| Venrock Adviser, LLC |
$25459433 |
3851654 |
12.56% |
股份
|
| ORBIMED ADVISORS LLC |
$21623954 |
3271400 |
10.66% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$20226600 |
3060000 |
9.97% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$17398551 |
2632156 |
8.58% |
股份
|
| Rosalind Advisors, Inc. |
$12934541 |
1956814 |
6.38% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$10713177 |
1620753 |
5.28% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$10181159 |
1540266 |
5.02% |
股份
|
| DCF Advisers, LLC |
$9485271 |
1434988 |
4.68% |
股份
|
| Sio Capital Management, LLC |
$8593000 |
1300000 |
4.24% |
股份
|
| Nan Fung Group Holdings Ltd |
$6525537 |
987222 |
3.22% |
股份
|
| Boxer Capital Management, LLC |
$5221900 |
790000 |
2.58% |
股份
|
| Logos Global Management LP |
$4957500 |
750000 |
2.44% |
股份
|
| CITADEL ADVISORS LLC |
$4104539 |
620959 |
2.02% |
股份
|
| DAFNA Capital Management LLC |
$3397943 |
514061 |
1.68% |
股份
|
| Walleye Capital LLC |
$3321882 |
502554 |
1.64% |
股份
|
| MORGAN STANLEY |
$3053067 |
461886 |
1.51% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2663830 |
403000 |
1.31% |
买入期权
|
| Knott David M Jr |
$2445700 |
370000 |
1.21% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$2230445 |
337435 |
1.10% |
股份
|
| AdvisorShares Investments LLC |
$1934820 |
292711 |
0.95% |
股份
|
| JANE STREET GROUP, LLC |
$1856769 |
280903 |
0.92% |
股份
|
| JPMORGAN CHASE & CO |
$1636257 |
237828 |
0.81% |
股份
|
| ROYCE & ASSOCIATES LP |
$1534036 |
232078 |
0.76% |
股份
|
| UBS Group AG |
$1445779 |
218726 |
0.71% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$1351243 |
204424 |
0.67% |
股份
|
| DIADEMA PARTNERS LP |
$1322000 |
200000 |
0.65% |
股份
|
| Balyasny Asset Management L.P. |
$1263786 |
191193 |
0.62% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1037109 |
156900 |
0.51% |
卖出期权
|
| Pale Fire Capital SE |
$1014668 |
153505 |
0.50% |
股份
|
| PDT Partners, LLC |
$993463 |
150297 |
0.49% |
股份
|
| Eversept Partners, LP |
$967724 |
146403 |
0.48% |
股份
|
| Ikarian Capital, LLC |
$873532 |
132153 |
0.43% |
股份
|
| Stonepine Capital Management, LLC |
$854541 |
129280 |
0.42% |
股份
|
| CITADEL ADVISORS LLC |
$795844 |
120400 |
0.39% |
买入期权
|
| Point72 Asset Management, L.P. |
$703681 |
106457 |
0.35% |
股份
|
| DIADEMA PARTNERS LP |
$661000 |
100000 |
0.33% |
买入期权
|
| ADAR1 Capital Management, LLC |
$537248 |
81278 |
0.26% |
股份
|
| BlackRock, Inc. |
$533552 |
80719 |
0.26% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$517002 |
78215 |
0.25% |
股份
|
| Altshuler Shaham Ltd |
$475920 |
72000 |
0.23% |
股份
|
| Independent Advisor Alliance |
$462259 |
69933 |
0.23% |
股份
|
| D. E. Shaw & Co., Inc. |
$408379 |
61782 |
0.20% |
股份
|
| Blue Owl Capital Holdings LP |
$396012 |
59911 |
0.20% |
股份
|
| Persistent Asset Partners Ltd |
$336971 |
50979 |
0.17% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$330500 |
50000 |
0.16% |
买入期权
|
| JANE STREET GROUP, LLC |
$326534 |
49400 |
0.16% |
买入期权
|
| Quadrature Capital Ltd |
$309275 |
46789 |
0.15% |
股份
|
| PEAK6 LLC |
$286986 |
43417 |
0.14% |
股份
|
| CITADEL ADVISORS LLC |
$250519 |
37900 |
0.12% |
卖出期权
|
| Fore Capital, LLC |
$240743 |
36421 |
0.12% |
股份
|
| ROYAL BANK OF CANADA |
$234000 |
35537 |
0.12% |
股份
|
| PDS Planning, Inc |
$200574 |
30344 |
0.10% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$194360 |
29404 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$172627 |
26116 |
0.09% |
股份
|
| Graham Capital Management, L.P. |
$154515 |
23376 |
0.08% |
股份
|
| Invesco Ltd. |
$152889 |
23130 |
0.08% |
股份
|
| GOLDMAN SACHS GROUP INC |
$130911 |
19805 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$129556 |
19600 |
0.06% |
卖出期权
|
| Jump Financial, LLC |
$128584 |
19453 |
0.06% |
股份
|
| Verdad Advisers, LP |
$122285 |
18500 |
0.06% |
股份
|
| Rockefeller Capital Management L.P. |
$99150 |
15000 |
0.05% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$94998 |
14372 |
0.05% |
股份
|
| Scientech Research LLC |
$93075 |
14081 |
0.05% |
股份
|
| AXQ CAPITAL, LP |
$74792 |
11315 |
0.04% |
股份
|
| Millington Financial Advisors, LLC |
$72500 |
10000 |
0.04% |
股份
|
| Mayflower Financial Advisors, LLC |
$68017 |
10290 |
0.03% |
股份
|
| LPL Financial LLC |
$66569 |
10071 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$56253 |
255 |
0.03% |
买入期权
|
| Formidable Asset Management, LLC |
$49042 |
10217 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$39660 |
6000 |
0.02% |
股份
|
| Caitlin John, LLC |
$33050 |
5000 |
0.02% |
股份
|
| Quent Capital, LLC |
$29431 |
4453 |
0.01% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$25067 |
5357 |
0.01% |
股份
|
| Federation des caisses Desjardins du Quebec |
$24173 |
3684 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$23453 |
3548 |
0.01% |
股份
|
| North Star Investment Management Corp. |
$22342 |
3380 |
0.01% |
股份
|
| Global Retirement Partners, LLC |
$19678 |
2977 |
0.01% |
股份
|
| IAG Wealth Partners, LLC |
$18177 |
2750 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$14681 |
2221 |
0.01% |
股份
|
| CITIGROUP INC |
$12159 |
1847 |
0.01% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$8263 |
1250 |
0.00% |
股份
|
| Ancora Advisors LLC |
$4382 |
663 |
0.00% |
股份
|
| Quarry LP |
$4349 |
658 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1322 |
200 |
0.00% |
股份
|
| Avalon Trust Co |
$1303 |
197 |
0.00% |
股份
|
| Atlantic Edge Private Wealth Management, LLC |
$906 |
137 |
0.00% |
股份
|
| AMERIFLEX GROUP, INC. |
$866 |
131 |
0.00% |
股份
|
| Tidemark, LLC |
$866 |
131 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$823 |
124658 |
0.00% |
股份
|
| Aspect Partners, LLC |
$780 |
118 |
0.00% |
股份
|
| Hilton Head Capital Partners, LLC |
$773 |
117 |
0.00% |
股份
|
| NewEdge Advisors, LLC |
$628 |
95 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$521 |
83 |
0.00% |
股份
|
| NVWM, LLC |
$390 |
59 |
0.00% |
股份
|
| Mitsubishi UFJ Asset Management (UK) Ltd. |
$205 |
31000 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$192 |
29 |
0.00% |
股份
|
| MCDONALD PARTNERS LLC |
$172 |
26 |
0.00% |
股份
|
| Westside Investment Management, Inc. |
$172 |
26 |
0.00% |
股份
|
| CENTRAL TRUST Co |
$172 |
26 |
0.00% |
股份
|
| City State Bank |
$165 |
25 |
0.00% |
股份
|
| Allworth Financial LP |
$133 |
20 |
0.00% |
股份
|
| Arax Advisory Partners |
$86 |
13 |
0.00% |
股份
|
| McIlrath & Eck, LLC |
$48 |
10 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$40 |
6 |
0.00% |
股份
|
| CNB Bank |
$26 |
4 |
0.00% |
股份
|
| MCGUIRE CAPITAL ADVISORS INC |
$7 |
1 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$0 |
100 |
0.00% |
股份
|
| TSFG, LLC |
$0 |
2 |
0.00% |
股份
|