| FMR LLC |
$300433246 |
16727909 |
14.19% |
股份
|
| BlackRock, Inc. |
$158534442 |
8827085 |
7.49% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$149694481 |
8334882 |
7.07% |
股份
|
| TCG Crossover Management, LLC |
$112138864 |
6243812 |
5.30% |
股份
|
| Commodore Capital LP |
$101474000 |
5650000 |
4.79% |
股份
|
| Saturn V Capital Management LP |
$83048854 |
4624101 |
3.92% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$75867063 |
4224224 |
3.58% |
股份
|
| VANGUARD GROUP INC |
$70123336 |
5804912 |
3.31% |
股份
|
| JANUS HENDERSON GROUP PLC |
$69256554 |
4986073 |
3.27% |
股份
|
| MORGAN STANLEY |
$56229311 |
3130808 |
2.66% |
股份
|
| Driehaus Capital Management LLC |
$54543981 |
3036970 |
2.58% |
股份
|
| First Light Asset Management, LLC |
$54297678 |
3023256 |
2.56% |
股份
|
| FRANKLIN RESOURCES INC |
$52986040 |
2950225 |
2.50% |
股份
|
| GOLDMAN SACHS GROUP INC |
$51333972 |
2858239 |
2.42% |
股份
|
| STATE STREET CORP |
$46755933 |
2603337 |
2.21% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$41949140 |
2335315 |
1.98% |
股份
|
| JPMORGAN CHASE & CO |
$34921895 |
1863650 |
1.65% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$34124000 |
1900000 |
1.61% |
股份
|
| Siren, L.L.C. |
$26591325 |
1480586 |
1.26% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$23844428 |
1327536 |
1.13% |
股份
|
| 683 Capital Management, LLC |
$22980036 |
1279512 |
1.09% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$19065151 |
1061534 |
0.90% |
股份
|
| Alyeska Investment Group, L.P. |
$18912149 |
1053015 |
0.89% |
股份
|
| Almitas Capital LLC |
$17508863 |
974881 |
0.83% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$16215061 |
902463 |
0.77% |
股份
|
| Jones Hill Capital LP |
$16057282 |
894058 |
0.76% |
股份
|
| Woodline Partners LP |
$15201111 |
846387 |
0.72% |
股份
|
| NORTHERN TRUST CORP |
$14938051 |
831740 |
0.71% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$14760265 |
821841 |
0.70% |
股份
|
| Boxer Capital Management, LLC |
$14368000 |
800000 |
0.68% |
股份
|
| Aberdeen Group plc |
$13248553 |
737670 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$13021539 |
725030 |
0.61% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$12949196 |
721002 |
0.61% |
股份
|
| GREAT POINT PARTNERS LLC |
$12572000 |
700000 |
0.59% |
股份
|
| Balyasny Asset Management L.P. |
$12302133 |
684974 |
0.58% |
股份
|
| Qube Research & Technologies Ltd |
$12237746 |
681389 |
0.58% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$11190481 |
623078 |
0.53% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$10658093 |
593435 |
0.50% |
股份
|
| DEUTSCHE BANK AG\ |
$10020549 |
557937 |
0.47% |
股份
|
| Rock Springs Capital Management LP |
$8975761 |
499764 |
0.42% |
股份
|
| ADAR1 Capital Management, LLC |
$8879029 |
494378 |
0.42% |
股份
|
| Nantahala Capital Management, LLC |
$8740845 |
486684 |
0.41% |
股份
|
| FEDERATED HERMES, INC. |
$8301202 |
462205 |
0.39% |
股份
|
| Nearwater Capital Markets, Ltd |
$7633000 |
425000 |
0.36% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$7279188 |
405300 |
0.34% |
买入期权
|
| Parkman Healthcare Partners LLC |
$7162125 |
398782 |
0.34% |
股份
|
| HighVista Strategies LLC |
$6933997 |
386080 |
0.33% |
股份
|
| STEMPOINT CAPITAL LP |
$6902100 |
384304 |
0.33% |
股份
|
| Logos Global Management LP |
$6286000 |
350000 |
0.30% |
股份
|
| Trexquant Investment LP |
$6275924 |
349439 |
0.30% |
股份
|
| Nuveen, LLC |
$5936157 |
330521 |
0.28% |
股份
|
| Ensign Peak Advisors, Inc |
$5485720 |
305441 |
0.26% |
股份
|
| JANE STREET GROUP, LLC |
$5380187 |
299565 |
0.25% |
股份
|
| Tetragon Partners GP Ltd |
$5350751 |
297926 |
0.25% |
股份
|
| JUPITER ASSET MANAGEMENT LTD |
$4937994 |
274944 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$4928853 |
274435 |
0.23% |
股份
|
| UBS Group AG |
$4882983 |
271881 |
0.23% |
股份
|
| FIRST TRUST ADVISORS LP |
$4572382 |
254587 |
0.22% |
股份
|
| SummitTX Capital, L.P. |
$4089312 |
227690 |
0.19% |
股份
|
| TWO SIGMA ADVISERS, LP |
$3967084 |
328401 |
0.19% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$3822642 |
212842 |
0.18% |
股份
|
| Cormorant Asset Management, LP |
$3592000 |
200000 |
0.17% |
股份
|
| Aldebaran Capital, LLC |
$3518220 |
195892 |
0.17% |
股份
|
| Walleye Capital LLC |
$3351120 |
186588 |
0.16% |
股份
|
| ORBIMED ADVISORS LLC |
$3293864 |
183400 |
0.16% |
股份
|
| CITADEL ADVISORS LLC |
$3209200 |
178686 |
0.15% |
股份
|
| D. E. Shaw & Co., Inc. |
$3130159 |
174285 |
0.15% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$3019345 |
168115 |
0.14% |
股份
|
| NORGES BANK |
$2871804 |
159900 |
0.14% |
股份
|
| Alpha Wave Global, LP |
$2791379 |
155422 |
0.13% |
股份
|
| Swiss National Bank |
$2589832 |
144200 |
0.12% |
股份
|
| PFM Health Sciences, LP |
$2580852 |
143700 |
0.12% |
股份
|
| Invesco Ltd. |
$2513358 |
139942 |
0.12% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2301823 |
128164 |
0.11% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2253693 |
125484 |
0.11% |
股份
|
| Lighthouse Investment Partners, LLC |
$2207446 |
122909 |
0.10% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2183537 |
157089 |
0.10% |
股份
|
| Ikarian Capital, LLC |
$2110301 |
117500 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$2028032 |
112920 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$2019548 |
112447 |
0.10% |
股份
|
| Elmind Capital, LP |
$2011520 |
112000 |
0.09% |
股份
|
| Campbell & CO Investment Adviser LLC |
$1813295 |
100963 |
0.09% |
股份
|
| Affinity Asset Advisors, LLC |
$1778022 |
98999 |
0.08% |
股份
|
| 683 Capital Management, LLC |
$1734936 |
96600 |
0.08% |
买入期权
|
| Russell Investments Group, Ltd. |
$1572829 |
87574 |
0.07% |
股份
|
| Quantinno Capital Management LP |
$1452066 |
80850 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1451160 |
104400 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1434501 |
79872 |
0.07% |
股份
|
| 1492 Capital Management LLC |
$1432328 |
79751 |
0.07% |
股份
|
| CITIGROUP INC |
$1233565 |
68684 |
0.06% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1199799 |
66804 |
0.06% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1100553 |
61278 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$1079396 |
60100 |
0.05% |
卖出期权
|
| Corient Private Wealth LP |
$1065424 |
59322 |
0.05% |
股份
|
| Moody Aldrich Partners LLC |
$1038124 |
57802 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1022786 |
56948 |
0.05% |
股份
|
| Legal & General Group Plc |
$1014328 |
56477 |
0.05% |
股份
|
| BARCLAYS PLC |
$1010394 |
56258 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$1000372 |
55700 |
0.05% |
股份
|
| Hudson Bay Capital Management LP |
$898000 |
50000 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$859404 |
47851 |
0.04% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$804913 |
44817 |
0.04% |
股份
|
| Allostery Investments LP |
$769963 |
120119 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$760624 |
42351 |
0.04% |
股份
|
| ADAR1 Capital Management, LLC |
$720196 |
40100 |
0.03% |
卖出期权
|
| Aquatic Capital Management LLC |
$708073 |
39425 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$679391 |
37828 |
0.03% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$647638 |
36060 |
0.03% |
股份
|
| JENNISON ASSOCIATES LLC |
$643705 |
35841 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$635964 |
35410 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$616028 |
34300 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$578312 |
32200 |
0.03% |
卖出期权
|
| OPTIMIZE FINANCIAL INC. |
$572744 |
31890 |
0.03% |
股份
|
| Jain Global LLC |
$516709 |
28770 |
0.02% |
股份
|
| Numerai GP LLC |
$514823 |
28665 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$495696 |
27600 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$487129 |
27123 |
0.02% |
股份
|
| Jump Financial, LLC |
$482962 |
26891 |
0.02% |
股份
|
| XTX Topco Ltd |
$464517 |
25864 |
0.02% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$455951 |
25387 |
0.02% |
股份
|
| Maven Securities LTD |
$449000 |
25000 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$417247 |
23232 |
0.02% |
股份
|
| WOLVERINE TRADING, LLC |
$408260 |
27400 |
0.02% |
买入期权
|
| MARTINGALE ASSET MANAGEMENT L P |
$405412 |
22573 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$402771 |
22426 |
0.02% |
股份
|
| PARSONS CAPITAL MANAGEMENT INC/RI |
$388745 |
21645 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$373909 |
20819 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$371952 |
20710 |
0.02% |
股份
|
| BROWN ADVISORY INC |
$357943 |
19930 |
0.02% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$357045 |
19880 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$356057 |
19825 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$355159 |
19775 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$354710 |
19750 |
0.02% |
股份
|
| Premier Path Wealth Partners, LLC |
$328039 |
18265 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$320532 |
17847 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$318125 |
17713 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$317802 |
17695 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$314300 |
17500 |
0.01% |
买入期权
|
| KLP KAPITALFORVALTNING AS |
$312504 |
17400 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$304530 |
16956 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$297723 |
16577 |
0.01% |
股份
|
| Creative Planning |
$285223 |
15881 |
0.01% |
股份
|
| ProShare Advisors LLC |
$281702 |
15685 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$271376 |
15110 |
0.01% |
股份
|
| HSBC HOLDINGS PLC |
$268958 |
14554 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$265054 |
14758 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$263000 |
14649 |
0.01% |
股份
|
| Seven Fleet Capital Management LP |
$261138 |
14540 |
0.01% |
股份
|
| STRS OHIO |
$251440 |
14000 |
0.01% |
股份
|
| GLENMEDE TRUST CO NA |
$245782 |
13685 |
0.01% |
股份
|
| Amundi |
$231594 |
12895 |
0.01% |
股份
|
| GREAT LAKES ADVISORS, LLC |
$230014 |
12807 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$222057 |
12364 |
0.01% |
股份
|
| Magnetar Financial LLC |
$210527 |
11722 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$208534 |
11611 |
0.01% |
股份
|
| PSP Research LLC |
$194650 |
10838 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$193393 |
10768 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$192298 |
10707 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$192172 |
10700 |
0.01% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$185688 |
10339 |
0.01% |
股份
|
| Harvest Investment Services, LLC |
$183443 |
10214 |
0.01% |
股份
|
| Valeo Financial Advisors, LLC |
$180408 |
10045 |
0.01% |
股份
|
| Tetragon Partners GP Ltd |
$152660 |
8500 |
0.01% |
买入期权
|
| Ameritas Investment Partners, Inc. |
$149894 |
8346 |
0.01% |
股份
|
| Point72 Asset Management, L.P. |
$147272 |
8200 |
0.01% |
买入期权
|
| Tower Research Capital LLC (TRC) |
$142495 |
7934 |
0.01% |
股份
|
| Point72 Asset Management, L.P. |
$136496 |
7600 |
0.01% |
卖出期权
|
| Walleye Capital LLC |
$118536 |
6600 |
0.01% |
卖出期权
|
| Mirae Asset Global Investments Co., Ltd. |
$89315 |
4973 |
0.00% |
股份
|
| AlphaQuest LLC |
$86916 |
7195 |
0.00% |
股份
|
| Fulcrum Asset Management LLP |
$82280 |
4400 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$81096 |
5967 |
0.00% |
股份
|
| Cubist Systematic Strategies, LLC |
$76139 |
5603 |
0.00% |
股份
|
| US BANCORP \DE\ |
$65357 |
3639 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$41775 |
2326 |
0.00% |
股份
|
| Arax Advisory Partners |
$40141 |
2235 |
0.00% |
股份
|
| State of Wyoming |
$39925 |
2223 |
0.00% |
股份
|
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA |
$32382 |
1803 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$29167 |
1624 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$24264 |
1351 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$22881 |
1274 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$20887 |
1163 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$17960 |
1000 |
0.00% |
股份
|
| CWM, LLC |
$17556 |
1263 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$17457 |
972 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$16667 |
928 |
0.00% |
股份
|
| Walleye Capital LLC |
$16164 |
900 |
0.00% |
买入期权
|
| Caption Management, LLC |
$14368 |
800 |
0.00% |
卖出期权
|
| EASTERN BANK |
$12949 |
721 |
0.00% |
股份
|
| Strive Financial Group ,LLC |
$11674 |
650 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$10621 |
597 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$8674 |
483 |
0.00% |
股份
|
| GAMMA Investing LLC |
$7777 |
433 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$7615 |
424 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$7543 |
420 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7292 |
406 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$7058 |
393 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$6286 |
350 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$5837 |
325 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5801 |
323 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$5657 |
315 |
0.00% |
股份
|
| iA Global Asset Management Inc. |
$5456 |
303786 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$4922 |
274 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4652 |
259 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3951 |
220 |
0.00% |
股份
|
| PICTON MAHONEY ASSET MANAGEMENT |
$3394 |
189 |
0.00% |
股份
|
| Caption Management, LLC |
$3125 |
174 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$2607 |
145133 |
0.00% |
股份
|
| Larson Financial Group LLC |
$2550 |
142 |
0.00% |
股份
|
| Quarry LP |
$2496 |
139 |
0.00% |
股份
|
| Caption Management, LLC |
$1796 |
100 |
0.00% |
买入期权
|
| SIGNATUREFD, LLC |
$1670 |
93 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$1616 |
90 |
0.00% |
股份
|
| Catherine Avery Investment Management LLC |
$1563 |
87 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$994 |
55321 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$988 |
55 |
0.00% |
股份
|
| SALEM INVESTMENT COUNSELORS INC |
$988 |
55 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$705 |
39241 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$503 |
28 |
0.00% |
股份
|
| Allworth Financial LP |
$467 |
26 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$428 |
23870 |
0.00% |
股份
|
| Essential Partners LLC |
$269 |
15 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$251 |
14 |
0.00% |
股份
|
| KBC Group NV |
$33 |
1863 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$18 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
33 |
0.00% |
股份
|