your badges 52W Range $1–$6 25% of range Analyst Rating STRONG BUY 16 analysts Price Target $9 +305% upside P/E -1.7 ROE -112.9% Net Profit Margin -574.5%

PYXS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $2.14
Market Cap (MRQ) $136M
P/E -1.7
EPS $-1.28
Revenue $14M
ROE -112.9%
52W Range $1–$6

PYXS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

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10-Year Performance Revenue, net income, margins and EPS trends

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Revenue$14M
2024-12-31 → 2025-12-31
EPS$-1.28
2021-12-31 → 2025-12-31
Free Cash Flow$-64M
2021-12-31 → 2025-12-31
Net margin-574.5%
2024-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend PYXS 5Y avg Peer Median Verdict
P/E -1.75Y avg ≈-0.9 ≈-0.9 · ·
P/S 9.7 · 48.5 Undervalued
P/B (MRQ) 11.95Y avg ≈1.0 ≈1.0 3.2 Overvalued
Price / FCF -2.15Y avg ≈-3.4 ≈-3.4 · ·
Price / Cash Flow -2.15Y avg ≈-3.5 ≈-3.5 · ·
Price / Tangible Book 2.55Y avg ≈0.9 ≈0.9 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

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Avg Surprise 4.3%
Next Report Nov 02, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 19, 2026 $-0.40 $-0.36 -11.0%
March 31, 2026 May 14, 2026 $-0.37 $-0.38 1.7%
Dec. 31, 2025 $-0.29 $-0.34 15.6%
Sept. 30, 2025 $-0.35 $-0.35 -1.4%
June 30, 2025 $-0.30 $-0.36 16.4%
March 31, 2025 $-0.35 $-0.30 -16.7%
Dec. 31, 2024 $-0.25 $-0.34 25.7%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

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Income Statement 15
Metric Trend 20252024
Revenue $14M$16M
Cost of Revenue $2M$475.0K
R&D Expense $74M$59M
SG&A Expense $22M$25M
Operating Income $-84M$-89M
Interest Income $650.0K$930.0K
Other Non-op $6M$10M
Pretax Income $-78M$-79M
Income Tax $1M$-2M
Net Income $-80M$-77M
EPS (Basic) $-1.28$-1.32
EPS (Diluted) $-1.28$-1.32
Shares (Basic) 62,143,16658,445,765
Shares (Diluted) 62,143,16658,445,765
EBITDA $-80M$-86M
Balance Sheet 23
Metric Trend 20252024
Cash & Equivalents $15M$19M
Short-term Investments $51M$107M
Prepaid Expense $4M$4M
Other Current Assets $626.0K$434.0K
Current Assets $72M$132M
PP&E (Net) $8M$10M
PP&E (Gross) $15M$15M
Accum. Depreciation $7M$5M
Intangibles $0$3M
Total Assets $92M$157M
Accounts Payable $11M$5M
Accrued Liabilities $9M$11M
Current Liabilities $21M$18M
Capital Leases $17M$19M
Deferred Tax ·$0
Total Liabilities $38M$36M
Common Stock $63.0K$60.0K
Paid-in Capital $496M$484M
Retained Earnings $-443M$-364M
AOCI $53.0K$170.0K
Stockholders' Equity $53M$121M
Liabilities + Equity $92M$157M
Shares Outstanding 62,690,22959,967,814
Cash Flow 11
Metric Trend 20252024
D&A $5M$3M
Stock-based Comp $12M$13M
Deferred Tax $0$-2M
Other Non-cash $-193.0K$4M
Operating Cash Flow $-64M$-58M
CapEx $9.0K$237.0K
Investing Cash Flow $59M$8M
Financing Cash Flow $594.0K$59M
Net Change in Cash $-4M$10M
Taxes Paid $1M$164.0K
Free Cash Flow $-64M$-58M
Profitability 7
Metric Trend 20252024
Operating Margin -609.2%-554.1%
Net Margin -574.5%-479.0%
Pretax Margin -564.6%-492.3%
EBITDA Margin -576.6%-535.6%
ROA -64.0%-46.7%
ROE -112.9%-56.4%
ROIC -160.9%-72.1%
Liquidity & Solvency 2
Metric Trend 20252024
Current Ratio 3.47.5
Quick Ratio 3.27.2
Efficiency 1
Metric Trend 20252024
Asset Turnover 0.10.1
Per Share 5
Metric Trend 20252024
Book Value / Share $0.85$2.01
Revenue / Share $0.22$0.28
Cash Flow / Share $-1.02$-0.99
Cash / Share $0.25$0.32
EPS (TTM) $-1.28$-1.32
Growth Rates 1
Metric Trend 20252024
Revenue YoY -14.2%·
Valuation (TTM) 10
Metric Trend 20252024
Revenue TTM $14M$16M
Net Income TTM $-80M$-77M
Market Cap $72M$94M
P/E -0.9-1.2
P/S 5.25.8
P/B 1.30.8
P / Tangible Book 1.30.8
P / Cash Flow -1.1-1.6
P / FCF -1.1-1.6
Earnings Yield -111.3%-84.6%

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

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Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $14M $16M · · ·
Operating Margin % -609.2% -554.1% · · ·
Net Income $-80M $-77M $-74M $-121M $-76M
Diluted EPS $-1.28 $-1.32 $-1.85 $-3.65 $-8.95

Institutional owners (13F) 87 filers · $105.2M total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 87
Value held $105.2M
New positions 12
Exited positions 9
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
12 (-3 vs prior Q) 9 (-2 vs prior Q) 26 (+15 vs prior Q) 25 (-13 vs prior Q) +7.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
GordonMD Global Investments LP $30,174,976 10,024,909 28.68% Shares
Pfizer Inc $19,480,773 7,032,770 18.51% Shares
Laurion Capital Management LP $14,751,673 4,900,888 14.02% Shares
VANGUARD CAPITAL MANAGEMENT LLC $6,248,751 2,075,997 5.94% Shares
Atle Fund Management AB $2,909,041 966,459 2.76% Shares
VANGUARD GROUP INC $2,686,133 2,335,768 2.55% Shares
BlackRock, Inc. $2,612,481 867,934 2.48% Shares
Palo Alto Investors LP $2,601,474 864,277 2.47% Shares
MARSHALL WACE, LLP $2,499,936 830,544 2.38% Shares
RENAISSANCE TECHNOLOGIES LLC $2,324,418 772,232 2.21% Shares
GEODE CAPITAL MANAGEMENT, LLC $1,782,698 591,849 1.69% Shares
Woodline Partners LP $1,577,237 523,999 1.50% Shares
683 Capital Management, LLC $1,382,695 459,367 1.31% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $1,290,104 428,606 1.23% Shares
DIADEMA PARTNERS LP $1,168,482 388,200 1.11% Call option
Longaeva Partners L.P. $1,064,282 353,582 1.01% Shares
Decheng Capital LLC $983,698 326,810 0.93% Shares
VANGUARD FIDUCIARY TRUST CO $911,988 302,986 0.87% Shares
JANE STREET GROUP, LLC $873,171 290,090 0.83% Shares
STATE STREET CORP $748,999 248,837 0.71% Shares
MILLENNIUM MANAGEMENT LLC $701,342 233,004 0.67% Shares
UBS Group AG $467,203 155,217 0.44% Shares
Bank of New York Mellon Corp $403,328 133,996 0.38% Shares
NORTHERN TRUST CORP $373,117 123,959 0.35% Shares
NewEdge Wealth, LLC $349,178 116,006 0.33% Shares
XTX Topco Ltd $333,926 110,939 0.32% Shares
TWO SIGMA INVESTMENTS, LP $252,723 83,961 0.24% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $244,593 81,260 0.23% Shares
BANK OF AMERICA CORP /DE/ $242,197 80,464 0.23% Shares
JANE STREET GROUP, LLC $221,837 73,700 0.21% Call option
STIFEL FINANCIAL CORP $212,015 70,437 0.20% Shares
Cable Car Capital, LP $185,434 61,606 0.18% Shares
MYDA Advisors LLC $150,500 50,000 0.14% Shares
Qube Research & Technologies Ltd $150,295 49,932 0.14% Shares
UNIVERSITY OF CHICAGO $146,680 48,731 0.14% Shares
CITADEL ADVISORS LLC $142,424 47,317 0.14% Shares
Quadrature Capital Ltd $141,672 47,067 0.13% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $139,062 46,200 0.13% Call option
GOLDMAN SACHS GROUP INC $138,159 45,900 0.13% Shares
Verdad Advisers, LP $135,146 44,899 0.13% Shares
LPL Financial LLC $131,098 43,554 0.12% Shares
COMMONWEALTH EQUITY SERVICES, LLC $127,790 42,455 0.12% Shares
J. Derek Lewis & Associates Inc. $126,420 42,000 0.12% Shares
CITIGROUP INC $114,997 38,205 0.11% Shares
SIMPLEX TRADING, LLC $114,085 37,902 0.11% Shares
Point72 Asset Management, L.P. $111,647 37,092 0.11% Shares
Walleye Capital LLC $110,702 36,778 0.11% Shares
DIMENSIONAL FUND ADVISORS LP $108,887 36,175 0.10% Shares
MORGAN STANLEY $100,679 33,448 0.10% Shares
MACKENZIE FINANCIAL CORP $79,292 26,343 0.08% Shares

Show all 87 institutional owners →

Activists & 5%+ owners 2 positions

18

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Lara Sullivan, M.D. ×2 filings April 2, 2025 11.21% Amendment · SEC
Lara Sullivan ×4 filings April 3, 2024 · Initial filing · SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 17 insiders · 8 officers · 9 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Thomas Civik CEO & Chairman of the Board Sept. 4, 2026 A 206,186 0 0 $0
Lara Sullivan, M.D. President ,CEO & CMO March 31, 2025 A 2,403,882 0 0 $0
Connealy Pamela Yanchik CFO & COO March 31, 2025 A 1,199,143 0 0 $0
Ritu Shah Chief Operating Officer Oct. 7, 2021 A · 0 0 $0
Jitendra Wadhane Prin Fin & Acct Officer March 24, 2026 A 512,882 0 0 $0
Ken Kobayashi Chief Medical Officer Dec. 29, 2023 A · 0 0 $0
Jay Feingold Chief Medical Officer March 24, 2023 A 730,345 0 0 $0
Ronald Herbst Chief Scientific Officer Oct. 7, 2021 A · 0 0 $0
Jakob Dupont Director Aug. 20, 2026 A 38,741 0 1 $-107,100
Santhosh Palani Director March 24, 2026 A 6,000 0 0 $0
Darren S Cline Director March 24, 2026 A 251,405 0 0 $0
Rachel Humphrey Director March 24, 2026 A 81,309 0 3 $-15,865
Michael A Metzger Director March 24, 2026 A · 0 0 $0
Freda C Lewis-Hall Director March 24, 2026 A 241,405 0 0 $0
John L Flavin Director March 24, 2026 A 413,015 0 0 $0
BARCLAYS PLC 10% owner April 26, 2022 · 0 0 $0
Mark Chin · April 21, 2022 S 0 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 5 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.04% 165,468 SH Sept. 11, 2026 Daily
IBB · iShares Trust 0.02% 513,768 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.01% 5,892 SH Oct. 2, 2026 Daily
VXF · VANGUARD INDEX FUNDS 0.00% 600,185 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 1,422,296 SH Aug. 19, 2026 Daily

PYXS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

21
rating · 16 analysts BUY
Median target $8.00 +273.8%
7 43.8% Strong Buy
7 43.8% Buy
2 12.5% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

9 analysts · 2026-10-04

Mean target $8.67 +305.0%

← Below all targets Current price $2.14
Low$6.00 Mean$8.67 High$19.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
PYXS $72M -0.9 -14.2% -574.5% -112.9% ·
ELDN $114M -2.9 · · -69.4% ·
CUE $29M -1.1 195.8% -96.9% -119.3% ·
NKTX $131M -1.3 · · -31.1% ·
CHRS $172M 1.0 59.8% 398.4% 185.8% ·
CNTN $112M -2.7 · · -18.0% ·
DTIL $100M -1.2 -50.1% -133.4% -72.4% ·
ALXO $61M -0.6 · · -225.0% ·
ORGO $658M 34.5 17.0% 6.6% 13.9% ·
AVXL · -16.5 -36.1% -991.4% · ·
VYGR $232M -1.9 -49.5% -296.5% -54.4% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

26

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Source: SEC 10-Q filed Aug 13, 2026