| FMR LLC |
$359966248 |
16987553 |
16.40% |
股份
|
| BlackRock, Inc. |
$186588376 |
8805492 |
8.50% |
股份
|
| VANGUARD GROUP INC |
$129705133 |
6038414 |
5.91% |
股份
|
| STATE STREET CORP |
$116431104 |
5494625 |
5.30% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$110404477 |
5210216 |
5.03% |
股份
|
| Redmile Group, LLC |
$104076592 |
4911590 |
4.74% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$97080523 |
4581431 |
4.42% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$96441814 |
4551289 |
4.39% |
股份
|
| Driehaus Capital Management LLC |
$92094685 |
4346139 |
4.20% |
股份
|
| ENAVATE SCIENCES GP, LLC |
$76576401 |
3613799 |
3.49% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$58387674 |
2754889 |
2.66% |
股份
|
| MORGAN STANLEY |
$51024322 |
2407942 |
2.32% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$42740421 |
2017009 |
1.95% |
股份
|
| JPMORGAN CHASE & CO |
$38989792 |
1848548 |
1.78% |
股份
|
| Sofinnova Investments, Inc. |
$36453496 |
1720316 |
1.66% |
股份
|
| READYSTATE ASSET MANAGEMENT LP |
$34027326 |
1605820 |
1.55% |
股份
|
| GOLDMAN SACHS GROUP INC |
$32049642 |
1512489 |
1.46% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$28584865 |
1348979 |
1.30% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$28550515 |
1347358 |
1.30% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$26493328 |
1250275 |
1.21% |
股份
|
| Woodline Partners LP |
$21198434 |
1000398 |
0.97% |
股份
|
| NORTHERN TRUST CORP |
$20519253 |
968346 |
0.93% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$18778430 |
886193 |
0.86% |
股份
|
| MetLife Investment Management, LLC |
$18203820 |
859076 |
0.83% |
股份
|
| JANUS HENDERSON GROUP PLC |
$17672168 |
808019 |
0.81% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$16025933 |
756297 |
0.73% |
股份
|
| Pivotal bioVenture Partners Investment Advisor LLC |
$15521929 |
732512 |
0.71% |
股份
|
| TD Asset Management Inc |
$15241374 |
719272 |
0.69% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$15141378 |
714553 |
0.69% |
股份
|
| Candriam S.C.A. |
$14398131 |
680132 |
0.66% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$13728746 |
647888 |
0.63% |
股份
|
| Parkman Healthcare Partners LLC |
$12591140 |
594202 |
0.57% |
股份
|
| MARSHALL WACE, LLP |
$10606379 |
500537 |
0.48% |
股份
|
| Qube Research & Technologies Ltd |
$9306351 |
439186 |
0.42% |
股份
|
| ALERUS FINANCIAL NA |
$8124691 |
383421 |
0.37% |
股份
|
| Granahan Investment Management, LLC |
$8021305 |
378542 |
0.37% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$7796866 |
367967 |
0.36% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$7623738 |
359780 |
0.35% |
股份
|
| Rock Springs Capital Management LP |
$7367043 |
347666 |
0.34% |
股份
|
| UBS Group AG |
$6960767 |
328493 |
0.32% |
股份
|
| Bank of New York Mellon Corp |
$6332970 |
298866 |
0.29% |
股份
|
| Atom Investors LP |
$6303792 |
297489 |
0.29% |
股份
|
| Nuveen, LLC |
$6122258 |
288922 |
0.28% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$5870986 |
277064 |
0.27% |
股份
|
| Atika Capital Management LLC |
$5570851 |
262900 |
0.25% |
股份
|
| FIRST TRUST ADVISORS LP |
$5569219 |
262823 |
0.25% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$5320851 |
251102 |
0.24% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$4913134 |
231861 |
0.22% |
股份
|
| CITADEL ADVISORS LLC |
$4748234 |
224079 |
0.22% |
股份
|
| Burkehill Global Management, LP |
$4238000 |
200000 |
0.19% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$4089929 |
187011 |
0.19% |
股份
|
| Swiss National Bank |
$3848104 |
181600 |
0.18% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3663603 |
172893 |
0.17% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3388281 |
159900 |
0.15% |
买入期权
|
| GILDER GAGNON HOWE & CO LLC |
$3226495 |
152265 |
0.15% |
股份
|
| CITIGROUP INC |
$3013239 |
142201 |
0.14% |
股份
|
| FEDERATED HERMES, INC. |
$3011035 |
142097 |
0.14% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$2919645 |
133500 |
0.13% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$2870000 |
135451 |
0.13% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2816279 |
132906 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$2807216 |
132479 |
0.13% |
股份
|
| Schonfeld Strategic Advisors LLC |
$2799007 |
132091 |
0.13% |
股份
|
| XTX Topco Ltd |
$2683671 |
126648 |
0.12% |
股份
|
| Sio Capital Management, LLC |
$2631120 |
124168 |
0.12% |
股份
|
| Aristotle Atlantic Partners, LLC |
$2599483 |
122675 |
0.12% |
股份
|
| ALPS ADVISORS INC |
$2424984 |
114440 |
0.11% |
股份
|
| DEUTSCHE BANK AG\ |
$2364656 |
111593 |
0.11% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2293478 |
108234 |
0.10% |
股份
|
| TEMA ETFS LLC |
$2192141 |
102055 |
0.10% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2148539 |
101394 |
0.10% |
股份
|
| AXA Investment Managers S.A. |
$2108456 |
180056 |
0.10% |
股份
|
| JANE STREET GROUP, LLC |
$1981265 |
93500 |
0.09% |
买入期权
|
| Legal & General Group Plc |
$1899111 |
89623 |
0.09% |
股份
|
| Trexquant Investment LP |
$1873005 |
88391 |
0.09% |
股份
|
| BIT Capital GmbH |
$1767246 |
83400 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$1762372 |
83170 |
0.08% |
股份
|
| Neo Ivy Capital Management |
$1713762 |
80876 |
0.08% |
股份
|
| Cerity Partners LLC |
$1643518 |
77561 |
0.07% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1574926 |
74324 |
0.07% |
股份
|
| Edgestream Partners, L.P. |
$1523243 |
71885 |
0.07% |
股份
|
| Invesco Ltd. |
$1460795 |
68938 |
0.07% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1414009 |
66730 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$1324018 |
62483 |
0.06% |
股份
|
| Freestone Capital Holdings, LLC |
$1283881 |
60589 |
0.06% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$1272375 |
60046 |
0.06% |
股份
|
| Ikarian Capital, LLC |
$1271401 |
60000 |
0.06% |
股份
|
| SummitTX Capital, L.P. |
$1260296 |
59476 |
0.06% |
股份
|
| FRANKLIN RESOURCES INC |
$1250168 |
58998 |
0.06% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1231808 |
58200 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$1229020 |
58000 |
0.06% |
买入期权
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$1222091 |
57673 |
0.06% |
股份
|
| BAKER BROS. ADVISORS LP |
$1171934 |
55306 |
0.05% |
股份
|
| Erste Asset Management GmbH |
$1094080 |
52000 |
0.05% |
股份
|
| Birchview Capital, LP |
$1059500 |
50000 |
0.05% |
股份
|
| AlphaQuest LLC |
$1051833 |
48968 |
0.05% |
股份
|
| Lido Advisors, LLC |
$1045536 |
49341 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$1040090 |
49084 |
0.05% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1007034 |
47524 |
0.05% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$1000740 |
47227 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$983216 |
46400 |
0.04% |
卖出期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$962937 |
45443 |
0.04% |
股份
|
| Scharf Investments, LLC |
$940603 |
44389 |
0.04% |
股份
|
| Corient Private Wealth LP |
$915981 |
43227 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$903436 |
42635 |
0.04% |
股份
|
| Magnus Financial Group LLC |
$884873 |
41759 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$784030 |
37000 |
0.04% |
股份
|
| Palumbo Wealth Management LLC |
$692045 |
32659 |
0.03% |
股份
|
| Magnetar Financial LLC |
$690561 |
32589 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$678228 |
32007 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$658797 |
31090 |
0.03% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$645447 |
30460 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$634872 |
29961 |
0.03% |
股份
|
| State of New Jersey Common Pension Fund D |
$620125 |
29265 |
0.03% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$576368 |
27200 |
0.03% |
股份
|
| Campbell & CO Investment Adviser LLC |
$563760 |
26605 |
0.03% |
股份
|
| BARCLAYS PLC |
$558378 |
26351 |
0.03% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$551682 |
26035 |
0.03% |
股份
|
| Baldwin Investment Management, LLC |
$538099 |
25394 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$535408 |
25267 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$529178 |
24973 |
0.02% |
股份
|
| Creative Planning |
$508730 |
24008 |
0.02% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$507310 |
23941 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$495994 |
23407 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$491608 |
23200 |
0.02% |
卖出期权
|
| CITADEL ADVISORS LLC |
$449228 |
21200 |
0.02% |
卖出期权
|
| KLP KAPITALFORVALTNING AS |
$432276 |
20400 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$429839 |
20285 |
0.02% |
股份
|
| CITIZENS FINANCIAL GROUP INC/RI |
$423800 |
20000 |
0.02% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$416954 |
19676883 |
0.02% |
股份
|
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. |
$412718 |
19477 |
0.02% |
股份
|
| Sequoia Financial Advisors, LLC |
$405302 |
19127 |
0.02% |
股份
|
| Northeast Financial Consultants Inc |
$399463 |
42953 |
0.02% |
股份
|
| D.A. DAVIDSON & CO. |
$394134 |
18600 |
0.02% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$390193 |
18414 |
0.02% |
股份
|
| PSP Research LLC |
$381420 |
18000 |
0.02% |
股份
|
| Jain Global LLC |
$377860 |
17832 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$377224 |
17802 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$365528 |
17250 |
0.02% |
股份
|
| US BANCORP \DE\ |
$362964 |
17129 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$333531 |
15740 |
0.02% |
股份
|
| Maltin Wealth Management, Inc. |
$317850 |
15000 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$309777 |
14619 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$298885 |
14105 |
0.01% |
股份
|
| Anfield Capital Management, LLC |
$298460 |
13647 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$296554 |
13995 |
0.01% |
股份
|
| ProShare Advisors LLC |
$292506 |
13804 |
0.01% |
股份
|
| Cetera Investment Advisers |
$254683 |
12019 |
0.01% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$254089 |
11991 |
0.01% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$249618 |
11780 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$248495 |
11727 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$224508 |
10595 |
0.01% |
股份
|
| Blackstone Inc. |
$223978 |
10570 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$223449 |
10545 |
0.01% |
股份
|
| Blueshift Asset Management, LLC |
$223215 |
10534 |
0.01% |
股份
|
| Sandia Investment Management LP |
$214800 |
10000 |
0.01% |
股份
|
| XPONANCE LLC |
$214083 |
10103 |
0.01% |
股份
|
| Gotham Asset Management, LLC |
$214019 |
10100 |
0.01% |
股份
|
| Velan Capital Investment Management LP |
$211900 |
10000 |
0.01% |
股份
|
| Sterling Investment Advisors, Ltd. |
$210162 |
9918 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$202704 |
9566 |
0.01% |
股份
|
| Jump Financial, LLC |
$201305 |
9500 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$174203 |
8221 |
0.01% |
股份
|
| ANTIPODES PARTNERS Ltd |
$168905 |
7971 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$156806 |
7400 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$145088 |
6847 |
0.01% |
股份
|
| State of Wyoming |
$108917 |
5140 |
0.00% |
股份
|
| ASSETMARK, INC |
$107454 |
5071 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$101000 |
4775 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$99678 |
4704 |
0.00% |
股份
|
| Aquatic Capital Management LLC |
$86031 |
4060 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$62064 |
2929 |
0.00% |
股份
|
| TOKIO MARINE ASSET MANAGEMENT CO LTD |
$51810 |
2445 |
0.00% |
股份
|
| MB, LEVIS & ASSOCIATES, LLC |
$50284 |
2373 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$37576 |
1773229 |
0.00% |
股份
|
| GAMMA Investing LLC |
$35599 |
1680 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$26347 |
1320 |
0.00% |
股份
|
| Allworth Financial LP |
$24644 |
1163 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$20427 |
964 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$19410 |
916 |
0.00% |
股份
|
| ORG Partners LLC |
$18900 |
880 |
0.00% |
股份
|
| Optiver Holding B.V. |
$12799 |
604 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7840 |
370 |
0.00% |
股份
|
| CWM, LLC |
$7808 |
357 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$4323 |
204 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4238 |
200 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$3829 |
182 |
0.00% |
股份
|
| Financial Network Wealth Advisors LLC |
$3793 |
179 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$2924 |
138 |
0.00% |
股份
|
| Arax Advisory Partners |
$2416 |
114 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$2140 |
101 |
0.00% |
股份
|
| Basepoint Wealth LLC |
$1928 |
91 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1590 |
75 |
0.00% |
股份
|
| Larson Financial Group LLC |
$1483 |
70 |
0.00% |
股份
|
| Vanguard National Trust Co |
$1335 |
63 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1271 |
60 |
0.00% |
股份
|
| Mitsubishi UFJ Asset Management (UK) Ltd. |
$954 |
45000 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$686 |
102 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$551 |
26 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$505 |
23833 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$495 |
23 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$487 |
23 |
0.00% |
股份
|
| Bear Mountain Capital, Inc. |
$452 |
20 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$375 |
32 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$316 |
15 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$272 |
12817 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$233 |
11 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$212 |
10 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$212 |
10 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$148 |
7 |
0.00% |
股份
|
| IFP Advisors, Inc |
$127 |
6 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$106 |
5 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$85 |
4 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$85 |
4 |
0.00% |
股份
|
| KBC Group NV |
$58 |
2739 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$29 |
1389 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
26 |
0.00% |
股份
|