| RA CAPITAL MANAGEMENT, L.P. |
$171873684 |
11189693 |
16.64% |
股份
|
| BlackRock, Inc. |
$94228481 |
6134667 |
9.12% |
股份
|
| Prosight Management, LP |
$58436828 |
3804481 |
5.66% |
股份
|
| JANUS HENDERSON GROUP PLC |
$58279971 |
4196409 |
5.64% |
股份
|
| STATE STREET CORP |
$46155249 |
3004899 |
4.47% |
股份
|
| VANGUARD GROUP INC |
$40108126 |
2906386 |
3.88% |
股份
|
| FMR LLC |
$37060986 |
2412825 |
3.59% |
股份
|
| FEDERATED HERMES, INC. |
$36140959 |
2352927 |
3.50% |
股份
|
| Point72 Asset Management, L.P. |
$30625336 |
1993837 |
2.97% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$28528911 |
1857351 |
2.76% |
股份
|
| TCG Crossover Management, LLC |
$27488517 |
1789617 |
2.66% |
股份
|
| Alyeska Investment Group, L.P. |
$25300070 |
1647140 |
2.45% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$23153049 |
1507360 |
2.24% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20439706 |
1330710 |
1.98% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$18543360 |
1207250 |
1.80% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$18499798 |
1204150 |
1.79% |
股份
|
| CITADEL ADVISORS LLC |
$18443321 |
1200737 |
1.79% |
股份
|
| ALGERT GLOBAL LLC |
$17063255 |
1110889 |
1.65% |
股份
|
| D. E. Shaw & Co., Inc. |
$16842378 |
1096509 |
1.63% |
股份
|
| GOLDMAN SACHS GROUP INC |
$14633088 |
952675 |
1.42% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$13984665 |
910460 |
1.35% |
股份
|
| MORGAN STANLEY |
$12855801 |
836966 |
1.24% |
股份
|
| Nantahala Capital Management, LLC |
$12440279 |
809914 |
1.20% |
股份
|
| Qube Research & Technologies Ltd |
$10783596 |
702057 |
1.04% |
股份
|
| Squarepoint Ops LLC |
$8176451 |
532321 |
0.79% |
股份
|
| ORBIMED ADVISORS LLC |
$8059392 |
524700 |
0.78% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7749796 |
504544 |
0.75% |
股份
|
| ADAR1 Capital Management, LLC |
$6464732 |
420881 |
0.63% |
股份
|
| Cubist Systematic Strategies, LLC |
$6293960 |
257527 |
0.61% |
股份
|
| NORTHERN TRUST CORP |
$6118902 |
398366 |
0.59% |
股份
|
| JANE STREET GROUP, LLC |
$6020981 |
391991 |
0.58% |
股份
|
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
$5782979 |
376496 |
0.56% |
股份
|
| Woodline Partners LP |
$5683692 |
370032 |
0.55% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$5670774 |
369191 |
0.55% |
股份
|
| Rock Springs Capital Management LP |
$5637258 |
367009 |
0.55% |
股份
|
| Jump Financial, LLC |
$5555174 |
361665 |
0.54% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$5525376 |
359725 |
0.54% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4842563 |
315271 |
0.47% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$4133576 |
269113 |
0.40% |
股份
|
| Man Group plc |
$3821583 |
248801 |
0.37% |
股份
|
| Balyasny Asset Management L.P. |
$3250714 |
211635 |
0.31% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$3219348 |
209593 |
0.31% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$3018040 |
196487 |
0.29% |
股份
|
| JPMORGAN CHASE & CO |
$2736049 |
178535 |
0.26% |
股份
|
| Allspring Global Investments Holdings, LLC |
$2434909 |
166092 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2403840 |
156500 |
0.23% |
卖出期权
|
| BML Capital Management, LLC |
$2380201 |
154961 |
0.23% |
股份
|
| UBS Group AG |
$2314767 |
150701 |
0.22% |
股份
|
| Springhill Fund Asset Management (HK) Co Ltd |
$2119500 |
78500 |
0.21% |
股份
|
| Bank of New York Mellon Corp |
$2074706 |
135072 |
0.20% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$2056243 |
133870 |
0.20% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1744896 |
113600 |
0.17% |
买入期权
|
| AQR CAPITAL MANAGEMENT LLC |
$1660063 |
108077 |
0.16% |
股份
|
| FRANKLIN RESOURCES INC |
$1617116 |
105281 |
0.16% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$1566289 |
101972 |
0.15% |
股份
|
| Rangeley Capital, LLC |
$1504942 |
97978 |
0.15% |
股份
|
| Nuveen, LLC |
$1491763 |
97120 |
0.14% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1436580 |
104100 |
0.14% |
股份
|
| WINTON GROUP Ltd |
$1387008 |
90300 |
0.13% |
股份
|
| AVALON VENTURES MANAGEMENT, LLC |
$1302652 |
53300 |
0.13% |
股份
|
| Russell Investments Group, Ltd. |
$1253390 |
81601 |
0.12% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1219822 |
87757 |
0.12% |
股份
|
| Swiss National Bank |
$1218048 |
79300 |
0.12% |
股份
|
| XTX Topco Ltd |
$1186299 |
77233 |
0.11% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$1177000 |
76601 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$1165824 |
75900 |
0.11% |
买入期权
|
| Quantinno Capital Management LP |
$1078840 |
70237 |
0.10% |
股份
|
| CITIGROUP INC |
$1078809 |
70235 |
0.10% |
股份
|
| CONGRESS ASSET MANAGEMENT CO |
$1038490 |
67610 |
0.10% |
股份
|
| BARCLAYS PLC |
$978110 |
63679 |
0.09% |
股份
|
| Trexquant Investment LP |
$973133 |
63355 |
0.09% |
股份
|
| Walleye Capital LLC |
$957512 |
62338 |
0.09% |
股份
|
| Raiffeisen Bank International AG |
$919500 |
60000 |
0.09% |
股份
|
| Invesco Ltd. |
$890911 |
58002 |
0.09% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$860160 |
56000 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$848184 |
55221 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$847344 |
60960 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$823419 |
53608 |
0.08% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$782316 |
50932 |
0.08% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$749169 |
48774 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$748432 |
48726 |
0.07% |
股份
|
| HighVista Strategies LLC |
$743056 |
48376 |
0.07% |
股份
|
| AXQ CAPITAL, LP |
$729723 |
47508 |
0.07% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$713871 |
46476 |
0.07% |
股份
|
| Engineers Gate Manager LP |
$696008 |
45313 |
0.07% |
股份
|
| HSBC HOLDINGS PLC |
$686212 |
44101 |
0.07% |
股份
|
| Creative Planning |
$679398 |
44232 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$664750 |
43278 |
0.06% |
股份
|
| Jain Global LLC |
$636349 |
41429 |
0.06% |
股份
|
| Verdad Advisers, LP |
$620329 |
40386 |
0.06% |
股份
|
| Schonfeld Strategic Advisors LLC |
$616871 |
40161 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$589824 |
38400 |
0.06% |
买入期权
|
| TEMA ETFS LLC |
$511870 |
37092 |
0.05% |
股份
|
| MARSHALL WACE, LLP |
$502794 |
32734 |
0.05% |
股份
|
| Legal & General Group Plc |
$476129 |
30998 |
0.05% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$475807 |
30977 |
0.05% |
股份
|
| Hudson Bay Capital Management LP |
$460800 |
30000 |
0.04% |
股份
|
| Walleye Capital LLC |
$459264 |
29900 |
0.04% |
买入期权
|
| CenterBook Partners LP |
$437791 |
28502 |
0.04% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$431155 |
28070 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$414305 |
26973 |
0.04% |
股份
|
| Entropy Technologies, LP |
$411571 |
26795 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$401247 |
26137 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$399836 |
26031 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$394752 |
25700 |
0.04% |
卖出期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$375383 |
24439 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$370637 |
24130 |
0.04% |
股份
|
| Point72 (DIFC) Ltd |
$370046 |
15141 |
0.04% |
股份
|
| Aigen Investment Management, LP |
$350838 |
22841 |
0.03% |
股份
|
| Bleakley Financial Group, LLC |
$305649 |
19899 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$303805 |
19779 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$302362 |
19685 |
0.03% |
股份
|
| Lion Point Capital, LP |
$291840 |
19000 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$288445 |
18779 |
0.03% |
股份
|
| ALLSTATE CORP |
$284160 |
18500 |
0.03% |
股份
|
| INCEPTIONR LLC |
$280673 |
18273 |
0.03% |
股份
|
| MML INVESTORS SERVICES, LLC |
$263240 |
17138 |
0.03% |
股份
|
| Orion Portfolio Solutions, LLC |
$263042 |
4913 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$258677 |
16841 |
0.03% |
股份
|
| Brevan Howard Capital Management LP |
$248893 |
16204 |
0.02% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$218696 |
14238 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$214426 |
13960 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$211968 |
13800 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$210877 |
13729 |
0.02% |
股份
|
| OXFORD ASSET MANAGEMENT LLP |
$197284 |
12844 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$196378 |
12785 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$195287 |
12714 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$184643 |
12021 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$180419 |
11746 |
0.02% |
股份
|
| Caption Management, LLC |
$178176 |
11600 |
0.02% |
买入期权
|
| AlphaQuest LLC |
$177399 |
12855 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$176640 |
11500 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$176225 |
11473 |
0.02% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$174336 |
11350 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$167578 |
10910 |
0.02% |
股份
|
| Inscription Capital, LLC |
$160527 |
10451 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$155136 |
10100 |
0.02% |
股份
|
| ExodusPoint Capital Management, LP |
$154813 |
10079 |
0.01% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$153762 |
10292 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$149084 |
9706 |
0.01% |
股份
|
| Walleye Capital LLC |
$147456 |
9600 |
0.01% |
卖出期权
|
| Vanguard Investments Australia, Ltd. |
$139576 |
9087 |
0.01% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$135660 |
8832 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$126720 |
8250 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$110469 |
7192 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$91438 |
5953 |
0.01% |
股份
|
| Quantbot Technologies LP |
$84434 |
5497 |
0.01% |
股份
|
| Versant Capital Management, Inc |
$71712 |
4150 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$69151 |
4502 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$60933 |
3967 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$60273 |
3924 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$41887 |
2727 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$30770 |
1259 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$26235 |
1708 |
0.00% |
股份
|
| US BANCORP \DE\ |
$25129 |
1636 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$24000 |
1548 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$19799 |
1289 |
0.00% |
股份
|
| Arax Advisory Partners |
$19645 |
1279 |
0.00% |
股份
|
| GAMMA Investing LLC |
$15068 |
981 |
0.00% |
股份
|
| Allworth Financial LP |
$14285 |
930 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$13379 |
871 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$11920 |
776 |
0.00% |
股份
|
| Larson Financial Group LLC |
$11612 |
756 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$9446 |
615 |
0.00% |
股份
|
| Fourth Dimension Wealth, LLC |
$9216 |
600 |
0.00% |
股份
|
| CWM, LLC |
$7701 |
554 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$7541 |
491001 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$7480 |
487 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$6205 |
404 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$4179 |
171 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$3671 |
239 |
0.00% |
股份
|
| CITIGROUP INC |
$3072 |
200 |
0.00% |
买入期权
|
| CITIGROUP INC |
$3072 |
200 |
0.00% |
卖出期权
|
| ROTHSCHILD INVESTMENT LLC |
$2703 |
176 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2502 |
163 |
0.00% |
股份
|
| Quarry LP |
$2181 |
142 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$2074 |
135 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$1966 |
128 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$1859 |
121 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1812 |
118 |
0.00% |
股份
|
| Thrivent Financial for Lutherans |
$1766 |
115030 |
0.00% |
股份
|
| BFSG, LLC |
$1536 |
100 |
0.00% |
股份
|
| Aventura Private Wealth, LLC |
$1352 |
88 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$1306 |
85 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1306 |
84981 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1183 |
77 |
0.00% |
股份
|
| Essential Partners LLC |
$1075 |
70 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1060 |
69 |
0.00% |
股份
|
| Fulcrum Asset Management LLP |
$1042 |
68 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$967 |
63 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$739 |
48139 |
0.00% |
股份
|
| DekaBank Deutsche Girozentrale |
$643 |
49500 |
0.00% |
股份
|
| LRI Investments, LLC |
$630 |
41 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$614 |
40 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$597 |
38875 |
0.00% |
股份
|
| Jackson Creek Investment Advisors LLC |
$527 |
34719 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$473 |
30850 |
0.00% |
股份
|
| Cornerstone Planning Group LLC |
$469 |
30 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$461 |
30 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$450 |
29278 |
0.00% |
股份
|
| COMERICA BANK |
$386 |
28 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$384 |
25 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$378 |
14 |
0.00% |
股份
|
| Lester Murray Antman dba SimplyRich |
$373 |
24315 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$353 |
23 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$352 |
23 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$292 |
19 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$247 |
17800 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$15 |
1 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$15 |
1 |
0.00% |
股份
|
| IFP Advisors, Inc |
$15 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$14 |
895 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
29 |
0.00% |
股份
|
| Avion Wealth |
$0 |
36 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$0 |
8 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$0 |
28 |
0.00% |
股份
|