SLN Silence Therapeutics Plc - American Depository Share

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$14.07
Price · Aug 19, 2026
Fundamentals as of Aug 10, 2026

SLN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$14.06
Market Cap
$1.99B
P/E (TTM)
-22.3
EPS (TTM)
$-0.63
Revenue (TTM)
$559.0K
Div Yield
ROE
-113.3%
Debt/Equity
52W Range
$4 – $18

SLN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $559.0K
4-point trend, -97.4%
2022-12-31 2025-12-31
EPS $-0.63
4-point trend, -21.2%
2022-12-31 2025-12-31
Free Cash Flow $-62M
2025-12-31 2025-12-31
Margins -15851.9%
2025-12-31 2025-12-31

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
SLN
Peer Median
P/E (TTM)
2-point trend, +53.7%
-22.3
P/S (TTM)
3565.4
13.4
P/B
32.0
1.7
Price / FCF
-32.0

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
SLN
Peer Median
Gross Margin
61.5%
66.0%
Operating Margin
-16292.8%
Net Profit Margin
-15851.9%
-662.1%
ROA
-53.0%
-59.3%
ROE
-113.3%
-98.1%
ROIC
-146.2%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
SLN
Peer Median
Current Ratio
8.7
6.2
Quick Ratio
6.3

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
SLN
Peer Median
Revenue YoY
4-point trend, -97.4%
-98.7%
Revenue CAGR 3Y
4-point trend, -97.4%
-70.5%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
SLN
Peer Median
EPS (Diluted)
4-point trend, -21.2%
$-0.63

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
SLN
Peer Median

SLN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

12-Month Price Target

6 analysts · 2026-08-18
Median target $29.50 +109.7%
Mean target $33.00 +134.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.26
Dec. 31, 2024 $0.21
Dec. 31, 2023 $-0.37

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
SLN $862M -9.7 -98.7% -15851.9% -113.3% 61.5%
KNSA $3.15B 55.0 60.1% 8.7% 11.1%
CMPS $663M -2.2 -524.8%
IMCR $1.76B -48.9 28.9% -8.9% -9.2%
AUTL -1.8 644.9% -381.4% -109.6%
BCYC $491M -2.2 105.8% -301.7% -34.2%
TLSA

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for SLN
Metric Trend 202520242023
Revenue 3-point trend, -98.2% $559.0K $43M $32M
Cost of Revenue 3-point trend, -98.3% $215.0K $12M $13M
Gross Profit 3-point trend, -98.2% $344.0K $31M $19M
R&D Expense 3-point trend, +19.0% $68M $68M $57M
SG&A Expense 3-point trend, -14.8% $22M $27M $26M
Operating Income 3-point trend, -41.5% $-91M $-63M $-64M
Pretax Income 3-point trend, -66.3% $-89M $-44M $-53M
Income Tax 3-point trend, -98.8% $11.0K $845.0K $956.0K
Net Income 3-point trend, -63.4% $-89M $-45M $-54M
EPS (Basic) 3-point trend, -28.6% $-0.63 $-0.33 $-0.49
EPS (Diluted) 3-point trend, -28.6% $-0.63 $-0.33 $-0.49
Shares (Basic) 3-point trend, +27.3% 141,694,702 138,752,224 111,277,250
Shares (Diluted) 3-point trend, +27.3% 141,694,702 138,752,224 111,277,250
EBITDA $-91M · ·
Balance Sheet 21
Annual Balance Sheet data for SLN
Metric Trend 202520242023
Cash & Equivalents 3-point trend, -83.6% $11M $121M $69M
Short-term Investments 2-point trend, +183.9% $74M $26M ·
Receivables 3-point trend, -100.0% $0 $972.0K $290.0K
Other Current Assets 3-point trend, -0.8% $12M $15M $12M
Current Assets 3-point trend, +15.0% $119M $187M $103M
PP&E (Net) 3-point trend, -18.4% $2M $2M $2M
PP&E (Gross) 3-point trend, -13.9% $6M $6M $6M
Accum. Depreciation 3-point trend, -11.9% $4M $5M $4M
Goodwill 3-point trend, +6.4% $11M $9M $10M
Intangibles 2-point trend, -7.7% $288.0K $312.0K ·
Other Non-current Assets 3-point trend, -96.5% $127.0K $4M $4M
Total Assets 3-point trend, +10.0% $131M $203M $119M
Current Liabilities 3-point trend, -39.1% $14M $17M $22M
Capital Leases 3-point trend, -39.8% $71.0K $0 $118.0K
Total Liabilities 3-point trend, -29.1% $69M $69M $97M
Common Stock 3-point trend, +16.3% $10M $10M $9M
Retained Earnings 3-point trend, -30.3% $-563M $-474M $-432M
AOCI 3-point trend, +72.3% $-3M $-12M $-11M
Stockholders' Equity 3-point trend, +183.3% $62M $134M $22M
Liabilities + Equity 3-point trend, +10.0% $131M $203M $119M
Shares Outstanding 3-point trend, +19.2% 141,701,848 141,674,074 118,846,966
Cash Flow 11
Annual Cash Flow data for SLN
Metric Trend 202520242023
Stock-based Comp 3-point trend, -50.4% $8M $16M $16M
Deferred Tax 3-point trend, -98.8% $11.0K $845.0K $956.0K
Restructuring 2-point trend, +1324000.00 $1M $0 ·
Operating Cash Flow 3-point trend, -25.9% $-62M $-68M $-49M
CapEx 3-point trend, -1.8% $55.0K $211.0K $56.0K
Investing Cash Flow 3-point trend, -348.7% $-48M $-22M $19M
Stock Issued 3-point trend, -100.0% $15.0K $142M $32M
Net Stock Activity $15.0K · ·
Financing Cash Flow 3-point trend, -100.0% $15.0K $142M $32M
Taxes Paid 3-point trend, +179.5% $637.0K $433.0K $-801.0K
Free Cash Flow $-62M · ·
Profitability 8
Annual Profitability data for SLN
Metric Trend 202520242023
Gross Margin 61.5% · ·
Operating Margin -16292.8% · ·
Net Margin -15851.9% · ·
Pretax Margin -15849.9% · ·
EBITDA Margin -16292.8% · ·
ROA -53.0% · ·
ROE -113.3% · ·
ROIC -146.2% · ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for SLN
Metric Trend 202520242023
Current Ratio 8.7 · ·
Quick Ratio 6.3 · ·
Efficiency 2
Annual Efficiency data for SLN
Metric Trend 202520242023
Asset Turnover 0.0 · ·
Receivables Turnover 1.2 · ·
Per Share 5
Annual Per Share data for SLN
Metric Trend 202520242023
Book Value / Share $0.44 · ·
Revenue / Share $0.00 · ·
Cash Flow / Share $-0.44 · ·
Cash / Share $0.08 · ·
EPS (TTM) 2-point trend, -90.9% $-0.63 $-0.33 ·
Growth Rates 2
Annual Growth Rates data for SLN
Metric Trend 202520242023
Revenue YoY 3-point trend, -314.0% -98.7% 36.7% 46.1%
Revenue CAGR 3Y -70.5% · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for SLN
Metric Trend 202520242023
Revenue TTM 2-point trend, -98.7% $559.0K $43M ·
Net Income TTM 2-point trend, -95.6% $-89M $-45M ·
Market Cap $862M · ·
P/E 2-point trend, +53.7% -9.7 -20.8 ·
P/S 1541.2 · ·
P/B 13.8 · ·
P / Tangible Book 2-point trend, +113.8% 16.8 7.8 ·
P / Cash Flow -13.8 · ·
P / FCF -13.8 · ·
Earnings Yield 2-point trend, -115.8% -10.4% -4.8% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-31
Revenue $559.0K$43M$32M$22M
Gross Margin % 61.5%
Operating Margin % -16292.8%
Net Income $-89M$-45M$-54M$-50M
Diluted EPS $-0.63$-0.33$-0.49$-0.52
Balance Sheet
2025-12-312024-12-312023-12-312022-12-31
Current Ratio 8.7
Quick Ratio 6.3
Cash Flow
2025-12-312024-12-312023-12-312022-12-31
Free Cash Flow $-62M

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Institutional owners (13F) 79 filers · $241.4M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
23 (+16 vs prior Q) 4 (-2 vs prior Q) 22 (-1 vs prior Q) 18 (+5 vs prior Q) +2.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Siren, L.L.C. $36,359,589 3,311,438 15.06% Shares
TCG Crossover Management, LLC $33,308,489 3,033,560 13.80% Shares
Redmile Group, LLC $23,769,251 2,164,777 9.85% Shares
Nantahala Capital Management, LLC $14,787,106 1,346,731 6.13% Shares
CITADEL ADVISORS LLC $13,509,638 1,230,386 5.60% Shares
Nextech Invest Ltd. $10,457,352 952,400 4.33% Shares
MILLENNIUM MANAGEMENT LLC $9,983,883 909,279 4.14% Shares
Tetragon Partners GP Ltd $8,391,531 764,256 3.48% Shares
Soleus Capital Management, L.P. $6,917,400 630,000 2.87% Shares
Balyasny Asset Management L.P. $6,708,560 610,980 2.78% Shares
Nextech Invest Ltd. $6,552,512 952,400 2.71% Shares
5AM Venture Management, LLC $5,228,676 476,200 2.17% Shares
GREAT POINT PARTNERS LLC $4,941,000 450,000 2.05% Shares
AMERIPRISE FINANCIAL INC $4,063,171 370,052 1.68% Shares
ADAR1 Capital Management, LLC $3,715,336 338,373 1.54% Shares
SummitTX Capital, L.P. $3,586,595 326,648 1.49% Shares
Tetragon Partners GP Ltd $3,294,000 300,000 1.36% Call option
Caption Management, LLC $3,270,942 297,900 1.36% Call option
Schonfeld Strategic Advisors LLC $2,957,439 269,348 1.23% Shares
Ishara Investments LP $2,434,847 55,350 1.01% Shares
JANE STREET GROUP, LLC $2,234,847 203,538 0.93% Shares
BOOTHBAY FUND MANAGEMENT, LLC $2,177,850 198,347 0.90% Shares
BANK OF MONTREAL /CAN/ $2,160,139 196,734 0.90% Shares
Propel Bio Management, LLC $2,105,228 191,733 0.87% Shares
BlackRock, Inc. $2,061,133 187,717 0.85% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,026,019 184,519 0.84% Shares
FRED ALGER MANAGEMENT, LLC $1,943,460 177,000 0.81% Shares
Ikarian Capital, LLC $1,827,725 830,784 0.76% Shares
Qube Research & Technologies Ltd $1,800,116 163,945 0.75% Shares
Caption Management, LLC $1,783,986 162,476 0.74% Shares
BNP PARIBAS FINANCIAL MARKETS $1,745,271 158,950 0.72% Shares
GOLDMAN SACHS GROUP INC $1,712,100 155,929 0.71% Shares
TWO SIGMA INVESTMENTS, LP $1,328,624 121,004 0.55% Shares
HSBC HOLDINGS PLC $1,324,151 122,834 0.55% Shares
Quadrature Capital Ltd $1,297,056 118,129 0.54% Shares
Squarepoint Ops LLC $1,272,780 115,918 0.53% Shares
XTX Topco Ltd $1,181,217 107,579 0.49% Shares
M28 Capital Management LP $1,111,209 101,203 0.46% Shares
MARSHALL WACE, LLP $790,989 72,039 0.33% Shares
Birchview Capital, LP $781,974 71,218 0.32% Shares
Seven Fleet Capital Management LP $659,975 60,107 0.27% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $327,204 29,800 0.14% Put option
GEODE CAPITAL MANAGEMENT, LLC $324,327 29,538 0.13% Shares
BANK OF AMERICA CORP /DE/ $277,574 25,280 0.12% Shares
Trexquant Investment LP $261,785 23,842 0.11% Shares
Verdad Advisers, LP $223,992 20,400 0.09% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $213,012 19,400 0.09% Call option
Scientech Research LLC $210,080 19,133 0.09% Shares
JANE STREET GROUP, LLC $202,032 18,400 0.08% Call option
RENAISSANCE TECHNOLOGIES LLC $185,891 16,930 0.08% Shares
Arrowpoint Investment Partners (Singapore) Pte. Ltd. $179,347 16,334 0.07% Shares
Persistent Asset Partners Ltd $166,567 15,170 0.07% Shares
RAYMOND JAMES FINANCIAL INC $164,700 15,000 0.07% Shares
RHUMBLINE ADVISERS $151,680 13,815 0.06% Shares
CITIGROUP INC $145,123 13,217 0.06% Shares
AXQ CAPITAL, LP $137,975 12,566 0.06% Shares
GAMMA Investing LLC $121,472 11,063 0.05% Shares
CenterBook Partners LP $114,368 10,416 0.05% Shares
TWO SIGMA ADVISERS, LP $96,672 15,900 0.04% Shares
China Universal Asset Management Co., Ltd. $82,076 7,475 0.03% Shares
JPMORGAN CHASE & CO $41,682 3,863 0.02% Shares
BARCLAYS PLC $37,530 3,418 0.02% Shares
JONES FINANCIAL COMPANIES LLLP $25,350 2,500 0.01% Shares
Mirae Asset Global Investments Co., Ltd. $23,069 2,101 0.01% Shares
Tower Research Capital LLC (TRC) $17,996 1,639 0.01% Shares
Parallel Advisors, LLC $14,274 1,300 0.01% Shares
UBS Group AG $13,176 1,200 0.01% Shares
Rialto Wealth Management, LLC $11,211 1,021 0.00% Shares
GF FUND MANAGEMENT CO. LTD. $10,706 975 0.00% Shares
MORGAN STANLEY $4,139 377 0.00% Shares
Steward Partners Investment Advisory, LLC $1,098 100 0.00% Shares
Rockefeller Capital Management L.P. $494 45 0.00% Shares
Caitong International Asset Management Co., Ltd $450 41 0.00% Shares
HRT FINANCIAL LP $337 30,748 0.00% Shares
SBI Securities Co., Ltd. $307 28 0.00% Shares
Virtu Financial LLC $282 25,641 0.00% Shares
SG Americas Securities, LLC $132 12,056 0.00% Shares
ACADIAN ASSET MANAGEMENT LLC $129 11,836 0.00% Shares
ROYAL BANK OF CANADA $0 10 0.00% Shares

Company insiders 3 insiders · 0 officers · 0 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Richard Ian Griffiths Aug. 10, 2026 S 0 0 $0
Timothy Mcinerney Jan. 2, 2026 A 0 0 $0
Iain Ross Dec. 18, 2025 A 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Richard Griffiths ×7 filings Aug. 13, 2026 7.97% Amendment SEC
Richard Ian Griffiths (2), Ora Capital Limited (2) ×5 filings March 27, 2024 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 4 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 2,533 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.02% 191,985 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.02% 1,736 NS May 31, 2026 N-PORT
APIE · Trust for Professional Managers 0.01% 8,695 NS May 31, 2026 N-PORT