ANTX AN2 Therapeutics, Inc. - Common Stock

NASDAQ · Pharmaceuticals · View on SEC EDGAR ↗
$5.71
Price · Aug 24, 2026
Fundamentals as of Aug 11, 2026

ANTX Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$5.71
Market Cap
$157M
P/E (TTM)
-4.9
EPS (TTM)
$-1.16
Revenue (TTM)
Div Yield
ROE
-57.7%
Debt/Equity
52W Range
$1 – $7

ANTX Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income
EPS $-1.16
5-point trend, +89.1%
2021-12-31 2025-12-31
Free Cash Flow
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ANTX
Peer Median
P/E (TTM)
4-point trend, +71.2%
-4.9
11.2
P/B
3-point trend, -69.6%
3.0
2.2

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ANTX
Peer Median
ROA
3-point trend, +6.4%
-45.7%
-16.0%
ROE
3-point trend, -41.6%
-57.7%
-29.0%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ANTX
Peer Median
Current Ratio
2-point trend, -49.9%
6.9
5.1
Quick Ratio
2-point trend, -39.6%
2.3

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ANTX
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ANTX
Peer Median
EPS (Diluted)
5-point trend, +89.1%
$-1.16

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ANTX
Peer Median

ANTX Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 8 analysts
  • Strong Buy 4 50.0%
  • Buy 3 37.5%
  • Hold 1 12.5%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

2 analysts · 2026-08-22
Median target $9.00 +57.6%
Mean target $9.00 +57.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.02%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.29 $-0.23 -0.06%
Dec. 31, 2025 $-0.29 $-0.24 -0.05%
Sept. 30, 2025 $-0.31 $-0.22 -0.09%
June 30, 2025 $-0.21 $-0.34 0.13%
March 31, 2025 $-0.35 $-0.26 -0.09%
Dec. 31, 2024 $-0.25 $-0.26 0.01%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ANTX $31M -1.0 -57.7%
TTRX $116M -32.8 -141.7%
DERM -16.4 10.2% -18.5% -44.7%
SIGA $438M 19.1 -31.8% 24.6% 11.4%
ORMP $112M 1.9 -50.4% 3202.5% 37.0% 0.65%
NRXP
AARD $286M -4.5 -47.3%
LLY 46.8 44.7% 31.7% 101.2%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 13
Annual Income Statement data for ANTX
Metric Trend 20252024202320222021
R&D Expense 5-point trend, +53.3% $25M $40M $55M $29M $16M
SG&A Expense 5-point trend, +185.8% $13M $14M $15M $13M $5M
Operating Expenses 5-point trend, +76.6% $38M $57M $70M $42M $22M
Operating Income 5-point trend, -76.6% $-38M $-57M $-70M $-42M $-22M
Interest Income 3-point trend, -39.6% $3M $5M $5M · ·
Other Non-op 5-point trend, +102.6% $1.0K $1.0K $43.0K $1M $-38.0K
Income Tax Flat — no change across 5 periods $0 $0 $0 $0 $0
Net Income 5-point trend, -63.3% $-35M $-51M $-65M $-41M $-22M
EPS (Basic) 5-point trend, +89.1% $-1.16 $-1.72 $-2.74 $-2.79 $-10.64
EPS (Diluted) 5-point trend, +89.1% $-1.16 $-1.72 $-2.74 $-2.79 $-10.64
Shares (Basic) 5-point trend, +1045.3% 30,215,747 29,828,227 23,600,107 15,340,134 2,638,197
Shares (Diluted) 5-point trend, +1045.3% 30,215,747 29,828,227 23,600,107 15,340,134 2,638,197
EBITDA 3-point trend, +9.8% $-38M $-57M · $-42M ·
Balance Sheet 16
Annual Balance Sheet data for ANTX
Metric Trend 20252024202320222021
Cash & Equivalents 5-point trend, +64.8% $20M $21M $16M $27M $12M
Prepaid Expense 5-point trend, +24.8% $2M $3M $3M $3M $2M
Current Assets 5-point trend, -0.3% $60M $86M $111M $99M $60M
Other Non-current Assets 4-point trend, -100.0% $0 $804.0K $1M $720.0K ·
Total Assets 5-point trend, -5.2% $62M $92M $139M $103M $65M
Accounts Payable 5-point trend, +184.2% $3M $3M $3M $2M $1M
Accrued Liabilities 5-point trend, +46.7% $2M $4M $7M $3M $1M
Current Liabilities 5-point trend, +156.8% $9M $10M $14M $7M $3M
Other Non-current Liabilities 2-point trend, +170000.00 $170.0K $0 · · ·
Total Liabilities 5-point trend, +160.9% $9M $10M $14M $7M $3M
Paid-in Capital 4-point trend, +58.5% $294M $288M $279M $185M ·
Retained Earnings 5-point trend, -408.5% $-241M $-206M $-154M $-90M $-47M
AOCI 5-point trend, +311.1% $57.0K $31.0K $275.0K $-374.0K $-27.0K
Stockholders' Equity 5-point trend, +211.9% $53M $82M $125M $95M $-47M
Liabilities + Equity 5-point trend, -5.2% $62M $92M $139M $103M $65M
Shares Outstanding 5-point trend, +904.0% 27,413,171 29,919,634 29,741,445 19,402,658 2,730,298
Cash Flow 9
Annual Cash Flow data for ANTX
Metric Trend 20252024202320222021
Stock-based Comp 5-point trend, +541.3% $6M $8M $8M $4M $974.0K
Restructuring · $2M · · ·
Operating Cash Flow 5-point trend, -45.6% $-30M $-49M $-53M $-33M $-20M
Investing Cash Flow 5-point trend, +156.6% $28M $55M $-43M $-22M $-50M
Stock Issued 3-point trend, -76.5% $86.0K $147.0K $366.0K · ·
Net Stock Activity 2-point trend, -41.5% $86.0K $147.0K · · ·
Financing Cash Flow 5-point trend, -99.9% $113.0K $372.0K $85M $70M $79M
Net Change in Cash 5-point trend, -117.6% $-1M $6M $-12M $15M $8M
Taxes Paid Flat — no change across 2 periods $0 $0 · · ·
Profitability 2
Annual Profitability data for ANTX
Metric Trend 20252024202320222021
ROA 3-point trend, +6.4% -45.7% -44.5% · -48.8% ·
ROE 3-point trend, -41.6% -57.7% -60.6% · -40.8% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for ANTX
Metric Trend 20252024202320222021
Current Ratio 2-point trend, -49.9% 6.9 · · 13.7 ·
Quick Ratio 2-point trend, -39.6% 2.3 · · 3.8 ·
Per Share 4
Annual Per Share data for ANTX
Metric Trend 20252024202320222021
Book Value / Share 3-point trend, -60.6% $1.94 $2.74 · $4.92 ·
Cash Flow / Share 3-point trend, +54.7% $-0.99 $-1.65 · $-2.18 ·
Cash / Share 3-point trend, -48.1% $0.73 $0.71 · $1.40 ·
EPS (TTM) 4-point trend, +58.4% $-1.16 $-1.72 $-2.74 $-2.79 ·
Valuation (TTM) 7
Annual Valuation (TTM) data for ANTX
Metric Trend 20252024202320222021
Net Income TTM 4-point trend, +14.1% $-35M $-51M $-65M $-41M ·
Market Cap 3-point trend, -83.1% $31M $41M · $185M ·
P/E 4-point trend, +71.2% -1.0 -0.8 -7.5 -3.4 ·
P/B 3-point trend, -69.6% 0.6 0.5 · 1.9 ·
P / Tangible Book 4-point trend, -69.6% 0.6 0.5 4.9 1.9 ·
P / Cash Flow 3-point trend, +81.0% -1.0 -0.8 · -5.5 ·
Earnings Yield 4-point trend, -247.5% -101.8% -124.6% -13.4% -29.3% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-35M$-51M$-65M$-41M$-22M
Diluted EPS $-1.16$-1.72$-2.74$-2.79$-10.64
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 6.913.7
Quick Ratio 2.33.8

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 69 filers · $108.2M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
29 (+5 vs prior Q) 14 (+6 vs prior Q) 15 (+3 vs prior Q) 13 (+5 vs prior Q) +1.8M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Vivo Capital, LLC $15,263,618 3,153,640 14.10% Shares
Commodore Capital LP $14,199,011 2,933,680 13.12% Shares
MILLENNIUM MANAGEMENT LLC $11,222,469 2,318,692 10.37% Shares
Spruce Street Capital LP $8,039,593 1,661,073 7.43% Shares
Almitas Capital LLC $7,110,584 1,469,129 6.57% Shares
VANGUARD CAPITAL MANAGEMENT LLC $5,995,332 1,238,705 5.54% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $4,840,000 1,000,000 4.47% Shares
CITADEL ADVISORS LLC $4,432,825 915,873 4.10% Shares
Boxer Capital Management, LLC $3,625,329 749,035 3.35% Shares
GEODE CAPITAL MANAGEMENT, LLC $2,901,077 599,131 2.68% Shares
SummitTX Capital, L.P. $2,891,673 597,453 2.67% Shares
Balyasny Asset Management L.P. $2,691,171 556,027 2.49% Shares
Stonepine Capital Management, LLC $2,670,190 551,692 2.47% Shares
AMERIPRISE FINANCIAL INC $2,599,390 537,064 2.40% Shares
Sio Capital Management, LLC $2,564,876 529,933 2.37% Shares
Ally Bridge Group (NY) LLC $2,547,365 526,315 2.35% Shares
Prosight Management, LP $2,297,248 474,638 2.12% Shares
Woodline Partners LP $2,225,456 459,805 2.06% Shares
STATE STREET CORP $1,508,154 311,602 1.39% Shares
Seven Fleet Capital Management LP $1,011,299 208,946 0.93% Shares
VANGUARD FIDUCIARY TRUST CO $953,093 196,920 0.88% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $869,235 179,594 0.80% Shares
RENAISSANCE TECHNOLOGIES LLC $627,748 129,700 0.58% Shares
BANK OF AMERICA CORP /DE/ $532,056 109,929 0.49% Shares
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. $420,877 86,958 0.39% Shares
UBS Group AG $358,576 74,086 0.33% Shares
Walleye Capital LLC $349,153 72,139 0.32% Shares
DIMENSIONAL FUND ADVISORS LP $339,792 70,205 0.31% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $310,825 64,220 0.29% Shares
TWO SIGMA ADVISERS, LP $301,986 264,900 0.28% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $289,916 59,900 0.27% Shares
ADAR1 Capital Management, LLC $284,631 58,808 0.26% Shares
GOLDMAN SACHS GROUP INC $240,335 49,656 0.22% Shares
CAPTRUST FINANCIAL ADVISORS $194,399 40,165 0.18% Shares
Velan Capital Investment Management LP $193,600 40,000 0.18% Shares
Nuveen, LLC $171,012 35,333 0.16% Shares
DEUTSCHE BANK AG\ $125,056 25,838 0.12% Shares
RHUMBLINE ADVISERS $117,810 24,342 0.11% Shares
Bank of New York Mellon Corp $111,833 23,106 0.10% Shares
WELLS FARGO & COMPANY/MN $108,363 22,389 0.10% Shares
TWO SIGMA INVESTMENTS, LP $77,019 15,913 0.07% Shares
LPL Financial LLC $59,774 12,350 0.06% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $58,980 12,186 0.05% Shares
JPMORGAN CHASE & CO $55,184 10,971 0.05% Shares
Bronte Capital Management Pty Ltd. $52,732 10,895 0.05% Shares
CITIGROUP INC $51,982 10,740 0.05% Shares
Invesco Ltd. $51,072 10,552 0.05% Shares
BNP PARIBAS FINANCIAL MARKETS $49,295 10,185 0.05% Shares
Police & Firemen's Retirement System of New Jersey $41,697 8,615 0.04% Shares
Vanguard Global Advisers, LLC $35,497 7,334 0.03% Shares
MORGAN STANLEY $35,177 7,268 0.03% Shares
NEW YORK STATE COMMON RETIREMENT FUND $24,200 5,000 0.02% Shares
NORTHERN TRUST CORP $20,071 4,147 0.02% Shares
BARCLAYS PLC $18,799 3,884 0.02% Shares
BlackRock, Inc. $12,579 2,599 0.01% Shares
Legal & General Group Plc $12,429 2,576 0.01% Shares
Ameritas Investment Partners, Inc. $11,626 2,402 0.01% Shares
Russell Investments Group, Ltd. $10,222 2,112 0.01% Shares
Tower Research Capital LLC (TRC) $8,746 1,807 0.01% Shares
VANGUARD GROUP INC $8,361 7,334 0.01% Shares
ROYAL BANK OF CANADA $5,000 938 0.00% Shares
Sterling Capital Management LLC $2,343 484 0.00% Shares
FEDERATED HERMES, INC. $2,173 449 0.00% Shares
OSAIC HOLDINGS, INC. $1,452 300 0.00% Shares
Caitong International Asset Management Co., Ltd $1,326 274 0.00% Shares
SBI Securities Co., Ltd. $973 201 0.00% Shares
FMR LLC $295 61 0.00% Shares
PRICE T ROWE ASSOCIATES INC /MD/ $107 22,022 0.00% Shares
HUNTINGTON NATIONAL BANK $57 1 0.00% Shares

Company insiders 18 insiders · 7 officers · 5 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Eric Easom Chief Executive Officer March 19, 2026 D 368,630 0 0 $0
Lucy Day Chief Financial Officer March 19, 2026 D 118,363 0 2 $-8,862
Sanjay Chanda Chief Development Officer March 19, 2026 D 118,823 0 2 $-9,311
Stephen David Prior Chief Strategy Officer Jan. 6, 2026 S 59,086 0 3 $-7,363
Kevin Michael Krause Chief Strategy Officer Feb. 15, 2023 A 0 0 $0
Paul Eckburg Chief Medical Officer Feb. 15, 2023 A 0 0 $0
Michael Adrian Nazak Chief Accounting Officer Feb. 15, 2023 A 0 0 $0
Robin Shane Readnour Director Aug. 17, 2026 S 633,867 0 2 $-212,766
Margaret M Fitzpatrick Director March 19, 2026 D 8,610 0 0 $0
Stephanie Wong Director March 19, 2026 D 0 0 $0
Melvin K Spigelman Director March 19, 2026 D 0 0 $0
Joseph S Zakrzewski Aug. 14, 2026 G 0 0 0 $0
Gilbert Lynn Marks July 10, 2026 A 81,873 0 0 $0
Patricia A. Martin July 10, 2026 A 18,863 0 0 $0
Kabeer Aziz July 10, 2026 A 59,106 0 0 $0
Joshua M Eizen July 8, 2026 S 206,554 0 4 $-52,928
Sarah Joanne Williams May 29, 2026 S 66,583 0 2 $-1,521
Leonard Braden Michael May 28, 2025 S 3,017,432 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
BML Investment Partners, L.P. ×3 filings June 18, 2025 1.40% Amendment Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 12 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.03% 90,020 SH Aug. 21, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.01% 20,384 SH Aug. 19, 2026 Daily
IWN · iShares Trust 0.01% 194,136 SH Aug. 21, 2026 Daily
IWM · iShares Trust 0.00% 593,821 SH Aug. 21, 2026 Daily
IWO · iShares Trust 0.00% 29,625 SH Aug. 21, 2026 Daily
DFAS · Dimensional ETF Trust 0.00% 26,415 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 360,114 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 853,017 SH Aug. 19, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.00% 153,011 SH Aug. 19, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.00% 3,321 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 2,878 SH Aug. 19, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 3,416 NS April 30, 2026 N-PORT