| BAKER BROS. ADVISORS LP |
$776,051,487 |
19,919,186 |
34.06% |
주식
|
| BlackRock, Inc. |
$161,113,431 |
4,135,355 |
7.07% |
주식
|
| STATE STREET CORP |
$94,260,486 |
2,419,417 |
4.14% |
주식
|
| GOLDMAN SACHS GROUP INC |
$90,231,905 |
2,316,014 |
3.96% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$70,308,463 |
1,804,632 |
3.09% |
주식
|
| BRAIDWELL LP |
$69,633,909 |
1,787,318 |
3.06% |
주식
|
| VANGUARD GROUP INC |
$64,682,524 |
2,313,395 |
2.84% |
주식
|
| RTW INVESTMENTS, LP |
$57,969,909 |
1,487,934 |
2.54% |
주식
|
| Boxer Capital Management, LLC |
$57,567,296 |
1,477,600 |
2.53% |
주식
|
| TCG Crossover Management, LLC |
$56,318,161 |
1,445,538 |
2.47% |
주식
|
| JANUS HENDERSON GROUP PLC |
$50,539,675 |
1,325,457 |
2.22% |
주식
|
| ICONIQ Capital, LLC |
$49,345,294 |
1,266,563 |
2.17% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$41,420,974 |
1,062,955 |
1.82% |
주식
|
| Ikarian Capital, LLC |
$41,287,080 |
1,059,730 |
1.81% |
주식
|
| Artisan Partners Limited Partnership |
$37,714,722 |
968,037 |
1.66% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$30,919,164 |
793,613 |
1.36% |
주식
|
| Board of Trustees of The Leland Stanford Junior University |
$26,951,242 |
691,767 |
1.18% |
주식
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$21,282,134 |
546,256 |
0.93% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20,758,628 |
532,819 |
0.91% |
주식
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$19,480,000 |
500,000 |
0.85% |
주식
|
| Squadron Capital Management LLC |
$19,480,000 |
500,000 |
0.85% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$18,428,119 |
473,001 |
0.81% |
주식
|
| MORGAN STANLEY |
$16,948,748 |
435,029 |
0.74% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$14,949,303 |
383,709 |
0.66% |
주식
|
| BOONE CAPITAL MANAGEMENT LLC |
$14,727,270 |
378,010 |
0.65% |
주식
|
| NORTHERN TRUST CORP |
$14,291,579 |
366,827 |
0.63% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$13,949,862 |
358,056 |
0.61% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$12,174,462 |
312,595 |
0.53% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$11,375,112 |
291,969 |
0.50% |
주식
|
| FMR LLC |
$10,791,298 |
276,984 |
0.47% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$10,344,815 |
265,524 |
0.45% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$9,346,504 |
239,900 |
0.41% |
콜 옵션
|
| DIADEMA PARTNERS LP |
$8,497,838 |
218,117 |
0.37% |
주식
|
| Ikarian Capital, LLC |
$8,481,592 |
217,700 |
0.37% |
콜 옵션
|
| D. E. Shaw & Co., Inc. |
$8,232,248 |
211,300 |
0.36% |
주식
|
| DIADEMA PARTNERS LP |
$7,663,432 |
196,700 |
0.34% |
콜 옵션
|
| TD Asset Management Inc |
$7,563,383 |
194,132 |
0.33% |
주식
|
| PFM Health Sciences, LP |
$7,531,552 |
193,315 |
0.33% |
주식
|
| UBS Group AG |
$7,406,880 |
190,115 |
0.33% |
주식
|
| RENAISSANCE TECHNOLOGIES LLC |
$7,371,232 |
189,200 |
0.32% |
주식
|
| ALGERT GLOBAL LLC |
$7,265,105 |
186,476 |
0.32% |
주식
|
| Nuveen, LLC |
$6,807,481 |
174,730 |
0.30% |
주식
|
| CITADEL ADVISORS LLC |
$6,137,135 |
157,524 |
0.27% |
주식
|
| Squarepoint Ops LLC |
$5,886,778 |
151,098 |
0.26% |
주식
|
| Ghisallo Capital Management LLC |
$5,844,000 |
150,000 |
0.26% |
주식
|
| DIADEMA PARTNERS LP |
$5,723,224 |
146,900 |
0.25% |
풋 옵션
|
| Bruce & Co., Inc. |
$5,649,200 |
145,000 |
0.25% |
주식
|
| FEDERATED HERMES, INC. |
$5,612,772 |
144,065 |
0.25% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$4,694,485 |
120,495 |
0.21% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$4,444,907 |
114,089 |
0.20% |
주식
|
| Bank of New York Mellon Corp |
$4,360,988 |
111,935 |
0.19% |
주식
|
| CITADEL ADVISORS LLC |
$4,266,120 |
109,500 |
0.19% |
콜 옵션
|
| WELLS FARGO & COMPANY/MN |
$3,928,921 |
100,845 |
0.17% |
주식
|
| CITADEL ADVISORS LLC |
$3,884,312 |
99,700 |
0.17% |
풋 옵션
|
| Harvest Investment Services, LLC |
$3,812,080 |
97,846 |
0.17% |
주식
|
| Point72 Asset Management, L.P. |
$3,802,379 |
97,597 |
0.17% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$3,775,146 |
96,898 |
0.17% |
주식
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$3,662,824 |
94,015 |
0.16% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3,631,072 |
93,200 |
0.16% |
풋 옵션
|
| VICTORY CAPITAL MANAGEMENT INC |
$3,491,206 |
89,610 |
0.15% |
주식
|
| RIA Advisory Group LLC |
$3,398,442 |
87,229 |
0.15% |
주식
|
| JPMORGAN CHASE & CO |
$3,383,429 |
87,824 |
0.15% |
주식
|
| Caption Management, LLC |
$3,186,928 |
81,800 |
0.14% |
콜 옵션
|
| SPHERA FUNDS MANAGEMENT LTD. |
$3,186,772 |
81,796 |
0.14% |
주식
|
| Atom Investors LP |
$2,993,803 |
76,843 |
0.13% |
주식
|
| STEMPOINT CAPITAL LP |
$2,955,973 |
75,872 |
0.13% |
주식
|
| Invesco Ltd. |
$2,901,156 |
74,465 |
0.13% |
주식
|
| TWO SIGMA ADVISERS, LP |
$2,882,676 |
103,100 |
0.13% |
주식
|
| Qube Research & Technologies Ltd |
$2,882,183 |
73,978 |
0.13% |
주식
|
| FRANKLIN RESOURCES INC |
$2,769,900 |
71,096 |
0.12% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$2,639,812 |
67,757 |
0.12% |
주식
|
| ExodusPoint Capital Management, LP |
$2,636,501 |
67,672 |
0.12% |
주식
|
| Pictet Asset Management Holding SA |
$2,497,778 |
66,015 |
0.11% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2,446,688 |
62,800 |
0.11% |
콜 옵션
|
| CITIGROUP INC |
$2,430,325 |
62,380 |
0.11% |
주식
|
| Swiss National Bank |
$2,415,520 |
62,000 |
0.11% |
주식
|
| Persistent Asset Partners Ltd |
$2,183,786 |
56,052 |
0.10% |
주식
|
| Emerald Investment Advisers, LLC |
$2,167,384 |
55,631 |
0.10% |
주식
|
| DEUTSCHE BANK AG\ |
$2,156,320 |
55,347 |
0.09% |
주식
|
| Jain Global LLC |
$2,151,098 |
55,213 |
0.09% |
주식
|
| Resolute Capital Asset Partners LLC |
$2,001,960 |
51,385 |
0.09% |
주식
|
| RHUMBLINE ADVISERS |
$1,955,700 |
50,198 |
0.09% |
주식
|
| Informed Momentum Co LLC |
$1,894,157 |
48,618 |
0.08% |
주식
|
| Balyasny Asset Management L.P. |
$1,809,536 |
46,446 |
0.08% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$1,800,026 |
47,220 |
0.08% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1,717,123 |
44,074 |
0.08% |
주식
|
| JANE STREET GROUP, LLC |
$1,706,448 |
43,800 |
0.07% |
콜 옵션
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1,667,788 |
43,751 |
0.07% |
주식
|
| Rafferty Asset Management, LLC |
$1,619,294 |
41,563 |
0.07% |
주식
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1,585,672 |
40,700 |
0.07% |
주식
|
| HighVista Strategies LLC |
$1,581,387 |
40,590 |
0.07% |
주식
|
| POLEN CAPITAL MANAGEMENT LLC |
$1,381,872 |
35,469 |
0.06% |
주식
|
| Russell Investments Group, Ltd. |
$1,358,566 |
34,870 |
0.06% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1,335,977 |
34,291 |
0.06% |
주식
|
| PANAGORA ASSET MANAGEMENT INC |
$1,332,042 |
34,190 |
0.06% |
주식
|
| Caption Management, LLC |
$1,297,368 |
33,300 |
0.06% |
풋 옵션
|
| MILLENNIUM MANAGEMENT LLC |
$1,213,760 |
31,154 |
0.05% |
주식
|
| Vanguard Global Advisers, LLC |
$1,192,955 |
30,620 |
0.05% |
주식
|
| Trexquant Investment LP |
$1,171,332 |
30,065 |
0.05% |
주식
|
| Engineers Gate Manager LP |
$1,150,762 |
29,537 |
0.05% |
주식
|
| Legal & General Group Plc |
$1,141,880 |
29,309 |
0.05% |
주식
|
| XTX Topco Ltd |
$1,140,009 |
29,261 |
0.05% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$986,390 |
25,318 |
0.04% |
주식
|
| Aries Wealth Management |
$974,000 |
25,000 |
0.04% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$947,079 |
24,309 |
0.04% |
주식
|
| State of Wyoming |
$905,586 |
23,244 |
0.04% |
주식
|
| MetLife Investment Management, LLC |
$895,418 |
22,983 |
0.04% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$888,476 |
22,956 |
0.04% |
주식
|
| BARCLAYS PLC |
$819,717 |
21,040 |
0.04% |
주식
|
| PROFUND ADVISORS LLC |
$819,524 |
21,035 |
0.04% |
주식
|
| Y-Intercept (Hong Kong) Ltd |
$723,137 |
18,561 |
0.03% |
주식
|
| OPTIMIZE FINANCIAL INC. |
$692,202 |
17,767 |
0.03% |
주식
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$682,774 |
17,525 |
0.03% |
주식
|
| Artia Global Partners LP |
$663,060 |
17,019 |
0.03% |
주식
|
| SEI INVESTMENTS CO |
$620,547 |
15,928 |
0.03% |
주식
|
| Vanguard Personalized Indexing Management, LLC |
$606,296 |
15,562 |
0.03% |
주식
|
| Palumbo Wealth Management LLC |
$605,478 |
15,541 |
0.03% |
주식
|
| SIMPLEX TRADING, LLC |
$569,205 |
14,610 |
0.02% |
주식
|
| Brevan Howard Capital Management LP |
$546,336 |
14,023 |
0.02% |
주식
|
| Edgestream Partners, L.P. |
$527,207 |
13,532 |
0.02% |
주식
|
| Continuum Advisory, LLC |
$520,194 |
13,352 |
0.02% |
주식
|
| FRED ALGER MANAGEMENT, LLC |
$501,220 |
12,865 |
0.02% |
주식
|
| LPL Financial LLC |
$491,753 |
12,622 |
0.02% |
주식
|
| Cerity Partners LLC |
$488,871 |
12,548 |
0.02% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$478,702 |
12,287 |
0.02% |
주식
|
| Campbell & CO Investment Adviser LLC |
$476,442 |
12,229 |
0.02% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$460,624 |
11,823 |
0.02% |
주식
|
| Quantinno Capital Management LP |
$453,066 |
11,629 |
0.02% |
주식
|
| Creative Planning |
$445,430 |
11,433 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$422,755 |
10,851 |
0.02% |
주식
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$404,989 |
10,395 |
0.02% |
주식
|
| State of New Jersey Common Pension Fund D |
$389,561 |
9,999 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$388,003 |
9,959 |
0.02% |
주식
|
| Virtus Investment Advisers, LLC |
$374,250 |
9,606 |
0.02% |
주식
|
| STIFEL FINANCIAL CORP |
$369,193 |
9,476 |
0.02% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$360,926 |
9,264 |
0.02% |
주식
|
| Skopos Labs, Inc. |
$346,473 |
9,089 |
0.02% |
주식
|
| Persistent Asset Partners Ltd |
$344,930 |
372 |
0.02% |
풋 옵션
|
| ARIZONA STATE RETIREMENT SYSTEM |
$332,446 |
8,533 |
0.01% |
주식
|
| ALLSTATE CORP |
$327,615 |
8,409 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$319,472 |
8,200 |
0.01% |
주식
|
| NORGES BANK |
$298,083 |
7,651 |
0.01% |
주식
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$287,914 |
7,390 |
0.01% |
주식
|
| J. Goldman & Co LP |
$284,759 |
7,309 |
0.01% |
주식
|
| ProShare Advisors LLC |
$280,784 |
7,207 |
0.01% |
주식
|
| AMERICAN CENTURY COMPANIES INC |
$255,032 |
6,546 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$249,344 |
6,400 |
0.01% |
주식
|
| MANGROVE PARTNERS IM, LLC |
$239,565 |
6,149 |
0.01% |
주식
|
| PSP Research LLC |
$233,760 |
6,000 |
0.01% |
주식
|
| HSBC HOLDINGS PLC |
$232,415 |
6,004 |
0.01% |
주식
|
| E Fund Management Co., Ltd. |
$228,345 |
5,861 |
0.01% |
주식
|
| Persistent Asset Partners Ltd |
$215,919 |
502 |
0.01% |
콜 옵션
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$206,605 |
5,303 |
0.01% |
주식
|
| VARCOV Co. |
$204,696 |
5,254 |
0.01% |
주식
|
| GROUP ONE TRADING LLC |
$153,580 |
3,942 |
0.01% |
주식
|
| Mitsubishi UFJ Trust & Banking Corp |
$145,827 |
3,743 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$139,204 |
3,573 |
0.01% |
주식
|
| CWM, LLC |
$131,476 |
3,449 |
0.01% |
주식
|
| ROYAL BANK OF CANADA |
$131,000 |
3,362 |
0.01% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$126,567 |
3,248,611 |
0.01% |
주식
|
| Tower Research Capital LLC (TRC) |
$115,360 |
2,961 |
0.01% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$113,023 |
2,901 |
0.00% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$109,049 |
2,799 |
0.00% |
주식
|
| Bayforest Capital Ltd |
$105,932 |
2,719 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$96,582 |
2,479 |
0.00% |
주식
|
| T. Rowe Price Investment Management, Inc. |
$57,546 |
1,477,033 |
0.00% |
주식
|
| STRS OHIO |
$50,648 |
1,300 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$50,414 |
1,294 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$47,414 |
1,217 |
0.00% |
주식
|
| Point72 (DIFC) Ltd |
$41,183 |
2,516 |
0.00% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$39,622 |
1,017 |
0.00% |
주식
|
| Activest Wealth Management |
$38,999 |
1,001 |
0.00% |
주식
|
| GAMMA Investing LLC |
$34,752 |
892 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$27,876 |
730 |
0.00% |
주식
|
| FIFTH THIRD BANCORP |
$27,496 |
706 |
0.00% |
주식
|
| V-Square Quantitative Management LLC |
$26,960 |
692 |
0.00% |
주식
|
| Larson Financial Group LLC |
$25,675 |
659 |
0.00% |
주식
|
| OSAIC HOLDINGS, INC. |
$24,895 |
639 |
0.00% |
주식
|
| Spire Wealth Management |
$24,662 |
633 |
0.00% |
주식
|
| Physician Wealth Advisors, Inc. |
$23,766 |
610 |
0.00% |
주식
|
| Ameritas Advisory Services, LLC |
$20,727 |
532 |
0.00% |
주식
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$17,610 |
452 |
0.00% |
주식
|
| Allworth Financial LP |
$15,000 |
385 |
0.00% |
주식
|
| TOKIO MARINE ASSET MANAGEMENT CO LTD |
$13,285 |
341 |
0.00% |
주식
|
| Accent Capital Management, LLC |
$8,844 |
227 |
0.00% |
주식
|
| Arax Advisory Partners |
$7,247 |
186 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$5,922 |
152 |
0.00% |
주식
|
| AlphaQuest LLC |
$5,872 |
210 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$5,376 |
138 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$2,961 |
76 |
0.00% |
주식
|
| Bare Financial Services, Inc |
$1,714 |
44 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$1,636 |
42 |
0.00% |
주식
|
| FINANCIAL CONSULATE, INC |
$1,169 |
30 |
0.00% |
주식
|
| GSA CAPITAL PARTNERS LLP |
$1,072 |
27,525 |
0.00% |
주식
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$990 |
25,419 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$818 |
21 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$781 |
20,057 |
0.00% |
주식
|
| Parkside Financial Bank & Trust |
$585 |
15 |
0.00% |
주식
|
| True Wealth Design, LLC |
$507 |
13 |
0.00% |
주식
|
| Quarry LP |
$468 |
12 |
0.00% |
주식
|
| Keating Financial Advisory Services, Inc. |
$390 |
10 |
0.00% |
주식
|
| Axiom Investment Management LLC |
$390 |
10 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$273 |
7 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$253 |
6 |
0.00% |
주식
|
| IFP Advisors, Inc |
$234 |
6 |
0.00% |
주식
|
| Essential Partners LLC |
$195 |
5 |
0.00% |
주식
|
| CANADA LIFE ASSURANCE Co |
$192 |
4,951 |
0.00% |
주식
|
| Stone House Investment Management, LLC |
$156 |
4 |
0.00% |
주식
|
| Hughes Financial Services, LLC |
$78 |
2 |
0.00% |
주식
|
| ACADIAN ASSET MANAGEMENT LLC |
$54 |
1,415 |
0.00% |
주식
|
| KBC Group NV |
$40 |
1,014 |
0.00% |
주식
|
| Pacer Advisors, Inc. |
$27 |
694 |
0.00% |
주식
|
| Avion Wealth |
$13 |
352 |
0.00% |
주식
|
| Covestor Ltd |
$1 |
17 |
0.00% |
주식
|