| ORBIMED ADVISORS LLC |
$107045190 |
7165006 |
10.14% |
股份
|
| BlackRock, Inc. |
$106653837 |
7138811 |
10.10% |
股份
|
| STATE STREET CORP |
$66842920 |
4474091 |
6.33% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$49193087 |
3292710 |
4.66% |
股份
|
| ADAMS STREET PARTNERS LLC |
$48937703 |
3275616 |
4.63% |
股份
|
| Vivo Capital, LLC |
$41918891 |
2805816 |
3.97% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$40810581 |
2731632 |
3.87% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$39851569 |
2667441 |
3.77% |
股份
|
| Deep Track Capital, LP |
$37229569 |
2491939 |
3.53% |
股份
|
| BRAIDWELL LP |
$31766892 |
2126298 |
3.01% |
股份
|
| VANGUARD GROUP INC |
$29825811 |
3873482 |
2.82% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$27700900 |
1853659 |
2.62% |
股份
|
| Foresite Capital Management VI LLC |
$27358621 |
1831233 |
2.59% |
股份
|
| GOLDMAN SACHS GROUP INC |
$23550700 |
1576352 |
2.23% |
股份
|
| Hood River Capital Management LLC |
$23482767 |
1571805 |
2.22% |
股份
|
| MORGAN STANLEY |
$20090356 |
1344736 |
1.90% |
股份
|
| Boxer Capital Management, LLC |
$16434000 |
1100000 |
1.56% |
股份
|
| Catalio Capital Management, LP |
$16148467 |
1080888 |
1.53% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$15656896 |
1047985 |
1.48% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12172365 |
814750 |
1.15% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$11731008 |
785208 |
1.11% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$11321503 |
757798 |
1.07% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$11205000 |
750000 |
1.06% |
股份
|
| Eversept Partners, LP |
$11175030 |
747994 |
1.06% |
股份
|
| EMERALD ADVISERS, LLC |
$10244104 |
685683 |
0.97% |
股份
|
| DCF Advisers, LLC |
$9524250 |
637500 |
0.90% |
股份
|
| Blue Owl Capital Holdings LP |
$9092484 |
608600 |
0.86% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$8739900 |
585000 |
0.83% |
买入期权
|
| NORTHERN TRUST CORP |
$8592861 |
575158 |
0.81% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$7864252 |
526389 |
0.74% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$7776688 |
520528 |
0.74% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$6723000 |
450000 |
0.64% |
股份
|
| Nextech Invest Ltd. |
$6723000 |
450000 |
0.64% |
股份
|
| CITADEL ADVISORS LLC |
$6675192 |
446800 |
0.63% |
买入期权
|
| CITADEL ADVISORS LLC |
$5945388 |
397951 |
0.56% |
股份
|
| UBS Group AG |
$5917973 |
396116 |
0.56% |
股份
|
| BARCLAYS PLC |
$4717289 |
315749 |
0.45% |
股份
|
| Jump Financial, LLC |
$4682196 |
313400 |
0.44% |
股份
|
| Trexquant Investment LP |
$4427424 |
296347 |
0.42% |
股份
|
| DIADEMA PARTNERS LP |
$4404476 |
294811 |
0.42% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4101030 |
274500 |
0.39% |
卖出期权
|
| Polymer Capital Management (HK) LTD |
$3939110 |
263662 |
0.37% |
股份
|
| Brevan Howard Capital Management LP |
$3739348 |
250291 |
0.35% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$3659717 |
244961 |
0.35% |
股份
|
| Spruce Street Capital LP |
$3459880 |
231585 |
0.33% |
股份
|
| SEB Asset Management AB |
$3388938 |
226837 |
0.32% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$3298169 |
220761 |
0.31% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$3253185 |
217750 |
0.31% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3109298 |
208119 |
0.29% |
股份
|
| Bank of New York Mellon Corp |
$3026973 |
202609 |
0.29% |
股份
|
| CITADEL ADVISORS LLC |
$2959614 |
198100 |
0.28% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2848177 |
190641 |
0.27% |
股份
|
| Caption Management, LLC |
$2838600 |
190000 |
0.27% |
买入期权
|
| F/m Investments LLC |
$2497445 |
167165 |
0.24% |
股份
|
| Nuveen, LLC |
$2417606 |
161821 |
0.23% |
股份
|
| JANE STREET GROUP, LLC |
$2094588 |
140200 |
0.20% |
买入期权
|
| JPMORGAN CHASE & CO |
$2055957 |
141986 |
0.19% |
股份
|
| DIADEMA PARTNERS LP |
$1992996 |
133400 |
0.19% |
买入期权
|
| D. E. Shaw & Co., Inc. |
$1989664 |
133177 |
0.19% |
股份
|
| Swiss National Bank |
$1889910 |
126500 |
0.18% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1843282 |
123379 |
0.17% |
股份
|
| Aquatic Capital Management LLC |
$1762920 |
118000 |
0.17% |
股份
|
| ADAR1 Capital Management, LLC |
$1749489 |
117101 |
0.17% |
股份
|
| CITIGROUP INC |
$1722926 |
115323 |
0.16% |
股份
|
| Caption Management, LLC |
$1664316 |
111400 |
0.16% |
卖出期权
|
| MARSHALL WACE, LLP |
$1501082 |
100474 |
0.14% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1479239 |
99012 |
0.14% |
股份
|
| SIMPLEX TRADING, LLC |
$1379604 |
92343 |
0.13% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1322845 |
90420 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$1285128 |
86020 |
0.12% |
股份
|
| ALPS ADVISORS INC |
$1274980 |
85340 |
0.12% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1238631 |
82907 |
0.12% |
股份
|
| Seven Fleet Capital Management LP |
$1238377 |
82890 |
0.12% |
股份
|
| TD Asset Management Inc |
$1233984 |
82596 |
0.12% |
股份
|
| Rafferty Asset Management, LLC |
$1217520 |
81494 |
0.12% |
股份
|
| SEI INVESTMENTS CO |
$1195290 |
80006 |
0.11% |
股份
|
| Avidity Partners Management LP |
$1195200 |
80000 |
0.11% |
股份
|
| Persistent Asset Partners Ltd |
$1117452 |
74796 |
0.11% |
股份
|
| DEUTSCHE BANK AG\ |
$1113463 |
74529 |
0.11% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1059545 |
70920 |
0.10% |
股份
|
| Propel Bio Management, LLC |
$1051477 |
70380 |
0.10% |
股份
|
| TOWERVIEW LLC |
$1045800 |
70000 |
0.10% |
股份
|
| Caption Management, LLC |
$956668 |
64034 |
0.09% |
股份
|
| JACKSON SQUARE CAPITAL, LLC |
$952769 |
63773 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$922770 |
61765 |
0.09% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$902376 |
60400 |
0.09% |
买入期权
|
| Ancora Advisors LLC |
$847442 |
56723 |
0.08% |
股份
|
| FRANKLIN RESOURCES INC |
$847144 |
56703 |
0.08% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$747000 |
50000 |
0.07% |
股份
|
| GROUP ONE TRADING LLC |
$721482 |
48292 |
0.07% |
股份
|
| Vanguard Global Advisers, LLC |
$712459 |
47688 |
0.07% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$660632 |
44219 |
0.06% |
股份
|
| Squarepoint Ops LLC |
$660423 |
44205 |
0.06% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$653909 |
43769 |
0.06% |
股份
|
| Creative Planning |
$630080 |
42174 |
0.06% |
股份
|
| Invesco Ltd. |
$623028 |
41702 |
0.06% |
股份
|
| Legal & General Group Plc |
$622954 |
41697 |
0.06% |
股份
|
| TEMA ETFS LLC |
$613675 |
79698 |
0.06% |
股份
|
| PROFUND ADVISORS LLC |
$613197 |
41044 |
0.06% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$602897 |
40646 |
0.06% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$595031 |
39828 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$592341 |
39648 |
0.06% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$559159 |
37427 |
0.05% |
股份
|
| AVITY INVESTMENT MANAGEMENT INC. |
$555021 |
37150 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$538124 |
36019 |
0.05% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$417767 |
27963 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$414719 |
27759 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$409759 |
27427 |
0.04% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$403380 |
27000 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$378535 |
25337 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$374994 |
25100 |
0.04% |
股份
|
| SIMON QUICK ADVISORS, LLC |
$373500 |
25000 |
0.04% |
股份
|
| PEAK6 LLC |
$352584 |
23600 |
0.03% |
买入期权
|
| WINTON GROUP Ltd |
$346608 |
23200 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$328560 |
21992 |
0.03% |
股份
|
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. |
$325259 |
21771 |
0.03% |
股份
|
| China Universal Asset Management Co., Ltd. |
$319462 |
21383 |
0.03% |
股份
|
| State of New Jersey Common Pension Fund D |
$304313 |
20369 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$301788 |
20200 |
0.03% |
卖出期权
|
| AlphaQuest LLC |
$276984 |
35972 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$274383 |
340 |
0.03% |
买入期权
|
| FOX RUN MANAGEMENT, L.L.C. |
$269742 |
18055 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$269159 |
18016 |
0.03% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$259687 |
17382 |
0.02% |
股份
|
| Lido Advisors, LLC |
$242700 |
16245 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$241908 |
16192 |
0.02% |
股份
|
| Pictet Asset Management Holding SA |
$233497 |
15629 |
0.02% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$225773 |
15112 |
0.02% |
股份
|
| Sowell Financial Services LLC |
$223727 |
14975 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$213642 |
14300 |
0.02% |
股份
|
| PEAK6 LLC |
$212522 |
14225 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$210968 |
14121 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$191008 |
12785 |
0.02% |
股份
|
| Jain Global LLC |
$187124 |
12525 |
0.02% |
股份
|
| ProShare Advisors LLC |
$173633 |
11622 |
0.02% |
股份
|
| E Fund Management Co., Ltd. |
$171676 |
11491 |
0.02% |
股份
|
| SBI Securities Co., Ltd. |
$169778 |
11364 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$164265 |
10995 |
0.02% |
股份
|
| WHITTIER TRUST CO OF NEVADA INC |
$159426 |
10200 |
0.02% |
股份
|
| Mengis Capital Management, Inc. |
$156123 |
10450 |
0.01% |
股份
|
| Truvestments Capital LLC |
$152313 |
10195 |
0.01% |
股份
|
| OneDigital Investment Advisors LLC |
$149414 |
10001 |
0.01% |
股份
|
| Ghisallo Capital Management LLC |
$149400 |
10000 |
0.01% |
股份
|
| TWO SIGMA ADVISERS, LP |
$145530 |
18900 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$128000 |
8593 |
0.01% |
股份
|
| Masso Torrence Wealth Management Inc. |
$125290 |
17000 |
0.01% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$105357 |
7052 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$97439 |
6522 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$91806 |
6145 |
0.01% |
股份
|
| MEEDER ASSET MANAGEMENT INC |
$90462 |
6055 |
0.01% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$89477 |
6116 |
0.01% |
股份
|
| State of Wyoming |
$70741 |
4735 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$56611 |
3789126 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$56189 |
3761 |
0.01% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$47808 |
3200 |
0.00% |
股份
|
| FMR LLC |
$35199 |
2356 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$29910 |
2002 |
0.00% |
股份
|
| Western Pacific Wealth Management, LP |
$29880 |
2000 |
0.00% |
股份
|
| Northwest Capital Management Inc |
$26160 |
3397 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$26145 |
1750 |
0.00% |
股份
|
| CWM, LLC |
$18097 |
1237 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$10876 |
728 |
0.00% |
股份
|
| GAMMA Investing LLC |
$10144 |
679 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$6364 |
426 |
0.00% |
股份
|
| Allworth Financial LP |
$5663 |
379 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$4049 |
271 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3556 |
238 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$3093 |
207 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$2645 |
177 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2480 |
166 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2390 |
160 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1718 |
115 |
0.00% |
股份
|
| EASTERN BANK |
$1374 |
92 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$1135 |
76 |
0.00% |
股份
|
| KELLEHER FINANCIAL ADVISORS |
$1121 |
75 |
0.00% |
股份
|
| Arax Advisory Partners |
$1121 |
75 |
0.00% |
股份
|
| Larson Financial Group LLC |
$1031 |
69 |
0.00% |
股份
|
| Hikari Power Ltd |
$746 |
49959 |
0.00% |
股份
|
| Quarry LP |
$627 |
42 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$553 |
37 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$500 |
33458 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$463 |
30994 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$323 |
28 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$105 |
7 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$30 |
2 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$20 |
1361 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
28 |
0.00% |
股份
|