
$55120 |
13000 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$54182 |
13056 |
0.04% |
股份
|
| HORIZON KINETICS ASSET MANAGEMENT LLC |
$53356 |
12584 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$52334 |
12343 |
0.03% |
股份
|
| Jain Global LLC |
$50880 |
12000 |
0.03% |
股份
|
| Crossmark Global Holdings, Inc. |
$48344 |
11402 |
0.03% |
股份
|
| Pinnacle Wealth Management Advisory Group, LLC |
$46576 |
10985 |
0.03% |
股份
|
| State of Wyoming |
$45622 |
10760 |
0.03% |
股份
|
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
$42892 |
10116 |
0.03% |
股份
|
| GAMMA Investing LLC |
$32665 |
7704 |
0.02% |
股份
|
| Walleye Capital LLC |
$32648 |
7700 |
0.02% |
买入期权
|
| China Universal Asset Management Co., Ltd. |
$31461 |
7420 |
0.02% |
股份
|
| NATIXIS |
$19997 |
4645 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$15557 |
3669 |
0.01% |
股份
|
| BARCLAYS PLC |
$13352 |
3149 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$11000 |
2500 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$8840 |
2085 |
0.01% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$8319 |
1968025 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$8217 |
1938 |
0.01% |
股份
|
| ASSETMARK, INC |
$6733 |
1588 |
0.00% |
股份
|
| CITIGROUP INC |
$4982 |
1175 |
0.00% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$4308 |
1016 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$4079 |
962 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$3826 |
902150 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$2870 |
700 |
0.00% |
股份
|
| Quarry LP |
$2277 |
537 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$1844 |
435 |
0.00% |
股份
|
| Arax Advisory Partners |
$1289 |
304 |
0.00% |
股份
|
| Walleye Capital LLC |
$848 |
200 |
0.00% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$848 |
200 |
0.00% |
股份
|
| Winch Advisory Services, LLC |
$729 |
172 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$623 |
147 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$496 |
117 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$280 |
66237 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$131 |
30785 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$111 |
26250 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$42 |
10 |
0.00% |
股份
|
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. |
$38 |
9 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$25 |
6 |
0.00% |
股份
|
| Caitlin John, LLC |
$8 |
2 |
0.00% |
股份
|