| Avoro Capital Advisors LLC |
$162683327 |
23888888 |
7.59% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$160413963 |
23555648 |
7.48% |
股份
|
| GOLDMAN SACHS GROUP INC |
$154676334 |
22713118 |
7.21% |
股份
|
| BlackRock, Inc. |
$140912023 |
20691927 |
6.57% |
股份
|
| Vestal Point Capital, LP |
$132216150 |
19415000 |
6.17% |
股份
|
| MORGAN STANLEY |
$112279731 |
16487479 |
5.24% |
股份
|
| RTW INVESTMENTS, LP |
$92345357 |
13560258 |
4.31% |
股份
|
| FMR LLC |
$90820969 |
13336413 |
4.24% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$84979232 |
12478595 |
3.96% |
股份
|
| STATE STREET CORP |
$77783275 |
11421920 |
3.63% |
股份
|
| VANGUARD GROUP INC |
$72972929 |
13267805 |
3.40% |
股份
|
| Siren, L.L.C. |
$67055203 |
9846579 |
3.13% |
股份
|
| Octagon Capital Advisors LP |
$66010992 |
9693244 |
3.08% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$44685322 |
6560394 |
2.08% |
股份
|
| Polar Capital Holdings Plc |
$34847676 |
5117133 |
1.63% |
股份
|
| MPM BIOIMPACT LLC |
$30645000 |
4500000 |
1.43% |
股份
|
| D. E. Shaw & Co., Inc. |
$29954821 |
4398652 |
1.40% |
股份
|
| BAKER BROS. ADVISORS LP |
$27272388 |
4004756 |
1.27% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$27073870 |
3975605 |
1.26% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$26460262 |
3885501 |
1.23% |
股份
|
| GordonMD Global Investments LP |
$24501508 |
723185 |
1.14% |
股份
|
| Casdin Capital, LLC |
$22132500 |
3250000 |
1.03% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$21383461 |
3140009 |
1.00% |
股份
|
| ADAR1 Capital Management, LLC |
$20705573 |
3040466 |
0.97% |
股份
|
| Pictet Asset Management Holding SA |
$18868474 |
2770701 |
0.88% |
股份
|
| Aberdeen Group plc |
$15847905 |
2327152 |
0.74% |
股份
|
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
$15322500 |
2250000 |
0.71% |
股份
|
| NORGES BANK |
$15210816 |
2233600 |
0.71% |
股份
|
| NORTHERN TRUST CORP |
$15160491 |
2226210 |
0.71% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$14986733 |
2200695 |
0.70% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$14483767 |
2126838 |
0.68% |
股份
|
| ORBIMED ADVISORS LLC |
$13620000 |
2000000 |
0.64% |
股份
|
| RICE HALL JAMES & ASSOCIATES, LLC |
$13567079 |
1992229 |
0.63% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$12914988 |
1896474 |
0.60% |
股份
|
| B Group, Inc. |
$12261786 |
1800556 |
0.57% |
股份
|
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD |
$12099000 |
3700000 |
0.56% |
股份
|
| Affinity Asset Advisors, LLC |
$11917500 |
1750000 |
0.56% |
股份
|
| BARCLAYS PLC |
$11104787 |
1630659 |
0.52% |
股份
|
| CITADEL ADVISORS LLC |
$10455305 |
1535287 |
0.49% |
股份
|
| HEIGHTS CAPITAL MANAGEMENT, INC |
$10215000 |
1500000 |
0.48% |
股份
|
| Seven Fleet Capital Management LP |
$9940323 |
1504400 |
0.46% |
股份
|
| Palo Alto Investors LP |
$9475311 |
1391382 |
0.44% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$9349074 |
1372845 |
0.44% |
股份
|
| Granahan Investment Management, LLC |
$8888255 |
1305177 |
0.41% |
股份
|
| Quantum Private Wealth, LLC |
$5529903 |
812027 |
0.26% |
股份
|
| FIRST TRUST ADVISORS LP |
$5387860 |
791169 |
0.25% |
股份
|
| JPMORGAN CHASE & CO |
$5157078 |
766282 |
0.24% |
股份
|
| Sands Capital Alternatives, LLC |
$4936385 |
724873 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$4753180 |
697971 |
0.22% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$4358638 |
640035 |
0.20% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$4020535 |
590387 |
0.19% |
股份
|
| UBS Group AG |
$4007188 |
588427 |
0.19% |
股份
|
| AFFINITY WEALTH MANAGEMENT LLC |
$3928062 |
576808 |
0.18% |
股份
|
| Squarepoint Ops LLC |
$3876722 |
569269 |
0.18% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$3825912 |
561808 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3799980 |
558000 |
0.18% |
买入期权
|
| Nuveen, LLC |
$3784270 |
555693 |
0.18% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$3765930 |
553000 |
0.18% |
股份
|
| DIADEMA PARTNERS LP |
$3559035 |
522619 |
0.17% |
股份
|
| Woodline Partners LP |
$3499169 |
513828 |
0.16% |
股份
|
| Holocene Advisors, LP |
$3473100 |
510000 |
0.16% |
股份
|
| Ghisallo Capital Management LLC |
$3439050 |
505000 |
0.16% |
股份
|
| Burkehill Global Management, LP |
$3405000 |
500000 |
0.16% |
股份
|
| POLEN CAPITAL MANAGEMENT LLC |
$3331581 |
489219 |
0.16% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3162863 |
464771 |
0.15% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2896723 |
425363 |
0.14% |
股份
|
| Trexquant Investment LP |
$2584919 |
379577 |
0.12% |
股份
|
| Swiss National Bank |
$2512890 |
369000 |
0.12% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$2440527 |
358374 |
0.11% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2269869 |
333314 |
0.11% |
股份
|
| Jefferies Financial Group Inc. |
$2239128 |
328800 |
0.10% |
股份
|
| CITIGROUP INC |
$2090037 |
306907 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$2042820 |
299975 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$1978598 |
290543 |
0.09% |
股份
|
| Invesco Ltd. |
$1800421 |
264379 |
0.08% |
股份
|
| Ensign Peak Advisors, Inc |
$1790322 |
262896 |
0.08% |
股份
|
| Qube Research & Technologies Ltd |
$1767910 |
259605 |
0.08% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1702500 |
250000 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$1657411 |
243379 |
0.08% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1598416 |
234716 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$1555098 |
228355 |
0.07% |
股份
|
| ORACLE INVESTMENT MANAGEMENT INC |
$1457500 |
265000 |
0.07% |
股份
|
| Monashee Investment Management LLC |
$1362000 |
200000 |
0.06% |
股份
|
| Privium Fund Management B.V. |
$1354509 |
198900 |
0.06% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1345506 |
197578 |
0.06% |
股份
|
| Chicago Partners Investment Group LLC |
$1296283 |
222347 |
0.06% |
股份
|
| Balyasny Asset Management L.P. |
$1289351 |
189332 |
0.06% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1205976 |
177089 |
0.06% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1188104 |
265795 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1153437 |
169374 |
0.05% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1130746 |
166042 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1107130 |
247680 |
0.05% |
股份
|
| WEXFORD CAPITAL LP |
$1094054 |
160654 |
0.05% |
股份
|
| Rafferty Asset Management, LLC |
$1053548 |
154706 |
0.05% |
股份
|
| Palumbo Wealth Management LLC |
$1015869 |
149173 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$959161 |
140846 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$911321 |
133821 |
0.04% |
股份
|
| Persistent Asset Partners Ltd |
$908529 |
133411 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$903101 |
132614 |
0.04% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$876883 |
128764 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$869664 |
127915 |
0.04% |
股份
|
| Mariner, LLC |
$793923 |
116582 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$783150 |
115000 |
0.04% |
买入期权
|
| TWO SIGMA ADVISERS, LP |
$767696 |
139581 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$736896 |
108208 |
0.03% |
股份
|
| Legal & General Group Plc |
$736890 |
108207 |
0.03% |
股份
|
| FRANKLIN RESOURCES INC |
$723835 |
106290 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$709139 |
104132 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$708887 |
104095 |
0.03% |
股份
|
| XTX Topco Ltd |
$689138 |
101195 |
0.03% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$669736 |
98346 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$663294 |
97400 |
0.03% |
卖出期权
|
| PROFUND ADVISORS LLC |
$546162 |
80200 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$481596 |
70719 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$471933 |
69300 |
0.02% |
股份
|
| J. Goldman & Co LP |
$458647 |
67349 |
0.02% |
股份
|
| RED REEF ADVISORS LLC |
$449120 |
65950 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$447649 |
65734 |
0.02% |
股份
|
| Creative Planning |
$434349 |
63781 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$428349 |
62900 |
0.02% |
卖出期权
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$420678 |
61773 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$420210 |
61705 |
0.02% |
股份
|
| OMERS ADMINISTRATION Corp |
$402471 |
59100 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$390233 |
57303 |
0.02% |
股份
|
| LANARK FINANCIAL, INC. |
$374699 |
55022 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$358329 |
52618 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$335141 |
49213 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$325518 |
47800 |
0.02% |
股份
|
| Militia Capital Management LLC |
$316665 |
46500 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$316277 |
46443 |
0.01% |
股份
|
| JANUS HENDERSON GROUP PLC |
$308085 |
69000 |
0.01% |
股份
|
| Williams & Novak, LLC |
$306450 |
45000 |
0.01% |
股份
|
| Almanack Investment Partners, LLC. |
$306110 |
44950 |
0.01% |
股份
|
| FIRST MANHATTAN CO. LLC. |
$296235 |
43500 |
0.01% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$294131 |
43191 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$288744 |
42400 |
0.01% |
股份
|
| ProShare Advisors LLC |
$277965 |
40817 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$269901 |
39633 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$265862 |
39040 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$260142 |
38200 |
0.01% |
买入期权
|
| Militia Capital Partners, LP |
$255750 |
46500 |
0.01% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$254108 |
37314 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$244390 |
35887 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$218935 |
32149 |
0.01% |
股份
|
| Cetera Investment Advisers |
$215244 |
31607 |
0.01% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$202401 |
29721 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$184987 |
27164 |
0.01% |
股份
|
| Quadrature Capital Ltd |
$175378 |
25753 |
0.01% |
股份
|
| nVerses Capital, LLC |
$171285 |
25152 |
0.01% |
股份
|
| State of Wyoming |
$166041 |
24382 |
0.01% |
股份
|
| XPONANCE LLC |
$155820 |
22881 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$148553 |
21814 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$148192 |
21761 |
0.01% |
股份
|
| Lee Financial Co |
$136200 |
20000 |
0.01% |
股份
|
| ALLSTATE CORP |
$132434 |
19447 |
0.01% |
股份
|
| Weiss Asset Management LP |
$130371 |
19144 |
0.01% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$126346 |
18553 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$124855 |
18334 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$122437 |
17979 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$113972 |
16736 |
0.01% |
股份
|
| ST GERMAIN D J CO INC |
$96246 |
14133 |
0.00% |
股份
|
| SEI INVESTMENTS CO |
$95004 |
13952 |
0.00% |
股份
|
| BANK OF MONTREAL /CAN/ |
$93079 |
13668 |
0.00% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$91629 |
13455 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$91056 |
13371 |
0.00% |
股份
|
| CIBC Bancorp USA Inc. |
$90315 |
13262 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$87522 |
12852 |
0.00% |
股份
|
| Ethic Inc. |
$85207 |
12512 |
0.00% |
股份
|
| CIBC WORLD MARKETS CORP |
$80366 |
14612 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$78519 |
11530 |
0.00% |
股份
|
| Magnetar Financial LLC |
$78145 |
11475 |
0.00% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$76068 |
11170 |
0.00% |
股份
|
| Summit Financial, LLC |
$74147 |
10888 |
0.00% |
股份
|
| CHOREO, LLC |
$72309 |
10618 |
0.00% |
股份
|
| Capital Investment Advisors, LLC |
$68100 |
10000 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$60191 |
8838 |
0.00% |
股份
|
| CWM, LLC |
$58472 |
13081 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$51000 |
7386 |
0.00% |
股份
|
| Allworth Financial LP |
$47521 |
6978 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$39478 |
5797 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$39362 |
5780 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$34050 |
5000 |
0.00% |
股份
|
| Bordeaux Wealth Advisors LLC |
$23234 |
10058 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$20873 |
3065 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$20430 |
3000 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$17583 |
2582 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$14294 |
2099 |
0.00% |
股份
|
| Chung Wu Investment Group, LLC |
$13620 |
2000 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$13300 |
2000 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$13205 |
1939 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$12633 |
1855 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$9263 |
1461 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7845 |
1152 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7171 |
1053 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5734 |
842 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$3405 |
500 |
0.00% |
股份
|
| Quarry LP |
$3269 |
480 |
0.00% |
股份
|
| Larson Financial Group LLC |
$3194 |
469 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3017 |
443 |
0.00% |
股份
|
| Arax Advisory Partners |
$2451 |
360 |
0.00% |
股份
|
| Essential Partners LLC |
$2227 |
327 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1907 |
280 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$1811 |
266 |
0.00% |
股份
|
| GAMMA Investing LLC |
$1580 |
232 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1377 |
202260 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1359 |
199494 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1158 |
170 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$960 |
141 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$605 |
435 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$578 |
85 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$494 |
72573 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$375 |
55 |
0.00% |
股份
|
| True Wealth Design, LLC |
$205 |
30 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$177 |
26 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$103 |
15075 |
0.00% |
股份
|
| Thrivent Financial for Lutherans |
$98 |
14520 |
0.00% |
股份
|
| IFP Advisors, Inc |
$95 |
14 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$41 |
6 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$18 |
2584 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
94 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$1 |
79 |
0.00% |
股份
|