| FMR LLC |
$840231809 |
29093899 |
28.04% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$235014985 |
8137638 |
7.84% |
股份
|
| MONTANOVA CAPITAL, LLC |
$204181600 |
7070000 |
6.81% |
股份
|
| HHLR ADVISORS, LTD. |
$172833804 |
5984550 |
5.77% |
股份
|
| BlackRock, Inc. |
$136502311 |
4726534 |
4.56% |
股份
|
| WESTFIELD CAPITAL MANAGEMENT CO LP |
$127940224 |
4430063 |
4.27% |
股份
|
| GOLDMAN SACHS GROUP INC |
$105767658 |
3662315 |
3.53% |
股份
|
| Point72 Asset Management, L.P. |
$88838461 |
3076124 |
2.96% |
股份
|
| Kynam Capital Management, LP |
$86674800 |
3001205 |
2.89% |
股份
|
| Assenagon Asset Management S.A. |
$55306817 |
1915056 |
1.85% |
股份
|
| Artisan Partners Limited Partnership |
$45036656 |
1559441 |
1.50% |
股份
|
| STATE STREET CORP |
$43291671 |
1498704 |
1.44% |
股份
|
| Capital International Investors |
$41028488 |
1420654 |
1.37% |
股份
|
| MORGAN STANLEY |
$40274080 |
1394531 |
1.34% |
股份
|
| Soleus Capital Management, L.P. |
$34800400 |
1205000 |
1.16% |
股份
|
| Davern Capital Partners, LP |
$34411155 |
1191522 |
1.15% |
股份
|
| Driehaus Capital Management LLC |
$33466375 |
1158808 |
1.12% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$28885776 |
1000200 |
0.96% |
股份
|
| Ghisallo Capital Management LLC |
$28880000 |
1000000 |
0.96% |
股份
|
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC |
$26490642 |
917266 |
0.88% |
股份
|
| JOHNSON & JOHNSON |
$23525244 |
814586 |
0.79% |
股份
|
| IvyRock Asset Management (HK) Ltd |
$23132880 |
801000 |
0.77% |
股份
|
| EcoR1 Capital, LLC |
$23104000 |
800000 |
0.77% |
股份
|
| JPMORGAN CHASE & CO |
$22523437 |
766364 |
0.75% |
股份
|
| Squarepoint Ops LLC |
$22215998 |
769252 |
0.74% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$21948627 |
759994 |
0.73% |
股份
|
| Woodline Partners LP |
$19149924 |
663086 |
0.64% |
股份
|
| Triata Capital Ltd |
$18191916 |
629914 |
0.61% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$17328000 |
600000 |
0.58% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$16596903 |
574685 |
0.55% |
股份
|
| Elmind Capital, LP |
$16478033 |
570569 |
0.55% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16157962 |
563489 |
0.54% |
股份
|
| TWO SIGMA ADVISERS, LP |
$14991904 |
689600 |
0.50% |
股份
|
| Candriam S.C.A. |
$14568175 |
504924 |
0.49% |
股份
|
| UBS Group AG |
$14511218 |
502466 |
0.48% |
股份
|
| CenterBook Partners LP |
$13079954 |
452907 |
0.44% |
股份
|
| ArrowMark Colorado Holdings LLC |
$10477115 |
362781 |
0.35% |
股份
|
| Hudson Bay Capital Management LP |
$9819200 |
340000 |
0.33% |
股份
|
| Alyeska Investment Group, L.P. |
$8879849 |
307474 |
0.30% |
股份
|
| Empire Life Investments Inc. |
$8565404 |
296586 |
0.29% |
股份
|
| NORTHERN TRUST CORP |
$7937842 |
274856 |
0.26% |
股份
|
| Resolute Capital Asset Partners LLC |
$7533954 |
260871 |
0.25% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$7261847 |
251449 |
0.24% |
股份
|
| Burkehill Global Management, LP |
$7220000 |
250000 |
0.24% |
股份
|
| AMERIPRISE FINANCIAL INC |
$7213272 |
249767 |
0.24% |
股份
|
| Invesco Ltd. |
$7159409 |
247902 |
0.24% |
股份
|
| HSBC HOLDINGS PLC |
$6820611 |
236204 |
0.23% |
股份
|
| Legal & General Group Plc |
$6580800 |
227867 |
0.22% |
股份
|
| Longaeva Partners L.P. |
$6190572 |
214355 |
0.21% |
股份
|
| Balyasny Asset Management L.P. |
$6093564 |
210996 |
0.20% |
股份
|
| MARSHALL WACE, LLP |
$5840316 |
202227 |
0.19% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5649967 |
195636 |
0.19% |
股份
|
| JANE STREET GROUP, LLC |
$5227280 |
181000 |
0.17% |
买入期权
|
| BARCLAYS PLC |
$5063299 |
175322 |
0.17% |
股份
|
| DEUTSCHE BANK AG\ |
$5024918 |
173993 |
0.17% |
股份
|
| Sumitomo Mitsui Trust Group, Inc. |
$5012442 |
173561 |
0.17% |
股份
|
| Polymer Capital Management (HK) LTD |
$4771236 |
165209 |
0.16% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4733519 |
163903 |
0.16% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$4604021 |
159419 |
0.15% |
股份
|
| CITADEL ADVISORS LLC |
$4011432 |
138900 |
0.13% |
卖出期权
|
| Swiss National Bank |
$3993931 |
138294 |
0.13% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$3941802 |
136489 |
0.13% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$3910468 |
135404 |
0.13% |
股份
|
| Rockefeller Capital Management L.P. |
$3894873 |
134864 |
0.13% |
股份
|
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
$3774732 |
130704 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3638880 |
126000 |
0.12% |
买入期权
|
| CITADEL ADVISORS LLC |
$3347192 |
115900 |
0.11% |
买入期权
|
| Nuveen, LLC |
$3324435 |
115112 |
0.11% |
股份
|
| VANGUARD GROUP INC |
$3252717 |
149619 |
0.11% |
股份
|
| E Fund Management Co., Ltd. |
$3157364 |
109327 |
0.11% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$3032227 |
104994 |
0.10% |
股份
|
| Bank of New York Mellon Corp |
$3025600 |
104765 |
0.10% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$2804623 |
97113 |
0.09% |
股份
|
| Pictet Asset Management Holding SA |
$2726185 |
94397 |
0.09% |
股份
|
| XTX Topco Ltd |
$2544501 |
88106 |
0.08% |
股份
|
| Monashee Investment Management LLC |
$2465919 |
85385 |
0.08% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$2402000 |
83166 |
0.08% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2368593 |
82015 |
0.08% |
股份
|
| Quantinno Capital Management LP |
$2356493 |
81596 |
0.08% |
股份
|
| Raiffeisen Bank International AG |
$2351200 |
80000 |
0.08% |
股份
|
| Creative Planning |
$2308847 |
79946 |
0.08% |
股份
|
| ROYAL LONDON ASSET MANAGEMENT LTD |
$2166000 |
75000 |
0.07% |
股份
|
| CITIGROUP INC |
$2079360 |
72000 |
0.07% |
买入期权
|
| CITIGROUP INC |
$2079360 |
72000 |
0.07% |
卖出期权
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2022091 |
70017 |
0.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1845432 |
63900 |
0.06% |
卖出期权
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$1812104 |
62746 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$1753016 |
60700 |
0.06% |
卖出期权
|
| CITIGROUP INC |
$1624414 |
56247 |
0.05% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1603793 |
55533 |
0.05% |
股份
|
| AVIVA PLC |
$1544676 |
53486 |
0.05% |
股份
|
| NLB Skladi, upravljanje premozenja, d.o.o. |
$1444000 |
50000 |
0.05% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$1353201 |
46856 |
0.05% |
股份
|
| KLP KAPITALFORVALTNING AS |
$1311152 |
45400 |
0.04% |
股份
|
| Caption Management, LLC |
$1299600 |
45000 |
0.04% |
买入期权
|
| Caption Management, LLC |
$1299600 |
45000 |
0.04% |
卖出期权
|
| Connor, Clark & Lunn Investment Management Ltd. |
$1195170 |
41384 |
0.04% |
股份
|
| Privium Fund Management B.V. |
$1022352 |
35400 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1020850 |
35348 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$985992 |
34141 |
0.03% |
股份
|
| STOREBRAND ASSET MANAGEMENT AS |
$972101 |
33660 |
0.03% |
股份
|
| Rock Springs Capital Management LP |
$967480 |
33500 |
0.03% |
股份
|
| Bellevue Group AG |
$954600 |
33054 |
0.03% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$937647 |
32467 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$936261 |
32419 |
0.03% |
股份
|
| ROYAL BANK OF CANADA |
$929000 |
32184 |
0.03% |
股份
|
| Krane Funds Advisors LLC |
$909373 |
31488 |
0.03% |
股份
|
| Aberdeen Group plc |
$883959 |
30608 |
0.03% |
股份
|
| COOKSON PEIRCE & CO INC |
$866400 |
30000 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$839426 |
29066 |
0.03% |
股份
|
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp |
$825968 |
28600 |
0.03% |
股份
|
| E Fund Management (Hong Kong) Co., Ltd. |
$814676 |
28209 |
0.03% |
股份
|
| GROUP ONE TRADING LLC |
$771587 |
26717 |
0.03% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$756338 |
26189 |
0.03% |
股份
|
| Public Sector Pension Investment Board |
$744786 |
25789 |
0.02% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$724830 |
25098 |
0.02% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$720094 |
24934 |
0.02% |
股份
|
| Headlands Technologies LLC |
$692976 |
23995 |
0.02% |
股份
|
| PNC Financial Services Group, Inc. |
$673944 |
23336 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$673424 |
23318 |
0.02% |
股份
|
| TEXAS PERMANENT SCHOOL FUND CORP |
$670854 |
23229 |
0.02% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$625801 |
21669 |
0.02% |
股份
|
| OPPENHEIMER & CO INC |
$620516 |
21486 |
0.02% |
股份
|
| Resona Asset Management Co.,Ltd. |
$581031 |
20068 |
0.02% |
股份
|
| LMR Partners LLP |
$577600 |
20000 |
0.02% |
股份
|
| Allianz Asset Management GmbH |
$548720 |
19000 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$542655 |
18790 |
0.02% |
股份
|
| Cinctive Capital Management LP |
$522468 |
18091 |
0.02% |
股份
|
| Jain Global LLC |
$518454 |
17952 |
0.02% |
股份
|
| WELLS FARGO & COMPANY/MN |
$506728 |
17546 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$468838 |
16234 |
0.02% |
股份
|
| Advisors Asset Management, Inc. |
$454431 |
20903 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$443511 |
15357 |
0.01% |
股份
|
| Corient Private Wealth LP |
$436003 |
15097 |
0.01% |
股份
|
| RHUMBLINE ADVISERS |
$435130 |
15067 |
0.01% |
股份
|
| Avidity Partners Management LP |
$433200 |
15000 |
0.01% |
股份
|
| NOMURA HOLDINGS INC |
$433200 |
15000 |
0.01% |
股份
|
| Yorktown Management & Research Co Inc |
$411540 |
14250 |
0.01% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$405764 |
14050 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$387945 |
13433 |
0.01% |
股份
|
| Skopos Labs, Inc. |
$381609 |
21095 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$379194 |
13130 |
0.01% |
股份
|
| Vontobel Holding Ltd. |
$364206 |
12611 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$340443 |
11762 |
0.01% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$337434 |
11684 |
0.01% |
股份
|
| NOMURA ASSET MANAGEMENT CO LTD |
$320568 |
11100 |
0.01% |
股份
|
| Lansforsakringar Fondforvaltning AB (publ) |
$317680 |
11000 |
0.01% |
股份
|
| Sequoia Financial Advisors, LLC |
$316930 |
10974 |
0.01% |
股份
|
| Laird Norton Wetherby Trust Company, LLC |
$309478 |
10716 |
0.01% |
股份
|
| Forefront Analytics, LLC |
$305204 |
10568 |
0.01% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$299226 |
10361 |
0.01% |
股份
|
| Diametric Capital, LP |
$288800 |
10000 |
0.01% |
股份
|
| Eurizon Capital SGR S.p.A. |
$279356 |
9673 |
0.01% |
股份
|
| DNB Asset Management AS |
$276873 |
9587 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$276642 |
9579 |
0.01% |
股份
|
| Swiss Life Asset Management Ltd |
$273869 |
9483 |
0.01% |
股份
|
| NJ State Employees Deferred Compensation Plan |
$270663 |
8300 |
0.01% |
股份
|
| Caprock Group, LLC |
$268006 |
9280 |
0.01% |
股份
|
| OMERS ADMINISTRATION Corp |
$265696 |
9200 |
0.01% |
股份
|
| US BANCORP \DE\ |
$253509 |
8778 |
0.01% |
股份
|
| Granite Investment Partners, LLC |
$249408 |
8636 |
0.01% |
股份
|
| Caisse de depot et placement du Quebec |
$240166 |
8316 |
0.01% |
股份
|
| FIL Ltd |
$239906 |
8307 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$235978 |
8171 |
0.01% |
股份
|
| Avior Wealth Management, LLC |
$234881 |
8133 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$233553 |
8087 |
0.01% |
股份
|
| Rakuten Securities, Inc. |
$231184 |
8005 |
0.01% |
股份
|
| DANSKE BANK A/S |
$231040 |
8000 |
0.01% |
股份
|
| Mariner, LLC |
$226995 |
7860 |
0.01% |
股份
|
| FEDERATED HERMES, INC. |
$216600 |
7500 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$216167 |
7485 |
0.01% |
股份
|
| FIFTH THIRD BANCORP |
$211864 |
7336 |
0.01% |
股份
|
| Ballentine Partners, LLC |
$208947 |
7235 |
0.01% |
股份
|
| Asset Management One Co., Ltd. |
$191302 |
10575 |
0.01% |
股份
|
| Freestone Grove Partners LP |
$158638 |
5493 |
0.01% |
股份
|
| Allostery Investments LP |
$141960 |
4000 |
0.00% |
股份
|
| Fideuram Asset Management (Ireland) dac |
$126282 |
4626 |
0.00% |
股份
|
| MACQUARIE GROUP LTD |
$119996 |
4155 |
0.00% |
股份
|
| Korea Investment CORP |
$103968 |
3600 |
0.00% |
股份
|
| Ensign Peak Advisors, Inc |
$95304 |
3300 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$92416 |
3200 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$83954 |
2907 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$77334 |
2678 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$51637 |
1788 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$46352 |
1605 |
0.00% |
股份
|
| Arax Advisory Partners |
$45833 |
1587 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$39881 |
1381 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$34569 |
1197 |
0.00% |
股份
|
| NATIXIS |
$33414 |
1157 |
0.00% |
股份
|
| CWM, LLC |
$32870 |
1817 |
0.00% |
股份
|
| OFI INVEST ASSET MANAGEMENT |
$31020 |
1228 |
0.00% |
股份
|
| Intesa Sanpaolo Wealth Management |
$23537 |
815 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$23178 |
798 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$22556 |
781 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$18079 |
626 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$17819 |
617 |
0.00% |
股份
|
| GAMMA Investing LLC |
$17790 |
616 |
0.00% |
股份
|
| IAG Wealth Partners, LLC |
$14440 |
500 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$13603 |
471 |
0.00% |
股份
|
| FTB Advisors, Inc. |
$12492 |
352 |
0.00% |
股份
|
| Allworth Financial LP |
$11040 |
382 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$9386 |
325 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$7192 |
249 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$6106 |
307 |
0.00% |
股份
|
| iA Global Asset Management Inc. |
$6098 |
211135 |
0.00% |
股份
|
| FIRST HORIZON CORP |
$5834 |
202 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$5463 |
161 |
0.00% |
股份
|
| FINANCIAL CONSULATE, INC |
$4939 |
171 |
0.00% |
股份
|
| Aspect Partners, LLC |
$4621 |
160 |
0.00% |
股份
|
| True Wealth Design, LLC |
$3148 |
109 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$2791 |
96640 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$2744 |
95 |
0.00% |
股份
|
| Blue Trust, Inc. |
$2397 |
83 |
0.00% |
股份
|
| Larson Financial Group LLC |
$1848 |
64 |
0.00% |
股份
|
| ELEVATION WEALTH PARTNERS, LLC |
$1387 |
48 |
0.00% |
股份
|
| SHP Wealth Management |
$1386 |
48 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1126 |
39 |
0.00% |
股份
|
| FIDUCIARY FINANCIAL ADVISORS |
$982 |
36 |
0.00% |
股份
|
| GPS Wealth Strategies Group, LLC |
$978 |
45 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$824 |
28596 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$760 |
42000 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$491 |
17 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$405 |
14 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$375 |
13 |
0.00% |
股份
|
| HANTZ FINANCIAL SERVICES, INC. |
$318 |
11009 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$289 |
10 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$279 |
9656 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$258 |
9 |
0.00% |
股份
|
| Virtu Financial LLC |
$255 |
8831 |
0.00% |
股份
|
| KBC Group NV |
$242 |
8390 |
0.00% |
股份
|
| Trust Co |
$199 |
11 |
0.00% |
股份
|
| DekaBank Deutsche Girozentrale |
$178 |
9862 |
0.00% |
股份
|
| SHELL ASSET MANAGEMENT CO |
$169 |
5171 |
0.00% |
股份
|
| Transamerica Financial Advisors, LLC |
$28 |
1 |
0.00% |
股份
|
| Harvest Fund Management Co., Ltd |
$6 |
200 |
0.00% |
股份
|