PBYI Puma Biotechnology Inc - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$9.41
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026

About Puma Biotechnology Inc - Common Stock Company overview from Wikipedia

Puma Biotechnology is a publicly traded biopharmaceutical company headquartered in Los Angeles, CA.

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Puma Biotechnology is a publicly traded biopharmaceutical company (NASDAQ: PBYI) headquartered in Los Angeles, CA.

Creation

Puma was founded in September 2010 by Alan Auerbach to identify and in-license compounds that were already in clinical development. This was the same business plan Auerbach had followed at Cougar Biotechnology, which he founded in 2003, and through which he in-licensed abiraterone acetate from BTG plc. Cougar further developed abiraterone before the company was sold to Johnson & Johnson in 2009. Auerbach brought many Cougar employees with him after founding Puma in 2010.

Funding for development

In August 2011 Puma licensed two drug candidates from Pfizer: neratinib (PB272) and an analog (PB357) to serve as a backup candidate.

As part of an approximately $60 million financing round in October 2011, Puma entered into a reverse merger with the shell company Innovative Acquisitions Corp., formed in 2007. In April 2012 the company's stock began trading over the counter. In October 2012 the company raised around $138 million and its shares were listed on the New York Stock Exchange.

In 2016 Puma discovered that Robert Gadimian, senior director of regulatory affairs, had twice bought and sold stock based on his knowledge of unpublished clinical trial results; Puma quickly fired him after conducting an internal investigation and reported the insider trading to the SEC.

Approval and licensing of neratinib

In March 2016 Puma held a pre-NDA meeting with the FDA in which the FDA raised concerns about the design and conduct of clinical trials that Puma had run and recommended that Puma not file the NDA with that data.

Puma did file the NDA, and in May 2017 an FDA review panel recommended that the FDA approve neratinib but raised concerns that the intended use was too broad and should be limited to people with specific mutations. The FDA's briefing document to the panel had raised concerns about the marginal benefit of the drug and the side effects. In July 2017 the FDA approved neratinib for use in preventing the return of breast cancer after treatment that included trastuzumab and without any need for genetic testing, and with warnings about the risk of severe diarrhea. U.S. sales of neratinib totaled $200.5 million in 2018.

In January 2018 an EMA committee gave a negative review to neratinib. In June 2018 this same EMA committee recommended the approval of neratinib, which received European Commission (EC) approval in September 2018.

In 2019 Puma licensed commercialization rights in Europe and part of Africa to Pierre Fabre for an upfront payment of $60 million and milestone payments that could reach $345 million. Previously, Puma licensed rights in Greater China to CANbrdige Life Sciences, rights in Israel to Medison Pharma, rights in Canada to Knight Therapeutics, rights in South East Asian to Specialised Therapeutics and rights in Latin America to Pint Pharma.

== References ==

Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗

Wikidata ↗

PBYI Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$9.41
Market Cap
$479M
P/E (TTM)
15.6
EPS (TTM)
$0.61
Revenue (TTM)
$228M
Div Yield
ROE
26.5%
Debt/Equity
0.2
52W Range
$4 – $10

PBYI Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $228M
9-point trend, +724.9%
2017-12-31 2025-12-31
EPS $0.61
6-point trend, +140.1%
2020-12-31 2025-12-31
Free Cash Flow $42M
8-point trend, +128.6%
2016-12-31 2025-12-31
Margins 13.6%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
PBYI
Peer Median
P/E (TTM)
5-point trend, +244.5%
15.6
17.4
P/S (TTM)
5-point trend, +172.8%
2.1
52.3
P/B
5-point trend, +104.6%
3.7
4.8
EV / EBITDA
5-point trend, -94.3%
10.8
Price / FCF
5-point trend, +21.8%
11.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
PBYI
Peer Median
Operating Margin
5-point trend, +3102.0%
16.3%
Net Profit Margin
5-point trend, +218.3%
13.6%
-670.1%
ROA
5-point trend, +217.1%
14.5%
-41.1%
ROE
5-point trend, -93.9%
26.5%
-52.6%
ROIC
5-point trend, +1437.7%
21.2%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
PBYI
Peer Median
Debt / Equity
5-point trend, +100.4%
0.2
Current Ratio
5-point trend, +56.7%
2.0
7.7
Quick Ratio
5-point trend, +77.9%
1.9

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
PBYI
Peer Median
Revenue YoY
5-point trend, -9.8%
-0.91%
Revenue CAGR 3Y
5-point trend, -9.8%
0.05%
Revenue CAGR 5Y
5-point trend, -9.8%
0.29%
EPS YoY
5-point trend, +184.7%
-1.6%
Net Income YoY
5-point trend, +206.8%
2.8%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
PBYI
Peer Median
EPS (Diluted)
5-point trend, +184.7%
$0.61

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
PBYI
Peer Median

PBYI Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

SELL 6 analysts
  • Strong Buy 0 0.0%
  • Buy 0 0.0%
  • Hold 3 50.0%
  • Sell 1 16.7%
  • Strong Sell 2 33.3%

12-Month Price Target

1 analysts · 2026-08-18
Median target $6.00 -36.2%
Mean target $6.00 -36.2%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.07%
Period EPS Actual EPS Est Surprise
June 30, 2026 $0.16 $0.04 0.12%
March 31, 2026 $-0.07 $-0.13 0.06%
Dec. 31, 2025 $0.26 $0.23 0.03%
Sept. 30, 2025 $0.17 $0.05 0.12%
June 30, 2025 $0.12 $0.10 0.02%
March 31, 2025 $0.06 $-0.02 0.08%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
PBYI $300M 9.8 -0.91% 13.6% 26.5%
CABA $220M -1.0 -115.5%
QTTB $43M 1.4 55.5% 200.3%
OCGN $422M -5.6 8.8% -1537.4% 1488.8%
LRMR $317M -2.2 -167.4%
RZLT $388M -4.6 -56.9%
BNTC $307M -11.1 -43.8%
EDIT $201M -1.1 25.4% -395.0% -688.8%
CMPX $958M -45.9%
PROK 1075.0% -7725.2% 6.9%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 17
Annual Income Statement data for PBYI
Metric Trend 202520242023202220212020201920182017
Revenue 9-point trend, +724.9% $228M $230M $236M $228M $253M $225M $272M $251M $28M
Cost of Revenue 9-point trend, +943.7% $58M $64M $63M $55M $64M $39M $37M $35M $6M
R&D Expense 5-point trend, -65.4% · · · · $72M $98M $133M $165M $208M
SG&A Expense 9-point trend, -33.6% $71M $80M $90M $90M $116M $118M $142M $146M $107M
Operating Expenses 9-point trend, -40.3% $191M $200M $203M $204M $252M $256M $311M $346M $320M
Operating Income 9-point trend, +112.8% $37M $31M $33M $24M $1M $-30M $-39M $-95M $-292M
Interest Expense 7-point trend, +1751.4% · · $13M $12M $13M $14M $15M $11M $720.0K
Interest Income 9-point trend, +224.7% $4M $5M $3M $813.0K $160.0K $489.0K $3M $2M $1M
Other Non-op 9-point trend, +1116.8% $1M $862.0K $759.0K $-28.0K $292.0K $367.0K $128.0K $-714.0K $-101.0K
Pretax Income 8-point trend, +131.5% $36M $24M $23M $457.0K $-29M $-60M $-76M $-114M ·
Income Tax 9-point trend, +4671000.00 $5M $-6M $1M $455.0K $324.0K $207.0K $53.0K $17.0K $0
Net Income 9-point trend, +110.7% $31M $30M $22M $2.0K $-29M $-60M $-76M $-114M $-292M
EPS (Basic) 7-point trend, +100.0% $0.62 $0.62 $0.46 $0.00 $-0.72 $-1.52 $-75595.00 · ·
EPS (Diluted) 6-point trend, +140.1% $0.61 $0.62 $0.45 $0.00 $-0.72 $-1.52 · · ·
Shares (Basic) 6-point trend, +26.4% 50,011,485 48,648,701 47,134,331 44,674,501 40,638,852 39,576,107 · · ·
Shares (Diluted) 6-point trend, +28.0% 50,653,283 49,100,433 47,550,852 44,929,998 40,638,852 39,576,107 · · ·
EBITDA 9-point trend, +112.8% $37M $31M $33M $24M $1M $-30M $-39M $-95M $-292M
Balance Sheet 26
Annual Balance Sheet data for PBYI
Metric Trend 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, -63.7% $30M $69M $85M $76M $63M $85M $60M $108M $82M
Short-term Investments 8-point trend, +19.1% $68M $32M $11M $5M $19M $8M $52M $57M ·
Receivables 9-point trend, +454.9% $54M $32M $48M $40M $33M $26M $29M $21M $10M
Inventory 9-point trend, +171.8% $6M $9M $7M $5M $7M $3M $3M $3M $2M
Prepaid Expense 9-point trend, -72.0% $4M $6M $4M $6M $9M $11M $13M $12M $13M
Other Current Assets 8-point trend, -85.7% $256.0K $91.0K $912.0K $2M $447.0K $4M $323.0K $2M ·
Current Assets 9-point trend, +52.9% $163M $148M $156M $134M $140M $146M $166M $203M $106M
PP&E (Net) 9-point trend, -95.8% $187.0K $515.0K $855.0K $1M $2M $2M $3M $4M $4M
PP&E (Gross) 9-point trend, -43.9% $5M $8M $9M $9M $9M $9M $9M $9M $9M
Accum. Depreciation 9-point trend, +13.2% $5M $8M $8M $7M $7M $6M $6M $5M $4M
Intangibles 9-point trend, -14.4% $41M $51M $61M $71M $66M $74M $40M $44M $48M
Total Assets 9-point trend, +30.7% $216M $213M $231M $222M $227M $244M $235M $259M $166M
Accounts Payable 9-point trend, -81.7% $5M $6M $7M $6M $11M $12M $19M $21M $28M
Accrued Liabilities 9-point trend, +63.2% $50M $37M $53M $53M $93M $61M $69M $46M $31M
Current Liabilities 9-point trend, +39.3% $81M $96M $99M $77M $110M $114M $91M $67M $58M
Capital Leases 7-point trend, -79.2% $5M $1M $7M $12M $16M $20M $23M · ·
Other Non-current Liabilities 3-point trend, -100.0% $0 $121.0K $121.0K · · · · · ·
Total Liabilities 9-point trend, -23.4% $86M $121M $177M $200M $229M $250M $217M $225M $112M
Long-term Debt 9-point trend, -53.2% $23M $68M $102M $102M $102M $84M $95M $152M $48M
Total Debt 6-point trend, -77.1% $23M $67M $100M $98M $97M $98M · · ·
Common Stock 9-point trend, +25.0% $5.0K $5.0K $5.0K $5.0K $4.0K $4.0K $4.0K $4.0K $4.0K
Retained Earnings 9-point trend, -17.9% $-1.28B $-1.31B $-1.35B $-1.37B $-1.37B $-1.34B $-1.28B $-1.20B $-1.09B
AOCI 8-point trend, +400.0% $36.0K $6.0K $-4.0K $0 $-2.0K $0 $62.0K $-12.0K ·
Stockholders' Equity 9-point trend, +144.5% $130M $92M $53M $22M $-2M $-6M $17M $34M $53M
Liabilities + Equity 9-point trend, +30.7% $216M $213M $231M $222M $227M $244M $235M $259M $166M
Shares Outstanding 9-point trend, +34.1% 50,408,023 49,105,834 47,646,787 46,345,660 41,175,507 40,086,387 39,203,304 38,325,037 37,594,851
Cash Flow 14
Annual Cash Flow data for PBYI
Metric Trend 202520242023202220212020201920182017
D&A 9-point trend, +289.1% $11M $12M $12M $10M $11M $10M $8M $7M $3M
Stock-based Comp 9-point trend, -93.6% $7M $8M $10M $12M $33M $37M $57M $87M $109M
Deferred Tax 4-point trend, +3245000.00 $3M $-7M $0 $0 · · · · ·
Amort. of Intangibles 9-point trend, +506.2% $10M $10M $8M $8M $8M $6M $4M $4M $2M
Operating Cash Flow 9-point trend, +124.2% $42M $39M $27M $-16M $21M $773.0K $22M $-24M $-172M
CapEx 9-point trend, -83.5% $71.0K $56.0K $140.0K $0 $0 $46.0K $306.0K $439.0K $431.0K
Investing Cash Flow 9-point trend, -134.4% $-36M $-20M $-19M $7M $-11M $33M $5M $-58M $-15M
Debt Issued 3-point trend, -50.0% · · · · · · $25M $105M $50M
Net Debt Issued 3-point trend, -50.0% · · · · · · $25M $105M $50M
Financing Cash Flow 9-point trend, -160.2% $-45M $-34M $0 $12M $-32M $-10M $-67M $108M $75M
Net Change in Cash 9-point trend, +64.9% $-40M $-15M $8M $4M $-22M $24M $-40M $27M $-113M
Taxes Paid $1M · · · · · · · ·
Free Cash Flow 7-point trend, +124.1% $42M $39M $27M $-16M $21M · · $-25M $-173M
Levered FCF 3-point trend, +84.1% · · $14M $-16M $8M · · · ·
Profitability 7
Annual Profitability data for PBYI
Metric Trend 202520242023202220212020201920182017
Operating Margin 9-point trend, +101.5% 16.3% 13.4% 13.9% 10.4% 0.51% -13.5% -14.4% -37.7% -1056.1%
Net Margin 9-point trend, +101.3% 13.6% 13.1% 9.2% 0.00% -11.5% -26.7% -27.8% -45.2% -1054.6%
Pretax Margin 6-point trend, +159.0% 15.7% 10.5% 9.6% 0.20% -11.4% -26.6% · · ·
EBITDA Margin 9-point trend, +101.5% 16.3% 13.4% 13.9% 10.4% 0.51% -13.5% -14.4% -37.7% -1056.1%
ROA 9-point trend, +110.4% 14.5% 13.6% 9.5% 0.00% -12.4% -25.0% -30.6% -53.5% -139.6%
ROE 9-point trend, +111.9% 26.5% 37.1% 46.8% 0.01% 435.8% 1873.7% -436.4% -283.2% -221.9%
ROIC 6-point trend, +164.2% 21.2% 24.4% 20.3% 0.09% 1.4% -33.0% · · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for PBYI
Metric Trend 202520242023202220212020201920182017
Current Ratio 9-point trend, +9.8% 2.0 1.5 1.6 1.7 1.3 1.3 1.8 3.0 1.8
Quick Ratio 9-point trend, +18.8% 1.9 1.4 1.4 1.6 1.0 1.0 1.5 2.8 1.6
Debt / Equity 6-point trend, +101.0% 0.2 0.7 1.9 4.5 -39.7 -16.5 · · ·
LT Debt / Equity 6-point trend, +100.0% 0.0 0.2 1.2 4.5 -39.7 -14.1 · · ·
Interest Coverage 7-point trend, +100.6% · · 2.4 2.0 0.1 -2.2 -2.6 -8.6 -406.1
Efficiency 3
Annual Efficiency data for PBYI
Metric Trend 202520242023202220212020201920182017
Asset Turnover 9-point trend, +702.9% 1.1 1.0 1.0 1.0 1.1 0.9 1.1 1.2 0.1
Inventory Turnover 7-point trend, +48.7% 8.2 8.2 10.8 9.5 12.1 · · 14.9 5.5
Receivables Turnover 9-point trend, -6.9% 5.3 5.8 5.3 6.3 8.7 8.3 11.0 16.5 5.7
Per Share 5
Annual Per Share data for PBYI
Metric Trend 202520242023202220212020201920182017
Book Value / Share 9-point trend, +82.4% $2.59 $1.88 $1.12 $0.52 $-0.06 $-0.15 $0.45 $0.90 $1.42
Revenue / Share 4-point trend, -11.2% $4.51 $4.69 $4.96 $5.08 · · · · ·
Cash Flow / Share 4-point trend, +334.3% $0.83 $0.79 $0.57 $-0.35 · · · · ·
Cash / Share 9-point trend, -72.9% $0.59 $1.41 $1.78 $1.85 $1.57 $2.13 $1.53 $2.83 $2.17
EPS (TTM) 6-point trend, +140.1% $0.61 $0.62 $0.45 $0.00 $-0.72 $-1.52 · · ·
Growth Rates 6
Annual Growth Rates data for PBYI
Metric Trend 202520242023202220212020201920182017
Revenue YoY 5-point trend, -107.3% -0.91% -2.2% 3.3% -9.9% 12.5% · · · ·
Revenue CAGR 3Y 3-point trend, -96.8% 0.05% -3.1% 1.5% · · · · · ·
Revenue CAGR 5Y 0.29% · · · · · · · ·
EPS YoY 2-point trend, -104.3% -1.6% 37.8% · · · · · · ·
Net Income YoY 3-point trend, -100.0% 2.8% 40.2% 1079450.0% · · · · · ·
Net Income CAGR 3Y 2396.3% · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for PBYI
Metric Trend 202520242023202220212020201920182017
Revenue TTM 9-point trend, +724.9% $228M $230M $236M $228M $253M $225M $272M $251M $28M
Net Income TTM 9-point trend, +110.7% $31M $30M $22M $2.0K $-29M $-60M $-76M $-114M $-292M
Market Cap 9-point trend, -91.9% $300M $150M $206M $174M $122M $411M $343M $780M $3.72B
Enterprise Value 6-point trend, -46.0% $225M $116M $210M $191M $137M $416M · · ·
P/E 5-point trend, +244.5% 9.8 4.9 9.6 · -4.2 -6.8 · · ·
P/S 9-point trend, -99.0% 1.3 0.6 0.9 0.8 0.5 1.8 1.3 3.1 134.2
P/B 9-point trend, -96.7% 2.3 1.6 3.9 8.1 -49.8 -69.1 19.6 22.7 69.7
P / Tangible Book 2-point trend, -7.7% 3.4 3.7 · · · · · · ·
P / Cash Flow 9-point trend, +133.3% 7.2 3.8 7.6 -11.0 5.9 532.1 15.3 -32.4 -21.5
P / FCF 7-point trend, +133.4% 7.2 3.9 7.7 -11.0 5.9 · · -31.8 -21.5
EV / EBITDA 6-point trend, +144.0% 6.0 3.7 6.4 8.1 106.1 -13.7 · · ·
EV / FCF 5-point trend, -18.7% 5.4 3.0 7.8 -12.1 6.6 · · · ·
EV / Revenue 6-point trend, -46.7% 1.0 0.5 0.9 0.8 0.5 1.8 · · ·
Earnings Yield 6-point trend, +169.2% 10.2% 20.3% 10.4% 0.00% -23.7% -14.8% · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $228M$230M$236M$228M$253M
Operating Margin % 16.3%13.4%13.9%10.4%0.51%
Net Income $31M$30M$22M$2.0K$-29M
Diluted EPS $0.61$0.62$0.45$0.00$-0.72
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.20.71.94.5-39.7
Current Ratio 2.01.51.61.71.3
Quick Ratio 1.91.41.41.61.0
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $42M$39M$27M$-16M$21M

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Institutional owners (13F) 173 filers · $239.8M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
28 (+2 vs prior Q) 15 (-2 vs prior Q) 56 (+1 vs prior Q) 47 (+7 vs prior Q) +4.1M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
ACORN CAPITAL ADVISORS, LLC $33,504,835 4,131,299 13.97% Shares
VANGUARD GROUP INC $21,011,306 3,531,312 8.76% Shares
AMERICAN CENTURY COMPANIES INC $18,815,168 2,319,996 7.85% Shares
RENAISSANCE TECHNOLOGIES LLC $14,891,687 1,836,213 6.21% Shares
VANGUARD CAPITAL MANAGEMENT LLC $14,887,065 1,835,643 6.21% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $14,805,608 1,825,599 6.18% Shares
DIMENSIONAL FUND ADVISORS LP $11,407,283 1,406,570 4.76% Shares
GEODE CAPITAL MANAGEMENT, LLC $9,618,136 1,185,702 4.01% Shares
O'SHAUGHNESSY ASSET MANAGEMENT, LLC $9,113,880 1,123,783 3.80% Shares
STATE STREET CORP $7,722,058 952,165 3.22% Shares
KENNEDY CAPITAL MANAGEMENT LLC $7,082,082 873,253 2.95% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $6,420,006 791,616 2.68% Shares
RITHOLTZ WEALTH MANAGEMENT $6,080,862 749,798 2.54% Shares
Connor, Clark & Lunn Investment Management Ltd. $5,214,292 642,946 2.17% Shares
MILLENNIUM MANAGEMENT LLC $4,884,166 602,240 2.04% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $4,318,170 532,450 1.80% Shares
GLOBEFLEX CAPITAL L P $3,104,565 382,807 1.29% Shares
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $2,506,850 309,106 1.05% Shares
D. E. Shaw & Co., Inc. $2,300,377 283,647 0.96% Shares
Russell Investments Group, Ltd. $2,207,323 272,173 0.92% Shares
VANGUARD FIDUCIARY TRUST CO $2,182,158 269,070 0.91% Shares
FEDERATED HERMES, INC. $2,033,712 250,766 0.85% Shares
Empowered Funds, LLC $1,786,763 220,316 0.75% Shares
PANAGORA ASSET MANAGEMENT INC $1,764,290 217,545 0.74% Shares
GOLDMAN SACHS GROUP INC $1,758,256 216,801 0.73% Shares
FMR LLC $1,708,274 210,638 0.71% Shares
PRUDENTIAL FINANCIAL INC $1,600,095 197,299 0.67% Shares
STATE OF WISCONSIN INVESTMENT BOARD $1,526,562 188,232 0.64% Shares
Prospera Financial Services Inc $1,287,530 158,762 0.54% Shares
Haven Private, LLC $1,203,913 148,448 0.50% Shares
TWO SIGMA INVESTMENTS, LP $1,140,161 140,587 0.48% Shares
BlackRock, Inc. $1,134,784 139,924 0.47% Shares
FIRST TRUST ADVISORS LP $1,055,970 130,206 0.44% Shares
Bank of New York Mellon Corp $1,048,964 129,342 0.44% Shares
Round Rock Advisors LLC $1,045,476 128,912 0.44% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,040,051 128,243 0.43% Shares
STRS OHIO $686,106 84,600 0.29% Shares
CANADA PENSION PLAN INVESTMENT BOARD $596,085 73,500 0.25% Shares
Trexquant Investment LP $585,729 72,223 0.24% Shares
Vise Technologies, Inc. $584,163 72,030 0.24% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $520,662 64,200 0.22% Call option
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $497,000 61,255 0.21% Shares
OpenArc Corporate Advisory, LLC $482,472 59,491 0.20% Shares
RHUMBLINE ADVISERS $466,397 57,510 0.19% Shares
TWO SIGMA ADVISERS, LP $423,045 71,100 0.18% Shares
D'Orazio & Associates, Inc. $394,795 48,680 0.16% Shares
Vanguard Global Advisers, LLC $375,225 46,267 0.16% Shares
DEUTSCHE BANK AG\ $350,287 43,192 0.15% Shares
Man Group plc $336,614 41,506 0.14% Shares
WELLINGTON MANAGEMENT GROUP LLP $333,240 41,090 0.14% Shares
WINTON GROUP Ltd $328,528 40,509 0.14% Shares
XTX Topco Ltd $326,801 40,296 0.14% Shares
State of Wyoming $323,046 39,833 0.13% Shares
WELLS FARGO & COMPANY/MN $304,977 37,605 0.13% Shares
EntryPoint Capital, LLC $303,200 37,386 0.13% Shares
Baron Wealth Management LLC $294,977 36,372 0.12% Shares
Creative Planning $289,827 35,737 0.12% Shares
LPL Financial LLC $280,095 34,537 0.12% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $279,673 34,485 0.12% Shares
BANK OF AMERICA CORP /DE/ $257,468 31,747 0.11% Shares
Kathmere Capital Management, LLC $252,805 31,172 0.11% Shares
FRANKLIN RESOURCES INC $242,165 29,860 0.10% Shares
ENVESTNET ASSET MANAGEMENT INC $236,731 29,190 0.10% Shares
Y-Intercept (Hong Kong) Ltd $212,660 26,222 0.09% Shares
MARTINGALE ASSET MANAGEMENT L P $205,703 25,364 0.09% Shares
Metis Global Partners, LLC $204,891 25,264 0.09% Shares
MetLife Investment Management, LLC $201,720 24,873 0.08% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $195,451 24,100 0.08% Put option
C2C Wealth Management, LLC $191,558 23,620 0.08% Shares
Nuveen, LLC $187,982 23,179 0.08% Shares
PRELUDE CAPITAL MANAGEMENT, LLC $174,754 21,548 0.07% Shares
One Wealth Advisors, LLC $170,951 21,079 0.07% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $165,306 20,383 0.07% Shares
CITIGROUP INC $154,990 19,111 0.06% Shares
BAILARD, INC. $146,791 18,100 0.06% Shares
Invesco Ltd. $142,493 17,570 0.06% Shares
JANE STREET GROUP, LLC $141,925 17,500 0.06% Call option
Spark Investment Management LLC $137,870 17,000 0.06% Shares
MORGAN STANLEY $137,416 16,944 0.06% Shares
ALLIANCEBERNSTEIN L.P. $136,490 21,360 0.06% Shares
Brandywine Global Investment Management, LLC $129,710 21,800 0.05% Shares
Police & Firemen's Retirement System of New Jersey $127,481 15,719 0.05% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $125,510 15,476 0.05% Shares
Lido Advisors, LLC $122,015 15,045 0.05% Shares
Mariner, LLC $120,593 14,869 0.05% Shares
Caprock Group, LLC $112,421 13,862 0.05% Shares
PERKINS CAPITAL MANAGEMENT INC $108,674 13,400 0.05% Shares
TOCQUEVILLE ASSET MANAGEMENT L.P. $107,960 13,312 0.05% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $105,624 13,203 0.04% Shares
UBS Group AG $99,923 12,321 0.04% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $97,774 12,056 0.04% Shares
CWM, LLC $97,531 15,263 0.04% Shares
R Squared Ltd $97,247 11,991 0.04% Shares
Abel Hall, LLC $93,427 11,520 0.04% Shares
IEQ CAPITAL, LLC $86,542 10,671 0.04% Shares
Williams & Novak, LLC $85,066 10,489 0.04% Shares
Vanguard Personalized Indexing Management, LLC $84,409 10,408 0.04% Shares
Ethic Inc. $83,290 10,270 0.03% Shares
AQR CAPITAL MANAGEMENT LLC $83,136 10,251 0.03% Shares
INTECH INVESTMENT MANAGEMENT LLC $82,803 10,210 0.03% Shares

Company insiders 24 insiders · 10 officers · 12 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Alan H Auerbach President and CEO July 6, 2026 S 7,261,671 0 1 $-363,919
Maximo F Nougues Chief Financial Officer July 6, 2026 S 230,637 0 1 $-77,528
Douglas M Hunt The Reporting Person is the Senior Vice President of Regulatory Affairs of the Issuer. July 6, 2026 S 196,841 0 1 $-69,880
Alvin F Wong Chief Scientific Officer June 17, 2021 A 0 0 $0
Richard Paul Bryce Title of Reporting Person: Chief Medical and Scientific Officer April 5, 2021 S 121,662 0 0 $0
Jeffrey Jerome Ludwig Chief Commercial Officer Feb. 17, 2021 A 36,069 0 0 $0
Steven Lo Chief Commercial Officer July 22, 2019 S 19,557 0 0 $0
Charles R Eyler Title of Reporting Person: Senior Vice President, Finance and Administration and Treasurer Feb. 4, 2019 S 31,957 0 0 $0
Robert Charnas The Reporting Person is the Senior Vice President of Regulatory Affairs and Project Management of the Issuer. Feb. 16, 2017 A 26,453 0 0 $0
Richard Benton Phillips The Reporting Person is the Interim Head of Regulatory Affairs, Quality Assurance and Pharmacovigilance of the Issuer. April 15, 2016 A 0 0 $0
Brian M Stuglik Director June 12, 2026 S 113,858 0 1 $-58,320
Allison Dorval Director June 12, 2026 S 90,780 0 1 $-83,592
Adrian Senderowicz Director June 12, 2026 S 27,000 0 1 $-194,400
Troy Edward Wilson Director June 12, 2026 S 59,750 0 1 $-77,760
Jay M Moyes Director June 12, 2026 S 58,322 0 1 $-158,840
Alessandra Cesano Director June 11, 2026 A 68,850 0 0 $0
MILLER MICHAEL PATRICK Director June 11, 2026 A 81,000 0 0 $0
Ann Calby Miller Director June 15, 2021 A 40,732 0 0 $0
Hugh O'Dowd Director June 9, 2020 A 25,748 0 0 $0
Frank Zavrl Director June 9, 2020 A 50,993 0 0 $0
Thomas Malley Director Dec. 15, 2014 A 156,551 0 0 $0
Faraaz Siddiqi Oct. 4, 2011 D 0 0 0 $0
Kapil Munjal Oct. 4, 2011 D 0 0 0 $0
Robert Andrew Johnson Oct. 4, 2011 D 0 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 7 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Alan H. Auerbach ×6 filings Dec. 13, 2022 Initial filing SEC
Kapil Munjal 2) Oct. 4, 2011 Initial filing SEC
Faraaz Siddiqi 2) Oct. 4, 2011 Initial filing SEC
Robert Johnson 2) Oct. 4, 2011 Initial filing SEC
Robert Johnson Nov. 21, 2007 Initial filing SEC
Undisclosed reporting person Nov. 19, 2007 Initial filing SEC
Faraaz Siddiqi Nov. 19, 2007 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 36 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
ROSC · Lattice Strategies Trust 0.72% 52,608 NS April 30, 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 0.46% 233,908 SH Aug. 8, 2026 Daily
IWC · iShares Trust 0.08% 150,797 SH Aug. 8, 2026 Daily
VFQY · VANGUARD WELLINGTON FUND 0.06% 34,260 SH Aug. 8, 2026 Daily
AVUV · AMERICAN CENTURY ETF TRUST 0.05% 1,924,360 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.04% 55,680 NS May 31, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.03% 2,746 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.02% 95,559 NS May 31, 2026 N-PORT
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 32,358 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.02% 356,623 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.02% 1,879 NS May 31, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 55,064 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 1,153,241 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.01% 19,123 NS April 30, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.01% 16,014 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 254,380 SH Aug. 8, 2026 Daily
DFAS · Dimensional ETF Trust 0.01% 166,672 NS April 30, 2026 N-PORT
DFAT · Dimensional ETF Trust 0.01% 156,761 NS April 30, 2026 N-PORT
DFSV · Dimensional ETF Trust 0.01% 82,003 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.01% 2,027 NS May 31, 2026 N-PORT
DXUV · Dimensional ETF Trust 0.01% 3,611 NS April 30, 2026 N-PORT
EBI · RBB Fund Trust 0.01% 5,394 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.00% 1,585 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.00% 65,370 SH Aug. 8, 2026 Daily
URTY · ProShares Trust 0.00% 1,603 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 2,071 NS May 31, 2026 N-PORT
AVUS · AMERICAN CENTURY ETF TRUST 0.00% 34,919 NS May 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 6,348 NS April 30, 2026 N-PORT
HDG · ProShares Trust 0.00% 40 NS May 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 9,704 NS April 30, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 15,090 NS April 30, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 12,376 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 446,899 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 1,343,121 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.00% 7,680 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 2,979 SH Aug. 8, 2026 Daily