TSHA — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Avoro Capital Advisors LLC | $162 683 327 | 23 888 888 | 7,59% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $160 413 963 | 23 555 648 | 7,48% | Actions |
| GOLDMAN SACHS GROUP INC | $154 676 334 | 22 713 118 | 7,21% | Actions |
| BlackRock, Inc. | $140 912 023 | 20 691 927 | 6,57% | Actions |
| Vestal Point Capital, LP | $132 216 150 | 19 415 000 | 6,17% | Actions |
| MORGAN STANLEY | $112 279 731 | 16 487 479 | 5,24% | Actions |
| RTW INVESTMENTS, LP | $92 345 357 | 13 560 258 | 4,31% | Actions |
| FMR LLC | $90 820 969 | 13 336 413 | 4,24% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $84 979 232 | 12 478 595 | 3,96% | Actions |
| STATE STREET CORP | $77 783 275 | 11 421 920 | 3,63% | Actions |
| VANGUARD GROUP INC | $72 972 929 | 13 267 805 | 3,40% | Actions |
| Siren, L.L.C. | $67 055 203 | 9 846 579 | 3,13% | Actions |
| Octagon Capital Advisors LP | $66 010 992 | 9 693 244 | 3,08% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $44 685 322 | 6 560 394 | 2,08% | Actions |
| Polar Capital Holdings Plc | $34 847 676 | 5 117 133 | 1,63% | Actions |
| MPM BIOIMPACT LLC | $30 645 000 | 4 500 000 | 1,43% | Actions |
| D. E. Shaw & Co., Inc. | $29 954 821 | 4 398 652 | 1,40% | Actions |
| BAKER BROS. ADVISORS LP | $27 272 388 | 4 004 756 | 1,27% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $27 073 870 | 3 975 605 | 1,26% | Actions |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $26 460 262 | 3 885 501 | 1,23% | Actions |
| GordonMD Global Investments LP | $24 501 508 | 723 185 | 1,14% | Actions |
| Casdin Capital, LLC | $22 132 500 | 3 250 000 | 1,03% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $21 383 461 | 3 140 009 | 1,00% | Actions |
| ADAR1 Capital Management, LLC | $20 705 573 | 3 040 466 | 0,97% | Actions |
| Pictet Asset Management Holding SA | $18 868 474 | 2 770 701 | 0,88% | Actions |
| Aberdeen Group plc | $15 847 905 | 2 327 152 | 0,74% | Actions |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $15 322 500 | 2 250 000 | 0,71% | Actions |
| NORGES BANK | $15 210 816 | 2 233 600 | 0,71% | Actions |
| NORTHERN TRUST CORP | $15 160 491 | 2 226 210 | 0,71% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14 986 733 | 2 200 695 | 0,70% | Actions |
| MILLENNIUM MANAGEMENT LLC | $14 483 767 | 2 126 838 | 0,68% | Actions |
| ORBIMED ADVISORS LLC | $13 620 000 | 2 000 000 | 0,64% | Actions |
| RICE HALL JAMES & ASSOCIATES, LLC | $13 567 079 | 1 992 229 | 0,63% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $12 914 988 | 1 896 474 | 0,60% | Actions |
| B Group, Inc. | $12 261 786 | 1 800 556 | 0,57% | Actions |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | $12 099 000 | 3 700 000 | 0,56% | Actions |
| Affinity Asset Advisors, LLC | $11 917 500 | 1 750 000 | 0,56% | Actions |
| BARCLAYS PLC | $11 104 787 | 1 630 659 | 0,52% | Actions |
| CITADEL ADVISORS LLC | $10 455 305 | 1 535 287 | 0,49% | Actions |
| HEIGHTS CAPITAL MANAGEMENT, INC | $10 215 000 | 1 500 000 | 0,48% | Actions |
| Seven Fleet Capital Management LP | $9 940 323 | 1 504 400 | 0,46% | Actions |
| Palo Alto Investors LP | $9 475 311 | 1 391 382 | 0,44% | Actions |
| BANK OF AMERICA CORP /DE/ | $9 349 074 | 1 372 845 | 0,44% | Actions |
| Granahan Investment Management, LLC | $8 888 255 | 1 305 177 | 0,41% | Actions |
| Quantum Private Wealth, LLC | $5 529 903 | 812 027 | 0,26% | Actions |
| FIRST TRUST ADVISORS LP | $5 387 860 | 791 169 | 0,25% | Actions |
| JPMORGAN CHASE & CO | $5 157 078 | 766 282 | 0,24% | Actions |
| Sands Capital Alternatives, LLC | $4 936 385 | 724 873 | 0,23% | Actions |
| Bank of New York Mellon Corp | $4 753 180 | 697 971 | 0,22% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $4 358 638 | 640 035 | 0,20% | Actions |
| PANAGORA ASSET MANAGEMENT INC | $4 020 535 | 590 387 | 0,19% | Actions |
| UBS Group AG | $4 007 188 | 588 427 | 0,19% | Actions |
| AFFINITY WEALTH MANAGEMENT LLC | $3 928 062 | 576 808 | 0,18% | Actions |
| Squarepoint Ops LLC | $3 876 722 | 569 269 | 0,18% | Actions |
| ACUTA CAPITAL PARTNERS, LLC | $3 825 912 | 561 808 | 0,18% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3 799 980 | 558 000 | 0,18% | Option d'achat |
| Nuveen, LLC | $3 784 270 | 555 693 | 0,18% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3 765 930 | 553 000 | 0,18% | Actions |
| DIADEMA PARTNERS LP | $3 559 035 | 522 619 | 0,17% | Actions |
| Woodline Partners LP | $3 499 169 | 513 828 | 0,16% | Actions |
| Holocene Advisors, LP | $3 473 100 | 510 000 | 0,16% | Actions |
| Ghisallo Capital Management LLC | $3 439 050 | 505 000 | 0,16% | Actions |
| Burkehill Global Management, LP | $3 405 000 | 500 000 | 0,16% | Actions |
| POLEN CAPITAL MANAGEMENT LLC | $3 331 581 | 489 219 | 0,16% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $3 162 863 | 464 771 | 0,15% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $2 896 723 | 425 363 | 0,14% | Actions |
| Trexquant Investment LP | $2 584 919 | 379 577 | 0,12% | Actions |
| Swiss National Bank | $2 512 890 | 369 000 | 0,12% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $2 440 527 | 358 374 | 0,11% | Actions |
| WELLS FARGO & COMPANY/MN | $2 269 869 | 333 314 | 0,11% | Actions |
| Jefferies Financial Group Inc. | $2 239 128 | 328 800 | 0,10% | Actions |
| CITIGROUP INC | $2 090 037 | 306 907 | 0,10% | Actions |
| RHUMBLINE ADVISERS | $2 042 820 | 299 975 | 0,10% | Actions |
| ALPS ADVISORS INC | $1 978 598 | 290 543 | 0,09% | Actions |
| Invesco Ltd. | $1 800 421 | 264 379 | 0,08% | Actions |
| Ensign Peak Advisors, Inc | $1 790 322 | 262 896 | 0,08% | Actions |
| Qube Research & Technologies Ltd | $1 767 910 | 259 605 | 0,08% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 702 500 | 250 000 | 0,08% | Actions |
| DEUTSCHE BANK AG\ | $1 657 411 | 243 379 | 0,08% | Actions |
| TWO SIGMA INVESTMENTS, LP | $1 598 416 | 234 716 | 0,07% | Actions |
| JANE STREET GROUP, LLC | $1 555 098 | 228 355 | 0,07% | Actions |
| ORACLE INVESTMENT MANAGEMENT INC | $1 457 500 | 265 000 | 0,07% | Actions |
| Monashee Investment Management LLC | $1 362 000 | 200 000 | 0,06% | Actions |
| Privium Fund Management B.V. | $1 354 509 | 198 900 | 0,06% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $1 345 506 | 197 578 | 0,06% | Actions |
| Chicago Partners Investment Group LLC | $1 296 283 | 222 347 | 0,06% | Actions |
| Balyasny Asset Management L.P. | $1 289 351 | 189 332 | 0,06% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 205 976 | 177 089 | 0,06% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1 188 104 | 265 795 | 0,06% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1 153 437 | 169 374 | 0,05% | Actions |
| RAYMOND JAMES FINANCIAL INC | $1 130 746 | 166 042 | 0,05% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 107 130 | 247 680 | 0,05% | Actions |
| WEXFORD CAPITAL LP | $1 094 054 | 160 654 | 0,05% | Actions |
| Rafferty Asset Management, LLC | $1 053 548 | 154 706 | 0,05% | Actions |
| Palumbo Wealth Management LLC | $1 015 869 | 149 173 | 0,05% | Actions |
| MetLife Investment Management, LLC | $959 161 | 140 846 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $911 321 | 133 821 | 0,04% | Actions |
| Persistent Asset Partners Ltd | $908 529 | 133 411 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $903 101 | 132 614 | 0,04% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $876 883 | 128 764 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $869 664 | 127 915 | 0,04% | Actions |
| Mariner, LLC | $793 923 | 116 582 | 0,04% | Actions |
| CITADEL ADVISORS LLC | $783 150 | 115 000 | 0,04% | Option d'achat |
| TWO SIGMA ADVISERS, LP | $767 696 | 139 581 | 0,04% | Actions |
| Aquatic Capital Management LLC | $736 896 | 108 208 | 0,03% | Actions |
| Legal & General Group Plc | $736 890 | 108 207 | 0,03% | Actions |
| FRANKLIN RESOURCES INC | $723 835 | 106 290 | 0,03% | Actions |
| Engineers Gate Manager LP | $709 139 | 104 132 | 0,03% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $708 887 | 104 095 | 0,03% | Actions |
| XTX Topco Ltd | $689 138 | 101 195 | 0,03% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $669 736 | 98 346 | 0,03% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $663 294 | 97 400 | 0,03% | Option de vente |
| PROFUND ADVISORS LLC | $546 162 | 80 200 | 0,03% | Actions |
| Police & Firemen's Retirement System of New Jersey | $481 596 | 70 719 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $471 933 | 69 300 | 0,02% | Actions |
| J. Goldman & Co LP | $458 647 | 67 349 | 0,02% | Actions |
| RED REEF ADVISORS LLC | $449 120 | 65 950 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $447 649 | 65 734 | 0,02% | Actions |
| Creative Planning | $434 349 | 63 781 | 0,02% | Actions |
| CITADEL ADVISORS LLC | $428 349 | 62 900 | 0,02% | Option de vente |
| COMMONWEALTH EQUITY SERVICES, LLC | $420 678 | 61 773 | 0,02% | Actions |
| Russell Investments Group, Ltd. | $420 210 | 61 705 | 0,02% | Actions |
| OMERS ADMINISTRATION Corp | $402 471 | 59 100 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $390 233 | 57 303 | 0,02% | Actions |
| LANARK FINANCIAL, INC. | $374 699 | 55 022 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $358 329 | 52 618 | 0,02% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $335 141 | 49 213 | 0,02% | Actions |
| KLP KAPITALFORVALTNING AS | $325 518 | 47 800 | 0,02% | Actions |
| Militia Capital Management LLC | $316 665 | 46 500 | 0,01% | Actions |
| State of New Jersey Common Pension Fund D | $316 277 | 46 443 | 0,01% | Actions |
| JANUS HENDERSON GROUP PLC | $308 085 | 69 000 | 0,01% | Actions |
| Williams & Novak, LLC | $306 450 | 45 000 | 0,01% | Actions |
| Almanack Investment Partners, LLC. | $306 110 | 44 950 | 0,01% | Actions |
| FIRST MANHATTAN CO. LLC. | $296 235 | 43 500 | 0,01% | Actions |
| Mitsubishi UFJ Asset Management Co., Ltd. | $294 131 | 43 191 | 0,01% | Actions |
| Allianz Asset Management GmbH | $288 744 | 42 400 | 0,01% | Actions |
| ProShare Advisors LLC | $277 965 | 40 817 | 0,01% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $269 901 | 39 633 | 0,01% | Actions |
| PRUDENTIAL FINANCIAL INC | $265 862 | 39 040 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $260 142 | 38 200 | 0,01% | Option d'achat |
| Militia Capital Partners, LP | $255 750 | 46 500 | 0,01% | Actions |
| ENVESTNET ASSET MANAGEMENT INC | $254 108 | 37 314 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $244 390 | 35 887 | 0,01% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $218 935 | 32 149 | 0,01% | Actions |
| Cetera Investment Advisers | $215 244 | 31 607 | 0,01% | Actions |
| GUGGENHEIM CAPITAL LLC | $202 401 | 29 721 | 0,01% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $184 987 | 27 164 | 0,01% | Actions |
| Quadrature Capital Ltd | $175 378 | 25 753 | 0,01% | Actions |
| nVerses Capital, LLC | $171 285 | 25 152 | 0,01% | Actions |
| State of Wyoming | $166 041 | 24 382 | 0,01% | Actions |
| XPONANCE LLC | $155 820 | 22 881 | 0,01% | Actions |
| E Fund Management Co., Ltd. | $148 553 | 21 814 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $148 192 | 21 761 | 0,01% | Actions |
| Lee Financial Co | $136 200 | 20 000 | 0,01% | Actions |
| ALLSTATE CORP | $132 434 | 19 447 | 0,01% | Actions |
| Weiss Asset Management LP | $130 371 | 19 144 | 0,01% | Actions |
| Aster Capital Management (DIFC) Ltd | $126 346 | 18 553 | 0,01% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $124 855 | 18 334 | 0,01% | Actions |
| Vanguard Personalized Indexing Management, LLC | $122 437 | 17 979 | 0,01% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $113 972 | 16 736 | 0,01% | Actions |
| ST GERMAIN D J CO INC | $96 246 | 14 133 | 0,00% | Actions |
| SEI INVESTMENTS CO | $95 004 | 13 952 | 0,00% | Actions |
| BANK OF MONTREAL /CAN/ | $93 079 | 13 668 | 0,00% | Actions |
| CAPTRUST FINANCIAL ADVISORS | $91 629 | 13 455 | 0,00% | Actions |
| SIMPLEX TRADING, LLC | $91 056 | 13 371 | 0,00% | Actions |
| CIBC Bancorp USA Inc. | $90 315 | 13 262 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $87 522 | 12 852 | 0,00% | Actions |
| Ethic Inc. | $85 207 | 12 512 | 0,00% | Actions |
| CIBC WORLD MARKETS CORP | $80 366 | 14 612 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $78 519 | 11 530 | 0,00% | Actions |
| Magnetar Financial LLC | $78 145 | 11 475 | 0,00% | Actions |
| NEUBERGER BERMAN GROUP LLC | $76 068 | 11 170 | 0,00% | Actions |
| Summit Financial, LLC | $74 147 | 10 888 | 0,00% | Actions |
| CHOREO, LLC | $72 309 | 10 618 | 0,00% | Actions |
| Capital Investment Advisors, LLC | $68 100 | 10 000 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $60 191 | 8 838 | 0,00% | Actions |
| CWM, LLC | $58 472 | 13 081 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $51 000 | 7 386 | 0,00% | Actions |
| Allworth Financial LP | $47 521 | 6 978 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $39 478 | 5 797 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $39 362 | 5 780 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $34 050 | 5 000 | 0,00% | Actions |
| Bordeaux Wealth Advisors LLC | $23 234 | 10 058 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $20 873 | 3 065 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $20 430 | 3 000 | 0,00% | Actions |
| Kemnay Advisory Services Inc. | $17 583 | 2 582 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $14 294 | 2 099 | 0,00% | Actions |
| Chung Wu Investment Group, LLC | $13 620 | 2 000 | 0,00% | Actions |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $13 300 | 2 000 | 0,00% | Actions |
| GROUP ONE TRADING LLC | $13 205 | 1 939 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $12 633 | 1 855 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $9 263 | 1 461 | 0,00% | Actions |
| US BANCORP \DE\ | $7 845 | 1 152 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $7 171 | 1 053 | 0,00% | Actions |
| Sterling Capital Management LLC | $5 734 | 842 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $3 405 | 500 | 0,00% | Actions |
| Quarry LP | $3 269 | 480 | 0,00% | Actions |
| Larson Financial Group LLC | $3 194 | 469 | 0,00% | Actions |
| Optiver Holding B.V. | $3 017 | 443 | 0,00% | Actions |
| Arax Advisory Partners | $2 451 | 360 | 0,00% | Actions |
| Essential Partners LLC | $2 227 | 327 | 0,00% | Actions |
| Parallel Advisors, LLC | $1 907 | 280 | 0,00% | Actions |
| SIGNATUREFD, LLC | $1 811 | 266 | 0,00% | Actions |
| GAMMA Investing LLC | $1 580 | 232 | 0,00% | Actions |
| SG Americas Securities, LLC | $1 377 | 202 260 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1 359 | 199 494 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 158 | 170 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $960 | 141 | 0,00% | Actions |
| Lindbrook Capital, LLC | $605 | 435 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $578 | 85 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $494 | 72 573 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $375 | 55 | 0,00% | Actions |
| True Wealth Design, LLC | $205 | 30 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $177 | 26 | 0,00% | Actions |
| Cambridge Investment Research Advisors, Inc. | $103 | 15 075 | 0,00% | Actions |
| Thrivent Financial for Lutherans | $98 | 14 520 | 0,00% | Actions |
| IFP Advisors, Inc | $95 | 14 | 0,00% | Actions |
| Hughes Financial Services, LLC | $41 | 6 | 0,00% | Actions |
| Pacer Advisors, Inc. | $18 | 2 584 | 0,00% | Actions |
| Covestor Ltd | $1 | 94 | 0,00% | Actions |
| Capital Advisors, Ltd. LLC | $1 | 79 | 0,00% | Actions |