Ishara Investments LP
CIK 2111609 · View on SEC EDGAR ↗
- Portfolio value
- $136.1M
- Positions
- 41
- As of
- June 30, 2026
#7,688 of 9,443 by 13F value · top 81.4%
Portfolio value QoQ: +28.9% 13F does not disclose cash
- Top 10 holdings weight
- 50.98%
- Top 25 holdings weight
- 87.15%
- Positions above 1%
- 30
- Effective number of positions
- 26.0
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 41.5% Est. buys $67,332,881 · sells $50,153,102
- New positions
- 16
- Increased
- 13
- Decreased
- 8
- Closed
- 11
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- Biggest new bets Brand-new positions opened in the latest quarter.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 94.0% · Options excluded: 4.2%
Sector breakdown
Healthcare
100.0%
Full portfolio 41 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| ACAD ACADIA Pharmaceuticals Inc. - Common Stock | $10,373,000 | 7.62% | 410,000 | $7,635,020 | Up ×1 | ||
| XERS Xeris Biopharma Holdings, Inc. - Common Stock | $9,741,600 | 7.16% | 1,230,000 | $3,796,600 | Up ×2 | ||
| BMRN BioMarin Pharmaceutical Inc. - Common Stock | $8,211,070 | 6.03% | 143,500 | $3,578,890 | Up ×1 | ||
| PRAX Praxis Precision Medicines, Inc. - Common Stock | $7,549,515 | 5.55% | 22,550 | $284,130 | |||
| RARE Ultragenyx Pharmaceutical Inc. - Common Stock | $6,844,950 | 5.03% | 205,000 | $3,194,412 | Up ×2 | ||
| AGIO Agios Pharmaceuticals, Inc. - Common Stock | $6,086,040 | 4.47% | 164,000 | ||||
| INSM Insmed Incorporated - Common Stock | $5,464,275 | 4.01% | 51,250 | ||||
| CRNX Crinetics Pharmaceuticals, Inc. - Common Stock | $5,369,770 | 3.95% | 143,500 | Up ×1 | |||
| ZNTL Zentalis Pharmaceuticals, Inc. - common stock | $4,971,250 | 3.65% | 1,025,000 | $2,093,050 | Down ×2 | ||
| PCVX Vaxcyte, Inc. - Common Stock | $4,766,660 | 3.50% | 82,000 | $1,431,146 | Up ×2 | ||
| ANNX Annexon, Inc. - common stock | $4,682,200 | 3.44% | 820,000 | $3,716,855 | Up ×1 | ||
| TVTX Travere Therapeutics, Inc. - Common Stock | $4,658,420 | 3.42% | 82,000 | $1,369,523 | Down ×1 | ||
| TNXP Tonix Pharmaceuticals Holding Corp. - Common Stock | $4,316,070 | 3.17% | 338,250 | Up ×1 | |||
| BBIO BridgeBio Pharma, Inc. - Common Stock | $4,275,152 | 3.14% | 57,400 | ||||
| AXSM Axsome Therapeutics, Inc. - Common Stock | $4,014,228 | 2.95% | 16,400 | $-2,915,592 | Down ×1 | ||
| CTNM Contineum Therapeutics, Inc. - Common stock | $3,359,950 | 2.47% | 205,000 | $1,505,430 | Up ×1 | ||
| LXRX Lexicon Pharmaceuticals, Inc. - Common Stock | $3,050,400 | 2.24% | 1,271,000 | $1,643,280 | Up ×2 | ||
| KURA Kura Oncology, Inc. - Common Stock | $3,035,948 | 2.23% | 276,750 | Up ×1 | |||
| DBVT DBV Technologies S.A. - American Depositary Shares | $3,025,800 | 2.22% | 184,500 | $884,575 | Up ×1 | ||
| GMAB Genmab A/S - American Depositary Shares | $2,815,675 | 2.07% | 102,500 | $615,615 | Up ×2 | ||
| CYTK Cytokinetics, Incorporated - Common Stock | $2,794,232 | 2.05% | 32,800 | Up ×1 | |||
| MLYS Mineralys Therapeutics, Inc. - Common Stock | $2,765,450 | 2.03% | 102,500 | $544,070 | Up ×1 | ||
| SLN Silence Therapeutics Plc - American Depository Share | $2,434,847 | 1.79% | 55,350 | $1,694,412 | Down ×2 | ||
| NUVB Nuvation Bio Inc. Class A Common Stock | $2,095,920 | 1.54% | 369,000 | ||||
| WVE Wave Life Sciences Ltd. - Ordinary Shares | $1,905,680 | 1.40% | 328,000 | Up ×1 | |||
| NKTR Nektar Therapeutics - Common Stock | $1,860,437 | 1.37% | 26,650 | ||||
| SRRK Scholar Rock Holding Corporation - Common Stock | $1,691,250 | 1.24% | 30,750 | $-1,130,534 | Down ×1 | ||
| ELVN Enliven Therapeutics, Inc. - Common Stock | $1,664,600 | 1.22% | 32,800 | Up ×1 | |||
| ALNY Alnylam Pharmaceuticals, Inc. - Common Stock | $1,542,779 | 1.13% | 5,125 | $-152,930 | |||
| BEAM Beam Therapeutics Inc. - Common Stock | $1,407,120 | 1.03% | 41,000 | $39,278 | Down ×1 | ||
| SION Sionna Therapeutics, Inc. - Common Stock | $1,350,540 | 0.99% | 123,000 | $-621,888 | Up ×1 | ||
| ORIC Oric Pharmaceuticals, Inc. - Common Stock | $1,332,090 | 0.98% | 123,000 | $33,415 | Up ×1 | ||
| NAMS NewAmsterdam Pharma Company N.V. - Ordinary Shares | $1,250,541 | 0.92% | 36,900 | $69,372 | |||
| VRTX Vertex Pharmaceuticals Incorporated - Common Stock | $1,221,956 | 0.90% | 2,460 | Up ×1 | |||
| SPRY ARS Pharmaceuticals, Inc. - Common Stock | $1,149,355 | 0.84% | 143,490 | Up ×1 | |||
| MNPR Monopar Therapeutics Inc. - Common Stock | $1,138,857 | 0.84% | 12,300 | Up ×1 | |||
| ERAS Erasca, Inc. - Common Stock | $751,120 | 0.55% | 41,000 | Up ×1 | |||
| VERA Vera Therapeutics, Inc. - Class A Common Stock | $439,828 | 0.32% | 10,250 | $-2,859,032 | Down ×1 | ||
| IMTX Immatics N.V. - Ordinary Shares | $311,498 | 0.23% | 30,750 | $-1,201,402 | Down ×1 | ||
| MREO Mereo BioPharma Group plc - American Depositary Shares | $244,232 | 0.18% | 768,750 | Up ×1 | |||
| GOSS Gossamer Bio, Inc. - Common Stock | $134,972 | 0.10% | 820,000 | $-134,398 | |||
| No matches | |||||||
Biggest new bets
New positions opened this quarter, largest first.
| Security | Value | Shares | % of portfolio |
|---|---|---|---|
| AGIO | $6,086,040 | 164,000 | 4.47% |
| INSM | $5,464,275 | 51,250 | 4.01% |
| CRNX | $5,369,770 | 143,500 | 3.95% |
| TNXP | $4,316,070 | 338,250 | 3.17% |
| BBIO | $4,275,152 | 57,400 | 3.14% |
| KURA | $3,035,948 | 276,750 | 2.23% |
| CYTK | $2,794,232 | 32,800 | 2.05% |
| NUVB | $2,095,920 | 369,000 | 1.54% |
| WVE | $1,905,680 | 328,000 | 1.40% |
| NKTR | $1,860,437 | 26,650 | 1.37% |
| ELVN | $1,664,600 | 32,800 | 1.22% |
| VRTX | $1,221,956 | 2,460 | 0.90% |
| SPRY | $1,149,355 | 143,490 | 0.84% |
| MNPR | $1,138,857 | 12,300 | 0.84% |
| ERAS | $751,120 | 41,000 | 0.55% |
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| ACAD | Bought more | +287K | +$7.6M |
| XERS | Bought more | +205K | +$3.8M |
| ANNX | Bought more | +646K | +$3.7M |
| BMRN | Bought more | +62K | +$3.6M |
| RARE | Bought more | +31K | +$3.2M |
| AXSM | Trimmed | -25K | -$2.9M |
| ZNTL | Trimmed | -205K | +$2.1M |
| SLN | Trimmed | -85K | +$1.7M |
| LXRX | Bought more | +369K | +$1.6M |
| CTNM | Bought more | +63K | +$1.5M |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| KALV | June 30, 2026 | 276,750 | $5,570,978 | No longer tracked |
| FOLD | June 30, 2026 | 369,000 | $5,335,740 | No longer tracked |
| VSTM | June 30, 2026 | 820,000 | $4,346,000 | 81.9% |
| NUVB | March 31, 2026 | 400,000 | $3,584,000 | 62.8% |
| ARWR | June 30, 2026 | 55,350 | $3,470,445 | 8.2% |
| MLTX | June 30, 2026 | 174,250 | $3,248,020 | -18.5% |
| BBIO | March 31, 2026 | 36,000 | $2,753,640 | 11.3% |
| ARDX | June 30, 2026 | 451,000 | $2,701,490 | -22.4% |
| UTHR | March 31, 2026 | 5,500 | $2,679,875 | -11.3% |
| BCRX | March 31, 2026 | 300,000 | $2,340,000 | 3.1% |
| SNDX | March 31, 2026 | 100,000 | $2,101,000 | -15.2% |
| CPRX | June 30, 2026 | 82,000 | $2,030,320 | No longer tracked |
| TARS | March 31, 2026 | 24,000 | $1,965,120 | 3.0% |
| APOG | March 31, 2026 | 25,000 | $1,887,000 | 26.0% |
| INSM | March 31, 2026 | 10,000 | $1,740,400 | -23.3% |
| LGND | June 30, 2026 | 8,200 | $1,637,130 | -8.5% |
| EWTX | June 30, 2026 | 49,200 | $1,549,800 | 8.0% |
| CORT | March 31, 2026 | 44,000 | $1,531,200 | 204.2% |
| APLS | March 31, 2026 | 50,000 | $1,256,000 | No longer tracked |
| DNLI | March 31, 2026 | 70,000 | $1,155,700 | 31.0% |
| ASND | March 31, 2026 | 5,000 | $1,066,200 | 12.7% |
| BHVN | March 31, 2026 | 88,000 | $993,520 | 68.5% |
| DNTH | March 31, 2026 | 24,000 | $989,040 | 33.2% |
| NKTR | March 31, 2026 | 20,000 | $845,600 | 4.4% |
| IDYA | June 30, 2026 | 24,600 | $819,672 | 8.8% |
| AGIO | March 31, 2026 | 30,000 | $816,600 | -0.1% |
| IMVT | March 31, 2026 | 30,000 | $762,600 | 79.3% |
| OLMA | March 31, 2026 | 30,000 | $750,000 | -25.0% |
| PTCT | June 30, 2026 | 10,250 | $698,333 | -13.4% |
| ARQT | March 31, 2026 | 12,000 | $348,480 | 6.6% |