| BAKER BROS. ADVISORS LP |
$122271870 |
11045336 |
10.47% |
股份
|
| BlackRock, Inc. |
$99170982 |
8958535 |
8.49% |
股份
|
| RTW INVESTMENTS, LP |
$82046202 |
7411581 |
7.02% |
股份
|
| Ridgeback Capital Investments L.P. |
$80928962 |
7310656 |
6.93% |
股份
|
| GOLDMAN SACHS GROUP INC |
$50269070 |
4541018 |
4.30% |
股份
|
| STATE STREET CORP |
$49152394 |
4440144 |
4.21% |
股份
|
| MONTANOVA CAPITAL, LLC |
$48595485 |
4389836 |
4.16% |
股份
|
| Boxer Capital Management, LLC |
$44091810 |
3983000 |
3.77% |
股份
|
| VANGUARD GROUP INC |
$36704645 |
3776198 |
3.14% |
股份
|
| Caption Management, LLC |
$32687496 |
2952800 |
2.80% |
买入期权
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$32058764 |
2896004 |
2.74% |
股份
|
| FCPM III SERVICES B.V. |
$31088634 |
2808368 |
2.66% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$28408287 |
2566241 |
2.43% |
股份
|
| Logos Global Management LP |
$27675000 |
2500000 |
2.37% |
股份
|
| JANE STREET GROUP, LLC |
$25710573 |
2322545 |
2.20% |
股份
|
| Erste Asset Management GmbH |
$23744000 |
2120000 |
2.03% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22534696 |
2035187 |
1.93% |
股份
|
| D. E. Shaw & Co., Inc. |
$19814901 |
1789964 |
1.70% |
股份
|
| Opaleye Management Inc. |
$15331873 |
1384993 |
1.31% |
股份
|
| TORONTO DOMINION BANK |
$14114250 |
1275000 |
1.21% |
股份
|
| UBS Group AG |
$12490015 |
1128276 |
1.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$12216852 |
1103600 |
1.05% |
买入期权
|
| Artisan Partners Limited Partnership |
$10776601 |
973496 |
0.92% |
股份
|
| FMR LLC |
$10288181 |
929375 |
0.88% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$9099075 |
821958 |
0.78% |
股份
|
| CITADEL ADVISORS LLC |
$8681459 |
784233 |
0.74% |
股份
|
| Caption Management, LLC |
$8677474 |
783873 |
0.74% |
股份
|
| Invesco Ltd. |
$8017381 |
724244 |
0.69% |
股份
|
| Point72 Asset Management, L.P. |
$8006510 |
723262 |
0.69% |
股份
|
| DIADEMA PARTNERS LP |
$7708041 |
696300 |
0.66% |
买入期权
|
| MORGAN STANLEY |
$7671553 |
693003 |
0.66% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7547039 |
681756 |
0.65% |
股份
|
| CITADEL ADVISORS LLC |
$7501032 |
677600 |
0.64% |
买入期权
|
| Nuveen, LLC |
$7500191 |
677524 |
0.64% |
股份
|
| NORTHERN TRUST CORP |
$7368391 |
665618 |
0.63% |
股份
|
| ADAR1 Capital Management, LLC |
$7259529 |
655784 |
0.62% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7084645 |
639986 |
0.61% |
股份
|
| Eversept Partners, LP |
$6534090 |
590252 |
0.56% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$6034357 |
545109 |
0.52% |
股份
|
| DIADEMA PARTNERS LP |
$5562675 |
502500 |
0.48% |
卖出期权
|
| DIMENSIONAL FUND ADVISORS LP |
$5559490 |
502130 |
0.48% |
股份
|
| Jefferies Financial Group Inc. |
$5484798 |
495465 |
0.47% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5415333 |
489190 |
0.46% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5331312 |
481600 |
0.46% |
卖出期权
|
| CITADEL ADVISORS LLC |
$5163048 |
466400 |
0.44% |
卖出期权
|
| BANK OF AMERICA CORP /DE/ |
$3646292 |
329385 |
0.31% |
股份
|
| BARCLAYS PLC |
$3497013 |
315900 |
0.30% |
买入期权
|
| CITIGROUP INC |
$3321000 |
300000 |
0.28% |
卖出期权
|
| READYSTATE ASSET MANAGEMENT LP |
$3320535 |
299958 |
0.28% |
股份
|
| ARMISTICE CAPITAL, LLC |
$2922480 |
264000 |
0.25% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2805692 |
253450 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$2605936 |
235405 |
0.22% |
股份
|
| BARCLAYS PLC |
$2513588 |
227063 |
0.22% |
股份
|
| Caption Management, LLC |
$2447577 |
221100 |
0.21% |
卖出期权
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2383393 |
215302 |
0.20% |
股份
|
| D. E. Shaw & Co., Inc. |
$2214000 |
200000 |
0.19% |
卖出期权
|
| Woodline Partners LP |
$2119064 |
191424 |
0.18% |
股份
|
| Creative Planning |
$1927996 |
174164 |
0.17% |
股份
|
| Engineers Gate Manager LP |
$1915088 |
172998 |
0.16% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1865295 |
168500 |
0.16% |
卖出期权
|
| Cerity Partners LLC |
$1854271 |
167504 |
0.16% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1844173 |
166592 |
0.16% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1770923 |
159975 |
0.15% |
股份
|
| JANE STREET GROUP, LLC |
$1503306 |
135800 |
0.13% |
买入期权
|
| Squarepoint Ops LLC |
$1454089 |
131354 |
0.12% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$1441259 |
130195 |
0.12% |
股份
|
| Trexquant Investment LP |
$1422528 |
128503 |
0.12% |
股份
|
| Resolute Capital Asset Partners LLC |
$1383750 |
125000 |
0.12% |
股份
|
| JANE STREET GROUP, LLC |
$1366038 |
123400 |
0.12% |
卖出期权
|
| Mariner, LLC |
$1220930 |
110276 |
0.10% |
股份
|
| CITIGROUP INC |
$1205268 |
108877 |
0.10% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1197597 |
108184 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$1150640 |
103943 |
0.10% |
股份
|
| HSBC HOLDINGS PLC |
$1034889 |
92154 |
0.09% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$986293 |
89096 |
0.08% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$907740 |
82000 |
0.08% |
股份
|
| IEQ CAPITAL, LLC |
$907541 |
81982 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$891301 |
80515 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$857426 |
77455 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$845183 |
76349 |
0.07% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$730188 |
65961 |
0.06% |
股份
|
| LPL Financial LLC |
$724089 |
65410 |
0.06% |
股份
|
| JPMORGAN CHASE & CO |
$683457 |
61023 |
0.06% |
股份
|
| Russell Investments Group, Ltd. |
$660203 |
59639 |
0.06% |
股份
|
| LMR Partners LLP |
$561238 |
50699 |
0.05% |
股份
|
| Diametric Capital, LP |
$555559 |
50186 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$553095 |
72300 |
0.05% |
股份
|
| DLD Asset Management, LP |
$553000 |
50000 |
0.05% |
卖出期权
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$521080 |
47414 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$513360 |
46374 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$502899 |
45325 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$502600 |
45403 |
0.04% |
股份
|
| TEMA ETFS LLC |
$498461 |
51282 |
0.04% |
股份
|
| Quantinno Capital Management LP |
$481003 |
43451 |
0.04% |
股份
|
| Balyasny Asset Management L.P. |
$452243 |
40853 |
0.04% |
股份
|
| Exome Asset Management LLC |
$446796 |
40361 |
0.04% |
股份
|
| Verition Fund Management LLC |
$442800 |
40000 |
0.04% |
卖出期权
|
| KLCM Advisors, Inc. |
$442800 |
40000 |
0.04% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$440586 |
39800 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$429250 |
38776 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$407885 |
36846 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$396972 |
1774 |
0.03% |
买入期权
|
| Simplicity Wealth,LLC |
$344288 |
31101 |
0.03% |
股份
|
| Bleakley Financial Group, LLC |
$333550 |
30131 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$324340 |
29299 |
0.03% |
股份
|
| VERUS CAPITAL PARTNERS, LLC |
$304979 |
27550 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$300229 |
27121 |
0.03% |
股份
|
| Private Capital Advisors, Inc. |
$299621 |
27066 |
0.03% |
股份
|
| TWO SIGMA ADVISERS, LP |
$298404 |
30700 |
0.03% |
股份
|
| Manchester Capital Management LLC |
$284223 |
25675 |
0.02% |
股份
|
| Focus Partners Wealth |
$279053 |
25208 |
0.02% |
股份
|
| Blueshift Asset Management, LLC |
$278698 |
25176 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$277425 |
25061 |
0.02% |
股份
|
| AlphaQuest LLC |
$272938 |
28080 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$258606 |
23361 |
0.02% |
股份
|
| Focus Partners Advisor Solutions, LLC |
$256470 |
23168 |
0.02% |
股份
|
| SYON CAPITAL LLC |
$247326 |
22342 |
0.02% |
股份
|
| Ballentine Partners, LLC |
$244049 |
22046 |
0.02% |
股份
|
| IRONWOOD INVESTMENT MANAGEMENT LLC |
$238282 |
21525 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$230821 |
20851 |
0.02% |
股份
|
| Walleye Capital LLC |
$228042 |
20600 |
0.02% |
买入期权
|
| Merit Financial Group, LLC |
$222109 |
20064 |
0.02% |
股份
|
| PEAK6 LLC |
$221400 |
20000 |
0.02% |
买入期权
|
| Velan Capital Investment Management LP |
$221400 |
20000 |
0.02% |
股份
|
| Breakwater Capital Group |
$220293 |
19900 |
0.02% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$219186 |
19800 |
0.02% |
卖出期权
|
| Walleye Trading LLC |
$212544 |
19200 |
0.02% |
卖出期权
|
| STRS OHIO |
$207009 |
18700 |
0.02% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$198370 |
17920 |
0.02% |
股份
|
| OSAIC HOLDINGS, INC. |
$194863 |
17603 |
0.02% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$187991 |
16982 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$181581 |
16403 |
0.02% |
股份
|
| Arax Advisory Partners |
$178072 |
16086 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$170157 |
15371 |
0.01% |
股份
|
| Schonfeld Strategic Advisors LLC |
$169292 |
15293 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$154294 |
13938 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$150663 |
13610 |
0.01% |
股份
|
| Integrated Wealth Concepts LLC |
$150607 |
13605 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$145471 |
13141 |
0.01% |
股份
|
| ProShare Advisors LLC |
$144797 |
13080 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$142183 |
12844 |
0.01% |
股份
|
| HORIZON KINETICS ASSET MANAGEMENT LLC |
$139305 |
12584 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$138785 |
12537 |
0.01% |
股份
|
| Sterling Investment Advisors, Ltd. |
$136161 |
12300 |
0.01% |
股份
|
| Summit Financial, LLC |
$123718 |
11176 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$123597 |
11165 |
0.01% |
股份
|
| Headlands Technologies LLC |
$121217 |
10950 |
0.01% |
股份
|
| State of Wyoming |
$120862 |
10918 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$119169 |
10765 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$115200 |
1280 |
0.01% |
卖出期权
|
| WINTON GROUP Ltd |
$115128 |
10400 |
0.01% |
股份
|
| IFG Advisors, LLC |
$110700 |
10000 |
0.01% |
股份
|
| GOLDMAN SACHS GROUP INC |
$110700 |
10000 |
0.01% |
买入期权
|
| EagleClaw Capital Managment, LLC |
$110700 |
10000 |
0.01% |
股份
|
| Walleye Trading LLC |
$109593 |
9900 |
0.01% |
买入期权
|
| Larson Financial Group LLC |
$107634 |
9723 |
0.01% |
股份
|
| CWM, LLC |
$94929 |
12409 |
0.01% |
股份
|
| Legal & General Group Plc |
$85117 |
7689 |
0.01% |
股份
|
| SIGNATUREFD, LLC |
$84586 |
7641 |
0.01% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$81497 |
7362 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$80523 |
7274 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$79571 |
7188 |
0.01% |
股份
|
| WOLVERINE TRADING, LLC |
$75082 |
17300 |
0.01% |
买入期权
|
| WOLVERINE TRADING, LLC |
$66437 |
15308 |
0.01% |
股份
|
| StoneX Group Inc. |
$64613 |
10770 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$63041 |
5694 |
0.01% |
股份
|
| Allworth Financial LP |
$62147 |
5614 |
0.01% |
股份
|
| HAP Trading, LLC |
$61598 |
102500 |
0.01% |
买入期权
|
| WOLVERINE TRADING, LLC |
$60760 |
14000 |
0.01% |
卖出期权
|
| US BANCORP \DE\ |
$57940 |
5234 |
0.00% |
股份
|
| PEAK6 LLC |
$46516 |
4202 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$43981 |
3973 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$40882 |
3693 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$36475 |
3295 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$34439 |
3111 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$33660 |
3000 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$33166 |
2996 |
0.00% |
股份
|
| Walleye Capital LLC |
$30210 |
2729 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$30000 |
2724 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$29790 |
2691 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$28029 |
2532 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$25328 |
2288 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$24863 |
2246 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$23380 |
2112 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$21708 |
1961 |
0.00% |
股份
|
| GAMMA Investing LLC |
$21122 |
1908 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$19373 |
1750 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$18941 |
1711 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$18885 |
1706 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$18691 |
1917 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$17946 |
1620963 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$15398 |
1391 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$12212 |
1050 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$11114 |
1004 |
0.00% |
股份
|
| Walleye Capital LLC |
$11070 |
1000 |
0.00% |
卖出期权
|
| HAP Trading, LLC |
$10000 |
100000 |
0.00% |
卖出期权
|
| Wealth Enhancement Trust Services, Inc. |
$9642 |
871 |
0.00% |
股份
|
| COMERICA BANK |
$7649 |
787 |
0.00% |
股份
|
| Beaird Harris Wealth Management, LLC |
$7528 |
680 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$7008 |
633 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$5978 |
540 |
0.00% |
股份
|
| Hurley Capital, LLC |
$5336 |
482 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$4218 |
381 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$3697 |
334 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2968 |
388 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$2635 |
238 |
0.00% |
股份
|
| Bogart Wealth, LLC |
$2435 |
220 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$2425 |
219 |
0.00% |
股份
|
| Quarry LP |
$2214 |
200 |
0.00% |
股份
|
| Aventura Private Wealth, LLC |
$2214 |
200 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1959 |
177 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1672 |
151 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1328 |
120 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$1184 |
107 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1063 |
96 |
0.00% |
股份
|
| North Star Investment Management Corp. |
$1041 |
94 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1024 |
92476 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$1018 |
92 |
0.00% |
股份
|
| Cornerstone Planning Group LLC |
$978 |
91 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$885 |
79 |
0.00% |
股份
|
| Pineridge Advisors LLC |
$629 |
150 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$620 |
56 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$454 |
41 |
0.00% |
股份
|
| Cullen/Frost Bankers, Inc. |
$255 |
23 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$155 |
14 |
0.00% |
股份
|
| SHP Wealth Management |
$155 |
14 |
0.00% |
股份
|
| INGALLS & SNYDER LLC |
$111 |
10000 |
0.00% |
买入期权
|
| VESTOR CAPITAL, LLC |
$103 |
557 |
0.00% |
股份
|
| INGALLS & SNYDER LLC |
$33 |
3000 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$22 |
2 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$14 |
1275 |
0.00% |
股份
|
| Essential Partners LLC |
$11 |
1 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$6 |
592 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
85 |
0.00% |
股份
|
| Avion Wealth |
$1 |
98 |
0.00% |
股份
|