| FMR LLC |
$130629007 |
37429515 |
18.97% |
股份
|
| Flagship Pioneering, LLC |
$87256477 |
25001856 |
12.67% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$65437500 |
18750000 |
9.50% |
股份
|
| BlackRock, Inc. |
$58196354 |
16675173 |
8.45% |
股份
|
| VANGUARD GROUP INC |
$42552645 |
10455195 |
6.18% |
股份
|
| STATE STREET CORP |
$39098938 |
11203134 |
5.68% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$35662216 |
10218400 |
5.18% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$29230219 |
8375421 |
4.24% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$20062105 |
5748454 |
2.91% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16329082 |
4677959 |
2.37% |
股份
|
| Marex Group Ltd |
$13921959 |
3989100 |
2.02% |
股份
|
| MARSHALL WACE, LLP |
$10230711 |
2931436 |
1.49% |
股份
|
| Alphabet Inc. |
$9815625 |
2812500 |
1.43% |
股份
|
| GOLDMAN SACHS GROUP INC |
$8264094 |
2367935 |
1.20% |
股份
|
| Integral Health Asset Management, LLC |
$6980000 |
2000000 |
1.01% |
股份
|
| TORONTO DOMINION BANK |
$6883610 |
1972381 |
1.00% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6567095 |
1881689 |
0.95% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$6521826 |
1868718 |
0.95% |
股份
|
| NORTHERN TRUST CORP |
$5598252 |
1604084 |
0.81% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4813342 |
1379181 |
0.70% |
股份
|
| Woodline Partners LP |
$4599583 |
1317932 |
0.67% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4318655 |
1237437 |
0.63% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$4296539 |
1231100 |
0.62% |
股份
|
| MORGAN STANLEY |
$3977839 |
1139782 |
0.58% |
股份
|
| UBS Group AG |
$3704429 |
1061441 |
0.54% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3361383 |
963147 |
0.49% |
股份
|
| Omega Fund Management, LLC |
$2944688 |
843750 |
0.43% |
股份
|
| JPMORGAN CHASE & CO |
$2681678 |
777298 |
0.39% |
股份
|
| Crestline Management, L.P. |
$2637619 |
755736 |
0.38% |
股份
|
| ArrowMark Colorado Holdings LLC |
$2391086 |
685125 |
0.35% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2280725 |
653503 |
0.33% |
股份
|
| DEUTSCHE BANK AG\ |
$2251353 |
645087 |
0.33% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2229541 |
638837 |
0.32% |
股份
|
| Corient Private Wealth LP |
$2192069 |
628100 |
0.32% |
股份
|
| Point72 Asset Management, L.P. |
$2076868 |
595091 |
0.30% |
股份
|
| Invesco Ltd. |
$1759875 |
504262 |
0.26% |
股份
|
| Bank of New York Mellon Corp |
$1666621 |
477542 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1340450 |
384083 |
0.19% |
股份
|
| Nuveen, LLC |
$1290329 |
369722 |
0.19% |
股份
|
| Swiss National Bank |
$1214869 |
348100 |
0.18% |
股份
|
| BAKER BROS. ADVISORS LP |
$1083586 |
310483 |
0.16% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1028998 |
294842 |
0.15% |
股份
|
| CITIGROUP INC |
$951109 |
272524 |
0.14% |
股份
|
| TWO SIGMA ADVISERS, LP |
$902201 |
221671 |
0.13% |
股份
|
| XTX Topco Ltd |
$790799 |
226590 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$779695 |
223412 |
0.11% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$694510 |
199000 |
0.10% |
买入期权
|
| Rafferty Asset Management, LLC |
$686591 |
196731 |
0.10% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$674557 |
193283 |
0.10% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$667313 |
231706 |
0.10% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$634304 |
181749 |
0.09% |
股份
|
| Russell Investments Group, Ltd. |
$610006 |
174787 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$605676 |
173546 |
0.09% |
股份
|
| Clearstead Advisors, LLC |
$595880 |
170739 |
0.09% |
股份
|
| ALGERT GLOBAL LLC |
$588306 |
168569 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$562511 |
161178 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$538402 |
186945 |
0.08% |
股份
|
| PEAK6 LLC |
$523500 |
150000 |
0.08% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$517218 |
148200 |
0.08% |
卖出期权
|
| OPTIMIZE FINANCIAL INC. |
$489357 |
140217 |
0.07% |
股份
|
| Legal & General Group Plc |
$475272 |
136181 |
0.07% |
股份
|
| IEQ CAPITAL, LLC |
$449484 |
128792 |
0.07% |
股份
|
| Virtus Investment Advisers, LLC |
$426091 |
122089 |
0.06% |
股份
|
| GROUP ONE TRADING LLC |
$420004 |
120345 |
0.06% |
股份
|
| AMERIPRISE FINANCIAL INC |
$419755 |
120274 |
0.06% |
股份
|
| HSBC HOLDINGS PLC |
$391857 |
111959 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$383757 |
109959 |
0.06% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$382494 |
109597 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$380410 |
109000 |
0.06% |
买入期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$373996 |
107424 |
0.05% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$358947 |
102850 |
0.05% |
股份
|
| Clarius Group, LLC |
$357000 |
212500 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$354821 |
101668 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$347262 |
99502 |
0.05% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$332415 |
95248 |
0.05% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$313960 |
89960 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$306743 |
87892 |
0.04% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$287552 |
82393 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$286361 |
82052 |
0.04% |
股份
|
| SCS Capital Management LLC |
$283563 |
81250 |
0.04% |
股份
|
| VARCOV Co. |
$278834 |
79895 |
0.04% |
股份
|
| Quadrature Capital Ltd |
$268925 |
77056 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$252121 |
72241 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$250233 |
71700 |
0.04% |
卖出期权
|
| CWM, LLC |
$243202 |
84445 |
0.04% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$238034 |
61827 |
0.03% |
股份
|
| Creative Planning |
$211661 |
60648 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$210534 |
60325 |
0.03% |
股份
|
| Quinn Opportunity Partners LLC |
$209749 |
60100 |
0.03% |
股份
|
| Palumbo Wealth Management LLC |
$208608 |
59773 |
0.03% |
股份
|
| Arax Advisory Partners |
$207857 |
59558 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$207480 |
59450 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$202081 |
57903 |
0.03% |
股份
|
| State of New Jersey Common Pension Fund D |
$195747 |
56088 |
0.03% |
股份
|
| Brevan Howard Capital Management LP |
$183382 |
52545 |
0.03% |
股份
|
| BFSG, LLC |
$177990 |
51000 |
0.03% |
股份
|
| BARCLAYS PLC |
$172255 |
49357 |
0.03% |
股份
|
| JANUS HENDERSON GROUP PLC |
$167293 |
58189 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$167045 |
47864 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$164592 |
47161 |
0.02% |
股份
|
| COLDSTREAM CAPITAL MANAGEMENT INC |
$157050 |
45000 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$154572 |
44290 |
0.02% |
股份
|
| Focus Partners Wealth |
$145027 |
41555 |
0.02% |
股份
|
| D. E. Shaw & Co., Inc. |
$139914 |
40090 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$134745 |
38609 |
0.02% |
股份
|
| OP Asset Management Ltd |
$132575 |
37987 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$131821 |
37771 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$130955 |
37523 |
0.02% |
股份
|
| MAI Capital Management |
$130188 |
37303 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$126338 |
36200 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$125291 |
35900 |
0.02% |
买入期权
|
| Jain Global LLC |
$118039 |
33822 |
0.02% |
股份
|
| Summit X, LLC |
$116476 |
42665 |
0.02% |
股份
|
| ProShare Advisors LLC |
$115770 |
33172 |
0.02% |
股份
|
| WOLVERINE TRADING, LLC |
$112218 |
31700 |
0.02% |
买入期权
|
| Pictet Asset Management Holding SA |
$112141 |
32132 |
0.02% |
股份
|
| LPL Financial LLC |
$110050 |
31533 |
0.02% |
股份
|
| Pallas Capital Advisors LLC |
$105471 |
30221 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$103950 |
29785 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$99116 |
28400 |
0.01% |
股份
|
| BLAIR WILLIAM & CO/IL |
$98638 |
28263 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$96813 |
27740 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$93106 |
26678 |
0.01% |
股份
|
| Cetera Investment Advisers |
$92077 |
26383 |
0.01% |
股份
|
| Squarepoint Ops LLC |
$85585 |
24523 |
0.01% |
股份
|
| NewEdge Advisors, LLC |
$85052 |
24370 |
0.01% |
股份
|
| Viewpoint Capital Management LLC |
$82172 |
23545 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$79062 |
22654 |
0.01% |
股份
|
| LaSalle St. Investment Advisors, LLC |
$76780 |
22000 |
0.01% |
股份
|
| HOEY INVESTMENTS, INC |
$76780 |
22000 |
0.01% |
股份
|
| Cerity Partners LLC |
$74463 |
21336 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$70687 |
20254 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$70097 |
20085 |
0.01% |
股份
|
| Prodigy Asset Management LLC |
$69975 |
20050 |
0.01% |
股份
|
| ALLSTATE CORP |
$68502 |
19628 |
0.01% |
股份
|
| SYON CAPITAL LLC |
$64568 |
18501 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$63242 |
18122 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$61661 |
17668 |
0.01% |
股份
|
| XPONANCE LLC |
$61532 |
17631 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$58171 |
16668 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$57260 |
16407 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$56130 |
16083 |
0.01% |
股份
|
| Trace Wealth Advisors, LLC |
$55840 |
16000 |
0.01% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$54838 |
15713 |
0.01% |
股份
|
| Sequoia Financial Advisors, LLC |
$54277 |
15552 |
0.01% |
股份
|
| Freestone Capital Holdings, LLC |
$52699 |
15100 |
0.01% |
股份
|
| Leonteq Securities AG |
$52350 |
15000 |
0.01% |
股份
|
| GRIFFIN ASSET MANAGEMENT, INC. |
$51024 |
14620 |
0.01% |
股份
|
| Merit Financial Group, LLC |
$50563 |
14488 |
0.01% |
股份
|
| Arkadios Wealth Advisors |
$50280 |
14407 |
0.01% |
股份
|
| Swiss Life Asset Management Ltd |
$50225 |
14391 |
0.01% |
股份
|
| LANARK FINANCIAL, INC. |
$50161 |
14373 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$49021 |
14046 |
0.01% |
股份
|
| Good Life Advisors, LLC |
$45864 |
16800 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$45551 |
13052 |
0.01% |
股份
|
| CIBC WORLD MARKETS CORP |
$44485 |
10930 |
0.01% |
股份
|
| Savant Capital, LLC |
$43546 |
13666 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$43437 |
12446 |
0.01% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$43203 |
12379 |
0.01% |
股份
|
| MQS Management LLC |
$43129 |
12358 |
0.01% |
股份
|
| Callan Family Office, LLC |
$42662 |
12224 |
0.01% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$42110 |
12066 |
0.01% |
股份
|
| Centiva Capital, LP |
$41440 |
11874 |
0.01% |
股份
|
| Bay Colony Advisory Group, Inc d/b/a Bay Colony Advisors |
$40135 |
11500 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$39786 |
11400 |
0.01% |
卖出期权
|
| T3 Companies, LLC |
$39437 |
11300 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$38616 |
11065 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$37451 |
10731 |
0.01% |
股份
|
| LYELL WEALTH MANAGEMENT, LP |
$36645 |
10500 |
0.01% |
股份
|
| WOLVERINE TRADING, LLC |
$35754 |
10100 |
0.01% |
卖出期权
|
| TD Waterhouse Canada Inc. |
$35600 |
10000 |
0.01% |
股份
|
| CIBC Bancorp USA Inc. |
$35389 |
10140 |
0.01% |
股份
|
| Walleye Capital LLC |
$34900 |
10000 |
0.01% |
股份
|
| LRI Investments, LLC |
$34900 |
10000 |
0.01% |
股份
|
| Jacobi Capital Management LLC |
$34900 |
10000 |
0.01% |
股份
|
| Foguth Wealth Management, LLC. |
$34480 |
10981 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$30000 |
8605 |
0.00% |
股份
|
| Redwood Park Advisors LLC |
$24919 |
7140 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$19673 |
5637 |
0.00% |
股份
|
| IFP Advisors, Inc |
$19352 |
5545 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$19320 |
5649 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$19279 |
5524 |
0.00% |
股份
|
| Washington Trust Advisors, Inc. |
$17450 |
5000 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$17422 |
4992 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$12239 |
3507 |
0.00% |
股份
|
| Blue Trust, Inc. |
$11290 |
3235 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$10959 |
3140 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$10680 |
3000 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$9423 |
2700 |
0.00% |
股份
|
| True Wealth Design, LLC |
$8691 |
2490 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$8690 |
2490 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$7974 |
2285 |
0.00% |
股份
|
| Essential Partners LLC |
$7821 |
2241 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$7793 |
2233 |
0.00% |
股份
|
| Hurley Capital, LLC |
$6980 |
2000 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$5568 |
3314 |
0.00% |
股份
|
| Allworth Financial LP |
$4670 |
1338 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$4317 |
1237 |
0.00% |
股份
|
| Triumph Capital Management |
$3490 |
1000 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3403 |
975 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2743 |
786 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2251 |
645 |
0.00% |
股份
|
| Archer Investment Corp |
$2223 |
637 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$1835 |
532 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1780 |
510 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$1396 |
400 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1281 |
367 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1246 |
357 |
0.00% |
股份
|
| State of Wyoming |
$1071 |
307 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$988 |
282916 |
0.00% |
股份
|
| Pineridge Advisors LLC |
$710 |
200 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$698 |
200 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$650 |
186 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$507 |
145 |
0.00% |
股份
|
| Banque Cantonale Vaudoise |
$398 |
114000 |
0.00% |
股份
|
| US BANCORP \DE\ |
$373 |
107 |
0.00% |
股份
|
| BARTLETT & CO. WEALTH MANAGEMENT LLC |
$349 |
100 |
0.00% |
股份
|
| CREATIVE FINANCIAL DESIGNS INC /ADV |
$349 |
100 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$332 |
95039 |
0.00% |
股份
|
| HOLLENCREST CAPITAL MANAGEMENT |
$175 |
50 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$102 |
29239 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$79 |
22594 |
0.00% |
股份
|
| Axiom Investment Management LLC |
$70 |
20 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$63 |
22 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$14 |
4 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$11 |
3286 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$3 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
87 |
0.00% |
股份
|