| FMR LLC |
$508769634 |
10025017 |
13.10% |
股份
|
| ORBIMED ADVISORS LLC |
$343914074 |
6776632 |
8.86% |
股份
|
| Polar Capital Holdings Plc |
$326354777 |
6430636 |
8.40% |
股份
|
| BlackRock, Inc. |
$221254979 |
4359704 |
5.70% |
股份
|
| Vestal Point Capital, LP |
$203000000 |
4000000 |
5.23% |
股份
|
| Commodore Capital LP |
$166206250 |
3275000 |
4.28% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$130376852 |
2569002 |
3.36% |
股份
|
| CITADEL ADVISORS LLC |
$105001345 |
2068992 |
2.70% |
股份
|
| Fairmount Funds Management LLC |
$94173933 |
1855644 |
2.42% |
股份
|
| Siren, L.L.C. |
$90051358 |
1774411 |
2.32% |
股份
|
| Bellevue Group AG |
$75617500 |
1490000 |
1.95% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$71430882 |
1407202 |
1.84% |
股份
|
| First Light Asset Management, LLC |
$69058063 |
1360750 |
1.78% |
股份
|
| STATE STREET CORP |
$61591012 |
1213616 |
1.59% |
股份
|
| Pictet Asset Management Holding SA |
$58960538 |
1161784 |
1.52% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$54978135 |
1083313 |
1.42% |
股份
|
| NOVO HOLDINGS A/S |
$50750000 |
1000000 |
1.31% |
股份
|
| First Turn Management, LLC |
$48433770 |
954360 |
1.25% |
股份
|
| SAMLYN CAPITAL, LLC |
$46316328 |
912637 |
1.19% |
股份
|
| BAKER BROS. ADVISORS LP |
$45938443 |
905191 |
1.18% |
股份
|
| Candriam S.C.A. |
$45918733 |
905674 |
1.18% |
股份
|
| Tri Locum Partners LP |
$43985837 |
866716 |
1.13% |
股份
|
| VANGUARD GROUP INC |
$43145640 |
2801665 |
1.11% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$35129511 |
896161 |
0.90% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$34074507 |
671412 |
0.88% |
股份
|
| Balyasny Asset Management L.P. |
$30814842 |
607189 |
0.79% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$28732976 |
566165 |
0.74% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$28560222 |
562763 |
0.74% |
股份
|
| Avidity Partners Management LP |
$27912500 |
550000 |
0.72% |
股份
|
| MARSHALL WACE, LLP |
$27012653 |
532269 |
0.70% |
股份
|
| Venrock Adviser, LLC |
$26711298 |
526331 |
0.69% |
股份
|
| MORGAN STANLEY |
$25878866 |
509928 |
0.67% |
股份
|
| Affinity Asset Advisors, LLC |
$25375000 |
500000 |
0.65% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$24836137 |
489382 |
0.64% |
股份
|
| Logos Global Management LP |
$23598750 |
465000 |
0.61% |
股份
|
| Rock Springs Capital Management LP |
$23579719 |
464625 |
0.61% |
股份
|
| NORTHERN TRUST CORP |
$22377604 |
440938 |
0.58% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$21540330 |
424440 |
0.55% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$20876622 |
411362 |
0.54% |
股份
|
| Nicholas Investment Partners, LP |
$19870097 |
391529 |
0.51% |
股份
|
| ADAR1 Capital Management, LLC |
$19676689 |
387718 |
0.51% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$19462118 |
383490 |
0.50% |
股份
|
| Nuveen, LLC |
$18991513 |
374217 |
0.49% |
股份
|
| Seven Fleet Capital Management LP |
$18543340 |
365386 |
0.48% |
股份
|
| Woodline Partners LP |
$17617457 |
347142 |
0.45% |
股份
|
| STEMPOINT CAPITAL LP |
$17605886 |
346914 |
0.45% |
股份
|
| UBS Group AG |
$17362337 |
342115 |
0.45% |
股份
|
| Spruce Street Capital LP |
$16697055 |
329006 |
0.43% |
股份
|
| GOLDMAN SACHS GROUP INC |
$16349417 |
322156 |
0.42% |
股份
|
| Longaeva Partners L.P. |
$15862420 |
312560 |
0.41% |
股份
|
| JENNISON ASSOCIATES LLC |
$15692866 |
309219 |
0.40% |
股份
|
| Assenagon Asset Management S.A. |
$15558631 |
306574 |
0.40% |
股份
|
| D. E. Shaw & Co., Inc. |
$15514427 |
305703 |
0.40% |
股份
|
| AMERIPRISE FINANCIAL INC |
$12747995 |
251192 |
0.33% |
股份
|
| Deep Track Capital, LP |
$11418750 |
225000 |
0.29% |
股份
|
| Blackstone Inc. |
$10949008 |
215744 |
0.28% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$10877907 |
214343 |
0.28% |
股份
|
| Patient Square Capital LP |
$10784375 |
212500 |
0.28% |
股份
|
| Soleus Capital Management, L.P. |
$8408108 |
165677 |
0.22% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$8164610 |
160879 |
0.21% |
股份
|
| Squadron Capital Management LLC |
$8120000 |
160000 |
0.21% |
股份
|
| Integral Health Asset Management, LLC |
$7612500 |
150000 |
0.20% |
股份
|
| Cormorant Asset Management, LP |
$7612500 |
150000 |
0.20% |
股份
|
| HighVista Strategies LLC |
$6996700 |
137866 |
0.18% |
股份
|
| Eversept Partners, LP |
$6934023 |
136631 |
0.18% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$6757009 |
133143 |
0.17% |
股份
|
| Ikarian Capital, LLC |
$6421957 |
126541 |
0.17% |
股份
|
| Bank of New York Mellon Corp |
$6031790 |
118853 |
0.16% |
股份
|
| Invesco Ltd. |
$5733329 |
112972 |
0.15% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$5722824 |
112765 |
0.15% |
股份
|
| J. Goldman & Co LP |
$5690547 |
112129 |
0.15% |
股份
|
| TD Asset Management Inc |
$5569204 |
109738 |
0.14% |
股份
|
| Cinctive Capital Management LP |
$5465166 |
107688 |
0.14% |
股份
|
| Exome Asset Management LLC |
$5085302 |
100203 |
0.13% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$4974667 |
98023 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4892300 |
96400 |
0.13% |
买入期权
|
| Swiss National Bank |
$4799580 |
94573 |
0.12% |
股份
|
| Russell Investments Group, Ltd. |
$4665906 |
91938 |
0.12% |
股份
|
| DV EQUITIES, LLC |
$3869688 |
76250 |
0.10% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3819699 |
75265 |
0.10% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$3778490 |
74453 |
0.10% |
股份
|
| Artia Global Partners LP |
$3659075 |
72100 |
0.09% |
股份
|
| ALGERT GLOBAL LLC |
$3658568 |
72090 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$3654000 |
72000 |
0.09% |
卖出期权
|
| Informed Momentum Co LLC |
$3574424 |
70432 |
0.09% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$3552500 |
70000 |
0.09% |
股份
|
| GREAT POINT PARTNERS LLC |
$3552500 |
70000 |
0.09% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$3407913 |
67151 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$2904972 |
57241 |
0.07% |
股份
|
| Schonfeld Strategic Advisors LLC |
$2836112 |
55884 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2705736 |
53315 |
0.07% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2645019 |
67475 |
0.07% |
股份
|
| Allianz Asset Management GmbH |
$2639406 |
52008 |
0.07% |
股份
|
| Atom Investors LP |
$2543692 |
50122 |
0.07% |
股份
|
| Caption Management, LLC |
$2537500 |
50000 |
0.07% |
买入期权
|
| Jones Hill Capital LP |
$2529888 |
49850 |
0.07% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$2318514 |
45685 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$2289282 |
45109 |
0.06% |
股份
|
| JPMORGAN CHASE & CO |
$2059934 |
37890 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$2035989 |
40118 |
0.05% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1983259 |
39079 |
0.05% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1980823 |
39031 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$1908200 |
37600 |
0.05% |
买入期权
|
| Trexquant Investment LP |
$1902668 |
37491 |
0.05% |
股份
|
| TimesSquare Capital Management, LLC |
$1764000 |
45000 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1696674 |
33432 |
0.04% |
股份
|
| Legal & General Group Plc |
$1670893 |
32924 |
0.04% |
股份
|
| Ishara Investments LP |
$1664600 |
32800 |
0.04% |
股份
|
| Brevan Howard Capital Management LP |
$1660439 |
32718 |
0.04% |
股份
|
| FRANKLIN RESOURCES INC |
$1581522 |
31163 |
0.04% |
股份
|
| CITIGROUP INC |
$1558634 |
30712 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$1479464 |
29152 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$1361775 |
26833 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$1344875 |
26500 |
0.03% |
卖出期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1325083 |
26110 |
0.03% |
股份
|
| Erste Asset Management GmbH |
$1271250 |
25000 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$1267329 |
24972 |
0.03% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1154969 |
22758 |
0.03% |
股份
|
| BARCLAYS PLC |
$1056413 |
20816 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1055600 |
20800 |
0.03% |
卖出期权
|
| Lighthouse Investment Partners, LLC |
$1015000 |
20000 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1001247 |
19729 |
0.03% |
股份
|
| Creative Planning |
$983840 |
19386 |
0.03% |
股份
|
| Hudson Bay Capital Management LP |
$964250 |
19000 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$892185 |
17580 |
0.02% |
股份
|
| Verdad Advisers, LP |
$860568 |
16957 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$781550 |
15400 |
0.02% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$761402 |
15003 |
0.02% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$733947 |
14462 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$660105 |
13007 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$641226 |
12635 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$639044 |
12592 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$624225 |
12300 |
0.02% |
股份
|
| Bridgefront Capital, LLC |
$613872 |
12096 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$613568 |
12090 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$554850 |
10933 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$549572 |
10829 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$536783 |
10577 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$531860 |
10480 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$527648 |
10397 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$512321 |
10095 |
0.01% |
股份
|
| DIADEMA PARTNERS LP |
$507500 |
10000 |
0.01% |
股份
|
| XTX Topco Ltd |
$505318 |
9957 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$491920 |
9693 |
0.01% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$487200 |
9600 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$478725 |
9433 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$476000 |
9378 |
0.01% |
股份
|
| Skopos Labs, Inc. |
$457073 |
11660 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$438277 |
8636 |
0.01% |
股份
|
| JANUS HENDERSON GROUP PLC |
$431200 |
11000 |
0.01% |
股份
|
| Aquatic Capital Management LLC |
$426300 |
8400 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$392095 |
7726 |
0.01% |
股份
|
| ProShare Advisors LLC |
$386005 |
7606 |
0.01% |
股份
|
| BAMCO INC /NY/ |
$380625 |
7500 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$359970 |
7093 |
0.01% |
股份
|
| PSP Research LLC |
$355250 |
7000 |
0.01% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$340482 |
6709 |
0.01% |
股份
|
| Knott David M Jr |
$313787 |
6183 |
0.01% |
股份
|
| Amundi |
$306581 |
6041 |
0.01% |
股份
|
| CenterBook Partners LP |
$286788 |
5651 |
0.01% |
股份
|
| STRS OHIO |
$284200 |
5600 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$275420 |
5427 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$272426 |
5368 |
0.01% |
股份
|
| STIFEL FINANCIAL CORP |
$263041 |
5183 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$262428 |
5171 |
0.01% |
股份
|
| Squarepoint Ops LLC |
$258774 |
5099 |
0.01% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$228324 |
4499 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$228121 |
4495 |
0.01% |
股份
|
| XPONANCE LLC |
$214419 |
4225 |
0.01% |
股份
|
| Quarry LP |
$204675 |
4033 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$202645 |
3993 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$197316 |
3888 |
0.01% |
股份
|
| AlphaQuest LLC |
$159190 |
10337 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$147374 |
2903907 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$138243 |
2724 |
0.00% |
股份
|
| State of Wyoming |
$95613 |
1884 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$75668 |
1491 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$73940 |
1613 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$63844 |
1258 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$61357 |
1209 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$56764 |
2773 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$49735 |
980 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$39850 |
784 |
0.00% |
股份
|
| US BANCORP \DE\ |
$37403 |
737 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$31770 |
626 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$28725 |
566 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$23142 |
456 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$17052 |
336 |
0.00% |
股份
|
| Arax Advisory Partners |
$16798 |
331 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$16786 |
330759 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$15271 |
300891 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$15225 |
300 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$14567 |
712 |
0.00% |
股份
|
| GAMMA Investing LLC |
$11571 |
228 |
0.00% |
股份
|
| Optiver Holding B.V. |
$11114 |
219 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$10556 |
208 |
0.00% |
股份
|
| SMA Capital LLC |
$10353 |
204 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7613 |
150 |
0.00% |
股份
|
| CWM, LLC |
$5566 |
142 |
0.00% |
股份
|
| Larson Financial Group LLC |
$3096 |
61 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$2132 |
42 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2081 |
41 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$1776 |
35 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1624 |
32 |
0.00% |
股份
|
| Institute for Wealth Management, LLC. |
$1530 |
30 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1117 |
22 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$863 |
17 |
0.00% |
股份
|
| Penserra Capital Management LLC |
$845 |
16660 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$762 |
15 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$546 |
10751 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$355 |
7 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$276 |
14 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$226 |
4 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$153 |
3 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$126 |
2500 |
0.00% |
股份
|
| KBC Group NV |
$92 |
1805 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$51 |
1 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$51 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
15 |
0.00% |
股份
|