| Redmile Group, LLC |
$34756954 |
12872946 |
18.36% |
股份
|
| BlackRock, Inc. |
$19707016 |
7298895 |
10.41% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12273911 |
4545893 |
6.48% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$12002947 |
4445536 |
6.34% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$10360518 |
3837229 |
5.47% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$9692630 |
3589863 |
5.12% |
股份
|
| JOHNSON & JOHNSON |
$9123473 |
3379064 |
4.82% |
股份
|
| VANGUARD GROUP INC |
$8818834 |
8971347 |
4.66% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$8054824 |
2983268 |
4.25% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6571741 |
2433978 |
3.47% |
股份
|
| GOLDMAN SACHS GROUP INC |
$5532805 |
2049187 |
2.92% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$3571058 |
1322013 |
1.89% |
股份
|
| JANE STREET GROUP, LLC |
$2772919 |
1027007 |
1.46% |
股份
|
| CITADEL ADVISORS LLC |
$2681931 |
993308 |
1.42% |
股份
|
| Bruce & Co., Inc. |
$2670808 |
989188 |
1.41% |
股份
|
| MORGAN STANLEY |
$1875366 |
694580 |
0.99% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1729156 |
640428 |
0.91% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1649562 |
610949 |
0.87% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1622960 |
1651700 |
0.86% |
股份
|
| UBS Group AG |
$1593481 |
590178 |
0.84% |
股份
|
| Qube Research & Technologies Ltd |
$1561005 |
578150 |
0.82% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$1552487 |
574995 |
0.82% |
股份
|
| STATE STREET CORP |
$1509106 |
558928 |
0.80% |
股份
|
| DAFNA Capital Management LLC |
$1417500 |
525000 |
0.75% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1379835 |
511050 |
0.73% |
股份
|
| MARSHALL WACE, LLP |
$1329551 |
492426 |
0.70% |
股份
|
| IEQ CAPITAL, LLC |
$1316866 |
487728 |
0.70% |
股份
|
| Point72 Asset Management, L.P. |
$1194016 |
442228 |
0.63% |
股份
|
| Privium Fund Management B.V. |
$1118640 |
414311 |
0.59% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$949091 |
352226 |
0.50% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$912757 |
338058 |
0.48% |
股份
|
| Cerity Partners LLC |
$854028 |
341732 |
0.45% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$733412 |
271634 |
0.39% |
股份
|
| Invesco Ltd. |
$718151 |
265982 |
0.38% |
股份
|
| Headlands Technologies LLC |
$679865 |
251802 |
0.36% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$663697 |
245814 |
0.35% |
股份
|
| NORTHERN TRUST CORP |
$655212 |
242671 |
0.35% |
股份
|
| HSBC HOLDINGS PLC |
$635511 |
240724 |
0.34% |
股份
|
| LPL Financial LLC |
$550114 |
203746 |
0.29% |
股份
|
| Mariner, LLC |
$518762 |
192215 |
0.27% |
股份
|
| BARCLAYS PLC |
$507571 |
187989 |
0.27% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$499500 |
185000 |
0.26% |
股份
|
| XTX Topco Ltd |
$488230 |
180826 |
0.26% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$476820 |
176600 |
0.25% |
股份
|
| Man Group plc |
$475489 |
176107 |
0.25% |
股份
|
| Woodline Partners LP |
$431055 |
159650 |
0.23% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$415006 |
153706 |
0.22% |
股份
|
| Squarepoint Ops LLC |
$414785 |
153624 |
0.22% |
股份
|
| Arete Wealth Advisors, LLC |
$405000 |
150000 |
0.21% |
股份
|
| Assenagon Asset Management S.A. |
$393763 |
145838 |
0.21% |
股份
|
| National Philanthropic Trust |
$337500 |
125000 |
0.18% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$306126 |
113380 |
0.16% |
股份
|
| Creative Planning |
$294246 |
108980 |
0.16% |
股份
|
| Russell Investments Group, Ltd. |
$285664 |
105802 |
0.15% |
股份
|
| SCHULHOFF & CO INC |
$270000 |
100000 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$267840 |
99200 |
0.14% |
卖出期权
|
| JANE STREET GROUP, LLC |
$254880 |
94400 |
0.13% |
买入期权
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$248275 |
90481 |
0.13% |
股份
|
| Vanguard Global Advisers, LLC |
$247620 |
91711 |
0.13% |
股份
|
| CITADEL ADVISORS LLC |
$242730 |
89900 |
0.13% |
买入期权
|
| AMERICAN CENTURY COMPANIES INC |
$213081 |
78919 |
0.11% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$198752 |
73612 |
0.10% |
股份
|
| SEI INVESTMENTS CO |
$191653 |
70980 |
0.10% |
股份
|
| Corient Private Wealth LP |
$179591 |
66515 |
0.09% |
股份
|
| Schonfeld Strategic Advisors LLC |
$178624 |
66158 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$171843 |
63646 |
0.09% |
股份
|
| CWM, LLC |
$167755 |
139796 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$166860 |
61800 |
0.09% |
买入期权
|
| Focus Partners Wealth |
$160777 |
59547 |
0.08% |
股份
|
| Jefferies Financial Group Inc. |
$159629 |
59122 |
0.08% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$136123 |
50416 |
0.07% |
股份
|
| FMR LLC |
$132504 |
49076 |
0.07% |
股份
|
| RHUMBLINE ADVISERS |
$124793 |
46220 |
0.07% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$120887 |
44773 |
0.06% |
股份
|
| Arax Advisory Partners |
$119670 |
44322 |
0.06% |
股份
|
| AXQ CAPITAL, LP |
$110311 |
40856 |
0.06% |
股份
|
| Abel Hall, LLC |
$96854 |
35872 |
0.05% |
股份
|
| HighTower Advisors, LLC |
$90326 |
33454 |
0.05% |
股份
|
| BRIGHTON JONES LLC |
$89832 |
33271 |
0.05% |
股份
|
| Leo Wealth, LLC |
$84527 |
70439 |
0.04% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$81475 |
30176 |
0.04% |
股份
|
| Caitong International Asset Management Co., Ltd |
$78305 |
29002 |
0.04% |
股份
|
| Tower Research Capital LLC (TRC) |
$73899 |
27370 |
0.04% |
股份
|
| FPC INVESTMENT ADVISORY, INC. |
$73548 |
26456 |
0.04% |
股份
|
| Merit Financial Group, LLC |
$71191 |
26367 |
0.04% |
股份
|
| Proficio Capital Partners LLC |
$70880 |
26252 |
0.04% |
股份
|
| Hudson Bay Capital Management LP |
$67932 |
25160 |
0.04% |
股份
|
| THEORY FINANCIAL LLC |
$59999 |
22222 |
0.03% |
股份
|
| Bronte Capital Management Pty Ltd. |
$58698 |
21740 |
0.03% |
股份
|
| Parcion Private Wealth LLC |
$58199 |
21555 |
0.03% |
股份
|
| Pallas Capital Advisors LLC |
$56495 |
20924 |
0.03% |
股份
|
| CITIGROUP INC |
$53001 |
19630 |
0.03% |
股份
|
| Parametrica Management Ltd |
$49874 |
18472 |
0.03% |
股份
|
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC |
$47498 |
17592 |
0.03% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$45079 |
16696 |
0.02% |
股份
|
| Caerus Investment Advisors, LLC |
$43300 |
16037 |
0.02% |
股份
|
| Ameritas Advisory Services, LLC |
$43200 |
16000 |
0.02% |
股份
|
| Integrated Wealth Concepts LLC |
$40994 |
15183 |
0.02% |
股份
|
| DEUTSCHE BANK AG\ |
$40927 |
15158 |
0.02% |
股份
|
| Krilogy Financial LLC |
$40157 |
14873 |
0.02% |
股份
|
| Graham Capital Management, L.P. |
$38202 |
14149 |
0.02% |
股份
|
| Balyasny Asset Management L.P. |
$36215 |
13413 |
0.02% |
股份
|
| MAI Capital Management |
$35970 |
13322 |
0.02% |
股份
|
| R Squared Ltd |
$35429 |
13122 |
0.02% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$35270 |
13063 |
0.02% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$34501 |
12778 |
0.02% |
股份
|
| Narwhal Capital Management |
$34290 |
12700 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$33000 |
12151 |
0.02% |
股份
|
| Focus Partners Advisor Solutions, LLC |
$32489 |
12033 |
0.02% |
股份
|
| NorthCrest Asset Manangement, LLC |
$32216 |
10359 |
0.02% |
股份
|
| HB Wealth Management, LLC |
$30885 |
11439 |
0.02% |
股份
|
| Bank of New York Mellon Corp |
$30729 |
11381 |
0.02% |
股份
|
| Callan Family Office, LLC |
$29460 |
10911 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$28080 |
10400 |
0.01% |
卖出期权
|
| Westmount Partners, LLC |
$27265 |
10098 |
0.01% |
股份
|
| Northern Lights Advisors, Inc. |
$27108 |
10040 |
0.01% |
股份
|
| Allworth Financial LP |
$23426 |
8676 |
0.01% |
股份
|
| EverSource Wealth Advisors, LLC |
$22791 |
8441 |
0.01% |
股份
|
| JPMORGAN CHASE & CO |
$21770 |
8996 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$13138 |
4866 |
0.01% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$11742 |
4351250 |
0.01% |
股份
|
| Owl Creek Wealth Partners LLC |
$11313 |
4190 |
0.01% |
股份
|
| Dunhill Financial, LLC |
$8586 |
3180 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$8141 |
3015 |
0.00% |
股份
|
| Essential Partners LLC |
$6024 |
2231 |
0.00% |
股份
|
| Geneos Wealth Management Inc. |
$4860 |
1800 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4469 |
1678 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4379 |
1622 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3961 |
1467 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3689 |
1366 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$3594 |
1331 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$3164 |
1172 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$2917 |
1080320 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2840 |
1052 |
0.00% |
股份
|
| IFP Advisors, Inc |
$2754 |
1020 |
0.00% |
股份
|
| VALLEY NATIONAL ADVISERS INC |
$2700 |
1000 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2671 |
989 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2219 |
822 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1947 |
721 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$1890 |
900 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1809 |
670 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$1741 |
645 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$978 |
815 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$932 |
345 |
0.00% |
股份
|
| MARK SHEPTOFF FINANCIAL PLANNING, LLC |
$810 |
300 |
0.00% |
股份
|
| Hilltop National Bank |
$770 |
285 |
0.00% |
股份
|
| Quarry LP |
$689 |
255 |
0.00% |
股份
|
| ALBION FINANCIAL GROUP /UT |
$608 |
225 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$406 |
150 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$333 |
123488 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$303 |
112267 |
0.00% |
股份
|
| Boreal Capital Management LLC |
$270 |
100 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$257 |
95 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$222 |
82 |
0.00% |
股份
|
| Providence Capital Advisors, LLC |
$165 |
61 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$109 |
91 |
0.00% |
股份
|
| Caitlin John, LLC |
$108 |
40 |
0.00% |
股份
|
| Thrivent Financial for Lutherans |
$93 |
34105 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$85 |
35 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$85 |
31593 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$79 |
29 |
0.00% |
股份
|
| Leonteq Securities AG |
$51 |
19 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$40 |
14584 |
0.00% |
股份
|
| Optiver Holding B.V. |
$27 |
10 |
0.00% |
股份
|
| Grassi Investment Management |
$20 |
18000 |
0.00% |
股份
|
| Avion Wealth |
$2 |
858 |
0.00% |
股份
|