CRNX Crinetics Pharmaceuticals, Inc. - Common Stock

NASDAQ · Pharmaceuticals · 在 SEC EDGAR 上查看 ↗
$84.77
价格 · 八月 19, 2026
截至...的财报数据 八月 3, 2026

关于 Crinetics Pharmaceuticals, Inc. - Common Stock 公司概况(来自维基百科)

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

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Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

In July 2026, Vertex Pharmaceuticals agreed to acquire the company for $10 billion.

History

Struthers, Zhu, Kusnetzow, and Betz founded Crinetics in 2008 after previously working together on a small molecule drug for the treatment of endometriosis at Neurocrine Biosciences.

Crinetics expanded into a larger laboratory in 2010. After receiving NIH grant funding, Crinetics moved into its second laboratory.

In 2011, Crinetics Pharmaceuticals competed for the Michelson Prize, a competition sponsored by the Found Animals Foundation to develop a low-cost, non-surgical method for sterilizing dogs and cats, which would later lead to the licensing of a molecule for the treatment of acromegaly in large breed dogs.

Crinetics first synthesized its lead drug candidate to treat acromegaly. The drug was named paltusotine, in 2016. Crinetics Pharmaceuticals went public with an IPO in 2018. It conducted Phase II trials for paltusotine from 2019 to 2020. It conducted Phase III trials for paltusotine from 2021 to 2024. After the drug succeeded in a second Phase III study, the FDA accepted the company's new drug application for paltusotine and the company announced it was planning for a 2025 launch for the drug. The FDA set a Prescription Drug User Fee Act for the drug on September 25, 2025.

In 2021, Crinetics, together with 5AM Ventures and Frazier Healthcare Partners, formed an independently operated new company, Radionetics Oncology, aimed to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range of oncology indications.

Crinetics partnered with the veterinary medicine company Loyal to develop a pill to extend the lifespans of large dogs in 2023.

In 2024, Scott Struthers received the Ernst & Young Entrepreneur of the Year Award for his work with Crinetics. In 2024, Crinetics was reported to have patent activity in rare diseases, health technology, and addiction therapies.

In 2024, Radionetics formed a strategic relationship with Eli Lilly and Company to take forward Radionetics’ proprietary GPCR targeting small molecule radiopharmaceuticals. Under the terms of the agreement, Radionetics received a $140 million upfront cash payment. As part of the strategic agreement, Lilly obtained the exclusive right to acquire Radionetics upon conclusion of an exercise period for $1 billion.

Crinetics also established its first office outside the United States in Zug, Switzerland in 2024.

In 2025, Crinetics Pharmaceuticals plans to file an Investigational New Drug for an oral thyroid stimulating hormone receptor antagonist and its nonpeptide drug conjugate (CRN09682). A total of four development candidates are currently in IND-enabling studies, including a PTH antagonist (Hyperparathyrodism), non-peptide drug conjugate (NETs and SST2-expressing solid tumors), TSH antagonist (Graves’ disease & TED) and SST3 agonist (ADPKD).

In July 2026, Vertex Pharmaceuticals agreed to acquire Crinetics for $10 billion.

Treatments

Crinetics’ pipeline focuses on synthesizing novel molecules for rare endocrine diseases. It is most known for developing paltusotine, a drug designed to treat the hormonal disorder acromegaly. Paltusotine works by helping moderate elevated IGF-1 levels, which is the main symptom of acromegaly. Paltusotine has also been tested as a treatment for carcinoid syndrome.

Crinetics has also developed oral treatments for neuroendocrine tumors, hyperinsulism, and Cushing's disease. The company's drug for treating Cushing's disease, Atumeltnant (also known as CRN049894), works by reducing levels of ACTH.

The company's pipeline also includes an oral parathyroid hormone inhibitor program for hyperparathyroidism and treatments for thyroid eye disease, Graves' disease, and obesity. Additionally, Crinetics nonpeptide drug conjugates (NDCs) include CRN09682, which is a somatostatin receptor 2 (SST2) targeted drug. NDCs are a new technology developed in-house by Crinetics.

== References ==

来源:维基百科 (英语), CC BY-SA 4.0 · 在维基百科上查看 ↗

Wikidata ↗

CRNX 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围

价格
$84.77
市值
$8.10B
P/E (TTM)
-17.1
每股收益 (TTM)
$-4.95
营收 (TTM)
$8M
股息收益率
ROE
-43.0%
负债/权益
52周区间
$29 – $85

CRNX 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图

10年表现 收入、净利润、利润率和每股收益趋势

营收与净利润 $8M
10-point trend, +1206.6%
2016-12-31 2025-12-31
EPS $-4.95
6-point trend, -104.5%
2020-12-31 2025-12-31
自由现金流 $-384M
8-point trend, -1770.0%
2018-12-31 2025-12-31
利润率 -6046.2%

估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜?

指标
5年趋势
CRNX
同行中位数
P/E (TTM)
5-point trend, +7.3%
-17.1
47.9
P/S (TTM) (市销率 (TTM))
5-point trend, -53.9%
1052.7
16.2
P/B (市净率)
5-point trend, +10.1%
8.2
9.3
Price / FCF (股价/自由现金流)
5-point trend, +23.7%
-21.1

盈利能力 毛利率、营业利润率和净利率;股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)

指标
5年趋势
CRNX
同行中位数
Operating Margin (营业利润率)
5-point trend, +32.8%
-6714.8%
Net Profit Margin (净利润率)
5-point trend, +39.4%
-6046.2%
5.1%
ROA
5-point trend, +9.8%
-36.3%
0.81%
ROE
5-point trend, -5.0%
-43.0%
-15.3%
ROIC
5-point trend, -60.6%
-52.1%

财务健康 债务、流动性、偿付能力 — 资产负债表强度

指标
5年趋势
CRNX
同行中位数
Current Ratio (流动比率)
5-point trend, -42.8%
12.3
2.7
Quick Ratio (速动比率)
5-point trend, -42.1%
12.1

成长 营收、每股收益 (EPS) 和净利润增长:同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)

指标
5年趋势
CRNX
同行中位数
Revenue YoY (营收同比增长)
5-point trend, +613.9%
640.7%
Revenue CAGR 3Y (营收3年复合年增长率)
5-point trend, +613.9%
17.6%
Revenue CAGR 5Y (营收5年复合年增长率)
5-point trend, +613.9%
155.3%

每股指标 每股收益 (EPS)、每股净资产、每股现金流、每股股息

指标
5年趋势
CRNX
同行中位数
EPS (Diluted) (EPS (稀释))
5-point trend, -76.8%
$-4.95

资本效率 资产周转率、库存周转率、应收账款周转率

指标
5年趋势
CRNX
同行中位数

CRNX 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间

持有 21 位分析师
  • 强烈买入 3 14.3%
  • 买入 4 19.0%
  • 持有 14 66.7%
  • 卖出 0 0.0%
  • 强烈卖出 0 0.0%

12个月价格目标

10 位分析师 · 2026-08-13
中位数目标 $85.00 +0.3%
平均目标 $85.50 +0.9%

收益历史 每股收益实际值 vs 预估值,惊喜%,达标率,下次财报日期

平均惊喜
-0.01%
期间 EPS Actual EPS 预期 惊喜
2026年6月30日 $-1.14 $-1.23 0.09%
2026年3月31日 $-1.23 $-1.26 0.03%
2025年12月31日 $-1.29 $-1.39 0.10%
2025年9月30日 $-1.38 $-1.28 -0.10%
2025年6月30日 $-1.23 $-1.12 -0.11%
2025年3月31日 $-1.04 $-0.96 -0.08%

同行比较(GICS 子行业) 关键指标与行业同行对比

股票代码 市值 P/E 营收同比增长 净利润率 ROE 毛利率
CRNX $4.45B -9.4 640.7% -6046.2% -43.0%
CORT $3.69B 42.4 12.8% 13.1% 15.5%
ELAN $11.25B -48.1 6.2% -4.9% -3.5% 55.0%
AXSM $9.29B -49.6 65.5% -28.7% -227.0%
LQDA $3.01B -43.1 1031.2% -43.5% -230.0%
BLTE
DFTX $1.32B -6.5 212.0% -71.0%
AMRX 57.3 8.1% 2.4% -80.0% 36.9%
LGND $3.74B 30.8 60.4% 46.4% 13.5%
LLY 46.8 44.7% 31.7% 101.2%

完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表

损益表 17
CRNX 的年度损益表数据
指标 趋势 202520242023202220212020201920182017
Revenue 9-point trend, +276.3% $8M $1M $4M $5M $1M $71.0K $1M $2M $2M
Cost of Revenue 3-point trend, +1076000.00 $1M $0 $0 · · · · · ·
R&D Expense 9-point trend, +3496.4% $332M $240M $169M $130M $84M $57M $42M $24M $9M
SG&A Expense 9-point trend, +9767.5% $191M $100M $58M $42M $25M $18M $14M $7M $2M
Operating Expenses 9-point trend, +4594.5% $524M $340M $227M $173M $109M $75M $55M $31M $11M
Operating Income 9-point trend, -5562.0% $-517M $-339M $-223M $-168M $-108M $-75M $-54M $-29M $-9M
Interest Expense · · · · · · · · $8.0K
Interest Income 9-point trend, +199857.7% $52M $41M $13M $4M $157.0K $991.0K $3M $2M $26.0K
Other Non-op 9-point trend, -1090.0% $-357.0K $-519.0K $-159.0K $5M $61.0K $1M $3M $2M $-30.0K
Pretax Income 9-point trend, -4979.6% $-465M $-298M $-209M $-164M $-108M $-74M $-50M $-27M $-9M
Income Tax 9-point trend, +180000.00 $180.0K $0 $0 $0 $0 $0 $0 $0 $0
Net Income 9-point trend, -4981.5% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M $-9M
EPS (Basic) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
EPS (Diluted) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Shares (Basic) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
Shares (Diluted) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
EBITDA 8-point trend, -1686.4% $-513M $-339M $-223M $-168M $-108M $-75M $-54M $-29M ·
资产负债表 24
CRNX 的年度资产负债表数据
指标 趋势 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +615.4% $102M $265M $55M $33M $201M $93M $40M $45M $14M
Short-term Investments 8-point trend, +679.1% $926M $1.09B $504M $302M $133M $78M $78M $119M ·
Receivables 2-point trend, +592000.00 $592.0K $0 · · · · · · ·
Inventory 2-point trend, +2022000.00 $2M $0 · · · · · · ·
Prepaid Expense 9-point trend, +1733.4% $18M $21M $16M $11M $11M $7M $5M $3M $973.0K
Other Current Assets 9-point trend, +1346.0% $3M $2M $448.0K $2M $912.0K $1M $668.0K $876.0K $239.0K
Current Assets 9-point trend, +6812.9% $1.05B $1.38B $574M $345M $345M $177M $123M $167M $15M
PP&E (Net) 9-point trend, +3474.0% $14M $12M $11M $4M $3M $3M $4M $4M $400.0K
PP&E (Gross) 9-point trend, +3060.2% $22M $20M $16M $8M $6M $6M $6M $5M $704.0K
Accum. Depreciation 9-point trend, +2515.8% $8M $8M $5M $4M $3M $3M $2M $741.0K $304.0K
Other Non-current Assets 7-point trend, +8472.7% · $3M $2M $37.0K $0 $40.0K $82.0K · $33.0K
Total Assets 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Accounts Payable 9-point trend, +5510.7% $23M $6M $7M $7M $3M $6M $5M $5M $403.0K
Accrued Liabilities 2-point trend, +2240.8% · · · · · · · $4M $179.0K
Current Liabilities 9-point trend, +9384.1% $85M $60M $44M $28M $16M $10M $8M $8M $897.0K
Capital Leases 7-point trend, +767.2% $42M $45M $48M $2M $3M $4M $5M · ·
Other Non-current Liabilities 3-point trend, +3240000.00 $3M $829.0K $0 · · · · · ·
Total Liabilities 9-point trend, +14484.1% $134M $110M $96M $36M $19M $15M $13M $11M $920.0K
Common Stock 4-point trend, +25200.0% · · $253.0K $0 · · · $24.0K $1.0K
Retained Earnings 9-point trend, -8614.6% $-1.42B $-952M $-654M $-439M $-275M $-168M $-94M $-43M $-16M
AOCI 8-point trend, +2957.4% $2M $963.0K $977.0K $-4M $-382.0K $25.0K $148.0K $61.0K ·
Stockholders' Equity 9-point trend, +6704.2% $992M $1.32B $539M $316M $332M $169M $117M $160M $-15M
Liabilities + Equity 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Shares Outstanding 9-point trend, +6067.8% 95,575,000 92,926,000 68,175,000 53,877,000 47,597,000 33,001,000 24,263,000 24,061 1,549,575
现金流 13
CRNX 的年度现金流数据
指标 趋势 202520242023202220212020201920182017
D&A 9-point trend, +2946.9% $4M $3M $1M $983.0K $922.0K $948.0K $887.0K $471.0K $128.0K
Stock-based Comp 9-point trend, +33488.2% $91M $69M $41M $28M $17M $10M $6M $2M $271.0K
Deferred Tax Flat — no change across 3 periods $0 $0 $0 · · · · · ·
Other Non-cash $-8M · · · · · · · ·
Operating Cash Flow 9-point trend, -3886.9% $-378M $-230M $-169M $-115M $-89M $-62M $-46M $-19M $-9M
CapEx 9-point trend, +1795.4% $6M $4M $5M $2M $436.0K $186.0K $492.0K $1M $304.0K
Investing Cash Flow 9-point trend, +57306.6% $174M $-575M $-200M $-174M $-56M $217.0K $42M $-119M $-304.0K
Stock Issued 7-point trend, -100.0% $0 $985M $370M $117M $250M $114M · $106M ·
Net Stock Activity 6-point trend, -100.0% $0 $970M $369M $117M $250M $114M · · ·
Financing Cash Flow 9-point trend, +243.5% $41M $1.01B $391M $122M $253M $115M $67.0K $170M $12M
Net Change in Cash 8-point trend, +10176.9% · $210M $22M $-167M $108M $53M $-5M $31M $2M
Taxes Paid 3-point trend, +89000.00 $89.0K $0 $0 · · · · · ·
Free Cash Flow 8-point trend, -1770.0% $-384M $-230M $-171M $-117M $-89M $-62M $-47M $-21M ·
盈利能力 7
CRNX 的年度盈利能力数据
指标 趋势 202520242023202220212020201920182017
Operating Margin 8-point trend, -467.9% -6714.8% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
Net Margin 8-point trend, -441.4% -6046.2% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
Pretax Margin 8-point trend, -441.2% -6043.9% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
EBITDA Margin 8-point trend, -463.6% -6664.1% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
ROA 8-point trend, -25.3% -36.3% -28.8% -43.5% -46.6% -40.3% -47.0% -33.4% -29.0% ·
ROE 8-point trend, -159.9% -43.0% -27.7% -39.5% -49.1% -41.0% -41.4% -40.9% -16.6% ·
ROIC 8-point trend, -190.8% -52.1% -25.6% -41.3% -53.1% -32.5% -44.4% -46.0% -17.9% ·
流动性与偿付能力 2
CRNX 的年度流动性与偿付能力数据
指标 趋势 202520242023202220212020201920182017
Current Ratio 8-point trend, -41.4% 12.3 23.0 13.1 12.5 21.6 16.9 14.8 21.0 ·
Quick Ratio 8-point trend, -41.5% 12.1 22.7 12.7 12.1 20.9 16.3 14.2 20.7 ·
效率 3
CRNX 的年度效率数据
指标 趋势 202520242023202220212020201920182017
Asset Turnover 8-point trend, -76.9% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
Inventory Turnover 1.1 · · · · · · · ·
Receivables Turnover 26.0 · · · · · · · ·
每股 5
CRNX 的年度每股数据
指标 趋势 202520242023202220212020201920182017
Book Value / Share 8-point trend, +55.9% $10.38 $14.26 $7.91 $5.87 $6.97 $5.12 $4827.89 $6.66 ·
Revenue / Share 4-point trend, -10.2% $0.08 $0.01 $0.07 $0.09 · · · · ·
Cash Flow / Share 4-point trend, -81.3% $-4.02 $-2.80 $-2.86 $-2.22 · · · · ·
Cash / Share 8-point trend, -43.2% $1.06 $2.85 $0.81 $0.61 $4.22 $2.82 $1662.04 $1.87 ·
EPS (TTM) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
增长率 3
CRNX 的年度增长率数据
指标 趋势 202520242023202220212020201920182017
Revenue YoY 5-point trend, -54.8% 640.7% -74.1% -15.3% 339.4% 1418.3% · · · ·
Revenue CAGR 3Y 3-point trend, -93.8% 17.6% -1.2% 283.8% · · · · · ·
Revenue CAGR 5Y 155.3% · · · · · · · ·
估值 (TTM) 10
CRNX 的年度估值 (TTM)数据
指标 趋势 202520242023202220212020201920182017
Revenue TTM 8-point trend, +217.0% $8M $1M $4M $5M $1M $71.0K $1M $2M ·
Net Income TTM 8-point trend, -1616.1% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M ·
Market Cap 8-point trend, +516.6% $4.45B $4.75B $2.43B $986M $1.35B $466M $608.8K $722M ·
P/E 6-point trend, -61.3% -9.4 -13.9 -9.6 -5.8 -10.1 -5.8 · · ·
P/S 8-point trend, +94.5% 578.1 4573.0 604.5 208.1 1254.4 6558.4 0.5 297.2 ·
P/B 8-point trend, -0.4% 4.5 3.6 4.5 3.1 4.1 2.8 0.0 4.5 ·
P / Tangible Book 6-point trend, +62.7% 4.5 3.6 4.5 3.1 4.1 2.8 · · ·
P / Cash Flow 8-point trend, +68.3% -11.8 -21.0 -14.6 -8.6 -15.3 -7.5 -0.0 -37.1 ·
P / FCF 8-point trend, +67.0% -11.6 -20.7 -14.2 -8.4 -15.2 -7.5 -0.0 -35.2 ·
Earnings Yield 6-point trend, +38.0% -10.6% -7.2% -10.4% -17.2% -9.9% -17.2% · · ·

财务报表 损益表、资产负债表、现金流量表 — 年度,近5年

损益表
2025-12-312024-12-312023-12-312022-12-312021-12-31
收入 $8M$1M$4M$5M$1M
营业利润率 % -6714.8%-32613.5%-5547.2%-3544.1%-9990.9%
净收入 $-465M$-298M$-215M$-164M$-108M
稀释后每股收益 (EPS) $-4.95$-3.69$-3.69$-3.15$-2.80
资产负债表
2025-12-312024-12-312023-12-312022-12-312021-12-31
流动比率 12.323.013.112.521.6
速动比率 12.122.712.712.120.9
现金流
2025-12-312024-12-312023-12-312022-12-312021-12-31
自由现金流 $-384M$-230M$-171M$-117M$-89M

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机构持有人 (13F) 287 家申报者 · $3.2B 总计 · 截至 2026年6月30日

在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸;单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存,而非方向性判断。

机构活动 — Q2 2026 与上一季度对比
新仓位 已退出持仓 增加 减少 净股数变动
63 (+11 与上一季度对比) 30 (-13 与上一季度对比) 95 (-17 与上一季度对比) 63 (+3 与上一季度对比) +11.4M

与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天,外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过,优先显示最近一个已完整报告的季度对。

机构 价值 股份 % 已追踪的13F 类型
FMR LLC $486250673 12994406 15.13% 股份
FARALLON CAPITAL MANAGEMENT, L.L.C. $336372047 8989098 10.46% 股份
Driehaus Capital Management LLC $241866078 6463551 7.52% 股份
WELLINGTON MANAGEMENT GROUP LLP $237002526 6333579 7.37% 股份
VANGUARD PORTFOLIO MANAGEMENT LLC $180836416 4832614 5.63% 股份
VANGUARD CAPITAL MANAGEMENT LLC $177567704 4745262 5.52% 股份
STATE STREET CORP $100635477 2689350 3.13% 股份
Bellevue Group AG $98040400 2620000 3.05% 股份
BAKER BROS. ADVISORS LP $87991820 2351465 2.74% 股份
GEODE CAPITAL MANAGEMENT, LLC $87542675 2338905 2.72% 股份
Polar Capital Holdings Plc $85108460 2274411 2.65% 股份
Pictet Asset Management Holding SA $77572984 2075375 2.41% 股份
Siren, L.L.C. $53165887 1420788 1.65% 股份
First Light Asset Management, LLC $50923606 1360866 1.58% 股份
NOVO HOLDINGS A/S $49394400 1320000 1.54% 股份
AMERICAN CENTURY COMPANIES INC $47245129 1262562 1.47% 股份
ADAR1 Capital Management, LLC $45730234 1222080 1.42% 股份
DIMENSIONAL FUND ADVISORS LP $44555208 1190679 1.39% 股份
MONTANOVA CAPITAL, LLC $44390560 1186279 1.38% 股份
ORBIMED ADVISORS LLC $37382580 999000 1.16% 股份
Hood River Capital Management LLC $36259830 968996 1.13% 股份
GOLDMAN SACHS GROUP INC $34657132 926166 1.08% 股份
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $32841401 877643 1.02% 股份
Aberdeen Group plc $30699181 820395 0.95% 股份
Candriam S.C.A. $30618690 819032 0.95% 股份
VANGUARD FIDUCIARY TRUST CO $28230995 754436 0.88% 股份
Fisher Asset Management, LLC $27748912 741553 0.86% 股份
SCHRODER INVESTMENT MANAGEMENT GROUP $17709036 479400 0.55% 股份
AMERIPRISE FINANCIAL INC $17451149 466356 0.54% 股份
Impax Asset Management Group plc $16277700 435000 0.51% 股份
Prosight Management, LP $14020002 374666 0.44% 股份
Universal- Beteiligungs- und Servicegesellschaft mbH $13991714 373910 0.44% 股份
KENNEDY CAPITAL MANAGEMENT LLC $13685018 365714 0.43% 股份
BRAUN STACEY ASSOCIATES INC $13027511 348143 0.41% 股份
Fiera Capital Corp $12395263 331247 0.39% 股份
BANK OF AMERICA CORP /DE/ $11271877 301226 0.35% 股份
Defilade Capital Management, L.P. $8959845 239440 0.28% 股份
SEB Asset Management AB $8003786 213891 0.25% 股份
Foresite Capital Management VI LLC $7933414 212010 0.25% 股份
RICE HALL JAMES & ASSOCIATES, LLC $7346220 196318 0.23% 股份
TD Asset Management Inc $7152534 191142 0.22% 股份
Swiss National Bank $6877796 183800 0.21% 股份
SEGALL BRYANT & HAMILL, LLC $6855307 183199 0.21% 股份
BlackRock, Inc. $6781290 181221 0.21% 股份
JENNISON ASSOCIATES LLC $6056839 161861 0.19% 股份
New Leaf Venture Partners, L.L.C. $5872650 141000 0.18% 股份
SILVERCREST ASSET MANAGEMENT GROUP LLC $5865136 156738 0.18% 股份
Foresite Capital Management IV, LLC $5613000 150000 0.17% 股份
Bank of New York Mellon Corp $5581754 149165 0.17% 股份
NEW YORK STATE COMMON RETIREMENT FUND $5508898 147218 0.17% 股份
ENVESTNET ASSET MANAGEMENT INC $5471384 146216 0.17% 股份
Moody Aldrich Partners LLC $5466201 146077 0.17% 股份
Ishara Investments LP $5369770 143500 0.17% 股份
CITADEL ADVISORS LLC $5176271 138329 0.16% 股份
RHUMBLINE ADVISERS $4861141 129908 0.15% 股份
ALLIANCEBERNSTEIN L.P. $4782618 131680 0.15% 股份
GordonMD Global Investments LP $4751779 126985 0.15% 股份
MANUFACTURERS LIFE INSURANCE COMPANY, THE $4712974 125948 0.15% 股份
JANUS HENDERSON GROUP PLC $4700428 129392 0.15% 股份
Cormorant Asset Management, LP $4677500 125000 0.15% 股份
SECTOR GAMMA AS $4289380 114628 0.13% 股份
XTX Topco Ltd $4164547 111292 0.13% 股份
ALPS ADVISORS INC $3981825 106409 0.12% 股份
FEDERATED HERMES, INC. $3957390 105756 0.12% 股份
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3834048 105563 0.12% 股份
Nuveen Asset Management, LLC $3760151 73541 0.12% 股份
Burkehill Global Management, LP $3742000 100000 0.12% 股份
Nuveen, LLC $3619262 96720 0.11% 股份
VICTORY CAPITAL MANAGEMENT INC $3484251 93112 0.11% 股份
MORGAN STANLEY $3320829 88744 0.10% 股份
TWO SIGMA INVESTMENTS, LP $3266729 87299 0.10% 股份
VANGUARD ASSET MANAGEMENT, Ltd $3254754 86979 0.10% 股份
AWM Investment Company, Inc. $3180700 85000 0.10% 股份
Odyssean, LLC $3160344 84456 0.10% 股份
Affinity Asset Advisors, LLC $2806500 75000 0.09% 股份
ALGERT GLOBAL LLC $2714147 72532 0.08% 股份
ExodusPoint Capital Management, LP $2652404 70882 0.08% 股份
Ensign Peak Advisors, Inc $2507290 67004 0.08% 股份
BARCLAYS PLC $2466127 65904 0.08% 股份
FIRST TRUST ADVISORS LP $2370631 63352 0.07% 股份
Man Group plc $2284229 61043 0.07% 股份
MetLife Investment Management, LLC $2258709 60361 0.07% 股份
CITIGROUP INC $2255229 60268 0.07% 股份
Longaeva Partners L.P. $2184879 58388 0.07% 股份
Swedbank AB $2155392 57600 0.07% 股份
STATE OF WISCONSIN INVESTMENT BOARD $2068016 55265 0.06% 股份
Jump Financial, LLC $1923388 51400 0.06% 股份
Lighthouse Investment Partners, LLC $1871000 50000 0.06% 股份
Vestmark Advisory Solutions, Inc. $1823252 48724 0.06% 股份
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1787254 47762 0.06% 股份
VANGUARD GROUP INC $1774626 38123 0.06% 股份
Point72 Asset Management, L.P. $1735577 46381 0.05% 股份
BNP PARIBAS FINANCIAL MARKETS $1696398 45334 0.05% 股份
RAYMOND JAMES FINANCIAL INC $1606254 42925 0.05% 股份
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1549188 41400 0.05% 买入期权
Invesco Ltd. $1545446 41300 0.05% 股份
Vanguard Global Advisers, LLC $1485986 39711 0.05% 股份
HighMark Wealth Management LLC $1444224 38595 0.04% 股份
OAK RIDGE INVESTMENTS LLC $1405046 37548 0.04% 股份
Orion Porfolio Solutions, LLC $1404234 37526 0.04% 股份

公司内部人士 20 位内幕人士 · 9 位高管 · 10 位董事

内部人士 角色 上次活动 持股数量 买入 12个月 卖出 12个月 净额 12个月
Tobin Schilke Chief Financial Officer 2025年3月10日 A 52000 0 0 $0
Marc Wilson CFO 2024年9月26日 M 111092 0 0 $0
Jeff E. Knight Chief Operating Officer 2025年3月19日 S 87491 0 0 $0
Stephen F. Betz Chief Scientific Officer 2025年6月12日 M 99713 0 0 $0
Dana Pizzuti Chief Med and Dev Officer 2025年3月19日 S 72233 0 0 $0
Isabel Kalofonos Chief Commercial Officer 2025年1月10日 A 0 0 $0
James Hassard Chief Commercial Officer 2024年7月5日 M 29259 0 0 $0
Alan Seth Krasner Chief Medical Officer 2023年10月17日 M 43210 0 0 $0
Ajay Madan Chief Development Officer 2022年2月28日 A 176995 0 0 $0
Coelho Rogerio Vivaldi 董事 2026年7月2日 S 19225 0 1 $-120000
Caren Deardorf 董事 2026年6月18日 A 22225 0 0 $0
Weston Nichols 董事 2026年6月18日 A 22225 0 0 $0
Stephanie Okey 董事 2026年6月18日 A 12325 0 2 $-246143
Matthew K Fust 董事 2026年6月18日 A 28761 0 0 $0
Camille L Bedrosian 董事 2026年6月18日 A 22225 0 0 $0
Wendell Wierenga 董事 2026年6月18日 A 122071 0 0 $0
Wendall Wierenga 董事 2025年6月11日 A 116146 0 0 $0
Stephen W Kaldor 董事 2020年6月19日 A 0 0 $0
Jack Nielsen 董事 2019年6月21日 A 0 0 $0
Richard Scott Struthers 2026年8月7日 M 424706 0 0 $0

来自SEC表格3/4/5申报的内部人士;净额=仅公开市场买卖

激进投资者及 5%+ 股东 1 持仓

提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权,意图影响发行人(激进股东持股、董事会活动、并购)。每一行显示该申报人持仓的最新已知状态。

申报人 已申报 持股 状态 目的 申报
Perceptive Advisors LLC, Joseph Edelman, Perceptive Life Sciences Master Fund, Ltd. ×6 申报 2024年3月1日 初始申报 SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF持仓 由 55 只交易所交易基金持有

权重仅反映直接股权持仓(N-PORT);杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。

基金 权重 单位 截至 来源
SBIO · ALPS ETF Trust 2.37% 107892 NS 2026年5月31日 N-PORT
FMED · Fidelity Covington Trust 1.65% 19000 NS 2026年5月31日 N-PORT
PILL · Direxion Shares ETF Trust 1.40% 4666 NS 2026年4月30日 N-PORT
BBP · ETFis Series Trust I 1.23% 18743 NS 2026年4月30日 N-PORT
MMSC · First Trust Exchange-Traded Fund ... 0.75% 11043 NS 2026年5月31日 N-PORT
NUSC · Nushares ETF Trust 0.28% 93045 NS 2026年4月30日 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund ... 0.20% 38553 NS 2026年4月30日 N-PORT
BIB · ProShares Trust 0.19% 3872 NS 2026年5月31日 N-PORT
BKSE · BNY Mellon ETF Trust 0.15% 3142 NS 2026年4月30日 N-PORT
FNY · First Trust Exchange-Traded Alpha... 0.14% 18879 NS 2026年4月30日 N-PORT
RSSL · Global X Funds 0.12% 42391 NS 2026年4月30日 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0.10% 31759 NS 2026年4月30日 N-PORT
ITWO · ProShares Trust 0.09% 4601 NS 2026年5月31日 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.08% 492431 NS 2026年5月31日 N-PORT
FNX · First Trust Exchange-Traded Alpha... 0.07% 24991 NS 2026年4月30日 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.06% 41183 NS 2026年4月30日 N-PORT
DFAS · Dimensional ETF Trust 0.05% 196549 NS 2026年4月30日 N-PORT
UWM · ProShares Trust 0.05% 3599 NS 2026年5月31日 N-PORT
FAD · First Trust Exchange-Traded Alpha... 0.04% 5196 NS 2026年4月30日 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.04% 112 NS 2026年5月31日 N-PORT
URTY · ProShares Trust 0.04% 3643 NS 2026年5月31日 N-PORT
GSSC · Goldman Sachs ETF Trust 0.02% 5689 NS 2026年5月31日 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.02% 3773 NS 2026年5月31日 N-PORT
HDG · ProShares Trust 0.02% 91 NS 2026年5月31日 N-PORT
DFAC · Dimensional ETF Trust 0.01% 125853 NS 2026年4月30日 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 28694 NS 2026年5月31日 N-PORT
DCOR · Dimensional ETF Trust 0.01% 5863 NS 2026年4月30日 N-PORT
TILT · FlexShares Trust 0.01% 3388 NS 2026年4月30日 N-PORT
DFUS · Dimensional ETF Trust 0.01% 31413 NS 2026年4月30日 N-PORT
DFAU · Dimensional ETF Trust 0.01% 15024 NS 2026年4月30日 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.01% 60503 NS 2026年5月31日 N-PORT
DXUV · Dimensional ETF Trust 0.00% 468 NS 2026年4月30日 N-PORT
VXF · VANGUARD INDEX FUNDS 2026年7月15日 每日
VB · VANGUARD INDEX FUNDS 2026年7月15日 每日
VBK · VANGUARD INDEX FUNDS 2026年7月15日 每日
VTI · VANGUARD INDEX FUNDS 2026年7月15日 每日
VT · VANGUARD INTERNATIONAL EQUITY IND... 2026年7月15日 每日
VTWO · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
VTWG · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
VTHR · VANGUARD SCOTTSDALE FUNDS 2026年7月15日 每日
ITOT · iShares Trust 2026年8月5日 每日
IWV · iShares Trust 2026年8月18日 每日
IWO · iShares Trust 2026年8月18日 每日
IWM · iShares Trust 2026年8月18日 每日
IBB · iShares Trust 2026年8月18日 每日
IHE · iShares Trust 2026年8月18日 每日
PRFZ · Invesco Exchange-Traded Fund Trust 2026年8月4日 每日
OMFS · Invesco Exchange-Traded Self-Inde... 2026年7月13日 每日
VHT · VANGUARD WORLD FUND 2026年7月20日 每日
ESGV · VANGUARD WORLD FUND 2026年7月30日 每日