| MONTANOVA CAPITAL, LLC |
$118638163 |
8296375 |
8.06% |
股份
|
| BlackRock, Inc. |
$106723718 |
7463197 |
7.25% |
股份
|
| Cormorant Asset Management, LP |
$100100000 |
7000000 |
6.80% |
股份
|
| VANGUARD GROUP INC |
$88100480 |
4822139 |
5.99% |
股份
|
| FEDERATED HERMES, INC. |
$81239044 |
5681052 |
5.52% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$69037426 |
4827792 |
4.69% |
股份
|
| FRANKLIN RESOURCES INC |
$68741215 |
4807078 |
4.67% |
股份
|
| Commodore Capital LP |
$65780000 |
4600000 |
4.47% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$51912604 |
3630252 |
3.53% |
股份
|
| JANUS HENDERSON GROUP PLC |
$46419056 |
3601168 |
3.15% |
股份
|
| Paradigm Biocapital Advisors LP |
$41332677 |
2890397 |
2.81% |
股份
|
| STATE STREET CORP |
$33712894 |
2357545 |
2.29% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$29497382 |
2062390 |
2.00% |
股份
|
| Aberdeen Group plc |
$28725869 |
2008802 |
1.95% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$28600000 |
2000000 |
1.94% |
卖出期权
|
| CITADEL ADVISORS LLC |
$28279823 |
1977610 |
1.92% |
股份
|
| Balyasny Asset Management L.P. |
$25916719 |
1812358 |
1.76% |
股份
|
| Parkman Healthcare Partners LLC |
$18420731 |
1288163 |
1.25% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$17811837 |
1245583 |
1.21% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$16890345 |
1181143 |
1.15% |
股份
|
| Essex Woodlands Management, Inc. |
$15513455 |
1084857 |
1.05% |
股份
|
| ORBIMED ADVISORS LLC |
$15288802 |
1069147 |
1.04% |
股份
|
| 5AM Venture Management, LLC |
$15015000 |
1050000 |
1.02% |
股份
|
| Rosalind Advisors, Inc. |
$14131689 |
988230 |
0.96% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$13885500 |
971014 |
0.94% |
股份
|
| AMERIPRISE FINANCIAL INC |
$12132298 |
848410 |
0.82% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12035896 |
841746 |
0.82% |
股份
|
| HSBC HOLDINGS PLC |
$11918407 |
833455 |
0.81% |
股份
|
| Candriam S.C.A. |
$11254258 |
787769 |
0.76% |
股份
|
| Artia Global Partners LP |
$10969501 |
767098 |
0.75% |
股份
|
| Blue Owl Capital Holdings LP |
$10905094 |
762594 |
0.74% |
股份
|
| NORTHERN TRUST CORP |
$10309113 |
720917 |
0.70% |
股份
|
| Patient Square Capital LP |
$10296000 |
720000 |
0.70% |
股份
|
| Principia Wealth Advisory, LLC |
$9293530 |
649944 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$9260866 |
647613 |
0.63% |
股份
|
| Sio Capital Management, LLC |
$8910759 |
623130 |
0.61% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$7996789 |
559216 |
0.54% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$7899320 |
552400 |
0.54% |
买入期权
|
| Alyeska Investment Group, L.P. |
$7284463 |
509403 |
0.50% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7151330 |
500093 |
0.49% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6650744 |
465087 |
0.45% |
股份
|
| Simplify Asset Management Inc. |
$5720629 |
400044 |
0.39% |
股份
|
| Ikarian Capital, LLC |
$5296720 |
370400 |
0.36% |
买入期权
|
| Ikarian Capital, LLC |
$5296720 |
370400 |
0.36% |
卖出期权
|
| Ghisallo Capital Management LLC |
$5005000 |
350000 |
0.34% |
股份
|
| STEMPOINT CAPITAL LP |
$4840135 |
338471 |
0.33% |
股份
|
| MORGAN STANLEY |
$4815240 |
336730 |
0.33% |
股份
|
| E Fund Management Co., Ltd. |
$4730068 |
330774 |
0.32% |
股份
|
| Jump Financial, LLC |
$4586825 |
320757 |
0.31% |
股份
|
| Bleichroeder LP |
$4526165 |
316515 |
0.31% |
股份
|
| Woodline Partners LP |
$4296621 |
300463 |
0.29% |
股份
|
| Eversept Partners, LP |
$4257610 |
297735 |
0.29% |
股份
|
| Rock Springs Capital Management LP |
$3839822 |
268519 |
0.26% |
股份
|
| CITIGROUP INC |
$3816813 |
266910 |
0.26% |
股份
|
| Bank of New York Mellon Corp |
$3586192 |
250783 |
0.24% |
股份
|
| MYDA Advisors LLC |
$3575000 |
250000 |
0.24% |
股份
|
| AXA Investment Managers S.A. |
$3480640 |
244427 |
0.24% |
股份
|
| UBS Group AG |
$3451491 |
241363 |
0.23% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$3357768 |
234809 |
0.23% |
股份
|
| Schonfeld Strategic Advisors LLC |
$3285853 |
229780 |
0.22% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$3268393 |
228559 |
0.22% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3038750 |
212500 |
0.21% |
卖出期权
|
| Nuveen, LLC |
$2766764 |
193480 |
0.19% |
股份
|
| Propel Bio Management, LLC |
$2741954 |
191745 |
0.19% |
股份
|
| Qube Research & Technologies Ltd |
$2704159 |
189102 |
0.18% |
股份
|
| Walleye Capital LLC |
$2691560 |
188221 |
0.18% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$2685554 |
187801 |
0.18% |
股份
|
| CITADEL ADVISORS LLC |
$2559700 |
179000 |
0.17% |
卖出期权
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$2389303 |
169334 |
0.16% |
股份
|
| HighVista Strategies LLC |
$2226567 |
155704 |
0.15% |
股份
|
| DEUTSCHE BANK AG\ |
$2185025 |
152799 |
0.15% |
股份
|
| Granahan Investment Management, LLC |
$2136234 |
149387 |
0.15% |
股份
|
| Swiss National Bank |
$2034890 |
142300 |
0.14% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1998711 |
139770 |
0.14% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1931709 |
149861 |
0.13% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$1890660 |
132214 |
0.13% |
股份
|
| Corient Private Wealth LP |
$1818946 |
127199 |
0.12% |
股份
|
| ESSEX INVESTMENT MANAGEMENT CO LLC |
$1740081 |
121684 |
0.12% |
股份
|
| Invesco Ltd. |
$1661719 |
116204 |
0.11% |
股份
|
| Russell Investments Group, Ltd. |
$1573991 |
110069 |
0.11% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1548690 |
108300 |
0.11% |
买入期权
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1548690 |
108300 |
0.11% |
卖出期权
|
| DIADEMA PARTNERS LP |
$1520090 |
106300 |
0.10% |
买入期权
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1467752 |
102640 |
0.10% |
股份
|
| SILVERBACK ASSET MANAGEMENT LLC |
$1430000 |
100000 |
0.10% |
买入期权
|
| Squarepoint Ops LLC |
$1401429 |
98002 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$1393341 |
97437 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$1357070 |
94900 |
0.09% |
买入期权
|
| ALGERT GLOBAL LLC |
$1129557 |
78990 |
0.08% |
股份
|
| Waverly Advisors, LLC |
$1114170 |
77914 |
0.08% |
股份
|
| Cinctive Capital Management LP |
$1037923 |
72582 |
0.07% |
股份
|
| Caption Management, LLC |
$1036750 |
72500 |
0.07% |
买入期权
|
| WELLS FARGO & COMPANY/MN |
$1011568 |
70739 |
0.07% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1002430 |
70100 |
0.07% |
买入期权
|
| WOODSTOCK CORP |
$979049 |
68465 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$971081 |
75336 |
0.07% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$930186 |
65048 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$900027 |
62939 |
0.06% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$865708 |
60539 |
0.06% |
股份
|
| Legal & General Group Plc |
$846848 |
59220 |
0.06% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$836950 |
58528 |
0.06% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$732017 |
51190 |
0.05% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$716273 |
50089 |
0.05% |
股份
|
| SILVERBACK ASSET MANAGEMENT LLC |
$715000 |
50000 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$715000 |
50000 |
0.05% |
买入期权
|
| JPMORGAN CHASE & CO |
$706247 |
50053 |
0.05% |
股份
|
| Erste Asset Management GmbH |
$705500 |
50000 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$702545 |
49129 |
0.05% |
股份
|
| Point72 Asset Management, L.P. |
$694608 |
48574 |
0.05% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$644827 |
45700 |
0.04% |
股份
|
| BARCLAYS PLC |
$628457 |
43948 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$621607 |
43469 |
0.04% |
股份
|
| SCOTIA CAPITAL INC. |
$597039 |
41751 |
0.04% |
股份
|
| Marex Group Ltd |
$590590 |
41300 |
0.04% |
股份
|
| Magnetar Financial LLC |
$568239 |
39737 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$556098 |
38888 |
0.04% |
股份
|
| China Universal Asset Management Co., Ltd. |
$548305 |
38343 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$509581 |
35635 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$502416 |
35134 |
0.03% |
股份
|
| HighTower Advisors, LLC |
$479593 |
33538 |
0.03% |
股份
|
| Baird Financial Group, Inc. |
$468068 |
32732 |
0.03% |
股份
|
| WOLVERINE TRADING, LLC |
$448195 |
31900 |
0.03% |
买入期权
|
| NISA INVESTMENT ADVISORS, LLC |
$418690 |
29279 |
0.03% |
股份
|
| Creative Planning |
$396725 |
27743 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$396267 |
27711 |
0.03% |
股份
|
| Jain Global LLC |
$395538 |
27660 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$387730 |
27114 |
0.03% |
股份
|
| AlphaQuest LLC |
$377787 |
20678 |
0.03% |
股份
|
| FMR LLC |
$374022 |
26155 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$363520 |
25421 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$359087 |
25111 |
0.02% |
股份
|
| Cyndeo Wealth Partners, LLC |
$345917 |
24190 |
0.02% |
股份
|
| MARSHALL WACE, LLP |
$342256 |
23934 |
0.02% |
股份
|
| WOLVERINE TRADING, LLC |
$332985 |
23700 |
0.02% |
卖出期权
|
| Police & Firemen's Retirement System of New Jersey |
$331531 |
23184 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$327899 |
22930 |
0.02% |
股份
|
| Caption Management, LLC |
$326040 |
22800 |
0.02% |
卖出期权
|
| PROFUND ADVISORS LLC |
$316545 |
22136 |
0.02% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$298870 |
20900 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$292163 |
20431 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$282468 |
19753 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$279822 |
19568 |
0.02% |
股份
|
| LEVIN CAPITAL STRATEGIES, L.P. |
$271700 |
19000 |
0.02% |
股份
|
| Grant/GrossMendelsohn, LLC |
$248284 |
36620 |
0.02% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$245460 |
17165 |
0.02% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$239511 |
16749 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$234520 |
16400 |
0.02% |
股份
|
| Rafferty Asset Management, LLC |
$230387 |
16111 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$228000 |
15879 |
0.02% |
股份
|
| Point72 Asset Management, L.P. |
$214500 |
15000 |
0.01% |
买入期权
|
| Point72 Asset Management, L.P. |
$214500 |
15000 |
0.01% |
卖出期权
|
| OXFORD ASSET MANAGEMENT LLP |
$205648 |
14381 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$201458 |
14088 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$193422 |
13526 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$193050 |
13500 |
0.01% |
卖出期权
|
| Persistent Asset Partners Ltd |
$186441 |
269 |
0.01% |
买入期权
|
| BNP PARIBAS FINANCIAL MARKETS |
$184570 |
12907 |
0.01% |
股份
|
| ProShare Advisors LLC |
$184213 |
12882 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$181181 |
12670 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$165108 |
11546 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$163735 |
11450 |
0.01% |
股份
|
| Engineers Gate Manager LP |
$160832 |
11247 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$156757 |
10962 |
0.01% |
股份
|
| GREAT VALLEY ADVISOR GROUP, INC. |
$154000 |
10750 |
0.01% |
股份
|
| Corton Capital Inc. |
$152738 |
10726 |
0.01% |
股份
|
| PSP Research LLC |
$143000 |
10000 |
0.01% |
股份
|
| NATIXIS |
$120163 |
8403 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$100429 |
7023 |
0.01% |
股份
|
| MCF Advisors LLC |
$91806 |
6420 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$75787 |
5300 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$53625 |
3750 |
0.00% |
股份
|
| US BANCORP \DE\ |
$51766 |
3620 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$38316 |
2805 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$25082 |
1754 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$22165 |
1550 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$21593 |
1510 |
0.00% |
股份
|
| GAMMA Investing LLC |
$16860 |
1179 |
0.00% |
股份
|
| Cedar Mountain Advisors, LLC |
$14300 |
1000 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$12384 |
866 |
0.00% |
股份
|
| TOTH FINANCIAL ADVISORY CORP |
$11440 |
800 |
0.00% |
股份
|
| Allworth Financial LP |
$8709 |
609 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$8480 |
593 |
0.00% |
股份
|
| COMERICA BANK |
$8386 |
459 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$8137 |
569 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$7578 |
533 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$7121 |
498 |
0.00% |
股份
|
| Larson Financial Group LLC |
$6993 |
489 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6921 |
484 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$6364 |
445 |
0.00% |
股份
|
| CWM, LLC |
$4821 |
374 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$4564 |
346 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$3927 |
1201 |
0.00% |
股份
|
| Truvestments Capital LLC |
$3689 |
258 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$2116 |
148 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1873 |
131 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1788 |
124989 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1716 |
120 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$1573 |
110 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1270 |
88802 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$1258 |
88 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1115 |
78 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$818 |
57212 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$815 |
57 |
0.00% |
股份
|
| Arax Advisory Partners |
$744 |
52 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$701 |
49 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$406 |
28385 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$386 |
27 |
0.00% |
股份
|
| Virtu Financial LLC |
$377 |
26380 |
0.00% |
股份
|
| Essential Partners LLC |
$157 |
11 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$143 |
10 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$51 |
3579 |
0.00% |
股份
|
| KBC Group NV |
$32 |
2266 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$14 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
34 |
0.00% |
股份
|