| Catalys Pacific, LLC |
$213245549 |
7903838 |
7.51% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$207550395 |
7692750 |
7.31% |
股份
|
| BlackRock, Inc. |
$158832288 |
5887038 |
5.59% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$158400066 |
5871018 |
5.58% |
股份
|
| FMR LLC |
$121725382 |
4511689 |
4.29% |
股份
|
| VANGUARD GROUP INC |
$121676015 |
3352880 |
4.28% |
股份
|
| STATE STREET CORP |
$111741339 |
4141636 |
3.93% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$106786840 |
3958000 |
3.76% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$74377655 |
2756770 |
2.62% |
股份
|
| Laurion Capital Management LP |
$67615981 |
2506152 |
2.38% |
股份
|
| ORBIMED ADVISORS LLC |
$56935894 |
2110300 |
2.00% |
股份
|
| Capital World Investors |
$53895437 |
1997607 |
1.90% |
股份
|
| ARMISTICE CAPITAL, LLC |
$46837280 |
1736000 |
1.65% |
股份
|
| Troluce Capital Advisors LLC |
$46641756 |
1728753 |
1.64% |
股份
|
| FRANKLIN RESOURCES INC |
$44126329 |
1635520 |
1.55% |
股份
|
| ANDERA PARTNERS |
$42949921 |
1591917 |
1.51% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$42753193 |
1584326 |
1.51% |
股份
|
| SR One Capital Management, LP |
$42195803 |
1563966 |
1.49% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$40619658 |
1505547 |
1.43% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$39659818 |
1469971 |
1.40% |
股份
|
| GOLDMAN SACHS GROUP INC |
$39355079 |
1458676 |
1.39% |
股份
|
| Pictet Asset Management Holding SA |
$38598910 |
1430649 |
1.36% |
股份
|
| Polar Capital Holdings Plc |
$38334641 |
1420854 |
1.35% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$32963031 |
1221758 |
1.16% |
股份
|
| Ghisallo Capital Management LLC |
$30352500 |
1125000 |
1.07% |
股份
|
| Invesco Ltd. |
$29440036 |
1091180 |
1.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$28919686 |
1067541 |
1.02% |
股份
|
| Logos Global Management LP |
$28329000 |
1050000 |
1.00% |
股份
|
| ARMISTICE CAPITAL, LLC |
$28059200 |
1040000 |
0.99% |
买入期权
|
| AMERICAN CENTURY COMPANIES INC |
$27972049 |
1036767 |
0.99% |
股份
|
| MORGAN STANLEY |
$24746440 |
917213 |
0.87% |
股份
|
| Davern Capital Partners, LP |
$23169156 |
858753 |
0.82% |
股份
|
| Candriam S.C.A. |
$23100611 |
857037 |
0.81% |
股份
|
| Caption Management, LLC |
$22976168 |
851600 |
0.81% |
卖出期权
|
| Nantahala Capital Management, LLC |
$22136577 |
820481 |
0.78% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$21765199 |
806716 |
0.77% |
股份
|
| Affinity Asset Advisors, LLC |
$20235000 |
750000 |
0.71% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20171786 |
747657 |
0.71% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$19921223 |
738370 |
0.70% |
股份
|
| Aberdeen Group plc |
$18595560 |
689235 |
0.65% |
股份
|
| ALGERT GLOBAL LLC |
$17510748 |
649027 |
0.62% |
股份
|
| Catalio Capital Management, LP |
$17502520 |
648722 |
0.62% |
股份
|
| Pale Fire Capital SE |
$16573382 |
614284 |
0.58% |
股份
|
| STEMPOINT CAPITAL LP |
$16260468 |
602686 |
0.57% |
股份
|
| NORTHERN TRUST CORP |
$14879227 |
551491 |
0.52% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$14062408 |
521216 |
0.50% |
股份
|
| Rock Springs Capital Management LP |
$13083978 |
484951 |
0.46% |
股份
|
| TWO SIGMA ADVISERS, LP |
$12835773 |
353700 |
0.45% |
股份
|
| CITADEL ADVISORS LLC |
$12615794 |
467598 |
0.44% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12501914 |
463387 |
0.44% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$12150983 |
450370 |
0.43% |
股份
|
| Integral Health Asset Management, LLC |
$12141000 |
450000 |
0.43% |
股份
|
| Prosight Management, LP |
$12135469 |
449795 |
0.43% |
股份
|
| Rhenman & Partners Asset Management AB |
$11233690 |
416371 |
0.40% |
股份
|
| Caption Management, LLC |
$11145087 |
413087 |
0.39% |
股份
|
| JENNISON ASSOCIATES LLC |
$10326514 |
382747 |
0.36% |
股份
|
| Parkman Healthcare Partners LLC |
$10261951 |
380354 |
0.36% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$10206534 |
378300 |
0.36% |
股份
|
| CenterBook Partners LP |
$9864697 |
365630 |
0.35% |
股份
|
| UBS Group AG |
$9755860 |
361596 |
0.34% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$9593279 |
355570 |
0.34% |
股份
|
| D. E. Shaw & Co., Inc. |
$9516628 |
352729 |
0.34% |
股份
|
| Iron Triangle Partners LP |
$9329615 |
257085 |
0.33% |
股份
|
| TimesSquare Capital Management, LLC |
$9178038 |
338798 |
0.32% |
股份
|
| Eversept Partners, LP |
$8355409 |
309689 |
0.29% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$8257912 |
307214 |
0.29% |
股份
|
| ADAR1 Capital Management, LLC |
$8063944 |
298886 |
0.28% |
股份
|
| Longaeva Partners L.P. |
$7584186 |
281104 |
0.27% |
股份
|
| Nuveen, LLC |
$7415265 |
274843 |
0.26% |
股份
|
| Qube Research & Technologies Ltd |
$6738956 |
249776 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4818628 |
178600 |
0.17% |
卖出期权
|
| MONTANOVA CAPITAL, LLC |
$4691444 |
173886 |
0.17% |
股份
|
| Trexquant Investment LP |
$4578911 |
169715 |
0.16% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4372972 |
162082 |
0.15% |
股份
|
| Bank of New York Mellon Corp |
$4277678 |
158550 |
0.15% |
股份
|
| Brevan Howard Capital Management LP |
$4147420 |
153722 |
0.15% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$4114558 |
152504 |
0.14% |
股份
|
| Burkehill Global Management, LP |
$4047000 |
150000 |
0.14% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3976906 |
147402 |
0.14% |
股份
|
| Caption Management, LLC |
$3879724 |
143800 |
0.14% |
买入期权
|
| Artia Global Partners LP |
$3717844 |
137800 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3609924 |
133800 |
0.13% |
买入期权
|
| Russell Investments Group, Ltd. |
$3460113 |
128247 |
0.12% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$3399237 |
125991 |
0.12% |
股份
|
| Ensign Peak Advisors, Inc |
$3193946 |
118382 |
0.11% |
股份
|
| 22NW, LP |
$3071403 |
113840 |
0.11% |
股份
|
| Swiss National Bank |
$3010968 |
111600 |
0.11% |
股份
|
| Ishara Investments LP |
$2765450 |
102500 |
0.10% |
股份
|
| MARK ASSET MANAGEMENT LP |
$2732777 |
101289 |
0.10% |
股份
|
| ExodusPoint Capital Management, LP |
$2726383 |
101052 |
0.10% |
股份
|
| CITIGROUP INC |
$2679978 |
99332 |
0.09% |
股份
|
| Schonfeld Strategic Advisors LLC |
$2569628 |
95242 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$2400572 |
88976 |
0.08% |
股份
|
| Squarepoint Ops LLC |
$2329102 |
86327 |
0.08% |
股份
|
| HighVista Strategies LLC |
$2322573 |
86085 |
0.08% |
股份
|
| BlueCrest Capital Management Ltd |
$2297536 |
85157 |
0.08% |
股份
|
| KVP Capital Advisors, LP |
$2270853 |
84168 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$2154658 |
79537 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$2109458 |
78186 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$2045084 |
75800 |
0.07% |
买入期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1976690 |
73265 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$1912882 |
70900 |
0.07% |
买入期权
|
| RHUMBLINE ADVISERS |
$1894120 |
70205 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1813623 |
67221 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1782218 |
66057 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$1702438 |
63100 |
0.06% |
卖出期权
|
| PFM Health Sciences, LP |
$1684038 |
62418 |
0.06% |
股份
|
| BARCLAYS PLC |
$1650906 |
61190 |
0.06% |
股份
|
| Man Group plc |
$1609087 |
59640 |
0.06% |
股份
|
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
$1598349 |
59242 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$1588501 |
58877 |
0.06% |
股份
|
| DIADEMA PARTNERS LP |
$1520242 |
56347 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$1419148 |
52600 |
0.05% |
卖出期权
|
| JPMORGAN CHASE & CO |
$1402491 |
49615 |
0.05% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$1386772 |
51400 |
0.05% |
股份
|
| Troluce Capital Advisors LLC |
$1349000 |
50000 |
0.05% |
买入期权
|
| XTX Topco Ltd |
$1285678 |
47653 |
0.05% |
股份
|
| Erste Asset Management GmbH |
$1209600 |
45000 |
0.04% |
股份
|
| DAFNA Capital Management LLC |
$1200340 |
44490 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$1058291 |
39225 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1057265 |
39187 |
0.04% |
股份
|
| Legal & General Group Plc |
$1026589 |
38050 |
0.04% |
股份
|
| SIMPLEX TRADING, LLC |
$970713 |
35979 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$957151 |
35510 |
0.03% |
股份
|
| Verition Fund Management LLC |
$937069 |
34732 |
0.03% |
股份
|
| GOLDMAN SACHS GROUP INC |
$914622 |
33900 |
0.03% |
卖出期权
|
| VICTORY CAPITAL MANAGEMENT INC |
$914163 |
33883 |
0.03% |
股份
|
| WINTON GROUP Ltd |
$911924 |
33800 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$910710 |
33755 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$863549 |
32007 |
0.03% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$841776 |
31200 |
0.03% |
买入期权
|
| Magnetar Financial LLC |
$818492 |
30337 |
0.03% |
股份
|
| Greenland Capital Management LP |
$809400 |
30000 |
0.03% |
股份
|
| Quantinno Capital Management LP |
$799390 |
29629 |
0.03% |
股份
|
| Creative Planning |
$788220 |
29215 |
0.03% |
股份
|
| AMERIPRISE FINANCIAL INC |
$772437 |
28630 |
0.03% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$758138 |
28100 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$749585 |
27783 |
0.03% |
股份
|
| GROUP ONE TRADING LLC |
$687208 |
25471 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$544025 |
20164 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$537285 |
19848 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$509706 |
18892 |
0.02% |
股份
|
| MARSHALL WACE, LLP |
$485640 |
18000 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$485532 |
17996 |
0.02% |
股份
|
| Eleva Capital SAS |
$462724 |
17081 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$456690 |
16927 |
0.02% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$447868 |
16600 |
0.02% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$427579 |
15848 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$420187 |
15574 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$416000 |
15413 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$414332 |
15357 |
0.01% |
股份
|
| AlphaQuest LLC |
$411093 |
11328 |
0.01% |
股份
|
| Entropy Technologies, LP |
$405240 |
15020 |
0.01% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$392964 |
14565 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$388782 |
14410 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$373754 |
13853 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$354247 |
13130 |
0.01% |
股份
|
| Mariner, LLC |
$342027 |
12678 |
0.01% |
股份
|
| Quarry LP |
$340380 |
12616 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$339948 |
12600 |
0.01% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$333203 |
12350 |
0.01% |
股份
|
| MAI Capital Management |
$327106 |
12124 |
0.01% |
股份
|
| STRS OHIO |
$323760 |
12000 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$307167 |
11385 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$303309 |
11242 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$297454 |
11025 |
0.01% |
股份
|
| Velan Capital Investment Management LP |
$296780 |
11000 |
0.01% |
股份
|
| CreativeOne Wealth, LLC |
$290035 |
10750 |
0.01% |
股份
|
| Lion Point Capital, LP |
$283290 |
10500 |
0.01% |
股份
|
| ProShare Advisors LLC |
$275737 |
10220 |
0.01% |
股份
|
| Walleye Capital LLC |
$271203 |
10052 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$252398 |
9355 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$237243 |
8793 |
0.01% |
股份
|
| Bellevue Group AG |
$236156 |
8753 |
0.01% |
股份
|
| TEMA ETFS LLC |
$234542 |
6463 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$225931 |
8374 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$206991 |
7672 |
0.01% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$205938 |
7633 |
0.01% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$202350 |
7500 |
0.01% |
买入期权
|
| CWM, LLC |
$163922 |
6051 |
0.01% |
股份
|
| FEDERATED HERMES, INC. |
$161880 |
6000 |
0.01% |
股份
|
| Point72 (DIFC) Ltd |
$153088 |
4037 |
0.01% |
股份
|
| Aquatic Capital Management LLC |
$141348 |
5239 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$140539 |
5209 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$99556 |
3690 |
0.00% |
股份
|
| Coastal Bridge Advisors, LLC |
$66101 |
2450 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$61042 |
2262476 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$60273 |
2234 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$58034 |
2151 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$52449 |
1944 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$45218 |
1676 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$44056 |
1639 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$31836 |
1180 |
0.00% |
股份
|
| COMERICA BANK |
$28319 |
781 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$22420 |
831 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$21168 |
784 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$19690 |
738 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$16107 |
597 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$14902 |
593 |
0.00% |
股份
|
| GAMMA Investing LLC |
$13895 |
515 |
0.00% |
股份
|
| SMA Capital LLC |
$10441 |
387 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$9983 |
370 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$9578 |
355 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$8607 |
319 |
0.00% |
股份
|
| Coastal Bridge Advisors, LLC |
$7900 |
20000 |
0.00% |
买入期权
|
| Arax Advisory Partners |
$7717 |
286 |
0.00% |
股份
|
| State of Wyoming |
$7042 |
261 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$6583 |
244 |
0.00% |
股份
|
| FIL Ltd |
$6178 |
229 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$6097 |
226 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$5558 |
206 |
0.00% |
股份
|
| US BANCORP \DE\ |
$5531 |
205 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5450 |
202 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$4074 |
151 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3993 |
148 |
0.00% |
股份
|
| FSA Wealth Management LLC |
$3792 |
100 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$3157 |
117 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$3130 |
116 |
0.00% |
股份
|
| Allworth Financial LP |
$2725 |
101 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2185 |
81 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2051 |
76 |
0.00% |
股份
|
| Kilter Group LLC |
$1862 |
69 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1849 |
68565 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1645 |
60963 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$1636 |
103 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1187 |
44 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$808 |
30 |
0.00% |
股份
|
| Private Wealth Management Group, LLC |
$756 |
28 |
0.00% |
股份
|
| Essential Partners LLC |
$621 |
23 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$594 |
22 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$486 |
18 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$382 |
14100 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$324 |
12 |
0.00% |
股份
|
| Virtu Financial LLC |
$240 |
8886 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$216 |
8 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$216 |
8 |
0.00% |
股份
|
| Larson Financial Group LLC |
$162 |
6 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$162 |
6 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$108 |
4 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$67 |
2500 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$35 |
1306 |
0.00% |
股份
|
| KBC Group NV |
$33 |
1233 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$27 |
1 |
0.00% |
股份
|
| IFP Advisors, Inc |
$27 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$15 |
546 |
0.00% |
股份
|
| Avion Wealth |
$0 |
21 |
0.00% |
股份
|