| BlackRock, Inc. |
$35115146 |
9192447 |
8.84% |
股份
|
| VANGUARD GROUP INC |
$32058890 |
4152706 |
8.07% |
股份
|
| ARMISTICE CAPITAL, LLC |
$26831680 |
7024000 |
6.75% |
股份
|
| RTW INVESTMENTS, LP |
$25348729 |
6635793 |
6.38% |
股份
|
| Deep Track Capital, LP |
$21930047 |
5740850 |
5.52% |
股份
|
| STATE STREET CORP |
$19611341 |
5133859 |
4.93% |
股份
|
| Rosalind Advisors, Inc. |
$15228464 |
3986509 |
3.83% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$14712761 |
3851508 |
3.70% |
股份
|
| Nantahala Capital Management, LLC |
$13694012 |
3584820 |
3.45% |
股份
|
| Stonepine Capital Management, LLC |
$12795575 |
3349627 |
3.22% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12479443 |
3266870 |
3.14% |
股份
|
| Foresite Capital Management VI LLC |
$12020130 |
3146631 |
3.02% |
股份
|
| GOLDMAN SACHS GROUP INC |
$10394900 |
2721178 |
2.62% |
股份
|
| BAKER BROS. ADVISORS LP |
$9547471 |
2499338 |
2.40% |
股份
|
| Alyeska Investment Group, L.P. |
$8746368 |
2289625 |
2.20% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7937971 |
2078003 |
2.00% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7925110 |
2074145 |
1.99% |
股份
|
| AIGH Capital Management LLC |
$7361140 |
1927000 |
1.85% |
股份
|
| Opaleye Management Inc. |
$6876000 |
1800000 |
1.73% |
股份
|
| Balyasny Asset Management L.P. |
$6442717 |
1686575 |
1.62% |
股份
|
| Qube Research & Technologies Ltd |
$6220824 |
1628488 |
1.57% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$5612164 |
1469153 |
1.41% |
股份
|
| NEXTBio Capital Management LP |
$4991976 |
1306800 |
1.26% |
股份
|
| FRANKLIN RESOURCES INC |
$4221180 |
1105021 |
1.06% |
股份
|
| Pinnacle Financial Partners, Inc. |
$4150200 |
1086440 |
1.04% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3570038 |
934565 |
0.90% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3399704 |
889975 |
0.86% |
股份
|
| TWO SIGMA ADVISERS, LP |
$3080218 |
398992 |
0.78% |
股份
|
| MORGAN STANLEY |
$2734440 |
715822 |
0.69% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$2547459 |
666874 |
0.64% |
股份
|
| NORTHERN TRUST CORP |
$2488711 |
651495 |
0.63% |
股份
|
| J. Goldman & Co LP |
$2483283 |
650074 |
0.62% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$2416654 |
632632 |
0.61% |
股份
|
| FMR LLC |
$2392459 |
626298 |
0.60% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2356413 |
616862 |
0.59% |
股份
|
| UBS Group AG |
$2309114 |
604480 |
0.58% |
股份
|
| XTX Topco Ltd |
$2146042 |
561791 |
0.54% |
股份
|
| Jefferies Financial Group Inc. |
$1896741 |
496529 |
0.48% |
股份
|
| Torray Investment Partners LLC |
$1823878 |
477455 |
0.46% |
股份
|
| TORONTO DOMINION BANK |
$1758778 |
460413 |
0.44% |
股份
|
| Exome Asset Management LLC |
$1638937 |
429041 |
0.41% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1585300 |
415000 |
0.40% |
卖出期权
|
| CITADEL ADVISORS LLC |
$1212189 |
317327 |
0.31% |
股份
|
| Palo Alto Investors LP |
$1182997 |
309685 |
0.30% |
股份
|
| Jump Financial, LLC |
$1174650 |
307500 |
0.30% |
股份
|
| Virtus Investment Advisers, LLC |
$1083467 |
283630 |
0.27% |
股份
|
| Diametric Capital, LP |
$1014358 |
265539 |
0.26% |
股份
|
| Nuveen, LLC |
$989124 |
258933 |
0.25% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$931889 |
243950 |
0.23% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$910799 |
238429 |
0.23% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$898490 |
235207 |
0.23% |
股份
|
| Ikarian Capital, LLC |
$816965 |
213865 |
0.21% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$759558 |
198837 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$706485 |
184944 |
0.18% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$620577 |
117090 |
0.16% |
股份
|
| Knott David M Jr |
$592100 |
155000 |
0.15% |
股份
|
| CANTOR FITZGERALD, L. P. |
$534800 |
140000 |
0.13% |
股份
|
| Invesco Ltd. |
$477795 |
125077 |
0.12% |
股份
|
| CITIGROUP INC |
$459298 |
120235 |
0.12% |
股份
|
| ROYAL BANK OF CANADA |
$415000 |
108863 |
0.10% |
股份
|
| ExodusPoint Capital Management, LP |
$379082 |
99236 |
0.10% |
股份
|
| Rafferty Asset Management, LLC |
$359859 |
94204 |
0.09% |
股份
|
| BARCLAYS PLC |
$356819 |
93408 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$334892 |
87668 |
0.08% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$326228 |
85400 |
0.08% |
买入期权
|
| RHUMBLINE ADVISERS |
$319642 |
83678 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$308224 |
80687 |
0.08% |
股份
|
| ADAR1 Capital Management, LLC |
$289556 |
75800 |
0.07% |
股份
|
| Brevan Howard Capital Management LP |
$276141 |
72383 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$265872 |
69600 |
0.07% |
卖出期权
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$261827 |
68541 |
0.07% |
股份
|
| Man Group plc |
$258221 |
67597 |
0.06% |
股份
|
| HSBC HOLDINGS PLC |
$231620 |
59466 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$226331 |
59249 |
0.06% |
股份
|
| Jain Global LLC |
$211009 |
55238 |
0.05% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$197494 |
51700 |
0.05% |
股份
|
| ALGERT GLOBAL LLC |
$195966 |
51300 |
0.05% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$190824 |
49954 |
0.05% |
股份
|
| Creative Planning |
$181786 |
47588 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$181710 |
47568 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$181389 |
47484 |
0.05% |
股份
|
| Quadrature Capital Ltd |
$179471 |
46982 |
0.05% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$179059 |
46874 |
0.05% |
股份
|
| Quantinno Capital Management LP |
$177007 |
46337 |
0.04% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$170299 |
44581 |
0.04% |
股份
|
| Cetera Investment Advisers |
$165834 |
43412 |
0.04% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$163507 |
42803 |
0.04% |
股份
|
| Graham Capital Management, L.P. |
$153300 |
40131 |
0.04% |
股份
|
| STIFEL FINANCIAL CORP |
$146518 |
38353 |
0.04% |
股份
|
| Caption Management, LLC |
$146306 |
38300 |
0.04% |
买入期权
|
| Quantbot Technologies LP |
$139961 |
36639 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$135178 |
35387 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$123175 |
32245 |
0.03% |
股份
|
| Aries Wealth Management |
$117782 |
30833 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$116586 |
30520 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$112987 |
29578 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$108870 |
28500 |
0.03% |
买入期权
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$107828 |
19499 |
0.03% |
股份
|
| NewEdge Wealth, LLC |
$106295 |
27826 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$101696 |
26622 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$95500 |
25000 |
0.02% |
买入期权
|
| JANE STREET GROUP, LLC |
$95118 |
24900 |
0.02% |
卖出期权
|
| Verdad Advisers, LP |
$92585 |
24237 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$92444 |
24200 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$85010 |
22254 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$83822 |
21943 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$75151 |
19673 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$74051 |
19385 |
0.02% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$70540 |
18466 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$61437 |
16083 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$53862 |
14100 |
0.01% |
买入期权
|
| Regal Investment Advisors LLC |
$53751 |
14071 |
0.01% |
股份
|
| Nebula Research & Development LLC |
$52659 |
12689 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$50741 |
13283 |
0.01% |
股份
|
| Merit Financial Group, LLC |
$47300 |
12382 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$47085 |
12326 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$45664 |
11954 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$43674 |
11433 |
0.01% |
股份
|
| ProShare Advisors LLC |
$39946 |
10457 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$34586 |
9054 |
0.01% |
股份
|
| Legal & General Group Plc |
$29563 |
7739 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$28875 |
7559 |
0.01% |
股份
|
| Glass Jacobson Investment Advisors llc |
$26343 |
6896 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$20945 |
5483 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$20254 |
5200 |
0.01% |
股份
|
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA |
$17190 |
4500 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$15868 |
4154 |
0.00% |
股份
|
| AlphaQuest LLC |
$13610 |
1763 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$9816 |
1852 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$8966 |
2347 |
0.00% |
股份
|
| CWM, LLC |
$8454 |
1595 |
0.00% |
股份
|
| Arax Advisory Partners |
$7285 |
1907 |
0.00% |
股份
|
| Allworth Financial LP |
$5192 |
1359 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$4890 |
1280 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$3820 |
1000 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$3587 |
939 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2968 |
777 |
0.00% |
股份
|
| GAMMA Investing LLC |
$2808 |
735 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2709 |
709 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$2678 |
701 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2430 |
636 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$2278 |
596 |
0.00% |
股份
|
| State of Wyoming |
$2251 |
578 |
0.00% |
股份
|
| Essential Partners LLC |
$1883 |
493 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$1666 |
436 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1429 |
374 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1070 |
280 |
0.00% |
股份
|
| US BANCORP \DE\ |
$989 |
259 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$848 |
222 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$810 |
212 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$658 |
172266 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$633 |
105 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$582 |
152439 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$546 |
143 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$499 |
132 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$493 |
129 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$434 |
114 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$390 |
102 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$332 |
87 |
0.00% |
股份
|
| Virtu Financial LLC |
$314 |
82263 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$251 |
65565 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$249 |
47 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$230 |
60 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$157 |
41 |
0.00% |
股份
|
| IFP Advisors, Inc |
$157 |
41 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$141 |
37 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$31 |
8 |
0.00% |
股份
|
| Larson Financial Group LLC |
$31 |
8 |
0.00% |
股份
|
| Inspire Investing, LLC |
$20 |
4 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$6 |
1573 |
0.00% |
股份
|