| EcoR1 Capital, LLC |
$531,906,345 |
7,880,094 |
24.81% |
株式数
|
| BlackRock, Inc. |
$124,473,310 |
1,844,049 |
5.81% |
株式数
|
| TANG CAPITAL MANAGEMENT LLC |
$89,834,333 |
1,330,879 |
4.19% |
株式数
|
| STATE STREET CORP |
$86,818,095 |
1,286,194 |
4.05% |
株式数
|
| VANGUARD GROUP INC |
$74,854,914 |
1,544,037 |
3.49% |
株式数
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$61,170,728 |
906,233 |
2.85% |
株式数
|
| Affinity Asset Advisors, LLC |
$55,762,358 |
826,109 |
2.60% |
株式数
|
| Sanofi |
$55,479,398 |
821,917 |
2.59% |
株式数
|
| MILLENNIUM MANAGEMENT LLC |
$54,493,830 |
807,316 |
2.54% |
株式数
|
| Woodline Partners LP |
$48,398,445 |
717,014 |
2.26% |
株式数
|
| 683 Capital Management, LLC |
$44,550,001 |
660,000 |
2.08% |
株式数
|
| GEODE CAPITAL MANAGEMENT, LLC |
$43,064,353 |
637,873 |
2.01% |
株式数
|
| Palo Alto Investors LP |
$40,735,508 |
603,489 |
1.90% |
株式数
|
| GOLDMAN SACHS GROUP INC |
$39,424,725 |
584,070 |
1.84% |
株式数
|
| First Light Asset Management, LLC |
$39,285,270 |
582,004 |
1.83% |
株式数
|
| D. E. Shaw & Co., Inc. |
$36,427,456 |
539,666 |
1.70% |
株式数
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$35,630,415 |
527,858 |
1.66% |
株式数
|
| Apis Capital Advisors, LLC |
$33,547,500 |
497,000 |
1.56% |
株式数
|
| Sofinnova Investments, Inc. |
$33,313,680 |
493,536 |
1.55% |
株式数
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$32,983,943 |
488,651 |
1.54% |
株式数
|
| Nuveen, LLC |
$28,394,821 |
420,664 |
1.32% |
株式数
|
| BANK OF AMERICA CORP /DE/ |
$28,202,310 |
417,812 |
1.32% |
株式数
|
| CITADEL ADVISORS LLC |
$26,620,178 |
394,373 |
1.24% |
株式数
|
| FEDERATED HERMES, INC. |
$26,437,523 |
391,667 |
1.23% |
株式数
|
| Squarepoint Ops LLC |
$21,900,105 |
324,446 |
1.02% |
株式数
|
| TWO SIGMA INVESTMENTS, LP |
$17,752,163 |
262,995 |
0.83% |
株式数
|
| FIRST TRUST ADVISORS LP |
$17,481,757 |
258,989 |
0.82% |
株式数
|
| MORGAN STANLEY |
$17,353,682 |
257,091 |
0.81% |
株式数
|
| TWO SIGMA ADVISERS, LP |
$17,292,816 |
356,700 |
0.81% |
株式数
|
| Coppell Advisory Solutions LLC |
$16,575,695 |
3,638 |
0.77% |
株式数
|
| FMR LLC |
$16,234,486 |
240,511 |
0.76% |
株式数
|
| Qube Research & Technologies Ltd |
$15,442,448 |
228,777 |
0.72% |
株式数
|
| HSBC HOLDINGS PLC |
$14,928,261 |
216,949 |
0.70% |
株式数
|
| Empowered Funds, LLC |
$13,905,675 |
206,010 |
0.65% |
株式数
|
| NORTHERN TRUST CORP |
$13,686,773 |
202,767 |
0.64% |
株式数
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$13,655,588 |
202,305 |
0.64% |
株式数
|
| Invesco Ltd. |
$13,638,781 |
202,056 |
0.64% |
株式数
|
| DIMENSIONAL FUND ADVISORS LP |
$12,517,471 |
185,444 |
0.58% |
株式数
|
| Greenhaven Road Investment Management, L.P. |
$11,546,483 |
171,059 |
0.54% |
株式数
|
| VICTORY CAPITAL MANAGEMENT INC |
$11,422,823 |
169,227 |
0.53% |
株式数
|
| MACKENZIE FINANCIAL CORP |
$10,191,083 |
150,979 |
0.48% |
株式数
|
| UBS Group AG |
$9,911,161 |
146,832 |
0.46% |
株式数
|
| VANGUARD FIDUCIARY TRUST CO |
$9,903,870 |
146,724 |
0.46% |
株式数
|
| Connor, Clark & Lunn Investment Management Ltd. |
$9,519,256 |
141,026 |
0.44% |
株式数
|
| Ensign Peak Advisors, Inc |
$7,228,980 |
107,096 |
0.34% |
株式数
|
| FRANKLIN RESOURCES INC |
$7,219,058 |
106,949 |
0.34% |
株式数
|
| CITIGROUP INC |
$6,690,195 |
99,114 |
0.31% |
株式数
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$6,327,000 |
93,732 |
0.30% |
株式数
|
| PRUDENTIAL FINANCIAL INC |
$5,800,410 |
85,932 |
0.27% |
株式数
|
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
$5,666,085 |
83,942 |
0.26% |
株式数
|
| JPMORGAN CHASE & CO |
$5,293,169 |
80,236 |
0.25% |
株式数
|
| Granahan Investment Management, LLC |
$5,127,435 |
75,962 |
0.24% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4,893,750 |
72,500 |
0.23% |
プットオプション
|
| Irenic Capital Management LP |
$4,755,173 |
70,447 |
0.22% |
株式数
|
| Eversept Partners, LP |
$4,723,852 |
69,983 |
0.22% |
株式数
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$4,207,680 |
62,336 |
0.20% |
株式数
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$4,168,328 |
61,753 |
0.19% |
株式数
|
| RENAISSANCE TECHNOLOGIES LLC |
$3,935,250 |
58,300 |
0.18% |
株式数
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$3,884,963 |
57,555 |
0.18% |
株式数
|
| Bank of New York Mellon Corp |
$3,807,069 |
56,401 |
0.18% |
株式数
|
| DEUTSCHE BANK AG\ |
$3,164,671 |
46,884 |
0.15% |
株式数
|
| AQR CAPITAL MANAGEMENT LLC |
$3,126,804 |
46,323 |
0.15% |
株式数
|
| MARSHALL WACE, LLP |
$2,957,985 |
43,822 |
0.14% |
株式数
|
| Bleakley Financial Group, LLC |
$2,886,368 |
42,761 |
0.13% |
株式数
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2,821,231 |
41,796 |
0.13% |
株式数
|
| WELLS FARGO & COMPANY/MN |
$2,815,253 |
41,707 |
0.13% |
株式数
|
| Camber Capital Management LP |
$2,775,000 |
125,000 |
0.13% |
株式数
|
| HighMark Wealth Management LLC |
$2,680,830 |
39,716 |
0.13% |
株式数
|
| CAPITAL FUND MANAGEMENT S.A. |
$2,642,085 |
39,142 |
0.12% |
株式数
|
| Trexquant Investment LP |
$2,389,770 |
35,404 |
0.11% |
株式数
|
| Atom Investors LP |
$2,289,398 |
33,917 |
0.11% |
株式数
|
| Swiss National Bank |
$2,139,750 |
31,700 |
0.10% |
株式数
|
| Voleon Capital Management LP |
$2,121,188 |
31,425 |
0.10% |
株式数
|
| Moody Aldrich Partners LLC |
$2,087,505 |
30,926 |
0.10% |
株式数
|
| Aquatic Capital Management LLC |
$2,079,878 |
30,813 |
0.10% |
株式数
|
| SummitTX Capital, L.P. |
$1,942,583 |
28,779 |
0.09% |
株式数
|
| ALLIANCEBERNSTEIN L.P. |
$1,820,197 |
32,820 |
0.08% |
株式数
|
| RHUMBLINE ADVISERS |
$1,778,349 |
26,346 |
0.08% |
株式数
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1,704,119 |
30,727 |
0.08% |
株式数
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,620,000 |
24,000 |
0.08% |
コールオプション
|
| BURNEY CO/ |
$1,522,598 |
22,557 |
0.07% |
株式数
|
| Rafferty Asset Management, LLC |
$1,475,820 |
21,864 |
0.07% |
株式数
|
| XTX Topco Ltd |
$1,445,243 |
21,411 |
0.07% |
株式数
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$1,417,500 |
21,000 |
0.07% |
株式数
|
| TUDOR INVESTMENT CORP ET AL |
$1,351,283 |
20,019 |
0.06% |
株式数
|
| CREDIT AGRICOLE S A |
$1,350,000 |
20,000 |
0.06% |
株式数
|
| MARTINGALE ASSET MANAGEMENT L P |
$1,346,085 |
19,942 |
0.06% |
株式数
|
| Creative Planning |
$1,267,178 |
18,773 |
0.06% |
株式数
|
| Y-Intercept (Hong Kong) Ltd |
$1,246,590 |
18,468 |
0.06% |
株式数
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1,189,958 |
17,629 |
0.06% |
株式数
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1,183,681 |
17,536 |
0.06% |
株式数
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$1,164,375 |
17,250 |
0.05% |
株式数
|
| Diametric Capital, LP |
$1,138,590 |
16,868 |
0.05% |
株式数
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$1,113,750 |
16,500 |
0.05% |
株式数
|
| Legal & General Group Plc |
$1,108,013 |
16,415 |
0.05% |
株式数
|
| Russell Investments Group, Ltd. |
$1,100,317 |
16,301 |
0.05% |
株式数
|
| TEMA ETFS LLC |
$1,093,709 |
22,560 |
0.05% |
株式数
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$1,071,225 |
15,870 |
0.05% |
株式数
|
| MILLENNIUM MANAGEMENT LLC |
$1,012,500 |
15,000 |
0.05% |
コールオプション
|
| Cresset Asset Management, LLC |
$972,810 |
14,412 |
0.05% |
株式数
|
| Vanguard Global Advisers, LLC |
$939,533 |
13,919 |
0.04% |
株式数
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$904,838 |
13,405 |
0.04% |
株式数
|
| Brevan Howard Capital Management LP |
$899,708 |
13,329 |
0.04% |
株式数
|
| SEI INVESTMENTS CO |
$888,368 |
13,161 |
0.04% |
株式数
|
| Orion Porfolio Solutions, LLC |
$801,630 |
11,876 |
0.04% |
株式数
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$783,676 |
11,610 |
0.04% |
株式数
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$781,747 |
11,639 |
0.04% |
株式数
|
| Clear Harbor Asset Management, LLC |
$779,625 |
11,550 |
0.04% |
株式数
|
| MetLife Investment Management, LLC |
$779,490 |
11,548 |
0.04% |
株式数
|
| VOYA INVESTMENT MANAGEMENT LLC |
$760,388 |
11,265 |
0.04% |
株式数
|
| PROFUND ADVISORS LLC |
$745,470 |
11,044 |
0.03% |
株式数
|
| CITADEL ADVISORS LLC |
$722,250 |
10,700 |
0.03% |
プットオプション
|
| Quantedge Capital Pte Ltd |
$702,000 |
10,400 |
0.03% |
株式数
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$699,705 |
10,366 |
0.03% |
株式数
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$654,075 |
9,690 |
0.03% |
株式数
|
| DCF Advisers, LLC |
$615,195 |
9,114 |
0.03% |
株式数
|
| AMERICAN CENTURY COMPANIES INC |
$599,197 |
8,877 |
0.03% |
株式数
|
| CIBC WORLD MARKET INC. |
$587,250 |
8,700 |
0.03% |
株式数
|
| CITADEL ADVISORS LLC |
$580,500 |
8,600 |
0.03% |
コールオプション
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$544,725 |
8,070 |
0.03% |
株式数
|
| BNP PARIBAS FINANCIAL MARKETS |
$537,772 |
7,967 |
0.03% |
株式数
|
| Verition Fund Management LLC |
$506,250 |
7,500 |
0.02% |
株式数
|
| Lombard Odier Asset Management (USA) Corp |
$499,500 |
7,400 |
0.02% |
株式数
|
| GLENMEDE TRUST CO NA |
$473,580 |
7,016 |
0.02% |
株式数
|
| Quantinno Capital Management LP |
$441,922 |
6,547 |
0.02% |
株式数
|
| Duncan Williams Asset Management, LLC |
$440,438 |
6,525 |
0.02% |
株式数
|
| Gotham Asset Management, LLC |
$424,710 |
6,292 |
0.02% |
株式数
|
| Vinva Investment Management Ltd |
$420,234 |
4,383 |
0.02% |
株式数
|
| JANUS HENDERSON GROUP PLC |
$413,879 |
7,464 |
0.02% |
株式数
|
| Virtus Investment Advisers, LLC |
$393,863 |
5,835 |
0.02% |
株式数
|
| Police & Firemen's Retirement System of New Jersey |
$393,390 |
5,828 |
0.02% |
株式数
|
| Savant Capital, LLC |
$387,156 |
5,736 |
0.02% |
株式数
|
| Ascent Group, LLC |
$377,865 |
5,598 |
0.02% |
株式数
|
| FMB WEALTH MANAGEMENT |
$377,460 |
5,592 |
0.02% |
株式数
|
| AlphaQuest LLC |
$376,253 |
7,761 |
0.02% |
株式数
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$373,005 |
5,526 |
0.02% |
株式数
|
| INTECH INVESTMENT MANAGEMENT LLC |
$364,298 |
5,397 |
0.02% |
株式数
|
| ENVESTNET ASSET MANAGEMENT INC |
$359,640 |
5,328 |
0.02% |
株式数
|
| Hillsdale Investment Management Inc. |
$347,625 |
5,150 |
0.02% |
株式数
|
| State of New Jersey Common Pension Fund D |
$345,128 |
5,113 |
0.02% |
株式数
|
| Nebula Research & Development LLC |
$344,833 |
15,533 |
0.02% |
株式数
|
| BARCLAYS PLC |
$344,723 |
5,107 |
0.02% |
株式数
|
| Ancora Advisors LLC |
$337,500 |
5,000 |
0.02% |
株式数
|
| Marex Group Ltd |
$334,935 |
4,962 |
0.02% |
株式数
|
| Susquehanna Portfolio Strategies, LLC |
$329,535 |
4,882 |
0.02% |
株式数
|
| China Universal Asset Management Co., Ltd. |
$312,593 |
4,631 |
0.01% |
株式数
|
| Latash Investments, LLC |
$296,528 |
4,393 |
0.01% |
株式数
|
| ARIZONA STATE RETIREMENT SYSTEM |
$294,503 |
4,363 |
0.01% |
株式数
|
| Allen Capital Group, LLC |
$272,633 |
4,039 |
0.01% |
株式数
|
| Moran Wealth Management, LLC |
$268,718 |
3,981 |
0.01% |
株式数
|
| Mitsubishi UFJ Trust & Banking Corp |
$261,360 |
3,872 |
0.01% |
株式数
|
| ROYAL BANK OF CANADA |
$252,000 |
3,740 |
0.01% |
株式数
|
| ADAR1 Capital Management, LLC |
$249,615 |
3,698 |
0.01% |
株式数
|
| Swiss Life Asset Management Ltd |
$244,418 |
3,621 |
0.01% |
株式数
|
| Vanguard Investments Australia, Ltd. |
$241,313 |
3,575 |
0.01% |
株式数
|
| nVerses Capital, LLC |
$240,097 |
3,557 |
0.01% |
株式数
|
| ProShare Advisors LLC |
$239,221 |
3,544 |
0.01% |
株式数
|
| Verdad Advisers, LP |
$236,115 |
3,498 |
0.01% |
株式数
|
| MANGROVE PARTNERS IM, LLC |
$234,563 |
3,475 |
0.01% |
株式数
|
| JANE STREET GROUP, LLC |
$209,250 |
3,100 |
0.01% |
コールオプション
|
| E Fund Management Co., Ltd. |
$208,103 |
3,083 |
0.01% |
株式数
|
| Kestra Advisory Services, LLC |
$206,955 |
3,066 |
0.01% |
株式数
|
| KLP KAPITALFORVALTNING AS |
$202,500 |
3,000 |
0.01% |
株式数
|
| Rangeley Capital, LLC |
$202,500 |
3,000 |
0.01% |
株式数
|
| State of Wyoming |
$158,422 |
2,347 |
0.01% |
株式数
|
| OSAIC HOLDINGS, INC. |
$146,948 |
2,177 |
0.01% |
株式数
|
| GROUP ONE TRADING LLC |
$139,995 |
2,074 |
0.01% |
株式数
|
| Ameritas Investment Partners, Inc. |
$121,028 |
1,793 |
0.01% |
株式数
|
| Larson Financial Group LLC |
$109,620 |
1,624 |
0.01% |
株式数
|
| US BANCORP \DE\ |
$107,663 |
1,595 |
0.01% |
株式数
|
| Mirae Asset Global Investments Co., Ltd. |
$87,818 |
1,301 |
0.00% |
株式数
|
| SIMPLEX TRADING, LLC |
$85,522 |
1,267 |
0.00% |
株式数
|
| Spire Wealth Management |
$81,000 |
1,200 |
0.00% |
株式数
|
| Tower Research Capital LLC (TRC) |
$65,475 |
970 |
0.00% |
株式数
|
| CWM, LLC |
$56,292 |
1,015 |
0.00% |
株式数
|
| Smartleaf Asset Management LLC |
$55,415 |
840 |
0.00% |
株式数
|
| NISA INVESTMENT ADVISORS, LLC |
$41,175 |
610 |
0.00% |
株式数
|
| GF FUND MANAGEMENT CO. LTD. |
$38,880 |
576 |
0.00% |
株式数
|
| Persistent Asset Partners Ltd |
$38,813 |
575 |
0.00% |
株式数
|
| GAMMA Investing LLC |
$30,173 |
447 |
0.00% |
株式数
|
| Farther Finance Advisors, LLC |
$26,620 |
395 |
0.00% |
株式数
|
| SIGNATUREFD, LLC |
$23,963 |
355 |
0.00% |
株式数
|
| Versant Capital Management, Inc |
$22,818 |
454 |
0.00% |
株式数
|
| Pinnacle Wealth Planning Services, Inc. |
$22,545 |
334 |
0.00% |
株式数
|
| Caitong International Asset Management Co., Ltd |
$19,508 |
289 |
0.00% |
株式数
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$16,672 |
247 |
0.00% |
株式数
|
| Silver Grove Financial Group, Inc. |
$13,838 |
205 |
0.00% |
株式数
|
| Arax Advisory Partners |
$11,846 |
176 |
0.00% |
株式数
|
| Quantbot Technologies LP |
$11,813 |
175 |
0.00% |
株式数
|
| ROTHSCHILD INVESTMENT LLC |
$11,138 |
165 |
0.00% |
株式数
|
| Rockefeller Capital Management L.P. |
$10,328 |
153 |
0.00% |
株式数
|
| Allworth Financial LP |
$10,125 |
150 |
0.00% |
株式数
|
| PNC Financial Services Group, Inc. |
$7,020 |
104 |
0.00% |
株式数
|
| Physician Wealth Advisors, Inc. |
$5,738 |
85 |
0.00% |
株式数
|
| Sterling Capital Management LLC |
$4,658 |
69 |
0.00% |
株式数
|
| SG Americas Securities, LLC |
$4,504 |
66,730 |
0.00% |
株式数
|
| EverSource Wealth Advisors, LLC |
$4,389 |
65 |
0.00% |
株式数
|
| Parallel Advisors, LLC |
$3,713 |
55 |
0.00% |
株式数
|
| HOLLENCREST CAPITAL MANAGEMENT |
$3,375 |
50 |
0.00% |
株式数
|
| Optiver Holding B.V. |
$3,038 |
45 |
0.00% |
株式数
|
| Steward Partners Investment Advisory, LLC |
$2,903 |
43 |
0.00% |
株式数
|
| Decker Retirement Planning Inc. |
$2,903 |
43 |
0.00% |
株式数
|
| MassMutual Private Wealth & Trust, FSB |
$2,498 |
37 |
0.00% |
株式数
|
| Global Retirement Partners, LLC |
$2,430 |
36 |
0.00% |
株式数
|
| ASSETMARK, INC |
$2,430 |
36 |
0.00% |
株式数
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$2,186 |
32,374 |
0.00% |
株式数
|
| Quarry LP |
$1,958 |
29 |
0.00% |
株式数
|
| Parkside Financial Bank & Trust |
$1,688 |
25 |
0.00% |
株式数
|
| Blue Trust, Inc. |
$1,283 |
19 |
0.00% |
株式数
|
| Essential Partners LLC |
$1,148 |
17 |
0.00% |
株式数
|
| Stone House Investment Management, LLC |
$810 |
12 |
0.00% |
株式数
|
| ACADIAN ASSET MANAGEMENT LLC |
$787 |
11,697 |
0.00% |
株式数
|
| NATIONAL BANK OF CANADA /FI/ |
$540 |
8 |
0.00% |
株式数
|
| FIFTH THIRD BANCORP |
$405 |
6 |
0.00% |
株式数
|
| True Wealth Design, LLC |
$270 |
4 |
0.00% |
株式数
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$247 |
3,652 |
0.00% |
株式数
|
| Lindbrook Capital, LLC |
$223 |
12 |
0.00% |
株式数
|
| Sunbelt Securities, Inc. |
$222 |
4 |
0.00% |
株式数
|
| CANADA LIFE ASSURANCE Co |
$114 |
1,698 |
0.00% |
株式数
|
| BESSEMER GROUP INC |
$96 |
1,428 |
0.00% |
株式数
|
| TFC Financial Management, Inc. |
$68 |
1 |
0.00% |
株式数
|
| IFP Advisors, Inc |
$68 |
1 |
0.00% |
株式数
|
| CIBC Private Wealth Group LLC |
$31 |
1 |
0.00% |
株式数
|
| Pacer Advisors, Inc. |
$25 |
365 |
0.00% |
株式数
|
| Covestor Ltd |
$1 |
9 |
0.00% |
株式数
|
| Avion Wealth |
$0 |
7 |
0.00% |
株式数
|