PYXS Pyxis Oncology, Inc. - Common Stock
$1.96
Price · May 20, 2026
Fundamentals as of May 14, 2026
52W Range
$1–$6
22% of range
Analyst Rating
STRONG BUY
15 analysts
Price Target
$7
+246% upside
P/E (TTM)
-0.9
ROE
-112.9%
Net Profit Margin
-574.5%
PYXS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$1.96
Market Cap
$72M
P/E (TTM)
-0.9
EPS (TTM)
$-1.28
Revenue (TTM)
$14M
Div Yield
—
ROE
-112.9%
Debt/Equity
—
52W Range
$1 – $6
PYXS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$14M
2024-12-31
→
2025-12-31
EPS
$-1.28
2021-12-31
→
2025-12-31
Free Cash Flow
$-64M
2021-12-31
→
2025-12-31
Margins
-574.5%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
PYXS
Peer Median
P/E (TTM)
-0.9
579.2
P/S (TTM)
5.2
14.1
P/B
1.3
2.2
Price / FCF
-1.1
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
PYXS
Peer Median
Operating Margin
-609.2%
—
Net Profit Margin
-574.5%
-505.5%
ROA
-64.0%
-57.6%
ROE
-112.9%
-77.2%
ROIC
-160.9%
—
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
PYXS
Peer Median
Current Ratio
3.4
3.6
Quick Ratio
3.2
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
PYXS
Peer Median
Revenue YoY
-14.2%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
PYXS
Peer Median
PYXS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
15 analysts
- Strong Buy 7 46.7%
- Buy 6 40.0%
- Hold 2 13.3%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
9 analysts · 2026-05-17
Median
$7.00
← Below all targets
$1.96
Low
$5.00
High
$9.00
Median target
$7.00
+257.1%
Mean target
$6.78
+245.8%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.03%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.37 | $-0.38 | 0.01% |
| Dec. 31, 2025 | $-0.29 | $-0.34 | 0.05% |
| Sept. 30, 2025 | $-0.35 | $-0.35 | -0.00% |
| June 30, 2025 | $-0.30 | $-0.36 | 0.06% |
| March 31, 2025 | $-0.35 | $-0.30 | -0.05% |
| Dec. 31, 2024 | $-0.25 | $-0.34 | 0.09% |
Peer Comparison Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| PYXS | $72M | -0.9 | -14.2% | -574.5% | -112.9% | — |
| AGEN | $111M | — | 10.4% | -2.7% | 1.0% | — |
| GNLX | $166M | -5.1 | 0.00% | -401812.5% | -181.4% | — |
| CYPH | $97M | 16.6 | — | — | 6.1% | — |
| CRDF | $192M | -4.1 | -13.2% | -7732.0% | -88.2% | — |
| EQ | $95M | -4.0 | 13.9% | — | -133.1% | — |
| CADL | $310M | -7.8 | — | — | -53.7% | — |
| CBUS | — | -0.6 | -14.6% | -3492.3% | -223.0% | — |
| COYA | $121M | -4.6 | 123.6% | -267.1% | -59.5% | — |
| KLRS | $193M | -3.0 | — | — | -65.8% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 15
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue | $14M | $16M | |
| Cost of Revenue | $2M | $475.0K | |
| R&D Expense | $74M | $59M | |
| SG&A Expense | $22M | $25M | |
| Operating Income | $-84M | $-89M | |
| Interest Income | $650.0K | $930.0K | |
| Other Non-op | $6M | $10M | |
| Pretax Income | $-78M | $-79M | |
| Income Tax | $1M | $-2M | |
| Net Income | $-80M | $-77M | |
| EPS (Basic) | $-1.28 | $-1.32 | |
| EPS (Diluted) | $-1.28 | $-1.32 | |
| Shares (Basic) | 62,143,166 | 58,445,765 | |
| Shares (Diluted) | 62,143,166 | 58,445,765 | |
| EBITDA | $-80M | $-86M |
Balance Sheet 23
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Cash & Equivalents | $15M | $19M | |
| Short-term Investments | $51M | $107M | |
| Prepaid Expense | $4M | $4M | |
| Other Current Assets | $626.0K | $434.0K | |
| Current Assets | $72M | $132M | |
| PP&E (Net) | $8M | $10M | |
| PP&E (Gross) | $15M | $15M | |
| Accum. Depreciation | $7M | $5M | |
| Intangibles | $0 | $3M | |
| Total Assets | $92M | $157M | |
| Accounts Payable | $11M | $5M | |
| Accrued Liabilities | $9M | $11M | |
| Current Liabilities | $21M | $18M | |
| Capital Leases | $17M | $19M | |
| Deferred Tax | · | $0 | |
| Total Liabilities | $38M | $36M | |
| Common Stock | $63.0K | $60.0K | |
| Paid-in Capital | $496M | $484M | |
| Retained Earnings | $-443M | $-364M | |
| AOCI | $53.0K | $170.0K | |
| Stockholders' Equity | $53M | $121M | |
| Liabilities + Equity | $92M | $157M | |
| Shares Outstanding | 62,690,229 | 59,967,814 |
Cash Flow 11
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| D&A | $5M | $3M | |
| Stock-based Comp | $12M | $13M | |
| Deferred Tax | $0 | $-2M | |
| Other Non-cash | $-193.0K | $4M | |
| Operating Cash Flow | $-64M | $-58M | |
| CapEx | $9.0K | $237.0K | |
| Investing Cash Flow | $59M | $8M | |
| Financing Cash Flow | $594.0K | $59M | |
| Net Change in Cash | $-4M | $10M | |
| Taxes Paid | $1M | $164.0K | |
| Free Cash Flow | $-64M | $-58M |
Profitability 7
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Operating Margin | -609.2% | -554.1% | |
| Net Margin | -574.5% | -479.0% | |
| Pretax Margin | -564.6% | -492.3% | |
| EBITDA Margin | -576.6% | -535.6% | |
| ROA | -64.0% | -46.7% | |
| ROE | -112.9% | -56.4% | |
| ROIC | -160.9% | -72.1% |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Current Ratio | 3.4 | 7.5 | |
| Quick Ratio | 3.2 | 7.2 |
Efficiency 1
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Asset Turnover | 0.1 | 0.1 |
Growth Rates 1
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue YoY | -14.2% | · |
Valuation (TTM) 10
| Metric | Trend | 2025 | 2024 |
|---|---|---|---|
| Revenue TTM | $14M | $16M | |
| Net Income TTM | $-80M | $-77M | |
| Market Cap | $72M | $94M | |
| P/E | -0.9 | -1.2 | |
| P/S | 5.2 | 5.8 | |
| P/B | 1.3 | 0.8 | |
| P / Tangible Book | 1.3 | 0.8 | |
| P / Cash Flow | -1.1 | -1.6 | |
| P / FCF | -1.1 | -1.6 | |
| Earnings Yield | -111.3% | -84.6% |
Income Statement 16
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | · | $11M | $0 | $3M | · | $0 | $0 | $0 | $16M | |
| Cost of Revenue | · | · | · | · | · | $0 | $0 | $0 | $475.0K | |
| R&D Expense | $20M | $22M | $18M | $17M | $17M | $14M | $18M | $14M | $13M | |
| SG&A Expense | $4M | $5M | $6M | $5M | $6M | $5M | $6M | $6M | $8M | |
| Operating Expenses | $24M | · | · | · | $23M | · | · | · | · | |
| Operating Income | $-24M | $-18M | $-23M | $-20M | $-23M | $-40M | $-24M | $-20M | $-6M | |
| Interest Income | $218.0K | $225.0K | $242.0K | $99.0K | $84.0K | $87.0K | $194.0K | $387.0K | $262.0K | |
| Other Non-op | $1M | $1M | $1M | $2M | $2M | $2M | $3M | $3M | $2M | |
| Pretax Income | · | $-17M | $-22M | $-18M | · | $-38M | $-21M | $-17M | · | |
| Income Tax | · | $1M | $0 | $283.0K | · | · | · | · | · | |
| Net Income | $-23M | $-18M | $-22M | $-18M | $-21M | $-36M | $-21M | $-17M | $-3M | |
| EPS (Basic) | $-0.37 | $-0.28 | $-0.35 | $-0.30 | $-0.35 | $-0.62 | $-0.35 | $-0.29 | $-0.06 | |
| EPS (Diluted) | $-0.37 | $-0.28 | $-0.35 | $-0.30 | $-0.35 | $-0.62 | $-0.35 | $-0.29 | $-0.06 | |
| Shares (Basic) | 63,469,850 | -123,381,994 | 62,557,386 | 61,918,826 | 61,048,948 | -114,054,235 | 60,715,041 | 60,495,675 | 51,289,284 | |
| Shares (Diluted) | 63,469,850 | -123,381,994 | 62,557,386 | 61,918,826 | 61,048,948 | -114,054,235 | 60,715,041 | 60,495,675 | 51,289,284 | |
| EBITDA | $-24M | · | $-23M | $-20M | $-22M | · | $-24M | $-20M | $-4M |
Balance Sheet 24
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $6M | $15M | $9M | $11M | $13M | $19M | $12M | $25M | $28M | |
| Short-term Investments | $35M | $51M | $67M | $78M | $93M | $107M | $133M | $131M | $129M | |
| Receivables | · | · | · | $3M | · | · | · | · | $8M | |
| Prepaid Expense | $3M | $4M | $5M | $7M | $5M | $4M | $3M | $4M | $6M | |
| Other Current Assets | · | $626.0K | · | · | · | $434.0K | · | · | · | |
| Current Assets | $46M | $72M | $83M | $100M | $112M | $132M | $149M | $161M | $172M | |
| PP&E (Net) | $8M | $8M | $8M | $9M | $9M | $10M | $10M | $11M | $11M | |
| PP&E (Gross) | · | $15M | · | · | · | $15M | · | · | · | |
| Accum. Depreciation | · | $7M | · | · | · | $5M | · | · | · | |
| Intangibles | · | $0 | $2M | $2M | $3M | $3M | $24M | $24M | $24M | |
| Total Assets | $64M | $92M | $106M | $123M | $136M | $157M | $195M | $208M | $220M | |
| Accounts Payable | $5M | $11M | $10M | $9M | $3M | $5M | $5M | $5M | $2M | |
| Accrued Liabilities | $10M | $9M | $8M | $7M | $10M | $11M | $14M | $10M | $11M | |
| Current Liabilities | $17M | $21M | $19M | $18M | $14M | $18M | $20M | $17M | $14M | |
| Capital Leases | $16M | $17M | $17M | $18M | $18M | $19M | $19M | $19M | $20M | |
| Deferred Tax | · | · | · | · | · | · | $2M | $2M | $2M | |
| Total Liabilities | $33M | $38M | $37M | $36M | $33M | $36M | $42M | $39M | $36M | |
| Common Stock | $63.0K | $63.0K | $62.0K | $62.0K | $62.0K | $60.0K | $59.0K | $59.0K | $59.0K | |
| Paid-in Capital | $498M | $496M | $494M | $491M | $488M | $484M | $481M | $477M | $474M | |
| Retained Earnings | $-466M | $-443M | $-425M | $-403M | $-385M | $-364M | $-328M | $-307M | $-289M | |
| AOCI | $0 | $53.0K | $69.0K | $-5.0K | $49.0K | $170.0K | $351.0K | $-102.0K | $-60.0K | |
| Stockholders' Equity | $31M | $53M | $69M | $88M | $103M | $121M | $154M | $170M | $184M | |
| Liabilities + Equity | $64M | $92M | $106M | $123M | $136M | $157M | $195M | $208M | $220M | |
| Shares Outstanding | 62,831,246 | 62,690,229 | 62,149,664 | 62,018,135 | 61,631,376 | 59,967,814 | 59,449,998 | 58,914,712 | 58,803,126 |
Cash Flow 9
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $459.0K | $3M | $527.0K | $535.0K | $552.0K | $550.0K | $731.0K | $585.0K | $1M | |
| Stock-based Comp | $1M | $2M | $3M | $3M | $4M | $3M | $3M | $3M | $4M | |
| Other Non-cash | $-4M | · | · | · | $-6M | · | · | · | $-23M | |
| Operating Cash Flow | $-26M | $-10M | $-13M | $-17M | $-23M | $-19M | $-15M | $-3M | $-21M | |
| CapEx | · | $0 | · | · | · | $0 | $0 | $0 | $237.0K | |
| Investing Cash Flow | $16M | $16M | $11M | $15M | $16M | $27M | $-8.0K | $4.0K | $-18M | |
| Financing Cash Flow | $-25.0K | $669.0K | $-8.0K | $-67.0K | $0 | $50.0K | $2M | $110.0K | $58M | |
| Net Change in Cash | $-10M | $7M | $-2M | $-2M | $-7M | $7M | $-13M | $-3M | $18M | |
| Free Cash Flow | · | · | · | · | · | · | · | · | $-21M |
Profitability 7
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | · | · | · | -700.4% | · | · | · | · | -34.7% | |
| Net Margin | · | · | · | -650.9% | · | · | · | · | -20.2% | |
| Pretax Margin | · | · | · | -640.8% | · | · | · | · | · | |
| EBITDA Margin | · | · | · | -700.4% | · | · | · | · | -27.8% | |
| ROA | -23.2% | · | -14.6% | -11.1% | -11.9% | · | -11.1% | -9.0% | -1.6% | |
| ROE | -34.6% | · | -19.8% | -14.3% | -14.7% | · | -14.5% | -11.0% | -1.9% | |
| ROIC | · | · | · | -22.9% | · | · | · | · | · |
Liquidity & Solvency 2
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.8 | · | 4.3 | 5.7 | 7.8 | · | 7.3 | 9.5 | 12.2 | |
| Quick Ratio | 2.5 | · | 3.9 | 5.2 | 7.3 | · | 7.1 | 9.2 | 11.7 |
Efficiency 2
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | · | · | · | 0.0 | · | · | · | · | 0.1 | |
| Receivables Turnover | · | · | · | 1.9 | · | · | · | · | 4.0 |
Valuation (TTM) 8
| Metric | Trend | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-85M | · | $-83M | $-78M | $-63M | · | $-65M | $-60M | $-61M | |
| Market Cap | $92M | · | $138M | $68M | $60M | · | $218M | $195M | $251M | |
| P/E | -1.1 | · | -1.6 | -0.9 | -0.9 | · | -2.9 | -2.5 | -2.7 | |
| P/B | 2.9 | · | 2.0 | 0.8 | 0.6 | · | 1.4 | 1.1 | 1.4 | |
| P / Tangible Book | 2.9 | · | 2.1 | 0.8 | 0.6 | · | 1.7 | 1.3 | 1.6 | |
| P / Cash Flow | -3.5 | · | · | · | -2.7 | · | · | · | -12.1 | |
| P / FCF | · | · | · | · | · | · | · | · | -12.0 | |
| Earnings Yield | -93.8% | · | -60.8% | -117.3% | -107.1% | · | -34.3% | -39.9% | -36.9% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Revenue | $14M | $16M | — | — | — |
| Operating Margin % | -609.2% | -554.1% | — | — | — |
| Net Income | $-80M | $-77M | $-74M | $-121M | $-76M |
| Diluted EPS | $-1.28 | $-1.32 | $-1.85 | $-3.65 | $-8.95 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 3.4 | 7.5 | 4.8 | — | 14.9 |
| Quick Ratio | 3.2 | 7.2 | 4.6 | — | 14.7 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | $-64M | $-58M | $-77M | — | $-36M |
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