ACAD ACADIA Pharmaceuticals Inc. - Common Stock

NASDAQ · Biotechnology · 在 SEC EDGAR 上查看 ↗
$30.66
价格 · 八月 19, 2026
截至...的财报数据 八月 5, 2026

关于 ACADIA Pharmaceuticals Inc. - Common Stock 公司概况(来自维基百科)

Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, California.

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Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, California.

Product development

Nuplazid, a drug developed by Acadia in the late 1990s, "was designed to stimulate a subset of the brain’s serotonin receptors, or the proteins that govern memory, cognition and learning." On April 29, 2016, the FDA approved Acadia's drug, Nuplazid, for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. Nuplazid is the trade name for Acadia's proprietary molecule, pimavanserin, a selective serotonin inverse agonist preferentially targeting 5-HT2a receptors. Acadia had partnered with Biovail in the late-stage clinical testing of the drug, which showed trial failures as of 2009.

Acadia is running multiple Phase 2 and Phase 3 trials with pimavanserin in several central nervous system conditions: dementia-related psychosis, major depressive disorder, schizophrenia inadequate response, and schizophrenia negative symptoms.

As of 1997, Acadia was among several companies that licensed compounds from Genzyme's small-molecule compound library.

In 2023, the FDA approved trofinetide (marketed as Daybue) for use in Rett syndrome.

History

Acadia started in 1993 as Receptor Technologies, based in Winooski, Vermont. In 1997, the company relocated all operations and management from Vermont to San Diego, California, as a strategic move to garner partnerships with other biotechnology companies. However, the company also had an office in Denmark, in which it received a crucial part of its early investments from BankInvest, under managing director Florian Schönharting, Kommunernes Pensionsforsikring A/S and Dansk Kapitalanlæg Aktieselskab as well as private investor Lars Christiansen. At the time, the company had fifty employees, fourteen of whom were in the Denmark office. The focus of the company in its early years was on genetic screens for receptors, aiming to accelerate early stage drug discovery.

The company planned to conduct an initial public offering (IPO) consisting of 31.6% of the company in 2001, with the intention of raising US$64 million and listing on the NASDAQ exchange under the symbol ACAD. At the time, Acadia and Allergan were collaborating on development of a treatment for glaucoma, and Allergan would retain a 6.3% ownership stake in Acadia after the IPO. However, the company's IPO, which ultimately took place in May 2004, did not fare as well as expected and netted only US$35 million. At the time, the company had five drugs in development and was running two in human trials. The company had a subsequent round of stock offering in May 2007 which raised US$102 million.

In September 2020, Acadia Pharmaceuticals acquired clinical-stage biotechnology company CerSci Therapeutics.

Corporate governance

In 2001, the company's chief executive officer at the time, Leonard R. Borrmann, left Acadia to lead Maret Pharmaceuticals. He was succeeded by Uli Hacksell, who left Acadia to lead Cerecor at the beginning of 2016.

== References ==

来源:维基百科 (英语), CC BY-SA 4.0 · 在维基百科上查看 ↗

Wikidata ↗

ACAD 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围

价格
$30.66
市值
$5.22B
P/E (TTM)
13.3
每股收益 (TTM)
$2.30
营收 (TTM)
$1.07B
股息收益率
ROE
38.1%
负债/权益
52周区间
$20 – $31

ACAD 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图

10年表现 收入、净利润、利润率和每股收益趋势

营收与净利润 $1.07B
10-point trend, +6082.6%
2016-12-31 2025-12-31
EPS $2.30
6-point trend, +228.5%
2020-12-31 2025-12-31
自由现金流 $105M
10-point trend, +149.6%
2016-12-31 2025-12-31
利润率 36.5%
8-point trend, +14.6%
2016-12-31 2023-12-31

估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜?

指标
5年趋势
ACAD
同行中位数
P/E (TTM)
5-point trend, +152.2%
13.3
13.2
P/S (TTM) (市销率 (TTM))
5-point trend, -45.3%
4.9
55.3
P/B (市净率)
5-point trend, -46.7%
4.3
3.5
Price / FCF (股价/自由现金流)
5-point trend, +246.0%
49.7

盈利能力 毛利率、营业利润率和净利率;股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)

指标
5年趋势
ACAD
同行中位数
Operating Margin (营业利润率)
5-point trend, +127.8%
9.8%
Net Profit Margin (净利润率)
5-point trend, +205.2%
36.5%
-151.2%
ROA
5-point trend, +225.5%
28.4%
-42.2%
ROE
5-point trend, +225.9%
38.1%
-52.8%
ROIC
5-point trend, +176.1%
24.0%

财务健康 债务、流动性、偿付能力 — 资产负债表强度

指标
5年趋势
ACAD
同行中位数
Current Ratio (流动比率)
5-point trend, -40.4%
3.8
10.3
Quick Ratio (速动比率)
5-point trend, -51.0%
1.1

成长 营收、每股收益 (EPS) 和净利润增长:同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)

指标
5年趋势
ACAD
同行中位数
Revenue YoY (营收同比增长)
5-point trend, +121.3%
11.9%
Revenue CAGR 3Y (营收3年复合年增长率)
5-point trend, +121.3%
27.5%
Revenue CAGR 5Y (营收5年复合年增长率)
5-point trend, +121.3%
19.4%
EPS YoY
5-point trend, +319.0%
69.1%
Net Income YoY (净利润同比增长)
5-point trend, +332.9%
72.7%

每股指标 每股收益 (EPS)、每股净资产、每股现金流、每股股息

指标
5年趋势
ACAD
同行中位数
EPS (Diluted) (EPS (稀释))
5-point trend, +319.0%
$2.30

资本效率 资产周转率、库存周转率、应收账款周转率

指标
5年趋势
ACAD
同行中位数

ACAD 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间

买入 27 位分析师
  • 强烈买入 7 25.9%
  • 买入 14 51.9%
  • 持有 5 18.5%
  • 卖出 1 3.7%
  • 强烈卖出 0 0.0%

12个月价格目标

20 位分析师 · 2026-08-18
中位数目标 $36.00 +17.4%
平均目标 $33.85 +10.4%

收益历史 每股收益实际值 vs 预估值,惊喜%,达标率,下次财报日期

平均惊喜
0.30%
期间 EPS Actual EPS 预期 惊喜
2026年6月30日 $0.18 $0.06 0.12%
2026年3月31日 $0.02 $0.06 -0.04%
2025年12月31日 $1.60 $0.14 1.5%
2025年9月30日 $0.42 $0.15 0.27%
2025年6月30日 $0.16 $0.14 0.02%
2025年3月31日 $0.11 $0.11 -0.00%

同行比较(GICS 子行业) 关键指标与行业同行对比

股票代码 市值 P/E 营收同比增长 净利润率 ROE 毛利率
ACAD $4.55B 11.6 11.9% 36.5% 38.1%
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8%
ERAS $1.06B -8.5 -35.7%
CAI $7.62B -8.4 97.0% -8.4% -13.2%
PTCT $6.19B 9.8 114.5% 39.4% -331.5%
TVTX $3.47B -131.8 110.5% -5.2% -34.6%
DYN $3.23B -5.6 -57.8%
PBLS
CELC $4.81B -26.3 -244.3%
RLAY $1.47B -5.3 53.4% -1800.6% -44.9%

完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表

损益表 16
ACAD 的年度损益表数据
指标 趋势 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +892820.8% $1.07B $958M $726M $517M $484M $442M $339M $224M $125M $17M $61.0K $120.0K
Cost of Revenue 10-point trend, +2794.2% $89M $82M $42M $10M $19M $10M $11M $12M $9M $3M · ·
Gross Profit 8-point trend, +4704.9% · · $685M $507M $473M $432M $328M $211M $116M $14M · ·
R&D Expense 12-point trend, +442.6% $329M $303M $352M $362M $239M $319M $240M $187M $149M $99M $74M $61M
SG&A Expense 12-point trend, +1576.1% $549M $488M $407M $369M $396M $389M $326M $266M $255M $186M $88M $33M
Operating Expenses 12-point trend, +935.6% $967M $727M $800M $741M $655M $728M $586M $471M $417M $290M $165M $93M
Operating Income 12-point trend, +212.4% $105M $231M $-73M $-224M $-170M $-287M $-247M $-247M $-292M $-273M $-165M $-93M
Other Non-op 8-point trend, +228.9% $2M $2M $5M $4M $2M $-997.0K $997.0K $-2M · · · ·
Pretax Income 12-point trend, +250.2% $139M $258M $-51M $-213M $-168M $-281M $-234M $-244M $-288M $-270M $-164M $-92M
Income Tax 12-point trend, -252096000.00 $-252M $32M $10M $3M $351.0K $611.0K $876.0K $1M $1M $1M $330.0K $0
Net Income 12-point trend, +522.8% $391M $226M $-61M $-216M $-168M $-282M $-235M $-245M $-289M $-271M $-164M $-92M
EPS (Basic) 6-point trend, +229.6% $2.32 $1.37 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
EPS (Diluted) 6-point trend, +228.5% $2.30 $1.36 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
Shares (Basic) 6-point trend, +106907.5% 168,356,000 165,717,000 163,819,000 161,683,000 160,493 157,331 · · · · · ·
Shares (Diluted) 6-point trend, +107901.0% 169,919,000 166,362,000 163,819,000 161,683,000 160,493 157,331 · · · · · ·
EBITDA 12-point trend, +212.4% $105M $231M $-73M $-224M $-170M $-287M $-247M $-247M $-292M $-273M $-165M $-93M
资产负债表 25
ACAD 的年度资产负债表数据
指标 趋势 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +187.3% $178M $320M $189M $115M $147M $326M $190M $135M $69M $164M $102M $62M
Receivables 10-point trend, +1957.5% $121M $99M $98M $62M $64M $48M $36M $26M $17M $6M · ·
Inventory 10-point trend, +2567.6% $111M $92M $40M $12M $14M $10M $6M $4M $5M $4M · ·
Prepaid Expense 12-point trend, +4996.4% $60M $56M $39M $21M $24M $26M $19M $21M $8M $8M $2M $1M
Current Assets 12-point trend, +227.2% $1.06B $938M $616M $508M $618M $718M $760M $526M $373M $548M $219M $325M
PP&E (Net) 12-point trend, +1258.2% $8M $4M $5M $6M $8M $9M $3M $3M $3M $3M $2M $553.0K
PP&E (Gross) 12-point trend, +531.1% $17M $14M $14M $14M $14M $13M $9M $8M $7M $6M $5M $3M
Accum. Depreciation 12-point trend, +343.2% $9M $10M $10M $8M $6M $4M $5M $4M $4M $3M $3M $2M
Intangibles 10-point trend, +1452.3% $109M $120M $65M $0 $0 $1M $3M $4M $6M $7M · ·
Other Non-current Assets 12-point trend, +1257.5% $4M $359.0K $476.0K $8M $4M $2M $3M $2M $354.0K $785.0K $329.0K $287.0K
Total Assets 12-point trend, +380.6% $1.56B $1.19B $749M $588M $700M $783M $783M $540M $385M $561M $222M $325M
Accounts Payable 12-point trend, +440.8% $11M $16M $18M $13M $7M $8M $7M $3M $9M $4M $2M $2M
Accrued Liabilities 12-point trend, +1826.6% $266M $379M $237M $113M $89M $97M $68M $56M $40M $36M $20M $14M
Current Liabilities 12-point trend, +1650.1% $277M $395M $254M $126M $96M $106M $75M $60M $49M $43M $22M $16M
Capital Leases 7-point trend, +537.5% $41M $42M $48M $53M $56M $44M $6M · · · · ·
Deferred Tax 7-point trend, +345.4% $11M $11M $12M $13M $14M $13M $3M · · · · ·
Other Non-current Liabilities 8-point trend, +1128.3% $19M $18M $15M $9M $7M $5M $3M $2M · · · ·
Total Liabilities 12-point trend, +2009.1% $337M $455M $317M $187M $159M $156M $84M $61M $49M $43M $22M $16M
Common Stock 12-point trend, +60.0% $16.0K $16.0K $16.0K $16.0K $16.0K $16.0K $15.0K $14.0K $12.0K $12.0K $10.0K $10.0K
Paid-in Capital 3-point trend, +79.8% · · · · · · · · · $1.45B $862M $808M
Retained Earnings 12-point trend, -264.0% $-1.81B $-2.20B $-2.43B $-2.37B $-2.15B $-1.99B $-1.70B $-1.47B $-1.22B $-934M $-663M $-498M
AOCI 12-point trend, +16155.6% $1M $292.0K $24.0K $-975.0K $-192.0K $36.0K $297.0K $-372.0K $-399.0K $106.0K $11.0K $-9.0K
Stockholders' Equity 12-point trend, +296.6% $1.23B $733M $432M $400M $541M $627M $699M $479M $335M $518M $200M $309M
Liabilities + Equity 12-point trend, +380.6% $1.56B $1.19B $749M $588M $700M $783M $783M $540M $385M $561M $222M $325M
Shares Outstanding 12-point trend, +70.2% 170,309,376 166,708,856 164,650,219 162,064,872 161,012,695 159,637,771 155,275,300 143,853,597 124,410,552 121,367,169 101,938,702 100,047,331
现金流 13
ACAD 的年度现金流数据
指标 趋势 202520242023202220212020201920182017201620152014
D&A · · · · · · · · · · · $206.0K
Stock-based Comp 12-point trend, +225.1% $52M $67M $66M $68M $64M $84M $82M $82M $76M $55M $40M $16M
Deferred Tax 5-point trend, -71417.4% $-250M $0 $0 $3M $351.0K · · · · · · ·
Amort. of Intangibles 12-point trend, +10889000.00 $11M $15M $4M $0 $1M $1M $1M $1M $1M $985.0K $0 $0
Operating Cash Flow 12-point trend, +265.3% $110M $158M $17M $-114M $-126M $-136M $-151M $-167M $-218M $-208M $-122M $-66M
CapEx 12-point trend, +2505.6% $5M $523.0K $50.0K $0 $1M $8M $1M $2M $812.0K $2M $2M $180.0K
Investing Cash Flow 10-point trend, -15.5% $-303M $-31M $32M $73M $-71M $193M $-166M $-71M $92M $-262M · ·
Stock Issued 12-point trend, -75.5% $50M $7M $25M $8M $18M $81M $372M $307M $31M $519M $15M $204M
Net Stock Activity 12-point trend, -75.5% $50M $7M $25M $8M $18M $81M $372M $307M $31M $519M $15M $204M
Financing Cash Flow 10-point trend, -90.7% $50M $7M $25M $8M $18M $81M $372M $307M $31M $534M · ·
Net Change in Cash 12-point trend, -384.8% $-143M $134M $74M $-33M $-179M $137M $55M $68M $-94M $63M $40M $50M
Taxes Paid 11-point trend, +5965.1% $25M $20M $6M $2M $1M $1M $2M $1M $1M $-365.0K $415.0K ·
Free Cash Flow 12-point trend, +257.8% $105M $157M $17M $-114M $-127M $-144M $-152M $-170M $-219M $-212M $-124M $-67M
盈利能力 8
ACAD 的年度盈利能力数据
指标 趋势 202520242023202220212020201920182017201620152014
Gross Margin 8-point trend, +14.6% · · 94.3% 98.0% 97.8% 97.7% 96.7% 94.5% 92.7% 82.2% · ·
Operating Margin 12-point trend, +100.0% 9.8% 24.1% -10.1% -43.2% -35.2% -64.9% -72.7% -110.6% -234.1% -1574.1% -269855.7% -77691.7%
Net Margin 12-point trend, +100.0% 36.5% 23.6% -8.4% -41.8% -34.7% -63.7% -69.4% -109.6% -231.7% -1565.9% -269578.7% -77062.5%
Pretax Margin 11-point trend, +100.0% 13.0% 26.9% -7.0% -41.3% -34.6% -63.6% -69.1% -109.0% -230.8% -1558.2% -269037.7% ·
EBITDA Margin 12-point trend, +100.0% 9.8% 24.1% -10.1% -43.2% -35.2% -64.9% -72.7% -110.6% -234.1% -1574.1% -269855.7% -77691.7%
ROA 12-point trend, +179.1% 28.4% 23.4% -9.2% -33.5% -22.6% -36.0% -35.5% -53.0% -61.2% -69.3% -60.1% -35.9%
ROE 12-point trend, +201.4% 38.1% 34.6% -15.4% -52.3% -30.3% -43.9% -33.9% -69.8% -67.8% -75.6% -64.6% -37.6%
ROIC 11-point trend, +129.1% 24.0% 27.6% -20.4% -56.5% -31.6% -45.8% -35.4% -51.9% -87.5% -52.9% -82.6% ·
流动性与偿付能力 2
ACAD 的年度流动性与偿付能力数据
指标 趋势 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -81.3% 3.8 2.4 2.4 4.0 6.4 6.8 10.2 8.8 7.6 12.9 10.0 20.5
Quick Ratio 12-point trend, -72.4% 1.1 1.1 1.1 1.4 2.2 3.5 3.0 2.7 1.8 4.0 4.7 3.9
效率 3
ACAD 的年度效率数据
指标 趋势 202520242023202220212020201920182017201620152014
Asset Turnover 12-point trend, +155640.0% 0.8 1.0 1.1 0.8 0.7 0.6 0.5 0.5 0.3 0.0 0.0 0.0
Inventory Turnover 9-point trend, -40.5% 0.9 1.2 1.6 0.8 0.9 1.3 2.2 · 1.9 1.5 · ·
Receivables Turnover 10-point trend, +65.7% 9.7 9.7 9.1 8.2 8.6 10.5 11.0 10.3 10.7 5.9 · ·
每股 5
ACAD 的年度每股数据
指标 趋势 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, +133.0% $7.21 $4.40 $2.62 $2.47 $3.36 $3.93 $4.50 $3.33 $2.69 $4.27 $1.96 $3.09
Revenue / Share 4-point trend, -99.8% $6.31 $5.76 $4434.39 $3199.07 · · · · · · · ·
Cash Flow / Share 4-point trend, +100.1% $0.65 $0.95 $101.95 $-705.30 · · · · · · · ·
Cash / Share 12-point trend, +68.8% $1.04 $1.92 $1.15 $0.71 $0.92 $2.04 $1.22 $0.94 $0.56 $1.35 $1.00 $0.62
EPS (TTM) 6-point trend, +228.5% $2.30 $1.36 $-0.37 $-1.34 $-1.05 $-1.79 · · · · · ·
增长率 5
ACAD 的年度增长率数据
指标 趋势 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +23.6% 11.9% 31.9% 40.5% 6.8% 9.6% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +52.4% 27.5% 25.5% 18.0% · · · · · · · · ·
Revenue CAGR 5Y 19.4% · · · · · · · · · · ·
EPS YoY 69.1% · · · · · · · · · · ·
Net Income YoY 72.7% · · · · · · · · · · ·
估值 (TTM) 10
ACAD 的年度估值 (TTM)数据
指标 趋势 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +892820.8% $1.07B $958M $726M $517M $484M $442M $339M $224M $125M $17M $61.0K $120.0K
Net Income TTM 12-point trend, +522.8% $391M $226M $-61M $-216M $-168M $-282M $-235M $-245M $-289M $-271M $-164M $-92M
Market Cap 12-point trend, +43.2% $4.55B $3.06B $5.16B $2.58B $3.76B $8.53B $6.64B $2.33B $3.75B $3.50B $3.63B $3.18B
P/E 6-point trend, +138.9% 11.6 13.5 -84.6 -11.9 -22.2 -29.9 · · · · · ·
P/S 12-point trend, -100.0% 4.2 3.2 7.1 5.0 7.8 19.3 19.6 10.4 30.0 202.0 59575.7 26470.9
P/B 12-point trend, -63.9% 3.7 4.2 11.9 6.4 6.9 13.6 9.5 4.9 11.2 6.8 18.2 10.3
P / Tangible Book 6-point trend, -70.2% 4.1 5.0 14.1 6.4 6.9 13.6 · · · · · ·
P / Cash Flow 12-point trend, +186.6% 41.4 19.4 308.7 -22.6 -29.9 -62.7 -44.0 -13.9 -17.2 -16.6 -29.8 -47.8
P / FCF 12-point trend, +190.7% 43.3 19.5 309.6 -22.6 -29.6 -59.4 -43.6 -13.7 -17.1 -16.5 -29.3 -47.7
Earnings Yield 6-point trend, +357.0% 8.6% 7.4% -1.2% -8.4% -4.5% -3.4% · · · · · ·

财务报表 损益表、资产负债表、现金流量表 — 年度,近5年

损益表
2025-12-312024-12-312023-12-312022-12-312021-12-31
收入 $1.07B$958M$726M$517M$484M
毛利率 % 94.3%98.0%97.8%
营业利润率 % 9.8%24.1%-10.1%-43.2%-35.2%
净收入 $391M$226M$-61M$-216M$-168M
稀释后每股收益 (EPS) $2.30$1.36$-0.37$-1.34$-1.05
资产负债表
2025-12-312024-12-312023-12-312022-12-312021-12-31
流动比率 3.82.42.44.06.4
速动比率 1.11.11.11.42.2
现金流
2025-12-312024-12-312023-12-312022-12-312021-12-31
自由现金流 $105M$157M$17M$-114M$-127M

最新新闻 提及该公司的近期头条新闻

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机构持有人 (13F) 388 家申报者 · $3.3B 总计 · 截至 2026年6月30日

在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸;单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存,而非方向性判断。

机构活动 — Q2 2026 与上一季度对比
新仓位 已退出持仓 增加 减少 净股数变动
56 (+4 与上一季度对比) 36 (+8 与上一季度对比) 136 (+11 与上一季度对比) 101 (-12 与上一季度对比) +4.8M

与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天,外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过,优先显示最近一个已完整报告的季度对。

机构 价值 股份 % 已追踪的13F 类型
BAKER BROS. ADVISORS LP $1085696471 42912904 32.71% 股份
STATE STREET CORP $229628164 9076212 6.92% 股份
VANGUARD PORTFOLIO MANAGEMENT LLC $223612785 8838450 6.74% 股份
RTW INVESTMENTS, LP $180756457 7144524 5.45% 股份
VANGUARD CAPITAL MANAGEMENT LLC $145822875 5763750 4.39% 股份
DIMENSIONAL FUND ADVISORS LP $88971384 3516656 2.68% 股份
GEODE CAPITAL MANAGEMENT, LLC $73088127 2888204 2.20% 股份
Palo Alto Investors LP $72461629 2864096 2.18% 股份
Qube Research & Technologies Ltd $61899233 2446610 1.86% 股份
Point72 Asset Management, L.P. $61559150 2433168 1.85% 股份
CITADEL ADVISORS LLC $53414195 2111233 1.61% 股份
Pictet Asset Management Holding SA $50146450 1983198 1.51% 股份
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $49826959 1969445 1.50% 股份
MARSHALL WACE, LLP $44649289 1764794 1.35% 股份
BRAIDWELL LP $41653895 1646399 1.25% 股份
NORGES BANK $41069692 1623308 1.24% 股份
Frazier Life Sciences Management, L.P. $36386409 1438198 1.10% 股份
Artisan Partners Limited Partnership $33525890 1325134 1.01% 股份
RENAISSANCE TECHNOLOGIES LLC $32449679 1282596 0.98% 股份
GOLDMAN SACHS GROUP INC $32070584 1267612 0.97% 股份
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $30520301 1206336 0.92% 股份
D. E. Shaw & Co., Inc. $28330257 1119773 0.85% 股份
Allspring Global Investments Holdings, LLC $26143513 1037441 0.79% 股份
TWO SIGMA INVESTMENTS, LP $23452898 926992 0.71% 股份
VANGUARD FIDUCIARY TRUST CO $23082961 912370 0.70% 股份
BANK OF AMERICA CORP /DE/ $21702062 857789 0.65% 股份
PANAGORA ASSET MANAGEMENT INC $17985922 710906 0.54% 股份
Fisher Asset Management, LLC $17690535 699230 0.53% 股份
Allianz Asset Management GmbH $15730341 706664 0.47% 股份
RICE HALL JAMES & ASSOCIATES, LLC $15657841 618887 0.47% 股份
MILLENNIUM MANAGEMENT LLC $14925077 589924 0.45% 股份
MANUFACTURERS LIFE INSURANCE COMPANY, THE $14771456 583852 0.45% 股份
ADAGE CAPITAL PARTNERS GP, L.L.C. $12903000 510000 0.39% 股份
Hudson Bay Capital Management LP $11764500 465000 0.35% 股份
GLENMEDE TRUST CO NA $11656544 460733 0.35% 股份
JUPITER ASSET MANAGEMENT LTD $11599190 458466 0.35% 股份
Public Sector Pension Investment Board $11014988 435375 0.33% 股份
MACKENZIE FINANCIAL CORP $10646872 420825 0.32% 股份
Ishara Investments LP $10373000 410000 0.31% 股份
TWO SIGMA ADVISERS, LP $9888042 370200 0.30% 股份
Balyasny Asset Management L.P. $9817007 388024 0.30% 股份
BlackRock, Inc. $9281482 366857 0.28% 股份
SPHERA FUNDS MANAGEMENT LTD. $9020310 356534 0.27% 股份
AMERIPRISE FINANCIAL INC $8039177 317754 0.24% 股份
PRUDENTIAL FINANCIAL INC $7985313 315625 0.24% 股份
Alyeska Investment Group, L.P. $7850261 310287 0.24% 股份
RHUMBLINE ADVISERS $7663389 302902 0.23% 股份
Schonfeld Strategic Advisors LLC $7189171 284157 0.22% 股份
Edgestream Partners, L.P. $7167515 283301 0.22% 股份
Logos Global Management LP $6325000 250000 0.19% 股份
LAZARD ASSET MANAGEMENT LLC $6263496 247569 0.19% 股份
FMR LLC $6052317 239222 0.18% 股份
Swiss National Bank $5841871 230904 0.18% 股份
VICTORY CAPITAL MANAGEMENT INC $5432213 214712 0.16% 股份
ALPS ADVISORS INC $4985340 197049 0.15% 股份
ENVESTNET ASSET MANAGEMENT INC $4926239 194713 0.15% 股份
Legal & General Group Plc $4918245 194397 0.15% 股份
FIRST TRUST ADVISORS LP $4664965 184386 0.14% 股份
NEW YORK STATE COMMON RETIREMENT FUND $4364807 172522 0.13% 股份
Birchview Capital, LP $4326300 171000 0.13% 股份
MARTINGALE ASSET MANAGEMENT L P $4247693 167893 0.13% 股份
Tetragon Partners GP Ltd $4247238 167875 0.13% 股份
GREAT LAKES ADVISORS, LLC $3822526 151088 0.12% 股份
AMERICAN CENTURY COMPANIES INC $3635306 143688 0.11% 股份
STEMPOINT CAPITAL LP $3622125 143167 0.11% 股份
ALLIANCEBERNSTEIN L.P. $3585329 161066 0.11% 股份
Squarepoint Ops LLC $3542329 140013 0.11% 股份
ORBIMED ADVISORS LLC $3466100 137000 0.10% 股份
Erste Asset Management GmbH $3369240 133700 0.10% 股份
Emerald Investment Advisers, LLC $3333326 131752 0.10% 股份
Caption Management, LLC $3289000 130000 0.10% 卖出期权
VANGUARD ASSET MANAGEMENT, Ltd $3130217 123724 0.09% 股份
WELLS FARGO & COMPANY/MN $3084475 121916 0.09% 股份
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3077311 138244 0.09% 股份
Longaeva Partners L.P. $2968145 117318 0.09% 股份
JACOBS LEVY EQUITY MANAGEMENT, INC $2948791 116553 0.09% 股份
Trexquant Investment LP $2935357 116022 0.09% 股份
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $2909778 115011 0.09% 股份
JONES FINANCIAL COMPANIES LLLP $2868477 113289 0.09% 股份
Rafferty Asset Management, LLC $2789426 110254 0.08% 股份
Nan Fung Group Holdings Ltd $2605495 102984 0.08% 股份
RAYMOND JAMES FINANCIAL INC $2406232 95108 0.07% 股份
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $2344000 92648 0.07% 股份
ROYCE & ASSOCIATES LP $2324691 91885 0.07% 股份
HOHIMER WEALTH MANAGEMENT, LLC $2322540 91800 0.07% 股份
Point72 Europe (London) LLP $2305047 108015 0.07% 股份
VIRGINIA RETIREMENT SYSTEMS ET Al $2134076 79898 0.06% 股份
Campbell & CO Investment Adviser LLC $2108527 83341 0.06% 股份
Verdad Advisers, LP $2090514 82629 0.06% 股份
VOYA INVESTMENT MANAGEMENT LLC $2072576 81920 0.06% 股份
CITADEL ADVISORS LLC $2049300 81000 0.06% 买入期权
GUGGENHEIM CAPITAL LLC $1979776 78252 0.06% 股份
WESBANCO BANK INC $1978460 78200 0.06% 股份
Phocas Financial Corp. $1954299 77245 0.06% 股份
MetLife Investment Management, LLC $1899043 75061 0.06% 股份
STATE OF WISCONSIN INVESTMENT BOARD $1850493 73142 0.06% 股份
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1788331 70685 0.05% 股份
Freestone Grove Partners LP $1755643 69393 0.05% 股份
CenterBook Partners LP $1743878 68928 0.05% 股份
CANADA PENSION PLAN INVESTMENT BOARD $1722930 68100 0.05% 股份

公司内部人士 37 位内幕人士 · 19 位高管 · 19 位董事

内部人士 角色 上次活动 持股数量 买入 12个月 卖出 12个月 净额 12个月
Stephen Davis CEO 2024年1月6日 M 96521 0 0 $0
Uli Hacksell CEO 2011年3月25日 A 69916 0 0 $0
Elena Ridloff EVP and CFO 2021年4月29日 M 10553 0 0 $0
Todd S. Young EVP AND CFO 2018年10月15日 A 0 0 $0
Thomas H Aasen Exec. VP, CFO & CBO 2011年3月25日 A 13899 0 0 $0
Srdjan R. Stankovic President 2022年11月21日 M 61234 0 0 $0
Mark R Brann President & CSO 2006年6月16日 S 317756 0 0 $0
Brendan Teehan EVP, COO, Head of Commercial 2024年1月6日 M 30949 0 0 $0
Elizabeth H.Z. Thompson EVP, Head of Research & Dev 2026年7月29日 M 18994 0 2 $-432662
James Kihara PRINCIPAL ACCOUNTING OFFICER 2026年6月26日 S 13088 0 2 $-412253
Austin D. Kim EVP,General Counsel, Secretary 2024年1月6日 M 46901 0 0 $0
Douglas J Williamson Executive VP, Research & Dev 2023年2月10日 A 0 0 $0
Michael J. Yang EVP and CCO 2021年1月6日 M 8059 0 0 $0
Eric Alejandro Miller Controller & PAO 2019年10月15日 M 270 0 0 $0
Glenn Baity VP, GC & Sec. 2011年3月25日 A 0 0 $0
Roger Mills Executive VP, Development 2011年3月25日 A 0 0 $0
Bo-Ragnar Tolf VP/Mg. Dir. ACADIA Pharma AB 2009年7月8日 M 20000 0 0 $0
Brian Lundstrom Sr. VP, Bus. Development 2008年3月7日 A 0 0 0 $0
Robert E Davis Exec. VP, Drug Discovery 2005年3月11日 A 0 0 $0
Adora Ndu 董事 2026年5月29日 A 32908 0 0 $0
Elizabeth A. Garofalo 董事 2026年5月29日 A 33489 0 0 $0
Jonathan Poole 董事 2026年5月29日 A 2010 0 0 $0
James M Daly 董事 2026年5月29日 A 12148 0 0 $0
Laura Brege 董事 2026年5月29日 A 23202 0 0 $0
Edmund Harrigan 董事 2026年5月29日 A 43148 0 0 $0
Daniel B Soland 董事 2023年6月1日 A 28002 0 0 $0
Torsten Rasmussen 董事 2010年6月11日 A 4000 0 0 $0
Leslie L Iversen 董事 2010年6月11日 A 9000 0 0 $0
Mary Ann Gray 董事 2010年6月11日 A 0 0 $0
Michael T Borer 董事 2010年6月11日 A 0 0 $0
Lester J Ph D Kaplan 董事 2010年6月11日 A 4000 0 0 $0
Gordon M Binder 董事 2009年6月12日 A 14364 0 0 $0
Alan G Walton 董事 2009年6月12日 A 25979 0 0 $0
Martien Van Osch 董事 2005年6月10日 A 1168892 0 0 $0
GORDON CARL L 董事 2005年4月20日 A 774006 0 0 $0
Mark C. Schneyer 2026年8月6日 M 67828 0 3 $-587248
John Joseph Kaiser 2008年10月20日 A 0 0 $0

来自SEC表格3/4/5申报的内部人士;净额=仅公开市场买卖

激进投资者及 5%+ 股东 6 持仓

提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权,意图影响发行人(激进股东持股、董事会活动、并购)。每一行显示该申报人持仓的最新已知状态。

申报人 已申报 持股 状态 目的 申报
Baker Bros. Advisors LP, Baker Bros. Advisors (GP) LLC, Julian C. Baker, Felix J. Baker, FBB3 LLC ×14 申报 2026年2月26日 25.40% 修订 SEC
Baker Bros. Advisors, LLC, Felix J. Baker, Julian C. Baker ×4 申报 2013年6月6日 初始申报 SEC
未披露的报告人, 未披露的报告人, 未披露的报告人 2005年5月2日 初始申报 SEC
未披露的报告人, 未披露的报告人, 未披露的报告人 2005年5月2日 初始申报 SEC
未披露的报告人, 未披露的报告人, 未披露的报告人 2005年5月2日 初始申报 SEC
Oxford Bioscience Partners IV L.P., mRNA Fund II L.P., OBP Management IV L.P., Jeffrey T. Barnes, Mark P. Carthy, Jonathan J. Fleming, Michael E. Lytton, Alan G. Walton 2005年4月29日 初始申报 被动投资 SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF持仓 由 78 只交易所交易基金持有

权重仅反映直接股权持仓(N-PORT);杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。

基金 权重 单位 截至 来源
SBIO · ALPS ETF Trust 2.35% 175740 NS 2026年5月31日 N-PORT
BBP · ETFis Series Trust I 1.32% 34855 NS 2026年4月30日 N-PORT
LABU · Direxion Shares ETF Trust 0.85% 195542 NS 2026年4月30日 N-PORT
ROSC · Lattice Strategies Trust 0.56% 13607 NS 2026年4月30日 N-PORT
OASC · Unified Series Trust 0.39% 15269 NS 2026年5月31日 N-PORT
FNY · First Trust Exchange-Traded Alpha... 0.27% 61606 NS 2026年4月30日 N-PORT
BFOR · ALPS ETF Trust 0.24% 24003 NS 2026年5月31日 N-PORT
GSSC · Goldman Sachs ETF Trust 0.20% 89945 NS 2026年5月31日 N-PORT
BIB · ProShares Trust 0.19% 6303 NS 2026年5月31日 N-PORT
PSC · Principal Exchange-Traded Funds 0.18% 167685 NS 2026年6月30日 N-PORT
BKSE · BNY Mellon ETF Trust 0.17% 6035 NS 2026年4月30日 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund ... 0.15% 47683 NS 2026年4月30日 N-PORT
FNX · First Trust Exchange-Traded Alpha... 0.14% 81552 NS 2026年4月30日 N-PORT
SAA · ProShares Trust 0.12% 1498 NS 2026年5月31日 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.09% 115210 NS 2026年5月31日 N-PORT
DFAS · Dimensional ETF Trust 0.08% 526641 NS 2026年4月30日 N-PORT
FAD · First Trust Exchange-Traded Alpha... 0.08% 16957 NS 2026年4月30日 N-PORT
ITWO · ProShares Trust 0.07% 5921 NS 2026年5月31日 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.06% 599784 NS 2026年5月31日 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.04% 54956 NS 2026年4月30日 N-PORT
SMDX · Tidal Trust III 0.04% 2306 NS 2026年4月30日 N-PORT
UWM · ProShares Trust 0.04% 4631 NS 2026年5月31日 N-PORT
AFSM · First Trust Exchange-Traded Fund ... 0.03% 1517 NS 2026年5月31日 N-PORT
URTY · ProShares Trust 0.03% 4683 NS 2026年5月31日 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.03% 136 NS 2026年5月31日 N-PORT
DXUV · Dimensional ETF Trust 0.03% 4944 NS 2026年4月30日 N-PORT
DFAC · Dimensional ETF Trust 0.02% 348165 NS 2026年4月30日 N-PORT
DFUV · Dimensional ETF Trust 0.02% 112668 NS 2026年4月30日 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 4762 NS 2026年5月31日 N-PORT
HDG · ProShares Trust 0.01% 118 NS 2026年5月31日 N-PORT
EBI · RBB Fund Trust 0.01% 3525 NS 2026年5月31日 N-PORT
DCOR · Dimensional ETF Trust 0.01% 15114 NS 2026年4月30日 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 44472 NS 2026年5月31日 N-PORT
DFAU · Dimensional ETF Trust 0.01% 33470 NS 2026年4月30日 N-PORT
TILT · FlexShares Trust 0.00% 3816 NS 2026年4月30日 N-PORT
DFUS · Dimensional ETF Trust 0.00% 35634 NS 2026年4月30日 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 77742 NS 2026年5月31日 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 321 NS 2026年5月31日 N-PORT
DFAT · Dimensional ETF Trust 0.00% 6176 NS 2026年4月30日 N-PORT
VXF · VANGUARD INDEX FUNDS 2026年7月15日 每日
VB · VANGUARD INDEX FUNDS 2026年7月15日 每日
VBK · VANGUARD INDEX FUNDS 2026年7月15日 每日
VTI · VANGUARD INDEX FUNDS 2026年7月15日 每日
VT · VANGUARD INTERNATIONAL EQUITY IND... 2026年7月15日 每日
VIOO · VANGUARD ADMIRAL FUNDS 2026年7月15日 每日
VIOG · VANGUARD ADMIRAL FUNDS 2026年7月30日 每日
VTWO · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
VTWG · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
VTHR · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
IJR · iShares Trust 2026年8月13日 每日