5AM Venture Management, LLC
CIK 1799883 · View on SEC EDGAR ↗
- Portfolio value
- $287.9M
- Positions
- 16
- As of
- June 30, 2026
Portfolio value QoQ: -20.1% 13F does not disclose cash
- Top 10 holdings weight
- 85.57%
- Top 25 holdings weight
- 100.00%
- Positions above 1%
- 16
- Effective number of positions
- 12.3
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q2 2026: 0.0% Est. buys $0 · sells $93,163,842
Median holding: 5.0 quarters Tracked Q4 2024–Q2 2026 · 44.4% still held
- New positions
- 0
- Increased
- 0
- Decreased
- 1
- Closed
- 4
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Annualized: +41.8% · S&P 500: +18.0%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 98.7% · Options excluded: 0.0%
Sector breakdown
Full portfolio 16 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| MPLT MapLight Therapeutics, Inc. - Common Stock | $34,048,394 | 11.83% | 950,011 | $14,734,670 | |||
| TYRA Tyra Biosciences, Inc. - Common Stock | $32,875,778 | 11.42% | 1,029,298 | $-6,546,335 | |||
| TRDA Entrada Therapeutics, Inc. - Common Stock | $29,854,949 | 10.37% | 4,056,379 | $-21,336,554 | |||
| PHVS Pharvaris N.V. - Ordinary Shares | $27,581,008 | 9.58% | 797,600 | $5,048,808 | |||
| CAMP CAMP4 Therapeutics Corporation - Common Stock | $25,647,928 | 8.91% | 5,869,091 | $-234,763 | |||
| ARTV Artiva Biotherapeutics, Inc. - Common Stock | $22,827,049 | 7.93% | 2,353,304 | $7,671,771 | |||
| TECX Tectonic Therapeutic, Inc. - Common Stock | $20,853,938 | 7.24% | 606,660 | $2,102,077 | |||
| ZNTL Zentalis Pharmaceuticals, Inc. - common stock | $19,147,378 | 6.65% | 3,947,913 | $9,909,262 | |||
| CLDX Celldex Therapeutics, Inc. - Common Stock | $18,503,417 | 6.43% | 497,270 | $2,730,013 | |||
| EYPT EyePoint, Inc. - Common Stock | $15,015,000 | 5.22% | 1,050,000 | $1,480,500 | |||
| BHVN Biohaven Ltd. Common Shares | $10,995,903 | 3.82% | 738,972 | $4,744,200 | |||
| SRZN Surrozen, Inc. - Common Stock | $7,038,938 | 2.44% | 271,250 | $-4,248,937 | Down ×1 | ||
| SKYE Skye Bioscience, Inc. - Common Stock | $6,712,366 | 2.33% | 9,681,763 | $761,954 | |||
| ALXO ALX Oncology Holdings Inc. - Common Stock | $6,328,663 | 2.20% | 3,057,325 | $198,726 | |||
| TARA Protara Therapeutics, Inc. - Common Stock | $5,232,567 | 1.82% | 1,369,782 | $-1,903,997 | |||
| SLN Silence Therapeutics Plc - American Depository Share | $5,228,676 | 1.82% | 476,200 | $2,719,102 | |||
| No matches | |||||||
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| TRDA | Price move only | +0 | -$21.3M |
| MPLT | Price move only | +0 | +$14.7M |
| ZNTL | Price move only | +0 | +$9.9M |
| ARTV | Price move only | +0 | +$7.7M |
| TYRA | Price move only | +0 | -$6.5M |
| PHVS | Price move only | +0 | +$5.0M |
| BHVN | Price move only | +0 | +$4.7M |
| SRZN | Trimmed | -116K | -$4.2M |
| CLDX | Price move only | +0 | +$2.7M |
| SLN | Price move only | +0 | +$2.7M |
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| ERAS | June 30, 2026 | 3,485,971 | $56,403,011 | -3.8% |
| CNTA | June 30, 2026 | 580,945 | $23,075,135 | No longer tracked |
| VRDN | March 31, 2026 | 736,595 | $22,922,836 | 25.9% |
| DNTH | Dec. 31, 2025 | 365,053 | $14,364,836 | 171.3% |
| MLTX | Sept. 30, 2025 | 282,313 | $13,325,174 | 121.2% |
| ELVN | March 31, 2026 | 772,477 | $11,896,146 | 51.4% |
| VORXXXX | Sept. 30, 2025 | 6,361,723 | $10,305,991 | No longer tracked |
| PRAX | Dec. 31, 2025 | 170,000 | $9,010,000 | 25.4% |
| GHRS | June 30, 2026 | 572,665 | $8,051,670 | 7.6% |
| ANAB | June 30, 2025 | 357,733 | $6,650,256 | 158.9% |
| VKTX | Sept. 30, 2025 | 189,593 | $5,024,215 | 32.5% |
| AKRO | March 31, 2025 | 165,000 | $4,590,300 | No longer tracked |
| SCPH | Sept. 30, 2025 | 1,200,647 | $4,574,465 | No longer tracked |
| ALEC | Dec. 31, 2025 | 995,841 | $2,947,689 | 45.8% |
| RLYB | June 30, 2026 | 291,788 | $2,617,338 | 4.8% |
| ADVM | Dec. 31, 2025 | 541,666 | $2,453,747 | No longer tracked |
| CDTX | June 30, 2025 | 56,725 | $1,221,857 | No longer tracked |
| MRSN | Dec. 31, 2025 | 52,200 | $405,072 | No longer tracked |