| RA CAPITAL MANAGEMENT, L.P. |
$86996426 |
10860977 |
11.65% |
股份
|
| Rubric Capital Management LP |
$68412297 |
8540861 |
9.16% |
股份
|
| ORBIMED ADVISORS LLC |
$66390965 |
8288510 |
8.89% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$60105534 |
7503812 |
8.05% |
股份
|
| BlackRock, Inc. |
$42543666 |
5311319 |
5.70% |
股份
|
| VANGUARD GROUP INC |
$40881877 |
3509174 |
5.48% |
股份
|
| Tyro Capital Management LLC |
$35719289 |
4459337 |
4.78% |
股份
|
| Aberdeen Group plc |
$33406738 |
4170629 |
4.47% |
股份
|
| SR One Capital Management, LP |
$32143353 |
4012903 |
4.30% |
股份
|
| STATE STREET CORP |
$29882290 |
3730623 |
4.00% |
股份
|
| Capital World Investors |
$22066997 |
2754931 |
2.96% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$20453759 |
2553528 |
2.74% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$19231505 |
2400937 |
2.58% |
股份
|
| UBS Group AG |
$15536629 |
1939654 |
2.08% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$13612279 |
1699017 |
1.82% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$12828047 |
1601504 |
1.72% |
股份
|
| GENERAL AMERICAN INVESTORS CO INC |
$9075698 |
1133046 |
1.22% |
股份
|
| Third Point LLC |
$8010000 |
1000000 |
1.07% |
股份
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$5383833 |
672139 |
0.72% |
股份
|
| Tejara Capital Ltd |
$4862382 |
607039 |
0.65% |
股份
|
| ADAR1 Capital Management, LLC |
$4814002 |
600999 |
0.64% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4540300 |
566829 |
0.61% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4416842 |
551416 |
0.59% |
股份
|
| NORTHERN TRUST CORP |
$4398003 |
549064 |
0.59% |
股份
|
| LEVIN CAPITAL STRATEGIES, L.P. |
$4397210 |
548965 |
0.59% |
股份
|
| CITADEL ADVISORS LLC |
$4253814 |
531063 |
0.57% |
股份
|
| Empire Life Investments Inc. |
$3779567 |
471856 |
0.51% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$3731388 |
464681 |
0.50% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3710681 |
463256 |
0.50% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3692618 |
461001 |
0.49% |
股份
|
| FIL Ltd |
$3649156 |
455575 |
0.49% |
股份
|
| JPMORGAN CHASE & CO |
$3109986 |
363316 |
0.42% |
股份
|
| GOLDMAN SACHS GROUP INC |
$3049967 |
380770 |
0.41% |
股份
|
| Eversept Partners, LP |
$3019826 |
377007 |
0.40% |
股份
|
| K2 PRINCIPAL FUND, L.P. |
$3004807 |
375132 |
0.40% |
股份
|
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV |
$2991663 |
373491 |
0.40% |
股份
|
| FMR LLC |
$2796806 |
349164 |
0.37% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$2551850 |
318583 |
0.34% |
股份
|
| Trexquant Investment LP |
$2296731 |
286733 |
0.31% |
股份
|
| Jump Financial, LLC |
$2044152 |
255200 |
0.27% |
股份
|
| MORGAN STANLEY |
$1835091 |
229100 |
0.25% |
股份
|
| FAS Wealth Partners, Inc. |
$1718202 |
214507 |
0.23% |
股份
|
| Quinn Opportunity Partners LLC |
$1401750 |
175000 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$1346769 |
168136 |
0.18% |
股份
|
| DAFNA Capital Management LLC |
$1315923 |
164285 |
0.18% |
股份
|
| Nuveen, LLC |
$1292350 |
161342 |
0.17% |
股份
|
| Ishara Investments LP |
$1149355 |
143490 |
0.15% |
股份
|
| Engineers Gate Manager LP |
$1116746 |
139419 |
0.15% |
股份
|
| Steward Partners Investment Advisory, LLC |
$1030086 |
128600 |
0.14% |
股份
|
| BARCLAYS PLC |
$1011352 |
126261 |
0.14% |
股份
|
| AMERICAN ASSETS INC |
$1001250 |
125000 |
0.13% |
股份
|
| Quantinno Capital Management LP |
$996676 |
124429 |
0.13% |
股份
|
| MARSHALL WACE, LLP |
$990949 |
123714 |
0.13% |
股份
|
| CenterBook Partners LP |
$990228 |
123624 |
0.13% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$961200 |
120000 |
0.13% |
买入期权
|
| DIMENSIONAL FUND ADVISORS LP |
$925339 |
115523 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$922752 |
115200 |
0.12% |
买入期权
|
| SEI INVESTMENTS CO |
$838190 |
104643 |
0.11% |
股份
|
| Parkman Healthcare Partners LLC |
$822627 |
102700 |
0.11% |
股份
|
| Swiss National Bank |
$757746 |
94600 |
0.10% |
股份
|
| Kodai Capital Management LP |
$756196 |
60111 |
0.10% |
股份
|
| Corient Private Wealth LP |
$729248 |
91042 |
0.10% |
股份
|
| CITIGROUP INC |
$714484 |
89199 |
0.10% |
股份
|
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV |
$666633 |
83225 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$608660 |
75989 |
0.08% |
股份
|
| Headlands Technologies LLC |
$602985 |
75279 |
0.08% |
股份
|
| AssuredPartners Investment Advisors, LLC |
$586816 |
73260 |
0.08% |
股份
|
| XTX Topco Ltd |
$586228 |
73187 |
0.08% |
股份
|
| Norman Fields, Gottscho Capital Management, LLC |
$569351 |
71080 |
0.08% |
股份
|
| Matisse Capital |
$539849 |
67229 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$527587 |
65866 |
0.07% |
股份
|
| DIKER MANAGEMENT LLC |
$525000 |
65508 |
0.07% |
股份
|
| Balyasny Asset Management L.P. |
$517911 |
64658 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$509228 |
63574 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$504590 |
62995 |
0.07% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$481481 |
60110 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$477705 |
59490 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$474192 |
59200 |
0.06% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$467888 |
58413 |
0.06% |
股份
|
| Coastal Bridge Advisors, LLC |
$447262 |
55838 |
0.06% |
股份
|
| ROYCE & ASSOCIATES LP |
$432732 |
54024 |
0.06% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$419724 |
52400 |
0.06% |
股份
|
| SCHULHOFF & CO INC |
$409711 |
51150 |
0.05% |
股份
|
| K2 PRINCIPAL FUND, L.P. |
$384480 |
48000 |
0.05% |
买入期权
|
| AlphaQuest LLC |
$384101 |
32970 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$369445 |
46123 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$367619 |
45895 |
0.05% |
股份
|
| Permanent Capital Management, LP |
$347498 |
43383 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$323508 |
40388 |
0.04% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$320801 |
40050 |
0.04% |
股份
|
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management |
$317028 |
39579 |
0.04% |
股份
|
| Legal & General Group Plc |
$312490 |
38988 |
0.04% |
股份
|
| Invesco Ltd. |
$311516 |
38891 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$293518 |
36644 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$290452 |
35754 |
0.04% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$285764 |
35676 |
0.04% |
股份
|
| Everstar Asset Management, LLC |
$270193 |
33732 |
0.04% |
股份
|
| VARCOV Co. |
$263889 |
32945 |
0.04% |
股份
|
| WINTON GROUP Ltd |
$263529 |
32900 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$257914 |
32199 |
0.03% |
股份
|
| Verition Fund Management LLC |
$246308 |
30750 |
0.03% |
股份
|
| Cresset Asset Management, LLC |
$241518 |
30152 |
0.03% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$239499 |
29900 |
0.03% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$238113 |
29727 |
0.03% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$237096 |
29600 |
0.03% |
股份
|
| ALLSTATE CORP |
$236704 |
29551 |
0.03% |
股份
|
| WOLVERINE TRADING, LLC |
$235866 |
24266 |
0.03% |
股份
|
| WOLVERINE TRADING, LLC |
$218700 |
22500 |
0.03% |
买入期权
|
| AXQ CAPITAL, LP |
$214195 |
26741 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$212545 |
26535 |
0.03% |
股份
|
| LPL Financial LLC |
$209734 |
26184 |
0.03% |
股份
|
| Private Advisor Group, LLC |
$209002 |
26092 |
0.03% |
股份
|
| Belpointe Asset Management LLC |
$206306 |
25756 |
0.03% |
股份
|
| HighTower Advisors, LLC |
$205769 |
25689 |
0.03% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$200250 |
25000 |
0.03% |
股份
|
| Squarepoint Ops LLC |
$199481 |
24904 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$197438 |
24649 |
0.03% |
股份
|
| Creative Planning |
$194811 |
24321 |
0.03% |
股份
|
| Magnetar Financial LLC |
$182660 |
22804 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$173556 |
21600 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$165006 |
20600 |
0.02% |
买入期权
|
| Schonfeld Strategic Advisors LLC |
$164572 |
20546 |
0.02% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$161474 |
20159 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$155386 |
19399 |
0.02% |
股份
|
| SHERBROOKE PARK ADVISERS LLC |
$153069 |
13139 |
0.02% |
股份
|
| Mariner, LLC |
$150359 |
18771 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$144156 |
17997 |
0.02% |
股份
|
| Quarry LP |
$141969 |
17724 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$141833 |
17707 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$139285 |
17389 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$138717 |
17318 |
0.02% |
股份
|
| Tannin Capital LLC |
$131684 |
16440 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$126590 |
15804 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$122161 |
15251 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$119349 |
14900 |
0.02% |
卖出期权
|
| INTECH INVESTMENT MANAGEMENT LLC |
$118812 |
14833 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$111267 |
13891 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$104250 |
13015 |
0.01% |
股份
|
| nVerses Capital, LLC |
$102888 |
12845 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$98659 |
12317 |
0.01% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$94282 |
11040 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$92916 |
11600 |
0.01% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$92099 |
11498 |
0.01% |
股份
|
| ProShare Advisors LLC |
$90713 |
11325 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$84906 |
10600 |
0.01% |
股份
|
| Abel Hall, LLC |
$84393 |
10536 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$83000 |
10362 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$81702 |
10200 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$80460 |
10045 |
0.01% |
股份
|
| SYON CAPITAL LLC |
$80420 |
10040 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$66643 |
8320 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$43687 |
5454 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$39153 |
4888 |
0.01% |
股份
|
| DIADEMA PARTNERS LP |
$38929 |
4860 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$35572 |
4441 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$33786 |
4218 |
0.00% |
股份
|
| Arax Advisory Partners |
$33394 |
4169 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$31000 |
3874 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$27562 |
3441 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$25728 |
3212 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$24005 |
2997 |
0.00% |
股份
|
| OSTERWEIS CAPITAL MANAGEMENT INC |
$21122 |
2637 |
0.00% |
股份
|
| Bernard Wealth Management Corp. |
$19385 |
2420 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$17131 |
2160 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$16941 |
2115 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$16773 |
2094 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$16709 |
1952 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$16537 |
2064498 |
0.00% |
股份
|
| CAZ INVESTMENTS LP |
$16020 |
2000 |
0.00% |
股份
|
| US BANCORP \DE\ |
$12808 |
1599 |
0.00% |
股份
|
| GAMMA Investing LLC |
$10061 |
1256 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$9940 |
1241 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$9536 |
758 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$9085 |
2108 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$8138 |
1016 |
0.00% |
股份
|
| Heritage Wealth Advisors |
$8010 |
1000 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$7930 |
990 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$7097 |
886 |
0.00% |
股份
|
| CWM, LLC |
$6697 |
834 |
0.00% |
股份
|
| Allworth Financial LP |
$6609 |
825 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$4470 |
558 |
0.00% |
股份
|
| BROWN, LISLE/CUMMINGS, INC. |
$3204 |
400 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2997 |
374 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$2964 |
370 |
0.00% |
股份
|
| Hilton Head Capital Partners, LLC |
$2924 |
365 |
0.00% |
股份
|
| COMERICA BANK |
$2528 |
217 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1730 |
216 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$1602 |
200 |
0.00% |
股份
|
| Tidemark, LLC |
$1354 |
169 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1177 |
147 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1121 |
140 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$1001 |
125 |
0.00% |
股份
|
| Larson Financial Group LLC |
$873 |
109 |
0.00% |
股份
|
| SIT INVESTMENT ASSOCIATES INC |
$744 |
92875 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$737 |
92 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$698 |
87161 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$641 |
80 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$441 |
55 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$406 |
50579 |
0.00% |
股份
|
| Essential Partners LLC |
$264 |
33 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$256 |
32 |
0.00% |
股份
|
| Strategic Wealth Partners, Ltd. |
$160 |
20 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$140 |
17534 |
0.00% |
股份
|
| FOSTER & MOTLEY INC |
$118 |
14780 |
0.00% |
股份
|
| AMICA MUTUAL INSURANCE CO |
$115 |
14350 |
0.00% |
股份
|
| Virtu Financial LLC |
$88 |
10938 |
0.00% |
股份
|
| IFP Advisors, Inc |
$88 |
11 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$72 |
9 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$60 |
7525 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$42 |
5 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$40 |
5 |
0.00% |
股份
|
| GHP Investment Advisors, Inc. |
$25 |
3 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$16 |
2 |
0.00% |
股份
|
| CX Institutional |
$12 |
2890 |
0.00% |
股份
|
| Capital Analysts, LLC |
$10 |
1300 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$9 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$9 |
1062 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$8 |
1 |
0.00% |
股份
|
| LANARK FINANCIAL, INC. |
$8 |
1 |
0.00% |
股份
|
| Avion Wealth |
$4 |
500 |
0.00% |
股份
|
| Amica Retiree Medical Trust |
$3 |
346 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
46 |
0.00% |
股份
|