Sio Capital Management, LLC
CIK 1482416 · View on SEC EDGAR ↗
- Portfolio value
- $604.3M
- Positions
- 59
- As of
- June 30, 2026
#3,362 of 9,443 by 13F value · top 35.6%
Portfolio value QoQ: -13.3% 13F does not disclose cash
- Top 10 holdings weight
- 48.64%
- Top 25 holdings weight
- 80.77%
- Positions above 1%
- 32
- Effective number of positions
- 27.1
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 34.82% Est. buys $226,624,173 · sells $360,703,013
Median holding: 2.0 quarters Tracked Q4 2024–Q2 2026 · 42.1% still held
- New positions
- 17
- Increased
- 10
- Decreased
- 21
- Closed
- 34
Put-notional exposure: 3.0% puts 13F reports option positions at underlying notional value — may include hedges, not necessarily bearish bets
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- High-conviction bets The holdings this manager is most concentrated in.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Annualized: +34.8% · S&P 500: +18.0%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 99.1% · Options excluded: 2.0%
Sector breakdown
Healthcare
91.6%
Industrials
6.4%
Other/Unmapped
2.1%
Full portfolio 59 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| AVR Anteris Technologies Global Corp. - Common Stock | $54,627,942 | 9.04% | 5,545,984 | $24,752,486 | Up ×3 | ||
| COR Cencora, Inc. Common Stock | $49,121,932 | 8.13% | 173,588 | $17,427,091 | Up ×2 | ||
| MMS Maximus, Inc. Common Stock | $38,452,754 | 6.36% | 715,267 | $-10,828,929 | Down ×1 | ||
| ALLO Allogene Therapeutics, Inc. - Common Stock | $27,712,736 | 4.59% | 13,323,431 | Up ×1 | |||
| GMED Globus Medical, Inc. Class A Common Stock | $23,846,482 | 3.95% | 301,816 | ||||
| GSK GSK plc American Depositary Shares (Each representing two Ordinary Shares) | $22,891,814 | 3.79% | 436,700 | $1,595,152 | Up ×1 | ||
| TYRA Tyra Biosciences, Inc. - Common Stock | $22,208,361 | 3.68% | 695,315 | $-979,953 | Up ×3 | ||
| WAY Waystar Holding Corp. - Common Stock | $19,007,372 | 3.15% | 925,834 | $-20,586,938 | Down ×1 | ||
| SLS SELLAS Life Sciences Group, Inc. - Common Stock | $18,165,132 | 3.01% | 1,230,700 | Put option | Up ×1 | ||
| IDYA IDEAYA Biosciences, Inc. - Common Stock | $17,903,874 | 2.96% | 480,383 | ||||
| ORKA Oruka Therapeutics, Inc. - Common Stock | $16,856,320 | 2.79% | 177,118 | $10,357,391 | Up ×2 | ||
| CI The Cigna Group Common Stock | $15,920,520 | 2.63% | 57,750 | ||||
| SNY Sanofi - American Depositary Shares | $15,536,772 | 2.57% | 364,200 | $3,989,423 | Up ×1 | ||
| ICLR ICON plc - Ordinary Shares | $15,318,790 | 2.53% | 88,186 | $-18,582,786 | Down ×1 | ||
| VTRS Viatris Inc. - Common Stock | $15,154,268 | 2.51% | 954,299 | ||||
| CCRN Cross Country Healthcare, Inc. - Common Stock | $14,509,772 | 2.40% | 1,098,393 | $4,184,878 | |||
| RAPP Rapport Therapeutics, Inc. - Common Stock | $12,820,067 | 2.12% | 307,657 | $1,342,613 | Down ×1 | ||
| ABT Abbott Laboratories Common Stock | $11,674,245 | 1.93% | 128,656 | $-7,481,308 | Down ×1 | ||
| CELC Celcuity Inc. - Common Stock | $11,510,502 | 1.90% | 110,022 | $-10,614,738 | Down ×3 | ||
| ZBH Zimmer Biomet Holdings, Inc. Common Stock | $11,316,100 | 1.87% | 131,445 | $5,654,633 | Up ×1 | ||
| REGN Regeneron Pharmaceuticals, Inc. - Common Stock | $11,223,720 | 1.86% | 18,000 | Up ×1 | |||
| BMY Bristol-Myers Squibb Company Common Stock | $11,149,470 | 1.85% | 193,500 | Up ×1 | |||
| MDT Medtronic plc. Ordinary Shares | $11,147,775 | 1.84% | 142,500 | Up ×1 | |||
| VIR Vir Biotechnology, Inc. - Common Stock | $10,957,042 | 1.81% | 1,075,274 | $-2,470,593 | Down ×1 | ||
| SENS Senseonics Holdings, Inc. - Common Stock | $9,046,491 | 1.50% | 1,592,692 | $8,275,370 | Up ×1 | ||
| EYPT EyePoint, Inc. - Common Stock | $8,910,759 | 1.47% | 623,130 | $-393,050 | Down ×1 | ||
| HELP Cybin Inc. - Common Stock | $8,593,000 | 1.42% | 1,300,000 | Up ×1 | |||
| ANIP ANI Pharmaceuticals, Inc. - Common Stock | $8,054,908 | 1.33% | 97,305 | $-12,365,349 | Down ×1 | ||
| TARA Protara Therapeutics, Inc. - Common Stock | $7,341,551 | 1.21% | 1,921,872 | $-2,921,310 | Down ×1 | ||
| RLMD Relmada Therapeutics, Inc. - Common Stock | $6,944,649 | 1.15% | 1,003,562 | $228,249 | Up ×1 | ||
| TNGX Tango Therapeutics, Inc. - Common Stock | $6,517,710 | 1.08% | 208,500 | Up ×1 | |||
| AQST Aquestive Therapeutics, Inc. - Common Stock | $6,182,488 | 1.02% | 1,486,175 | $-1,797,493 | Down ×1 | ||
| DNTH Dianthus Therapeutics, Inc. - Common Stock | $5,776,080 | 0.96% | 59,254 | $-25,278,096 | Down ×3 | ||
| SION Sionna Therapeutics, Inc. - Common Stock | $5,622,274 | 0.93% | 127,808 | $-6,177,817 | Down ×1 | ||
| OCUL Ocular Therapeutix, Inc. - Common Stock | $5,297,821 | 0.88% | 539,493 | $-2,906,196 | Down ×1 | ||
| ZBIO Zenas BioPharma, Inc. - Common Stock | $5,293,177 | 0.88% | 208,557 | $-1,192,145 | Down ×1 | ||
| DRUG Bright Minds Biosciences Inc. - common stock | $5,191,430 | 0.86% | 73,952 | $-1,090,047 | Down ×1 | ||
| OKUR OnKure Therapeutics, Inc. - Class A Common Stock | $4,920,080 | 0.81% | 1,078,965 | $453,165 | |||
| SVRA Savara, Inc. - Common Stock | $3,804,878 | 0.63% | 617,675 | $453,050 | Up ×1 | ||
| PMVP PMV Pharmaceuticals, Inc. - Common Stock | $3,529,744 | 0.58% | 2,634,137 | $-285,215 | Down ×1 | ||
| AVAH Aveanna Healthcare Holdings Inc. - Common Stock | $3,162,639 | 0.52% | 369,036 | Up ×1 | |||
| OVID Ovid Therapeutics Inc. - Common Stock | $2,704,348 | 0.45% | 1,005,334 | $-75,938 | Down ×2 | ||
| IMNM Immunome, Inc. - Common Stock | $2,631,120 | 0.44% | 124,168 | $-979,836 | Down ×1 | ||
| HIMS Hims & Hers Health, Inc. Class A Common Stock | $2,600,250 | 0.43% | 75,000 | Call option | Up ×1 | ||
| ANTX AN2 Therapeutics, Inc. - Common Stock | $2,564,876 | 0.42% | 529,933 | $317,252 | Down ×1 | ||
| SER | $1,940,000 | 0.32% | 1,000,000 | $0 | |||
| ALGS Aligos Therapeutics, Inc. - Common stock | $1,888,157 | 0.31% | 327,237 | $-543,214 | |||
| IBIO iBio, Inc. - Common Stock | $1,582,469 | 0.26% | 904,268 | $-135,640 | |||
| Unknown issuer (CUSIP: 98422T209) | $1,460,605 | 0.24% | 152,464 | $178,383 | |||
| AORT Artivion, Inc. Common Stock | $1,089,368 | 0.18% | 48,481 | ||||
| BBOT BridgeBio Oncology Therapeutics, Inc. - Common Stock | $995,385 | 0.16% | 130,628 | $-173,736 | |||
| TELA TELA Bio, Inc. - Common stock | $477,225 | 0.08% | 636,300 | $82,719 | |||
| ADGM Adagio Medical Holdings, Inc - Common Stock | $455,461 | 0.08% | 698,989 | $-1,026,269 | Down ×1 | ||
| Unknown issuer (CUSIP: 64130M308) | $251,612 | 0.04% | 82,767 | Up ×1 | |||
| ENVB Enveric Biosciences, Inc. - Common Stock | $248,400 | 0.04% | 180,000 | Up ×1 | |||
| Unknown issuer (CUSIP: 60785L306) | $117,855 | 0.02% | 26,190 | $-20,428 | |||
| QTI QT Imaging Holdings, Inc. - Common Stock | $62,011 | 0.01% | 15,236 | Up ×1 | |||
| RCKTW Rocket Pharmaceuticals, Inc. - Warrant | $1,480 | 0.00% | 400,000 | $-5,540 | |||
| HUMAW Humacyte, Inc. - Warrant | $477 | 0.00% | 49,998 | $-4,095 | |||
| No matches | |||||||
Conviction holdings
Positions increased for 3+ consecutive quarters.
Share counts are as reported in 13F filings (not split-adjusted)
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| ALLO | $27,712,736 | 13,323,431 | 4.59% |
| GMED | $23,846,482 | 301,816 | 3.95% |
| SLS | $18,165,132 | 1,230,700 | 3.01% |
| IDYA | $17,903,874 | 480,383 | 2.96% |
| CI | $15,920,520 | 57,750 | 2.63% |
| VTRS | $15,154,268 | 954,299 | 2.51% |
| REGN | $11,223,720 | 18,000 | 1.86% |
| BMY | $11,149,470 | 193,500 | 1.85% |
| MDT | $11,147,775 | 142,500 | 1.84% |
| HELP | $8,593,000 | 1,300,000 | 1.42% |
| TNGX | $6,517,710 | 208,500 | 1.08% |
| AVAH | $3,162,639 | 369,036 | 0.52% |
| HIMS | $2,600,250 | 75,000 | 0.43% |
| AORT | $1,089,368 | 48,481 | 0.18% |
| Unknown issuer (CUSIP: 64130M308) | $251,612 | 82,767 | 0.04% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| AVR | Bought more | +163K | +$24.8M |
| WAY | Trimmed | -716K | -$20.6M |
| ICLR | Trimmed | -218K | -$18.6M |
| COR | Bought more | +73K | +$17.4M |
| ANIP | Trimmed | -168K | -$12.4M |
| MMS | Trimmed | -54K | -$10.8M |
| CELC | Trimmed | -84K | -$10.6M |
| ORKA | Bought more | +45K | +$10.4M |
| ABT | Trimmed | -58K | -$7.5M |
| SION | Trimmed | -167K | -$6.2M |
2 positions hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| CI | March 31, 2026 | 172,203 | $47,395,432 | 3.8% |
| ICLR | June 30, 2025 | 203,311 | $35,577,392 | 18.7% |
| RYTM | March 31, 2026 | 265,700 | $28,440,528 | 26.2% |
| CORT | June 30, 2026 | 674,759 | $27,199,535 | 41.0% |
| CI | March 31, 2025 | 98,003 | $27,062,548 | -15.9% |
| LIVN | June 30, 2026 | 421,615 | $26,797,849 | -4.8% |
| KVUE | March 31, 2026 | 1,465,442 | $25,278,875 | 9.9% |
| ZBH | June 30, 2025 | 187,685 | $21,242,188 | 8.9% |
| LH | June 30, 2025 | 83,873 | $19,520,602 | 26.6% |
| SNY | March 31, 2025 | 387,000 | $18,665,010 | -17.7% |
| EMBC | June 30, 2026 | 1,847,850 | $16,334,994 | 62.4% |
| ABVX | June 30, 2026 | 135,800 | $15,121,330 | -10.4% |
| TFX | June 30, 2025 | 107,780 | $14,894,118 | 14.0% |
| MRK | Dec. 31, 2025 | 177,300 | $14,880,789 | 44.1% |
| HSIC | Dec. 31, 2025 | 219,207 | $14,548,769 | 16.9% |
| GMED | Sept. 30, 2025 | 245,570 | $14,493,541 | 48.9% |
| NBIX | Sept. 30, 2025 | 100,725 | $12,660,125 | 9.7% |
| HAE | June 30, 2026 | 220,672 | $12,437,074 | 43.0% |
| GSK | Dec. 31, 2025 | 268,873 | $11,604,559 | 5.5% |
| BTSG | March 31, 2026 | 308,010 | $11,534,975 | 41.8% |
| TFX | June 30, 2026 | 94,800 | $11,339,028 | 6.5% |
| BMRN | June 30, 2026 | 194,226 | $10,971,827 | 18.2% |
| CRL | March 31, 2026 | 54,985 | $10,968,408 | 68.2% |
| GPCR | June 30, 2026 | 209,093 | $10,078,283 | -5.3% |
| BHVN | June 30, 2026 | 1,163,926 | $9,846,814 | -4.2% |
| ANNX | Sept. 30, 2025 | 4,095,764 | $9,829,834 | 70.5% |
| IDXX | Sept. 30, 2025 | 18,000 | $9,654,120 | -14.4% |
| MNPR | June 30, 2026 | 173,506 | $9,506,394 | 19.5% |
| VTRS | March 31, 2025 | 730,000 | $9,088,500 | 84.4% |
| CRNX | June 30, 2026 | 249,887 | $9,075,896 | 126.5% |
| OGN | March 31, 2025 | 606,410 | $9,047,637 | -7.8% |
| HAE | June 30, 2025 | 133,966 | $8,513,539 | 43.8% |
| EWTX | June 30, 2026 | 268,986 | $8,473,059 | 8.0% |
| CMPS | June 30, 2026 | 1,506,525 | $8,331,083 | -2.4% |
| KALV | Dec. 31, 2025 | 683,819 | $8,328,915 | No longer tracked |
| CRGX | March 31, 2025 | 473,292 | $6,824,871 | No longer tracked |
| NMRA | March 31, 2025 | 636,300 | $6,744,780 | 55.5% |
| TARA | June 30, 2025 | 1,514,300 | $6,450,918 | 29.4% |
| QDEL | June 30, 2026 | 359,011 | $5,898,551 | -17.8% |
| SLNO | June 30, 2025 | 78,300 | $5,594,535 | No longer tracked |
| REPL | June 30, 2026 | 720,036 | $5,508,275 | 32.1% |
| NVCR | Dec. 31, 2025 | 413,829 | $5,346,671 | 34.6% |
| MCK | March 31, 2026 | 6,400 | $5,249,856 | -1.0% |
| OGN | June 30, 2026 | 865,908 | $5,186,789 | 1.4% |
| AORT | Sept. 30, 2025 | 158,736 | $4,936,690 | -33.6% |
| SLP | Dec. 31, 2025 | 320,307 | $4,827,026 | 0.9% |
| FULC | March 31, 2026 | 382,000 | $4,320,420 | -49.4% |
| PRAX | June 30, 2025 | 112,500 | $4,260,375 | 778.7% |
| IRON | June 30, 2026 | 65,203 | $4,169,080 | 7.0% |
| ETNB | June 30, 2025 | 500,000 | $3,635,000 | No longer tracked |
| IART | June 30, 2026 | 383,140 | $3,609,179 | -8.1% |
| SEPN | Dec. 31, 2025 | 189,199 | $3,558,833 | 47.9% |
| AVNS | Sept. 30, 2025 | 288,849 | $3,535,512 | No longer tracked |
| VTYX | March 31, 2026 | 387,751 | $3,501,392 | No longer tracked |
| AKRO | June 30, 2025 | 85,000 | $3,440,800 | No longer tracked |
| MRUS | Sept. 30, 2025 | 62,719 | $3,299,019 | No longer tracked |
| CNC | June 30, 2026 | 100,000 | $3,274,000 | 0.0% |
| PRQR | June 30, 2026 | 1,954,715 | $3,166,638 | 25.0% |
| SI | June 30, 2026 | 210,641 | $3,060,614 | 8.9% |
| INMB | Sept. 30, 2025 | 1,299,300 | $3,001,383 | 7.7% |
| ERAS | Dec. 31, 2025 | 1,369,748 | $2,986,051 | 373.9% |
| MBX | Sept. 30, 2025 | 241,000 | $2,749,810 | 279.0% |
| KYMR | June 30, 2026 | 32,235 | $2,684,853 | 7.3% |
| ALKS | March 31, 2026 | 95,353 | $2,667,977 | 35.9% |
| IDYA | March 31, 2026 | 75,730 | $2,617,986 | 21.7% |
| ACOG | March 31, 2025 | 434,700 | $2,560,383 | 99.1% |
| CNTX | June 30, 2026 | 917,922 | $2,404,956 | -3.1% |
| QTTB | March 31, 2025 | 697,413 | $2,399,101 | 880.0% |
| VXRT | June 30, 2025 | 5,583,448 | $2,272,463 | No longer tracked |
| TVTX | Sept. 30, 2025 | 122,210 | $1,808,708 | 171.9% |
| OTLK | March 31, 2026 | 1,125,400 | $1,778,132 | 237.8% |
| NUVB | March 31, 2025 | 668,115 | $1,777,186 | 296.9% |
| ATXS | Sept. 30, 2025 | 318,256 | $1,705,852 | No longer tracked |
| IRWD | June 30, 2025 | 1,017,616 | $1,495,896 | 490.3% |
| XLO | March 31, 2026 | 2,134,537 | $1,366,531 | 8.5% |
| ENTA | Sept. 30, 2025 | 178,774 | $1,351,531 | 10.3% |
| AVTX | March 31, 2026 | 72,173 | $1,310,662 | 34.0% |
| ALEC | Sept. 30, 2025 | 845,531 | $1,183,743 | -23.1% |
| HYPR | June 30, 2026 | 1,000,000 | $1,080,000 | -33.8% |
| FHTX | June 30, 2026 | 122,889 | $587,409 | 47.4% |
| CCCC | March 31, 2025 | 155,000 | $558,000 | 151.3% |
| TERN | June 30, 2026 | 10,100 | $532,472 | No longer tracked |
| ENTA | June 30, 2026 | 40,000 | $505,200 | -9.5% |
| NMTC | June 30, 2026 | 496,614 | $385,621 | -31.3% |
| EMBC | Sept. 30, 2025 | 31,169 | $302,028 | -62.5% |
| MODD | March 31, 2026 | 785,824 | $286,119 | -35.2% |
| MESO | March 31, 2025 | 11,600 | $229,680 | 36.4% |
| BOLD | June 30, 2026 | 163,679 | $180,047 | 19.2% |
| APRE | Dec. 31, 2025 | 112,223 | $165,529 | -23.0% |
| NXTC | March 31, 2026 | 10,940 | $155,239 | -38.8% |
| NYXH | June 30, 2026 | 50,839 | $148,450 | -5.3% |
| ELTX | June 30, 2026 | 11,700 | $125,073 | -21.2% |
| ERAS | June 30, 2026 | 5,000 | $80,900 | -3.8% |
| OSCR | June 30, 2026 | 3,000 | $34,410 | 8.1% |
| ATYR | Sept. 30, 2025 | 1,100 | $5,577 | -27.9% |
| SLP | June 30, 2026 | 200 | $2,364 | 0.5% |