TSHA Taysha Gene Therapies, Inc. - Common Stock
$6,10
Prix · Aoû 20, 2026
Données fondamentales au Aoû 11, 2026
Fourchette 52 semaines
$3–$7
74% of range
Note des analystes
BUY
18 analysts
Objectif de cours
$13
+119% upside
P/E (TTM)
-18.1
ROE
-44.0%
Marge nette
-1115.3%
TSHA Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines
Prix
$6.10
Capitalisation Boursière
$1.75B
P/E (TTM)
-18.1
BPA (TTM)
$-0.34
Revenus (TTM)
$10M
Rendement div.
—
ROE
-44.0%
Dette/Capitaux propres
0.2
Fourchette 52 semaines
$3 – $7
TSHA Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue
Configure
Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA
Revenus et bénéfice net
$10M
2022-12-31
→
2025-12-31
BPA
$-0.34
2021-12-31
→
2025-12-31
Flux de trésorerie libre
$-94M
2020-12-31
→
2025-12-31
Marges
-1115.3%
Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?
Métrique
Tendance sur 5 ans
TSHA
Médiane des pairs
P/E (TTM)
-18.1
27.2
P/S (TTM)
179.3
25.4
P/B
7.1
5.1
EV / EBITDA
-13.4
—
Price / FCF (Cours / FCF)
-18.7
—
Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC
Métrique
Tendance sur 5 ans
TSHA
Médiane des pairs
Operating Margin (Marge d'exploitation)
-1130.7%
—
Net Profit Margin (Marge nette)
-1115.3%
-473.7%
ROA
-43.3%
-40.2%
ROE
-44.0%
-50.4%
Santé financière Dette, liquidité, solvabilité — solidité du bilan
Métrique
Tendance sur 5 ans
TSHA
Médiane des pairs
Debt / Equity (Dette / Capitaux propres)
0.2
—
Current Ratio (Ratio de liquidité)
12.2
9.0
Quick Ratio (Ratio de liquidité réduite)
12.0
—
Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans
Métrique
Tendance sur 5 ans
TSHA
Médiane des pairs
Revenue YoY (Chiffre d'affaires YoY)
17.3%
—
Revenue CAGR 3Y (CAGR du chiffre d'affaires 3 ans)
57.5%
—
Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances
Métrique
Tendance sur 5 ans
TSHA
Médiane des pairs
TSHA Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse
ACHAT
18 analystes
- Achat fort 6 33,3%
- Achat 11 61,1%
- Conserver 1 5,6%
- Vente 0 0,0%
- Vente forte 0 0,0%
Objectif de cours à 12 mois
12 analystes · 2026-08-16
Médiane
$12.50
Moyenne
$13.33
← En dessous de tous les objectifs
$6.10
Bas
$10.00
Haut
$19.00
Objectif médian
$12.50
+104,9%
Objectif moyen
$13.33
+118,6%
Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats
Surprise Moyenne
0.00%
| Période | EPS Actual | BPA est. | Surprise |
|---|---|---|---|
| 30 juin 2026 | $-0.13 | $-0.12 | -0.01% |
| 31 mars 2026 | $-0.12 | $-0.10 | -0.02% |
| 31 décembre 2025 | $-0.08 | $-0.10 | 0.02% |
| 30 septembre 2025 | $-0.09 | $-0.09 | 0.00% |
| 30 juin 2025 | $-0.09 | $-0.08 | -0.01% |
| 31 mars 2025 | $-0.08 | $-0.09 | 0.01% |
| 31 décembre 2024 | $-0.07 | $-0.08 | 0.01% |
Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur
| Ticker | Capitalisation Boursière | P/E | Revenus Année/Année | Marge Nette | ROE | Marge Brute |
|---|---|---|---|---|---|---|
| TSHA | $1.57B | -16.2 | 17.3% | -1115.3% | -44.0% | — |
| PVLA | $1.30B | -28.2 | 65.3% | -1610.6% | -110.1% | — |
| SRPT | $2.26B | -3.0 | 15.6% | -32.5% | -57.1% | — |
| STOK | $1.87B | -264.5 | 404.5% | -3.7% | -2.0% | — |
| ZBIO | $1.98B | -4.3 | 100.0% | -3777.4% | -156.8% | — |
| AGIO | $1.59B | -3.8 | 48.0% | -764.0% | -32.2% | — |
| DMRA | — | — | 38.3% | -17981.1% | -167.0% | — |
| PURR | — | — | — | — | — | — |
| SNDX | $1.84B | -6.4 | 627.8% | -165.6% | -257.1% | — |
| RXRX | $2.16B | -2.8 | 26.9% | -863.4% | -62.9% | — |
| NTLA | $1.05B | -2.4 | 16.9% | -609.8% | -59.5% | — |
Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie
Compte de résultat 15
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue | $10M | $8M | $15M | $3M | |
| R&D Expense | $86M | $66M | $57M | $91M | |
| SG&A Expense | $34M | $29M | $30M | $37M | |
| Operating Expenses | $120M | $100M | $88M | $165M | |
| Operating Income | $-110M | $-91M | $-72M | $-162M | |
| Interest Expense | · | · | $5M | $4M | |
| Interest Income | $9M | $7M | $4M | · | |
| Other Non-op | $-291.0K | $-110.0K | $-47.0K | $-18.0K | |
| Income Tax | $0 | $0 | $0 | $0 | |
| Net Income | $-109M | $-89M | $-112M | $-166M | |
| EPS (Basic) | $-0.34 | $-0.36 | $-0.96 | $-3.78 | |
| EPS (Diluted) | $-0.34 | $-0.36 | $-0.96 | $-3.78 | |
| Shares (Basic) | 319,711,972 | 250,134,421 | 116,121,482 | 43,952,015 | |
| Shares (Diluted) | 319,711,972 | 250,134,421 | 116,121,482 | 43,952,015 | |
| EBITDA | $-110M | $-91M | $-72M | · |
Bilan 23
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $320M | $139M | $144M | $88M | |
| Prepaid Expense | $4M | $3M | $3M | $9M | |
| Other Current Assets | $802.0K | $308.0K | $292.0K | $466.0K | |
| Current Assets | $325M | $142M | $150M | $96M | |
| PP&E (Net) | $7M | $7M | $11M | $15M | |
| PP&E (Gross) | $11M | $11M | $14M | $17M | |
| Accum. Depreciation | $5M | $4M | $3M | $2M | |
| Other Non-current Assets | $183.0K | $217.0K | $304.0K | $1M | |
| Total Assets | $343M | $160M | $173M | $126M | |
| Accounts Payable | $6M | $4M | $6M | $11M | |
| Current Liabilities | $27M | $26M | $37M | $63M | |
| Capital Leases | $18M | $17M | $19M | $20M | |
| Other Non-current Liabilities | $2M | $1M | $2M | $4M | |
| Total Liabilities | $96M | $89M | $98M | $125M | |
| Long-term Debt | · | · | · | $38M | |
| Total Debt | $50M | $44M | $41M | · | |
| Common Stock | $3.0K | $2.0K | $2.0K | $1.0K | |
| Paid-in Capital | $958M | $678M | $588M | $402M | |
| Retained Earnings | $-711M | $-602M | $-513M | $-401M | |
| AOCI | $-192.0K | $-4M | · | · | |
| Stockholders' Equity | $247M | $72M | $75M | $949.0K | |
| Liabilities + Equity | $343M | $160M | $173M | $126M | |
| Shares Outstanding | 285,051,648 | 204,943,306 | 186,960,193 | 63,207,507 |
Flux de trésorerie 8
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Stock-based Comp | $13M | $13M | $8M | $18M | |
| Operating Cash Flow | $-93M | $-81M | $-73M | $-88M | |
| CapEx | $738.0K | $374.0K | $4M | $21M | |
| Investing Cash Flow | $-604.0K | $-363.0K | $-7M | $-25M | |
| Stock Issued | · | · | $500.0K | · | |
| Financing Cash Flow | $275M | $77M | $136M | $52M | |
| Net Change in Cash | $181M | $-5M | $56M | $-61M | |
| Free Cash Flow | $-94M | $-82M | $-77M | · |
Rentabilité 5
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Operating Margin | -1130.7% | -1097.5% | -468.8% | · | |
| Net Margin | -1115.3% | -1071.6% | -722.1% | · | |
| EBITDA Margin | -1130.7% | -1097.5% | -468.8% | · | |
| ROA | -43.3% | -53.6% | -74.6% | · | |
| ROE | -44.0% | -111.4% | -864.1% | · |
Liquidité et Solvabilité 5
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 12.2 | 5.4 | 4.1 | · | |
| Quick Ratio | 12.0 | 5.3 | 3.9 | · | |
| Debt / Equity | 0.2 | 0.6 | 0.5 | · | |
| LT Debt / Equity | 0.2 | 0.6 | 0.5 | · | |
| Interest Coverage | · | · | -14.5 | · |
Efficacité 1
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.1 | 0.1 | · |
Taux de croissance 2
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue YoY | 17.3% | -46.1% | 517.6% | · | |
| Revenue CAGR 3Y | 57.5% | · | · | · |
Valorisation (TTM) 14
| Métrique | Tendance | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Revenue TTM | $10M | $8M | $15M | $3M | |
| Net Income TTM | $-109M | $-89M | $-112M | $-166M | |
| Market Cap | $1.57B | $355M | $331M | · | |
| Enterprise Value | $1.30B | $259M | $227M | · | |
| P/E | -16.2 | -4.8 | -1.8 | -0.6 | |
| P/S | 160.4 | 42.5 | 21.4 | · | |
| P/B | 6.3 | 5.0 | 4.4 | · | |
| P / Tangible Book | 6.3 | 5.0 | 4.4 | 150.5 | |
| P / Cash Flow | -16.8 | -4.4 | -4.5 | · | |
| P / FCF | -16.7 | -4.3 | -4.3 | · | |
| EV / EBITDA | -11.7 | -2.8 | -3.1 | · | |
| EV / FCF | -13.8 | -3.2 | -3.0 | · | |
| EV / Revenue | 132.8 | 31.1 | 14.7 | · | |
| Earnings Yield | -6.2% | -20.8% | -54.2% | -167.3% |
Compte de résultat 15
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $5M | $0 | $2M | $2M | $2M | $2M | $1M | $3M | $4M | $5M | $2M | $5M | |
| R&D Expense | $39M | $34M | $25M | $26M | $20M | $16M | $15M | $15M | $15M | $21M | $13M | $12M | $20M | $13M | |
| SG&A Expense | $12M | $10M | $9M | $8M | $9M | $8M | $7M | $8M | $7M | $7M | $7M | $9M | $6M | $9M | |
| Operating Expenses | $47M | $43M | $34M | $34M | $29M | $24M | $22M | $28M | $22M | $28M | $20M | $21M | $26M | $21M | |
| Operating Income | $-47M | $-43M | $-28M | $-34M | $-27M | $-21M | $-20M | $-26M | $-21M | $-24M | $-16M | $-16M | $-23M | $-17M | |
| Interest Expense | · | · | · | · | · | · | · | · | $27.0K | $29.0K | · | $1M | $1M | $1M | |
| Interest Income | $2M | $3M | $3M | $3M | $2M | $1M | $2M | $2M | $1M | $2M | $2M | $1M | · | · | |
| Other Non-op | $-88.0K | $-31.0K | $-30.0K | $-37.0K | $-237.0K | $13.0K | $-66.0K | $-81.0K | $42.0K | $-5.0K | $-23.0K | $-19.0K | $3.0K | $-8.0K | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | · | $0 | $0 | $0 | |
| Net Income | $-47M | $-42M | $-28M | $-33M | $-27M | $-22M | $-19M | $-26M | $-21M | $-24M | $48M | $-117M | $-25M | $-18M | |
| EPS (Basic) | $-0.13 | $-0.12 | $-0.08 | $-0.09 | $-0.09 | $-0.08 | $-0.07 | $-0.10 | $-0.09 | $-0.10 | $0.63 | $-0.93 | $-0.38 | $-0.28 | |
| EPS (Diluted) | $-0.13 | $-0.12 | $-0.08 | $-0.09 | $-0.09 | $-0.08 | $-0.07 | $-0.10 | $-0.09 | $-0.10 | $0.63 | $-0.93 | $-0.38 | $-0.28 | |
| Shares (Basic) | 369,044,040 | 366,632,827 | -600,892,861 | 353,309,524 | 297,988,978 | 269,306,331 | -481,760,521 | 267,824,045 | 232,821,553 | 231,249,344 | -137,084,753 | 125,700,799 | 64,244,531 | 63,260,905 | |
| Shares (Diluted) | 369,044,040 | 366,632,827 | -600,892,861 | 353,309,524 | 297,988,978 | 269,306,331 | -481,760,521 | 267,824,045 | 232,821,553 | 231,249,344 | -137,084,753 | 125,700,799 | 64,244,531 | 63,260,905 | |
| EBITDA | $-47M | $-43M | · | $-34M | $-27M | $-21M | · | $-26M | $-21M | $-24M | · | $-16M | $-23M | $-17M |
Bilan 23
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $455M | $277M | $320M | $297M | $313M | $117M | $139M | $158M | $173M | $124M | $144M | $164M | $45M | $63M | |
| Prepaid Expense | $6M | $5M | $4M | $2M | $3M | $4M | $3M | $3M | $3M | $4M | $3M | $6M | $9M | $9M | |
| Other Current Assets | $851.0K | $1M | $802.0K | $456.0K | $657.0K | $536.0K | $308.0K | $465.0K | $206.0K | $149.0K | $292.0K | $404.0K | $510.0K | $532.0K | |
| Current Assets | $461M | $282M | $325M | $300M | $316M | $121M | $142M | $162M | $178M | $131M | $150M | $172M | $54M | $72M | |
| PP&E (Net) | $2M | $6M | $7M | $7M | $7M | $7M | $7M | $8M | $11M | $11M | $11M | $11M | $14M | $15M | |
| PP&E (Gross) | $8M | $11M | $11M | $11M | $11M | $11M | $11M | $12M | $14M | $14M | $14M | $14M | $16M | $17M | |
| Accum. Depreciation | $5M | $5M | $5M | $4M | $4M | $4M | $4M | $4M | $4M | $3M | $3M | $3M | $2M | $2M | |
| Other Non-current Assets | $106.0K | $181.0K | $183.0K | $184.0K | $186.0K | $188.0K | $217.0K | $220.0K | $288.0K | $304.0K | $304.0K | $304.0K | $304.0K | $1M | |
| Total Assets | $470M | $300M | $343M | $317M | $333M | $138M | $160M | $180M | $200M | $153M | $173M | $196M | $82M | $102M | |
| Accounts Payable | $9M | $5M | $6M | $5M | $8M | $4M | $4M | $5M | $9M | $10M | $6M | $8M | $11M | $9M | |
| Current Liabilities | $26M | $20M | $27M | $29M | $25M | $23M | $26M | $29M | $34M | $39M | $37M | $180M | $51M | $54M | |
| Capital Leases | $6M | $18M | $18M | $17M | $17M | $17M | $17M | $18M | $18M | $18M | $19M | $19M | $20M | $20M | |
| Other Non-current Liabilities | $2M | $2M | $2M | $2M | $1M | $1M | $1M | $1M | $1M | $2M | $2M | $4M | $4M | $4M | |
| Total Liabilities | $83M | $88M | $96M | $98M | $85M | $83M | $89M | $91M | $92M | $99M | $98M | $245M | $119M | $117M | |
| Long-term Debt | · | · | · | · | · | · | · | · | · | · | · | · | $38M | $38M | |
| Total Debt | $49M | $49M | · | $51M | $41M | $42M | · | $43M | $38M | $41M | · | $39M | $38M | $38M | |
| Common Stock | $3.0K | $3.0K | $3.0K | $3.0K | $3.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $2.0K | $1.0K | $1.0K | |
| Paid-in Capital | $1.19B | $965M | $958M | $904M | $900M | $681M | $678M | $675M | $664M | $591M | $588M | $512M | $407M | $404M | |
| Retained Earnings | $-800M | $-754M | $-711M | $-683M | $-651M | $-624M | $-602M | $-584M | $-558M | $-537M | $-513M | $-561M | $-444M | $-419M | |
| AOCI | $769.0K | $985.0K | $-192.0K | $-1M | $-699.0K | $-2M | $-4M | $-2M | $2M | $-251.0K | · | · | · | · | |
| Stockholders' Equity | $387M | $212M | $247M | $219M | $249M | $55M | $72M | $89M | $109M | $54M | $75M | $-49M | $-37M | $-15M | |
| Liabilities + Equity | $470M | $300M | $343M | $317M | $333M | $138M | $160M | $180M | $200M | $153M | $173M | $196M | $82M | $102M | |
| Shares Outstanding | 325,302,280 | 287,276,885 | 285,051,648 | 273,915,373 | 272,730,060 | 205,054,570 | 204,943,306 | 204,943,306 | 201,381,450 | 187,018,275 | 186,960,193 | 186,960,193 | 64,432,637 | 63,473,349 |
Flux de trésorerie 8
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $6M | $6M | $4M | $3M | $3M | $3M | $3M | $3M | $3M | $3M | $2M | $2M | $2M | $2M | |
| Operating Cash Flow | $-40M | $-41M | $-27M | $-24M | $-20M | $-22M | $-18M | $-22M | $-22M | $-20M | $-16M | $-18M | $-19M | $-20M | |
| CapEx | $-1.0K | $24.0K | $250.0K | $108.0K | $2.0K | $378.0K | $-2.0K | $35.0K | $201.0K | $140.0K | $17.0K | $0 | $-48.0K | $4M | |
| Investing Cash Flow | $1.0K | $-3M | $-247.0K | $-48.0K | $62.0K | $-371.0K | $13.0K | $-35.0K | $-201.0K | $-140.0K | $-10.0K | $-3M | $48.0K | $-4M | |
| Stock Issued | · | · | · | · | · | · | · | · | · | · | $0 | · | · | · | |
| Financing Cash Flow | $217M | $711.0K | $50M | $9M | $216M | $-52.0K | $-357.0K | $7M | $70M | $-22.0K | $-4M | $141M | $377.0K | $-370.0K | |
| Net Change in Cash | $176M | $-43M | $23M | $-15M | $196M | $-22M | $-19M | $-15M | $49M | $-20M | $-20M | $119M | $-18M | $-24M | |
| Free Cash Flow | · | $-41M | · | · | · | · | · | · | · | $-20M | · | · | · | $-24M |
Rentabilité 5
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | · | · | · | · | -1347.1% | -930.5% | · | -1448.4% | -1915.4% | -713.3% | · | -342.4% | -976.4% | -351.9% | |
| Net Margin | · | · | · | · | -1353.6% | -935.2% | · | -1427.5% | -1882.0% | -705.4% | · | -2467.1% | -1027.1% | -374.5% | |
| EBITDA Margin | · | · | · | · | -1347.1% | -930.5% | · | -1448.4% | -1915.4% | -713.3% | · | -342.4% | -976.4% | -351.9% | |
| ROA | -11.6% | -19.3% | · | -13.2% | -10.1% | -14.8% | · | -13.6% | -14.8% | -18.9% | · | -76.2% | -22.0% | -13.2% | |
| ROE | -14.7% | -31.8% | · | -21.3% | -15.0% | -39.5% | · | -128.6% | -58.3% | -123.7% | · | 616.4% | 1117.1% | -98.5% |
Liquidité et Solvabilité 5
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 17.8 | 14.0 | · | 10.5 | 12.5 | 5.4 | · | 5.5 | 5.2 | 3.4 | · | 1.0 | 1.1 | 1.3 | |
| Quick Ratio | 17.5 | 13.8 | · | 10.4 | 12.3 | 5.2 | · | 5.4 | 5.1 | 3.2 | · | 0.9 | 0.9 | 1.2 | |
| Debt / Equity | 0.1 | 0.2 | · | 0.2 | 0.2 | 0.8 | · | 0.5 | 0.3 | 0.8 | · | -0.8 | -1.0 | -2.6 | |
| LT Debt / Equity | 0.1 | 0.2 | · | 0.2 | 0.2 | 0.8 | · | 0.5 | 0.3 | 0.8 | · | -0.8 | -1.0 | -2.6 | |
| Interest Coverage | · | · | · | · | · | · | · | · | -788.9 | -839.0 | · | -11.0 | -16.2 | -12.1 |
Efficacité 1
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 |
Valorisation (TTM) 14
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $2M | $4M | · | $6M | $7M | $9M | · | $11M | $12M | $15M | · | · | · | · | |
| Net Income TTM | $-149M | $-124M | · | $-107M | $-95M | $-92M | · | $-188M | $-187M | $-183M | · | $-186M | $-103M | $-129M | |
| Market Cap | $2.22B | $1.28B | · | $896M | $630M | $285M | · | $412M | $451M | $537M | · | $591M | $43M | $51M | |
| Enterprise Value | $1.81B | $1.06B | · | $649M | $358M | $211M | · | $297M | $316M | $453M | · | $465M | $36M | $25M | |
| P/E | -15.8 | -11.8 | · | -9.1 | -6.4 | -3.8 | · | -1.6 | -1.5 | -1.7 | · | -1.4 | -0.3 | -0.3 | |
| P/S | 1115.5 | 299.5 | · | 147.4 | 87.6 | 33.1 | · | 37.3 | 38.7 | 35.2 | · | · | · | · | |
| P/B | 5.7 | 6.1 | · | 4.1 | 2.5 | 5.2 | · | 4.6 | 4.1 | 10.0 | · | -12.0 | -1.1 | -3.4 | |
| P / Tangible Book | 5.7 | 6.1 | · | 4.1 | 2.5 | 5.2 | · | 4.6 | 4.1 | 10.0 | · | · | · | · | |
| P / Cash Flow | · | -31.4 | · | · | · | -12.9 | · | · | · | -27.1 | · | · | · | -2.5 | |
| P / FCF | · | -31.4 | · | · | · | · | · | · | · | -26.9 | · | · | · | -2.1 | |
| EV / EBITDA | -38.2 | -24.3 | · | -19.1 | -13.4 | -9.8 | · | -11.5 | -14.8 | -18.6 | · | -28.6 | -1.5 | -1.5 | |
| EV / FCF | · | -25.8 | · | · | · | · | · | · | · | -22.7 | · | · | · | -1.1 | |
| EV / Revenue | 911.0 | 246.4 | · | 106.8 | 49.8 | 24.5 | · | 26.9 | 27.1 | 29.7 | · | · | · | · | |
| Earnings Yield | -6.3% | -8.5% | · | -11.0% | -15.6% | -26.6% | · | -60.7% | -67.0% | -58.9% | · | -70.9% | -326.8% | -388.5% |
États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années
Compte de résultat
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Revenu | $10M | $8M | $15M | $3M | — |
| Marge d'exploitation % | -1130.7% | -1097.5% | -468.8% | — | — |
| Résultat net | $-109M | $-89M | $-112M | $-166M | $-175M |
| BPA dilué | $-0.34 | $-0.36 | $-0.96 | $-3.78 | $-4.64 |
Bilan
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Dette / Capitaux propres | 0.2 | 0.6 | 0.5 | — | 0.4 |
| Ratio de liquidité | 12.2 | 5.4 | 4.1 | — | 3.1 |
| Ratio de liquidité réduite | 12.0 | 5.3 | 3.9 | — | 2.9 |
Flux de trésorerie
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flux de trésorerie libre | $-94M | $-82M | $-77M | — | $-132M |
Dernières actualités Actualités récentes mentionnant cette entreprise
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Détenteurs institutionnels (13F) 223 déclarants · $1.7B total · Au 30 juin 2026
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
Activité institutionnelle — Q2 2026 vs trimestre précédent
| Nouvelles positions | Positions clôturées | Augmenté | Diminué | Variation nette des actions |
|---|---|---|---|---|
| 48 (+14 vs T. préc.) | 23 (-7 vs T. préc.) | 90 (+26 vs T. préc.) | 42 (-13 vs T. préc.) | +30.7M |
Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Avoro Capital Advisors LLC | $162 683 327 | 23 888 888 | 9,61% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $160 413 963 | 23 555 648 | 9,48% | Actions |
| Vestal Point Capital, LP | $132 216 150 | 19 415 000 | 7,81% | Actions |
| GOLDMAN SACHS GROUP INC | $92 490 887 | 13 581 628 | 5,46% | Actions |
| RTW INVESTMENTS, LP | $92 345 357 | 13 560 258 | 5,46% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $84 979 232 | 12 478 595 | 5,02% | Actions |
| STATE STREET CORP | $77 783 275 | 11 421 920 | 4,59% | Actions |
| Siren, L.L.C. | $67 055 203 | 9 846 579 | 3,96% | Actions |
| Octagon Capital Advisors LP | $66 010 992 | 9 693 244 | 3,90% | Actions |
| VANGUARD GROUP INC | $63 339 386 | 11 516 252 | 3,74% | Actions |
| FMR LLC | $53 647 634 | 7 877 773 | 3,17% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $38 279 203 | 5 619 701 | 2,26% | Actions |
| Polar Capital Holdings Plc | $34 847 676 | 5 117 133 | 2,06% | Actions |
| MPM BIOIMPACT LLC | $30 645 000 | 4 500 000 | 1,81% | Actions |
| BAKER BROS. ADVISORS LP | $27 272 388 | 4 004 756 | 1,61% | Actions |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $26 460 262 | 3 885 501 | 1,56% | Actions |
| GordonMD Global Investments LP | $24 501 508 | 723 185 | 1,45% | Actions |
| Casdin Capital, LLC | $22 132 500 | 3 250 000 | 1,31% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $21 383 461 | 3 140 009 | 1,26% | Actions |
| ADAR1 Capital Management, LLC | $20 705 573 | 3 040 466 | 1,22% | Actions |
| Pictet Asset Management Holding SA | $18 868 474 | 2 770 701 | 1,11% | Actions |
| Aberdeen Group plc | $15 847 905 | 2 327 152 | 0,94% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $15 761 752 | 2 314 501 | 0,93% | Actions |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $15 322 500 | 2 250 000 | 0,91% | Actions |
| NORGES BANK | $15 210 816 | 2 233 600 | 0,90% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14 986 733 | 2 200 695 | 0,89% | Actions |
| MILLENNIUM MANAGEMENT LLC | $14 483 767 | 2 126 838 | 0,86% | Actions |
| ORBIMED ADVISORS LLC | $13 620 000 | 2 000 000 | 0,80% | Actions |
| RICE HALL JAMES & ASSOCIATES, LLC | $13 567 079 | 1 992 229 | 0,80% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $12 914 988 | 1 896 474 | 0,76% | Actions |
| B Group, Inc. | $12 261 786 | 1 800 556 | 0,72% | Actions |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | $12 099 000 | 3 700 000 | 0,71% | Actions |
| Affinity Asset Advisors, LLC | $11 917 500 | 1 750 000 | 0,70% | Actions |
| BARCLAYS PLC | $11 020 670 | 1 618 307 | 0,65% | Actions |
| HEIGHTS CAPITAL MANAGEMENT, INC | $10 215 000 | 1 500 000 | 0,60% | Actions |
| Seven Fleet Capital Management LP | $9 940 323 | 1 504 400 | 0,59% | Actions |
| Palo Alto Investors LP | $9 475 311 | 1 391 382 | 0,56% | Actions |
| Granahan Investment Management, LLC | $8 888 255 | 1 305 177 | 0,53% | Actions |
| BANK OF AMERICA CORP /DE/ | $8 103 178 | 1 189 894 | 0,48% | Actions |
| CITADEL ADVISORS LLC | $7 471 292 | 1 097 106 | 0,44% | Actions |
| Quantum Private Wealth, LLC | $5 529 903 | 812 027 | 0,33% | Actions |
| FIRST TRUST ADVISORS LP | $5 387 860 | 791 169 | 0,32% | Actions |
| Sands Capital Alternatives, LLC | $4 936 385 | 724 873 | 0,29% | Actions |
| D. E. Shaw & Co., Inc. | $4 871 997 | 715 418 | 0,29% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $4 358 638 | 640 035 | 0,26% | Actions |
| PANAGORA ASSET MANAGEMENT INC | $4 020 535 | 590 387 | 0,24% | Actions |
| AFFINITY WEALTH MANAGEMENT LLC | $3 928 062 | 576 808 | 0,23% | Actions |
| Squarepoint Ops LLC | $3 876 722 | 569 269 | 0,23% | Actions |
| ACUTA CAPITAL PARTNERS, LLC | $3 825 912 | 561 808 | 0,23% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3 799 980 | 558 000 | 0,22% | Option d'achat |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3 765 930 | 553 000 | 0,22% | Actions |
| DIADEMA PARTNERS LP | $3 559 035 | 522 619 | 0,21% | Actions |
| Woodline Partners LP | $3 499 169 | 513 828 | 0,21% | Actions |
| Holocene Advisors, LP | $3 473 100 | 510 000 | 0,21% | Actions |
| Ghisallo Capital Management LLC | $3 439 050 | 505 000 | 0,20% | Actions |
| Burkehill Global Management, LP | $3 405 000 | 500 000 | 0,20% | Actions |
| POLEN CAPITAL MANAGEMENT LLC | $3 331 581 | 489 219 | 0,20% | Actions |
| Trexquant Investment LP | $2 584 919 | 379 577 | 0,15% | Actions |
| Swiss National Bank | $2 512 890 | 369 000 | 0,15% | Actions |
| MOORE CAPITAL MANAGEMENT, LP | $2 440 527 | 358 374 | 0,14% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $2 371 603 | 348 253 | 0,14% | Actions |
| Jefferies Financial Group Inc. | $2 239 128 | 328 800 | 0,13% | Actions |
| RHUMBLINE ADVISERS | $2 042 820 | 299 975 | 0,12% | Actions |
| CITIGROUP INC | $1 995 800 | 293 069 | 0,12% | Actions |
| ALPS ADVISORS INC | $1 978 598 | 290 543 | 0,12% | Actions |
| Ensign Peak Advisors, Inc | $1 790 322 | 262 896 | 0,11% | Actions |
| Qube Research & Technologies Ltd | $1 767 910 | 259 605 | 0,10% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 702 500 | 250 000 | 0,10% | Actions |
| Bank of New York Mellon Corp | $1 660 258 | 243 797 | 0,10% | Actions |
| TWO SIGMA INVESTMENTS, LP | $1 598 416 | 234 716 | 0,09% | Actions |
| WELLS FARGO & COMPANY/MN | $1 489 565 | 218 732 | 0,09% | Actions |
| ORACLE INVESTMENT MANAGEMENT INC | $1 457 500 | 265 000 | 0,09% | Actions |
| BlackRock, Inc. | $1 411 468 | 207 264 | 0,08% | Actions |
| Monashee Investment Management LLC | $1 362 000 | 200 000 | 0,08% | Actions |
| Privium Fund Management B.V. | $1 354 509 | 198 900 | 0,08% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $1 345 506 | 197 578 | 0,08% | Actions |
| Chicago Partners Investment Group LLC | $1 296 283 | 222 347 | 0,08% | Actions |
| Balyasny Asset Management L.P. | $1 289 351 | 189 332 | 0,08% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 205 976 | 177 089 | 0,07% | Actions |
| MORGAN STANLEY | $1 204 212 | 176 830 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 107 130 | 247 680 | 0,07% | Actions |
| WEXFORD CAPITAL LP | $1 094 054 | 160 654 | 0,06% | Actions |
| JANE STREET GROUP, LLC | $1 054 045 | 154 779 | 0,06% | Actions |
| Rafferty Asset Management, LLC | $1 053 548 | 154 706 | 0,06% | Actions |
| Palumbo Wealth Management LLC | $1 015 869 | 149 173 | 0,06% | Actions |
| MetLife Investment Management, LLC | $959 161 | 140 846 | 0,06% | Actions |
| Vanguard Global Advisers, LLC | $911 321 | 133 821 | 0,05% | Actions |
| Persistent Asset Partners Ltd | $908 529 | 133 411 | 0,05% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $903 101 | 132 614 | 0,05% | Actions |
| Mariner, LLC | $793 923 | 116 582 | 0,05% | Actions |
| CITADEL ADVISORS LLC | $783 150 | 115 000 | 0,05% | Option d'achat |
| TWO SIGMA ADVISERS, LP | $767 696 | 139 581 | 0,05% | Actions |
| Aquatic Capital Management LLC | $736 896 | 108 208 | 0,04% | Actions |
| Engineers Gate Manager LP | $709 139 | 104 132 | 0,04% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $708 887 | 104 095 | 0,04% | Actions |
| XTX Topco Ltd | $689 138 | 101 195 | 0,04% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $669 736 | 98 346 | 0,04% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $663 294 | 97 400 | 0,04% | Option de vente |
| Invesco Ltd. | $650 055 | 95 456 | 0,04% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $612 091 | 136 933 | 0,04% | Actions |
Initiés de la société 11 initiés · 4 dirigeants · 7 administrateurs
| Dirigeant | Rôle | Dernière activité | Actions détenues | Achats 12m | Ventes 12m | Net 12m |
|---|---|---|---|---|---|---|
| Sean P. Nolan | Chief Executive Officer | 2 janvier 2024 A | 1 185 858 | 0 | 0 | $0 |
| Kamran Alam | Chief Financial Officer | 2 janvier 2024 A | 842 225 | 0 | 0 | $0 |
| Sukumar Nagendran | President and Head of R&D | 2 janvier 2024 A | 897 843 | 0 | 0 | $0 |
| Suyash Prasad | CMO and Head of R&D | 6 juillet 2022 S | 530 589 | 0 | 0 | $0 |
| Alison S Long | Administrateur | 1 novembre 2023 A | — | 0 | 0 | $0 |
| John A Stalfort III | Administrateur | 16 août 2023 G | 1 049 381 | 0 | 0 | $0 |
| Phillip B. Donenberg | Administrateur | 16 août 2023 P | 114 111 | 0 | 0 | $0 |
| Kathleen Reape | Administrateur | 22 juin 2023 A | — | 0 | 0 | $0 |
| Laura Sepp-Lorenzino | Administrateur | 22 juin 2023 A | — | 0 | 0 | $0 |
| Paul B Manning | Détenteur de 10% | 17 novembre 2023 P | 16 566 667 | 0 | 0 | $0 |
| R.A. Session II | Détenteur de 10% | 13 juillet 2023 S | 8 871 747 | 0 | 0 | $0 |
Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché
Activistes et détenteurs de 5%+ 4 participations
Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.
| Déclarant | Déposé | Participation | Statut | Objectif | Dépôt |
|---|---|---|---|---|---|
| Paul B Manning, The Paul B. Manning Revocable Trust dated May 10, 2000, The PBM 2023 Grantor Retained Annuity Trust, The PBM 2025 Grantor Retained Annuity Trust, BKB Growth Investments, LLC, BKB G2 Investments, LLC | 3 juin 2025 | 9,80% | Amendement | — | SEC |
| Paul B. Manning, The Paul B. Manning Revocable Trust dated May 10, 2000, The PBM 2023 Grantor Retained Annuity Trust, BKB Growth Investments, LLC, BKB G2 Investments, LLC ×3 dépôts | 21 août 2023 | — | Dépôt initial | — | SEC |
| Astellas Pharma Inc., Astellas US Holding, Inc., Astellas Gene Therapies, Inc. (f/k/a Audentes Therapeutics, Inc.) ×2 dépôts | 18 août 2023 | — | Dépôt initial | — | SEC |
| RA Session II, RA Session II, as Trustee of the Session 2020 Annuity Trust I, RA Session II, as Trustee of the Session 2020 Annuity Trust II | 5 octobre 2020 | — | Dépôt initial | Investissement passif | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Détention d'ETF Détenu par 44 ETFs
Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.
| Fonds | Poids | Unités | Au | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 1,02% | 282 348 NS | 31 mai 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,82% | 47 669 NS | 30 avril 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0,40% | 322 791 NS | 30 avril 2026 | N-PORT |
| FYC · First Trust Exchange-Traded AlphaDE… | 0,32% | 522 481 NS | 30 avril 2026 | N-PORT |
| ESSC · Strategy Shares | 0,18% | 7 298 NS | 30 avril 2026 | N-PORT |
| FYX · First Trust Exchange-Traded AlphaDE… | 0,08% | 154 894 NS | 30 avril 2026 | N-PORT |
| BIB · ProShares Trust | 0,08% | 10 128 NS | 31 mai 2026 | N-PORT |
| FAD · First Trust Exchange-Traded AlphaDE… | 0,06% | 48 717 NS | 30 avril 2026 | N-PORT |
| GINN · Goldman Sachs ETF Trust | 0,06% | 23 348 NS | 31 mai 2026 | N-PORT |
| RSSL · Global X Funds | 0,04% | 95 596 NS | 30 avril 2026 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0,04% | 64 980 NS | 31 mai 2026 | N-PORT |
| ITWO · ProShares Trust | 0,03% | 10 394 NS | 31 mai 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,03% | 1 069 955 NS | 31 mai 2026 | N-PORT |
| UWM · ProShares Trust | 0,02% | 8 129 NS | 31 mai 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,01% | 62 485 NS | 30 avril 2026 | N-PORT |
| URTY · ProShares Trust | 0,01% | 8 221 NS | 31 mai 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,01% | 8 504 NS | 31 mai 2026 | N-PORT |
| HDG · ProShares Trust | 0,01% | 206 NS | 31 mai 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0,01% | 92 844 NS | 31 mai 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0,00% | 78 390 NS | 30 avril 2026 | N-PORT |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 131 780 NS | 31 mai 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,00% | 4 760 NS | 30 avril 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0,00% | 3 045 NS | 30 avril 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0,00% | 5 870 NS | 30 avril 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0,00% | 10 179 NS | 30 avril 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | — | — | 15 juillet 2026 | Quotidien |
| VTI · VANGUARD INDEX FUNDS | — | — | 15 juillet 2026 | Quotidien |
| VFMO · VANGUARD WELLINGTON FUND | — | — | 30 juillet 2026 | Quotidien |
| VTWO · VANGUARD SCOTTSDALE FUNDS | — | — | 15 juillet 2026 | Quotidien |
| VTWG · VANGUARD SCOTTSDALE FUNDS | — | — | 15 juillet 2026 | Quotidien |
| VTHR · VANGUARD SCOTTSDALE FUNDS | — | — | 15 juillet 2026 | Quotidien |
| ITOT · iShares Trust | — | — | 5 août 2026 | Quotidien |
| IWV · iShares Trust | — | — | 18 août 2026 | Quotidien |
| IWO · iShares Trust | — | — | 18 août 2026 | Quotidien |
| IWM · iShares Trust | — | — | 18 août 2026 | Quotidien |
| IBB · iShares Trust | — | — | 18 août 2026 | Quotidien |
| TEXN · iShares Trust | — | — | 5 août 2026 | Quotidien |
| PRFZ · Invesco Exchange-Traded Fund Trust | — | — | 13 juillet 2026 | Quotidien |
| VHT · VANGUARD WORLD FUND | — | — | 20 juillet 2026 | Quotidien |
| ISCB · iShares Trust | — | — | 5 août 2026 | Quotidien |
| ISCG · iShares Trust | — | — | 5 août 2026 | Quotidien |
| IBRN · iShares Trust | — | — | 6 août 2026 | Quotidien |
| WSML · iShares Trust | — | — | 5 août 2026 | Quotidien |
| IBBQ · Invesco Exchange-Traded Fund Trust … | — | — | 20 juillet 2026 | Quotidien |