AMRN Amarin Corporation plc - American Depositary Shares

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$14.37
Price · Aug 19, 2026
Fundamentals as of Jul 29, 2026

About Amarin Corporation plc - American Depositary Shares Company overview from Wikipedia

Amarin Corporation is an Irish-American biopharmaceutical company founded in 1993 and headquartered in Dublin, Ireland and Bridgewater, New Jersey. The company develops and markets medicines for the treatment of cardiovascular disease. It has developed the drug Vascepa (AMR-101), a prescription grade omega-3 fatty acid.

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Amarin Corporation is an Irish-American biopharmaceutical company founded in 1993 and headquartered in Dublin, Ireland and Bridgewater, New Jersey. The company develops and markets medicines for the treatment of cardiovascular disease. It has developed the drug Vascepa (AMR-101), a prescription grade omega-3 fatty acid.

In July 2012, their lead-candidate drug named Vascepa (AMR-101) received FDA-approval, competing against GlaxoSmithKline's Lovaza.

History

Amarin Corporation plc (formerly Ethical Holdings plc) was originally incorporated in England as a private limited company on March 1, 1989, and later re-registered as a public company on March 19, 1993. In 2002, the company suffered losses worth $37 million; 2003 losses exceeded $19 million. As of 2005, it was developing neurology drugs. It developed Miraxion to treat serious hereditary neurodegenerative disease.

In December 2007, Amarin acquired Ester Neurosciences Limited for US$8.1 million. In 2011, CEO Joe Zakrzewski said that the company would like to first work on building its infrastructure out to commercialize the drug in the United States.

Products and development

Vascepa (USA) / Vazkepa (EU)

Amarin´s sole product VASCEPA® came on the market in 2013 for triglyceride levels >=500 milligrams per deciliter. In December 2019, the FDA approved "...the use of Vascepa (icosapent ethyl) as an adjunctive (secondary) therapy to reduce the risk of cardiovascular events among adults with elevated triglyceride levels (a type of fat in the blood) of 150 milligrams per deciliter or higher. Patients must also have either established cardiovascular disease or diabetes and two or more additional risk factors for cardiovascular disease....Vascepa is the first FDA approved drug to reduce cardiovascular risk among patients with elevated triglyceride levels as an add-on to maximally tolerated statin therapy.

Furthermore, VASCEPA® is in use in clinical trials by 3rd parties to see, if it has an effect on Alzheimer, Colon Cancer, Nonalcoholic Steatohepatitis (NASH), and other diseases.

HLS Therapeutics, Amarin´s license partner in Canada, presented results of their COVID-19 clinical trial for Vascepa at National Lipid Association Scientific Sessions 2020, December 12. The results demonstrated a 25% reduction of hs-CRP, a biomarker for inflammation. Most people with COVID-19 die, because of a cytokine storm, which causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. Two more COVID-19 studies are actually running with Vascepa to validate and proof further benefits.

On January 28, the Committee for Medicinal Products for Human Use gave a positive recommendation for Vazcepa (its name in the EU), which the European Commission finally approved on March 30.

Patent disputes

On March 30, 2020, the designated patent judge in the U.S. District Court for the District of Nevada, Miranda Du, ruled for generic-drug makers Hikma Pharmaceuticals and Dr. Reddy's Laboratories in a lawsuit with Amarin over patents on Amarin's drug, Vascepa. Soon after, on April 2, 2020, Amarin filed an appeal of the ruling. The appeal was lost and an en-banc was also not granted, afterwards. On November 30, three weeks after Hikma Pharmaceuticals started the distribution of their generic version of Vascepa, Amarin filed a complaint of patent infringement against Hikma. On February 11, 2021, Amarin filed a petition for certiorari with the US Supreme Court. On June 21, 2021, the petition was denied.

== Finance ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

AMRN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$14.37
Market Cap
$5.98B
P/E (TTM)
-159.7
EPS (TTM)
$-0.09
Revenue (TTM)
$214M
Div Yield
ROE
-8.4%
Debt/Equity
52W Range
$13 – $21

AMRN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $214M
10-point trend, +64.2%
2016-12-31 2025-12-31
EPS $-0.09
10-point trend, +78.0%
2016-12-31 2025-12-31
Free Cash Flow
4-point trend, +69.4%
2016-12-31 2020-12-31
Margins -18.2%
7-point trend, -23.1%
2016-12-31 2025-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
AMRN
Peer Median
P/E (TTM)
5-point trend, -104.6%
-159.7
55.9
P/S (TTM)
5-point trend, -93.0%
28.0
5.5
P/B
5-point trend, -97.8%
13.0
1.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
AMRN
Peer Median
Gross Margin
5-point trend, -25.8%
56.6%
63.8%
Operating Margin
5-point trend, +50.3%
-23.5%
Net Profit Margin
5-point trend, +64.3%
-18.2%
-14.2%
ROA
5-point trend, +86.6%
-5.7%
-4.2%
ROE
5-point trend, +96.4%
-8.4%
-6.0%
ROIC
5-point trend, +74.7%
-11.8%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
AMRN
Peer Median
Current Ratio
5-point trend, +39.0%
3.3
3.7
Quick Ratio
5-point trend, +10.0%
2.2

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
AMRN
Peer Median
Revenue YoY
5-point trend, -63.4%
-6.6%
Revenue CAGR 3Y
5-point trend, -63.4%
-16.7%
Revenue CAGR 5Y
5-point trend, -63.4%
-19.0%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
AMRN
Peer Median
EPS (Diluted)
5-point trend, -550.0%
$-0.09

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
AMRN
Peer Median

AMRN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

SELL 6 analysts
  • Strong Buy 0 0.0%
  • Buy 0 0.0%
  • Hold 2 33.3%
  • Sell 2 33.3%
  • Strong Sell 2 33.3%

12-Month Price Target

1 analysts · 2026-08-15
Median target $12.00 -16.5%
Mean target $12.00 -16.5%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.20%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.04 $-0.01 0.05%
March 31, 2026 $-0.09 $0.09 -0.18%
Dec. 31, 2025 $0.01 $0.00 0.01%
Sept. 30, 2025 $0.08 $-0.58 0.66%
June 30, 2025 $0.66 $-0.18 0.84%
March 31, 2025 $-0.76 $-0.58 -0.18%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
AMRN $5.81B -155.1 -6.6% -18.2% -8.4% 56.6%
ALKS $4.63B 19.6 -5.2% 16.4% 14.0%
PRTA $514M -2.1 -92.8% -2520.6% -63.6%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 18
Annual Income Statement data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +294.2% $214M $229M $307M $369M $583M $614M $430M $229M $181M $130M $82M $54M
Cost of Revenue 8-point trend, +492.3% · · · · $121M $131M $96M $55M $45M $34M $28M $20M
Gross Profit 12-point trend, +258.5% $121M $81M $166M $242M $462M $483M $334M $175M $136M $96M $54M $34M
R&D Expense 12-point trend, -60.6% $20M $21M $22M $30M $29M $39M $34M $56M $47M $50M $51M $50M
SG&A Expense 12-point trend, +44.9% $115M $152M $200M $304M $408M $463M $324M $227M $135M $111M $101M $79M
Operating Expenses 12-point trend, +31.9% $171M $173M $233M $348M $451M $502M $358M $283M $182M $161M $152M $130M
Operating Income 12-point trend, +47.7% $-50M $-92M $-68M $-106M $11M $-20M $-24M $-108M $-46M $-66M $-98M $-96M
Interest Expense 12-point trend, -100.0% $7.0K $7.0K $8.0K $15.0K $129.0K $3M $7M $9M $10M $19M $20M $19M
Interest Income 12-point trend, +11205.2% $11M $13M $12M $3M $1M $5M $8M $1M $429.0K $234.0K $132.0K $96.0K
Other Non-op 12-point trend, -12.1% $3M $1M $2M $-740.0K $-302.0K $104.0K $-75.0K $-326.0K $74.0K $-482.0K $-228.0K $4M
Pretax Income 12-point trend, +39.1% $-36M $-77M $-54M $-104M $11M $-17M $-22M $-116M $-55M $-76M $-118M $-59M
Income Tax 12-point trend, +196.9% $3M $5M $5M $2M $4M $745.0K $164.0K $96.0K $13M $10M $-3M $-3M
Net Income 12-point trend, +31.2% $-39M $-82M $-59M $-106M $8M $-18M $-23M $-116M $-68M $-86M $-115M $-56M
EPS (Basic) 12-point trend, +71.9% $-0.09 $-0.20 $-0.15 $-0.26 $0.02 $-0.05 $-0.07 $-0.39 $-0.25 $-0.41 $-0.83 $-0.32
EPS (Diluted) 12-point trend, +75.0% $-0.09 $-0.20 $-0.15 $-0.26 $0.02 $-0.05 $-0.07 $-0.39 $-0.25 $-0.41 $-0.83 $-0.36
Shares (Basic) 12-point trend, +138.9% 414,984,000 410,937,000 407,655,000 401,155,000 395,992,000 381,759,000 342,538,000 297,237,000 270,652,000 211,874,000 180,654,000 173,719,000
Shares (Diluted) 12-point trend, +138.7% 414,984,000 410,937,000 407,655,000 401,155,000 402,480,000 381,759,000 342,538,000 297,237,000 270,652,000 211,874,000 180,654,000 173,824,000
EBITDA 9-point trend, +47.7% $-50M $-92M $-68M · · $-20M · $-108M $-46M $-66M $-98M $-96M
Balance Sheet 27
Annual Balance Sheet data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +12.6% $135M $121M $199M $218M $219M $187M $645M $249M $74M $98M $107M $120M
Short-term Investments 6-point trend, -46.5% $168M $173M $121M $92M $235M $314M · · · · · ·
Receivables 12-point trend, +1517.3% $127M $122M $134M $131M $164M $155M $116M $67M $45M $20M $14M $8M
Inventory 12-point trend, +1326.6% $196M $166M $259M $229M $235M $189M $77M $58M $30M $21M $19M $14M
Prepaid Expense 12-point trend, +824.8% $24M $13M $12M $19M $22M $31M $13M $3M $3M $7M $3M $3M
Other Current Assets · · · · · · · · · · · $3M
Current Assets 12-point trend, +347.3% $650M $595M $725M $689M $879M $879M $855M $378M $153M $146M $144M $145M
PP&E (Net) 12-point trend, -96.9% $12.0K $16.0K $114.0K $874.0K $1M $2M $2M $63.0K $28.0K $78.0K $243.0K $381.0K
PP&E (Gross) 12-point trend, +53.4% $1M $1M $1M $3M $3M $4M $3M $902.0K $844.0K $821.0K $997.0K $969.0K
Accum. Depreciation 12-point trend, +150.7% $1M $1M $1M $2M $2M $2M $1M $839.0K $816.0K $755.0K $754.0K $588.0K
Intangibles 12-point trend, +32.8% $13M $16M $19M $22M $24M $14M $15M $7M $8M $9M $9M $10M
Other Non-current Assets 12-point trend, -62.2% $1M $1M $1M $458.0K $456.0K $432.0K $1M $174.0K $174.0K $741.0K $174.0K $3M
Total Assets 12-point trend, +292.0% $671M $685M $832M $886M $1.07B $966M $882M $386M $162M $167M $173M $171M
Accounts Payable 12-point trend, +432.0% $45M $40M $53M $65M $115M $106M $50M $38M $25M $6M $11M $9M
Current Liabilities 12-point trend, +382.5% $194M $180M $259M $259M $371M $307M $242M $157M $109M $76M $51M $40M
Capital Leases 7-point trend, -35.6% $6M $8M $9M $10M $9M $9M $9M · · · · ·
Other Non-current Liabilities 12-point trend, +2738.1% $11M $12M $9M $8M $8M $6M $4M $11M $1M $710.0K $335.0K $386.0K
Total Liabilities 12-point trend, -18.5% $211M $199M $280M $291M $401M $339M $274M $233M $227M $176M $301M $260M
Long-term Debt 6-point trend, -52.7% · · · · · · $50M $80M $92M $94M $92M $105M
Total Debt 6-point trend, -100.0% · · · · · $0 · $80M $93M $101M $106M $105M
Common Stock 12-point trend, +116.7% $310M $305M $303M $299M $294M $290M $269M $247M $209M $207M $150M $143M
Paid-in Capital 9-point trend, +96.7% $1.92B $1.91B $1.90B $1.89B $1.86B $1.82B $1.76B $1.28B $978M · · ·
Retained Earnings 12-point trend, -76.0% $-1.71B $-1.67B $-1.59B $-1.53B $-1.42B $-1.43B $-1.41B $-1.39B $-1.27B $-1.20B $-1.12B $-970M
Treasury Stock 12-point trend, +30941.5% $67M $65M $64M $62M $61M $51M $36M $10M $4M $1M $411.0K $217.0K
Stockholders' Equity 12-point trend, +619.3% $459M $486M $552M $595M $667M $628M $608M $152M $-65M $-9M $-129M $-88M
Liabilities + Equity 12-point trend, +292.0% $671M $685M $832M $886M $1.07B $966M $882M $386M $162M $167M $173M $171M
Shares Outstanding 12-point trend, +138.4% 416,214,102 411,584,851 408,824,093 408,824,093 396,598,008 392,538,081 360,103,901 325,850,013 271,022,011 269,363,696 183,403,263 174,590,372
Cash Flow 17
Annual Cash Flow data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
D&A 5-point trend, -88.4% · · · · · · · $23.0K $62.0K $138.0K $166.0K $198.0K
Stock-based Comp 12-point trend, +54.5% $14M $18M $16M $26M $37M $46M $31M $19M $14M $14M $14M $9M
Deferred Tax 4-point trend, +406.6% · · · · · · · · $11M $9M $-4M $-4M
Amort. of Intangibles 12-point trend, +368.1% $3M $3M $3M $3M $2M $1M $679.0K $646.0K $646.0K $645.0K $646.0K $646.0K
Restructuring 5-point trend, +164.1% $36M $0 $11M $14M $14M · · · · · · ·
Operating Cash Flow 12-point trend, +109.0% $7M $-31M $7M $-180M $-67M $-22M $-9M $-95M $-33M $-72M $-84M $-75M
CapEx 6-point trend, +800.0% · · · · · $252.0K $2M $58.0K $12.0K $21.0K $28.0K ·
Investing Cash Flow 10-point trend, +42142.9% $9M $-46M $-26M $175M $104M $-377M $-2M $-58.0K $-12.0K $-21.0K · ·
Net Debt Issued 3-point trend, -1415.2% · · · · · $-50M · $-15M $-3M · · ·
Stock Issued 3-point trend, +581.1% · · · · · · $440M $265M · $65M · ·
Stock Repurchased · · · · · · · · · · $194.0K ·
Net Stock Activity 3-point trend, +136615.5% · · · · · · · $265M · $65M $-194.0K ·
Financing Cash Flow 10-point trend, -103.2% $-2M $-1M $230.0K $-379.0K $-5M $-59M $410M $271M $8M $63M · ·
Net Change in Cash 12-point trend, +118.8% $14M $-78M $-18M $-5M $32M $-458M $398M $176M $-25M $-9M $-13M $-72M
Taxes Paid 7-point trend, +1592.5% $1M $4M $2M $-2M $4M $-207.0K $-67.0K · · · · ·
Free Cash Flow 5-point trend, +74.1% · · · · · $-22M · $-95M $-33M $-72M $-85M ·
Levered FCF 5-point trend, +76.3% · · · · · $-25M · $-104M $-45M $-93M $-104M ·
Profitability 8
Annual Profitability data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Gross Margin 9-point trend, -9.1% 56.6% 35.6% 53.9% · · 78.6% · 76.2% 75.2% 73.6% 65.9% 62.2%
Operating Margin 9-point trend, +86.7% -23.5% -40.2% -22.0% · · -3.2% · -47.2% -25.1% -50.4% -120.1% -177.0%
Net Margin 9-point trend, +82.5% -18.2% -35.9% -19.3% · · -2.9% · -50.8% -37.5% -66.4% -140.9% -104.0%
Pretax Margin 9-point trend, +84.6% -16.9% -33.8% -17.5% · · -2.8% · -50.8% -30.3% -58.7% -144.7% -109.2%
EBITDA Margin 9-point trend, +86.7% -23.5% -40.2% -22.0% · · -3.2% · -47.2% -25.1% -50.4% -120.1% -177.0%
ROA 9-point trend, +78.5% -5.7% -10.8% -6.9% · · -1.9% · -42.5% -41.3% -50.8% -66.9% -26.6%
ROE 9-point trend, -109.1% -8.4% -16.2% -10.7% · · -2.9% · -234.1% 183.0% 124.9% 105.9% 92.2%
ROIC 9-point trend, +97.9% -11.8% -20.1% -13.5% · · -3.3% · -46.6% -200.8% -80.6% 417.0% -551.6%
Liquidity & Solvency 5
Annual Liquidity & Solvency data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 9-point trend, -7.3% 3.3 3.3 2.8 · · 2.9 · 2.4 1.4 1.9 2.8 3.6
Quick Ratio 9-point trend, -30.1% 2.2 2.3 1.8 · · 2.1 · 2.0 1.1 1.6 2.4 3.2
Debt / Equity 6-point trend, +100.0% · · · · · 0.0 · 0.5 -1.4 -11.2 -0.8 -1.2
LT Debt / Equity 5-point trend, +129.9% · · · · · · · 0.3 -1.1 -9.4 -0.7 -1.0
Interest Coverage 9-point trend, -138642.2% -7167.1 -13113.9 -8448.5 · · -7.5 · -12.2 -4.7 -3.5 -4.9 -5.2
Efficiency 3
Annual Efficiency data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 9-point trend, +23.1% 0.3 0.3 0.4 · · 0.7 · 0.8 1.1 0.8 0.5 0.3
Inventory Turnover 6-point trend, -15.6% · · · · · 1.0 · 1.2 1.8 1.7 1.7 1.2
Receivables Turnover 9-point trend, -81.8% 1.7 1.8 2.3 · · 4.5 · 4.1 5.5 7.7 7.5 9.4
Per Share 5
Annual Per Share data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 9-point trend, +317.8% $1.10 $1.18 $1.35 · · $1.60 · $0.47 $-0.24 $-0.03 $-0.70 $-0.51
Revenue / Share 9-point trend, +65.1% $0.51 $0.56 $0.75 · · $1.61 · $0.77 $0.67 $0.61 $0.45 $0.31
Cash Flow / Share 9-point trend, +103.9% $0.02 $-0.08 $0.02 · · $-0.06 · $-0.32 $-0.12 $-0.34 $-0.47 $-0.42
Cash / Share 9-point trend, -52.8% $0.32 $0.29 $0.49 · · $0.48 · $0.76 $0.27 $0.36 $0.58 $0.68
EPS (TTM) 12-point trend, +75.0% $-0.09 $-0.20 $-0.15 $-0.26 $0.02 $-0.05 $-0.07 $-0.39 $-0.25 $-0.41 $-0.83 $-0.36
Growth Rates 3
Annual Growth Rates data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -30.2% -6.6% -25.5% -16.9% -36.7% -5.0% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +19.2% -16.7% -26.8% -20.6% · · · · · · · · ·
Revenue CAGR 5Y -19.0% · · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for AMRN
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +294.2% $214M $229M $307M $369M $583M $614M $430M $229M $181M $130M $82M $54M
Net Income TTM 12-point trend, +31.2% $-39M $-82M $-59M $-106M $8M $-18M $-23M $-116M $-68M $-86M $-115M $-56M
Market Cap 9-point trend, +69.8% $5.81B $4.03B $7.11B · · $38.39B · $88.70B $21.74B $16.59B $6.93B $3.42B
Enterprise Value 6-point trend, +1012.0% · · · · · $37.89B · $88.53B $21.76B $16.60B $6.93B $3.41B
P/E 12-point trend, -184.9% -155.1 -49.0 -116.0 -93.1 3370.0 -1956.0 -6125.7 -697.9 -320.8 -150.2 -45.5 -54.4
P/S 9-point trend, -56.9% 27.2 17.6 23.2 · · 62.5 · 387.0 120.0 127.6 84.8 63.1
P/B 9-point trend, +132.7% 12.7 8.3 12.9 · · 61.2 · 582.3 -333.9 -1831.8 -53.7 -38.7
P / Tangible Book 6-point trend, -79.2% 13.0 8.6 13.4 17.1 41.5 62.6 · · · · · ·
P / Cash Flow 9-point trend, +1924.9% 863.6 -130.0 1033.9 · · -1765.4 · -936.6 -661.9 -231.0 -81.8 -47.3
P / FCF 5-point trend, -2034.1% · · · · · -1745.2 · -936.0 -661.7 -231.0 -81.8 ·
EV / EBITDA 6-point trend, -5328.5% · · · · · -1927.7 · -818.0 -477.6 -252.9 -70.6 -35.5
EV / FCF 5-point trend, -2006.5% · · · · · -1722.4 · -934.2 -662.3 -231.0 -81.8 ·
EV / Revenue 6-point trend, -1.8% · · · · · 61.7 · 386.2 120.1 127.6 84.8 62.9
Earnings Yield 12-point trend, +65.2% -0.64% -2.0% -0.86% -1.1% 0.03% -0.05% -0.02% -0.14% -0.31% -0.67% -2.2% -1.8%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $214M$229M$307M$369M$583M
Gross Margin % 56.6%35.6%53.9%
Operating Margin % -23.5%-40.2%-22.0%
Net Income $-39M$-82M$-59M$-106M$8M
Diluted EPS $-0.09$-0.20$-0.15$-0.26$0.02
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 3.33.32.8
Quick Ratio 2.22.31.8

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Institutional owners (13F) 90 filers · $59.1M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
23 (+15 vs prior Q) 7 (-12 vs prior Q) 19 (+1 vs prior Q) 10 (-3 vs prior Q) +89K

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Sarissa Capital Management LP $26,673,916 1,673,395 45.11% Shares
Kynam Capital Management, LP $8,495,733 532,982 14.37% Shares
Waterfront Wealth Inc. $3,183,561 213,949 5.38% Shares
Brooklands Fund Management Ltd $2,741,449 177,325 4.64% Shares
Eversept Partners, LP $2,316,018 145,296 3.92% Shares
MILLENNIUM MANAGEMENT LLC $1,845,980 115,808 3.12% Shares
TWO SIGMA INVESTMENTS, LP $1,602,145 100,511 2.71% Shares
BNP PARIBAS FINANCIAL MARKETS $1,144,699 71,813 1.94% Shares
CITADEL ADVISORS LLC $971,671 60,958 1.64% Shares
LCM Capital Management Inc $818,710 51,362 1.38% Shares
RENAISSANCE TECHNOLOGIES LLC $771,002 48,369 1.30% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $765,120 48,000 1.29% Call option
George Kaiser Family Foundation $593,080 37,207 1.00% Shares
JANE STREET GROUP, LLC $523,294 32,829 0.89% Shares
TWO SIGMA ADVISERS, LP $516,265 36,995 0.87% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $462,276 29,001 0.78% Shares
STATE STREET CORP $398,755 25,016 0.67% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $385,748 24,200 0.65% Put option
Bleakley Financial Group, LLC $374,670 23,505 0.63% Shares
State of New Jersey Common Pension Fund D $300,931 18,879 0.51% Shares
CITADEL ADVISORS LLC $299,672 18,800 0.51% Put option
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS $292,818 18,370 0.50% Shares
R Squared Ltd $269,992 16,938 0.46% Shares
State of Tennessee, Department of Treasury $239,164 15,004 0.40% Shares
MORGAN STANLEY $237,618 14,907 0.40% Shares
Quadrature Capital Ltd $236,581 14,842 0.40% Shares
Quinn Opportunity Partners LLC $228,022 14,305 0.39% Shares
Cubist Systematic Strategies, LLC $224,390 13,699 0.38% Shares
EntryPoint Capital, LLC $194,882 12,226 0.33% Shares
Jump Financial, LLC $191,407 12,008 0.32% Shares
GEODE CAPITAL MANAGEMENT, LLC $187,629 11,771 0.32% Shares
WELLS FARGO & COMPANY/MN $179,564 11,265 0.30% Shares
NJ State Employees Deferred Compensation Plan $178,542 10,900 0.30% Shares
Verdad Advisers, LP $166,270 10,431 0.28% Shares
CITADEL ADVISORS LLC $164,182 10,300 0.28% Call option
Steward Partners Investment Advisory, LLC $142,025 8,910 0.24% Shares
NEW YORK STATE COMMON RETIREMENT FUND $121,224 7,605 0.21% Shares
OSAIC HOLDINGS, INC. $104,537 6,559 0.18% Shares
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO $92,038 5,774 0.16% Shares
MERCER GLOBAL ADVISORS INC /ADV $80,099 5,025 0.14% Shares
UBS Group AG $67,171 4,214 0.11% Shares
RHUMBLINE ADVISERS $59,498 3,733 0.10% Shares
NATIONAL BANK OF CANADA /FI/ $40,137 2,518 0.07% Shares
AMERIPRISE FINANCIAL INC $30,318 1,902 0.05% Shares
ROYAL BANK OF CANADA $28,000 1,787 0.05% Shares
GAMMA Investing LLC $25,121 1,576 0.04% Shares
RAYMOND JAMES FINANCIAL INC $22,332 1,401 0.04% Shares
NewEdge Advisors, LLC $21,471 1,347 0.04% Shares
Farther Finance Advisors, LLC $15,271 958 0.03% Shares
BlackRock, Inc. $13,677 858 0.02% Shares
IFP Advisors, Inc $12,975 814 0.02% Shares
Beaird Harris Wealth Management, LLC $11,955 750 0.02% Shares
ACADIAN ASSET MANAGEMENT LLC $11,467 720,984 0.02% Shares
CoreCap Advisors, LLC $8,528 535 0.01% Shares
Integrated Wealth Concepts LLC $8,449 530 0.01% Shares
JONES FINANCIAL COMPANIES LLLP $7,844 493 0.01% Shares
BARCLAYS PLC $4,862 305 0.01% Shares
JPMORGAN CHASE & CO $3,853 242 0.01% Shares
CWM, LLC $3,644 252 0.01% Shares
Westside Investment Management, Inc. $3,268 205 0.01% Shares
Global Retirement Partners, LLC $2,646 166 0.00% Shares
GROUP ONE TRADING LLC $2,072 130 0.00% Shares
HARBOUR INVESTMENTS, INC. $1,562 98 0.00% Shares
Federation des caisses Desjardins du Quebec $1,435 90 0.00% Shares
Activest Wealth Management $797 50 0.00% Shares
HighMark Wealth Management LLC $797 50 0.00% Shares
Arax Advisory Partners $685 43 0.00% Shares
Darwin Wealth Management, LLC $398 25 0.00% Shares
Continuum Advisory, LLC $303 19 0.00% Shares
Caitong International Asset Management Co., Ltd $271 17 0.00% Shares
SEI INVESTMENTS CO $260 16 0.00% Shares
Hayek Kallen Investment Management $204 12,809 0.00% Shares
Atlantic Union Bankshares Corp $192 12 0.00% Shares
Truvestments Capital LLC $191 12 0.00% Shares
Parallel Advisors, LLC $159 10 0.00% Shares
Creative Capital Management Investments LLC $143 9 0.00% Shares
Key Financial Inc $128 8 0.00% Shares
CITIGROUP INC $128 8 0.00% Shares
MCGUIRE CAPITAL ADVISORS INC $112 7 0.00% Shares
EASTERN BANK $112 7 0.00% Shares
Lindbrook Capital, LLC $90 200 0.00% Shares
Oakmont Advisory Group, LLC $80 5 0.00% Shares
Allworth Financial LP $80 5 0.00% Shares
Crewe Advisors LLC $80 5 0.00% Shares
BFSG, LLC $80 5 0.00% Shares
SBI Securities Co., Ltd. $80 5 0.00% Shares
WHITTIER TRUST CO $63 4 0.00% Shares
Caitlin John, LLC $32 2 0.00% Shares
WHITTIER TRUST CO OF NEVADA INC $15 1 0.00% Shares
JFS WEALTH ADVISORS, LLC $15 1 0.00% Shares

Company insiders 37 insiders · 17 officers · 22 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Aaron Berg President and CEO June 26, 2026 M 85,648 0 0 $0
Patrick Holt President and CEO Jan. 22, 2024 P 314,426 0 0 $0
Karim Mikhail President and CEO Feb. 21, 2023 A 283,507 0 0 $0
John F Thero President and CEO Nov. 19, 2019 S 2,342,285 0 0 $0
Peter L. Fishman SVP, CFO Aug. 1, 2026 A 7,619 0 0 $0
Thomas Charles Reilly EVP and CFO July 1, 2024 M 94,305 0 0 $0
Michael Wayne Kalb SVP and CFO Dec. 16, 2019 M 21,552 0 0 $0
David Paul Keenan EVP, Chief Operating Officer July 1, 2026 A 13,470 0 0 $0
Jonathan Provoost EVP, Chief Legal Officer July 1, 2026 A 4,624 0 0 $0
Steven B Ketchum EVP, Chief Scientific Officer July 1, 2026 A 42,680 0 0 $0
Joseph T Kennedy General Counsel Oct. 7, 2019 F 125,723 0 0 $0
Mark Salyer Chief Commercial Officer Feb. 1, 2018 A 0 0 $0
Michael James Farrell VP, Finance Feb. 1, 2016 A 30,190 0 0 $0
Paul Huff Chief Commercial Officer July 26, 2012 A 0 0 0 $0
Stuart D Sedlack Senior Vice President July 26, 2012 A 0 0 0 $0
Paresh Soni SVP and Head of Development Feb. 1, 2012 A 0 0 0 $0
Frederick W Ahlholm Vice President Finance Feb. 1, 2012 A 0 0 0 $0
Oliver O'Connor Director April 18, 2026 M 801 0 0 $0
Paul Cohen Director April 18, 2026 M 836 0 0 $0
Diane E. Sullivan Director April 18, 2026 M 836 0 0 $0
Louis Sterling III Director April 18, 2026 M 4,049 0 0 $0
Patrice Eadon Bonfiglio Director April 18, 2026 M 836 0 0 $0
Keith Horn Director April 18, 2026 M 836 0 0 $0
Odysseas D Kostas Director April 18, 2026 M 836 0 0 $0
Mark Dipaolo Director April 18, 2025 M 401 0 0 $0
Olsen Per Wold Director Jan. 10, 2023 M 171,027 0 0 $0
David M Stack Director June 4, 2021 P 40,000 0 0 $0
Joseph S Zakrzewski Director Jan. 3, 2020 M 84,547 0 0 $0
Lars Ekman Director Nov. 12, 2019 M 0 0 0 $0
Kristine Peterson Director May 20, 2019 A 0 0 0 $0
Patrick J O'Sullivan Director May 20, 2019 A 0 0 $0
VAN HEEK G JAN Director May 20, 2019 A 14,168 0 0 $0
Dr. James I. Healy Director July 11, 2016 A 90,000 0 0 $0
GORDON CARL L Director Sept. 4, 2012 S 5,700 0 0 $0
Joseph Anderson Director July 10, 2012 A 11,683 0 0 $0
David W Feigal Jr Director July 12, 2011 A 0 0 $0
Abingworth LLP 10% owner April 19, 2012 S 1,599,168 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 34 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Sarissa Capital Management LP, Alexander J Denner ×3 filings March 25, 2025 8.08% Amendment Board campaign SEC
Feb. 28, 2023 Initial filing SEC
Feb. 27, 2023 Initial filing SEC
Feb. 21, 2023 Initial filing SEC
OR ×6 filings Feb. 15, 2023 Initial filing SEC
Feb. 14, 2023 Initial filing SEC
Feb. 10, 2023 Initial filing SEC
Jan. 19, 2023 Initial filing SEC
June 16, 2022 Initial filing SEC
Sofinnova Venture Partners VII, L.P. (“SVP VII”), Sofinnova Management VII, L.L.C. (“SM VII”), Dr. Michael F. Powell (“Powell”), Dr. James I. Healy (“Healy”), Eric P. Buatois (“Buatois”) ×4 filings Aug. 23, 2013 Initial filing Passive investment SEC
Abingworth LLP 98-051-8585, Abingworth Bioventures V Co-Invest Growth Equity Fund LP 98-057-9772, Abingworth Bioventures V L.P. 98-051-8587, Abingworth Bioequities Master Fund Limited 66-066-0960 ×10 filings July 22, 2013 Initial filing Board campaign SEC
Boxer Capital, LLC, Boxer Asset Management Inc., Joseph Lewis ×4 filings Aug. 24, 2011 Initial filing SEC
OrbiMed Advisors LLC, OrbiMed Capital GP III LLC, Samuel D. Isaly ×14 filings April 28, 2011 Initial filing SEC
Fountain Healthcare Partners Fund 1, L.P. (“ Fountain ”), Fountain Healthcare Partners Ltd., Manus Rogan, Aidan King, Ena Prosser, Justin Lynch ×2 filings Dec. 10, 2010 Initial filing SEC
Longitude Capital Partners, LLC (2), Longitude Venture Partners, L.P. (2), Longitude Capital Associates, L.P. (2), Patrick G. Enright (2), Juliet Tammenoms Bakker (2) Oct. 26, 2010 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.