TARA Protara Therapeutics, Inc. - Common Stock
$4.08
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$3–$8
23% of range
Analyst Rating
BUY
14 analysts
Price Target
$27
+552% upside
P/E (TTM)
-3.0
ROE
-33.7%
Net Profit Margin
—
About Protara Therapeutics, Inc. - Common Stock Company overview from Wikipedia
Proteon Therapeutics, Inc. is a developer of pharmaceuticals with offices in Waltham, Massachusetts and Kansas City, Missouri.
Read more
Proteon Therapeutics, Inc. is a developer of pharmaceuticals with offices in Waltham, Massachusetts and Kansas City, Missouri.
Company History
Proteon was founded by Dr. F. Nicholas Franano based on technology created at Johns Hopkins University. Major investors in the company include MPM Capital, Rockhill Partners, TVM Capital, Skyline Ventures, Prism VentureWorks, Vectis Life Sciences and Intersouth Partners. They have invested over $72 million in the company.
The company is led by Timothy Noyes, CEO; Steven Burke, CMO; George Eldridge, CFO; and Scott Toner, director of marketing.
On March 5, 2009, the company announced that it had raised $32 million from its existing investors plus MPM Capital and Vectis Life Sciences. Proteon also announced that it had entered into an option agreement to be acquired by Novartis for up to $550 million. The company went public in 2014.
In September 2019, Proteon Therapeutics merged with ArTara Therapeutics.
PRT-201
Proteon is developing PRT-201 (vonapanitase), a drug to improve blood flow following vascular surgery procedures, and, more broadly, is interested in vascular access for hemodialysis and peripheral arterial disease (PAD). PRT-201 is a recombinant human elastase manufactured for Proteon by Lonza.
In September 2008, the company announced that the Food and Drug Administration had granted fast track status to PRT-201.
In December 2016, they announced that the phase III trial of PRT-201 hadn't reached its primary endpoint, causing Proteon's stock price to drop more than 75%.
Source: Wikipedia, CC BY-SA 4.0 · View on Wikipedia ↗
TARA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$4.08
Market Cap
$218M
P/E (TTM)
-3.0
EPS (TTM)
$-1.34
Revenue (TTM)
—
Div Yield
—
ROE
-33.7%
Debt/Equity
—
52W Range
$3 – $8
TARA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-1.34
2021-12-31
→
2025-12-31
Free Cash Flow
$-56M
2016-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
TARA
Peer Median
P/E (TTM)
-3.0
88.5
P/B
1.1
3.6
Price / FCF
-3.9
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Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
TARA
Peer Median
ROA
-29.4%
-38.8%
ROE
-33.7%
-61.0%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
TARA
Peer Median
Current Ratio
14.6
3.9
Quick Ratio
14.2
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
TARA
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
TARA
Peer Median
TARA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
14 analysts
- Strong Buy 3 21.4%
- Buy 10 71.4%
- Hold 1 7.1%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
7 analysts · 2026-08-13
Median
$26.00
Mean
$26.57
← Below all targets
$4.08
Low
$24.00
High
$30.00
Median target
$26.00
+538.0%
Mean target
$26.57
+552.1%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.07%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.31 | $-0.38 | 0.07% |
| Dec. 31, 2025 | $-0.37 | $-0.33 | -0.04% |
| Sept. 30, 2025 | $-0.31 | $-0.39 | 0.08% |
| June 30, 2025 | $-0.35 | $-0.41 | 0.06% |
| March 31, 2025 | $-0.29 | $-0.46 | 0.17% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| TARA | $286M | -4.0 | — | — | -33.7% | — |
| CNXU | — | — | — | — | — | — |
| GLSI | $300M | -14.7 | — | — | -2159.7% | — |
| PYXS | $72M | -0.9 | -14.2% | -574.5% | -112.9% | — |
| RCEL | $105M | -2.0 | 11.5% | -67.8% | 328.9% | 82.1% |
| AKBA | $427M | -80.5 | 47.5% | -2.3% | -17.3% | — |
| ALEC | $172M | -1.1 | -79.1% | -679.2% | -280.7% | — |
| EBS | $644M | 13.3 | -28.8% | 7.1% | 9.9% | — |
| ARCT | $174M | -2.6 | -46.1% | -80.2% | -29.6% | — |
| NBP | — | — | — | — | — | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 16
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | · | · | · | · | · | · | · | · | · | · | · | $3M | |
| R&D Expense | $43M | $32M | $25M | $17M | $21M | $12M | $4M | $12M | $22M | $19M | $12M | $6M | |
| SG&A Expense | $22M | $17M | $19M | $21M | $26M | $22M | $4M | $10M | $9M | $10M | $8M | $4M | |
| Operating Expenses | $65M | $49M | $44M | $67M | $47M | $34M | $8M | $21M | $30M | $29M | $21M | $11M | |
| Operating Income | $-65M | $-49M | $-44M | $-67M | $-47M | $-34M | $-8M | $-21M | $-30M | $-29M | $-21M | $-8M | |
| Interest Expense | · | · | · | · | $0 | $34.0K | · | · | · | · | · | $857.0K | |
| Interest Income | $6M | $4M | $3M | $1M | $237.0K | $500.0K | · | · | · | · | · | · | |
| Other Non-op | $7M | $5M | $3M | $1M | $237.0K | $466.0K | · | $207.0K | $139.0K | $-14.0K | $-651.0K | $5M | |
| Pretax Income | $57M | $45M | · | · | · | · | $-15M | $-21M | $-30M | $-29M | $-21M | $-3M | |
| Income Tax | · | · | · | · | · | · | · | · | · | · | · | $-110.0K | |
| Net Income | $-57M | $-45M | $-40M | $-66M | $-47M | $-34M | $-8M | $-21M | $-30M | $-29M | $-21M | $-3M | |
| EPS (Basic) | $-1.34 | $-2.17 | $-3.57 | $-5.86 | $-4.21 | · | · | · | · | · | · | · | |
| EPS (Diluted) | $-1.34 | $-2.17 | $-3.57 | $-5.86 | $-4.21 | · | · | · | · | · | · | · | |
| Shares (Basic) | 42,836,129 | 20,592,847 | 11,331,338 | 11,259,615 | · | · | · | · | · | · | · | · | |
| Shares (Diluted) | 42,836,129 | 20,592,847 | 11,331,338 | 11,259,615 | 11,232,576 | · | · | · | · | · | · | · | |
| EBITDA | $-65M | $-49M | $-44M | $-67M | $-47M | $-34M | $-15M | · | · | $-29M | $-21M | $-8M |
Balance Sheet 23
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $50M | $163M | $40M | $24M | $36M | $169M | $564.0K | $19M | $21M | $36M | $40M | $69M | |
| Short-term Investments | $106M | $7M | $26M | $60M | $56M | · | · | $2M | $21M | $5M | $25M | $15M | |
| Prepaid Expense | $4M | $2M | $3M | $2M | $2M | $787.0K | $78.0K | $1M | $1M | $1M | $1M | $1M | |
| Other Current Assets | $65.0K | $2.0K | $37.0K | $127.0K | $34.0K | $52.0K | · | · | · | · | · | · | |
| Current Assets | $160M | $172M | $69M | $86M | $93M | $169M | $764.0K | $23M | $43M | $43M | $67M | $85M | |
| PP&E (Net) | $759.0K | $1M | $1M | $2M | $2M | $1M | $459.0K | $263.0K | $259.0K | $372.0K | $224.0K | $83.0K | |
| PP&E (Gross) | $2M | $2M | $2M | $2M | $2M | $1M | $475.0K | $1M | $971.0K | $937.0K | $665.0K | $467.0K | |
| Accum. Depreciation | $1M | $1M | $824.0K | $483.0K | $236.0K | $119.0K | $16.0K | $827.0K | $712.0K | $565.0K | $441.0K | $384.0K | |
| Goodwill | · | · | · | · | $30M | $30M | · | · | · | · | · | · | |
| Other Non-current Assets | $20.0K | $27.0K | $11.0K | $16.0K | $865.0K | $1M | · | · | $218.0K | $393.0K | $706.0K | $114.0K | |
| Total Assets | $209M | $181M | $79M | $113M | $173M | $203M | $1M | $24M | $44M | $44M | $68M | $85M | |
| Accounts Payable | $3M | $4M | $2M | $2M | $954.0K | $914.0K | $716.0K | $441.0K | $291.0K | $556.0K | $1M | $917.0K | |
| Accrued Liabilities | $6M | $5M | $3M | $3M | $2M | $2M | $3M | $3M | $9M | $5M | $3M | $1M | |
| Current Liabilities | $11M | $11M | $6M | $6M | $4M | $3M | $3M | $3M | $9M | $5M | $4M | $2M | |
| Capital Leases | $2M | $3M | $4M | $5M | $6M | $999.0K | · | · | · | · | · | · | |
| Total Liabilities | $13M | $14M | $11M | $11M | $11M | $4M | $3M | $3M | $9M | $5M | $4M | $2M | |
| Common Stock | $54.0K | $35.0K | $11.0K | $11.0K | $11.0K | $11.0K | $3.0K | · | $18.0K | $17.0K | $16.0K | $16.0K | |
| Paid-in Capital | $499M | $412M | $269M | $263M | $256M | $246M | $11M | $209M | $203M | $198M | $195M | $192M | |
| Retained Earnings | $-302M | $-245M | $-200M | $-160M | $-94M | $-47M | $-13M | $-210M | $-190M | $-160M | $-131M | $-110M | |
| AOCI | $90.0K | $2.0K | $-31.0K | $-688.0K | $-211.0K | · | $3.0K | $5.0K | $-14.0K | · | $-11.0K | $-6.0K | |
| Stockholders' Equity | $196M | $167M | $68M | $102M | $162M | $199M | $-2M | $5M | $35M | $38M | $63M | $82M | |
| Liabilities + Equity | $209M | $181M | $79M | $113M | $173M | $203M | $1M | $24M | $44M | $44M | $68M | $85M | |
| Shares Outstanding | 53,587,260 | 35,044,772 | 11,364,903 | 11,267,389 | 11,235,731 | 11,211,840 | 2,627,533 | 481,091 | 17,674,729 | 16,603,559 | 16,501,500 | 16,448,455 |
Cash Flow 14
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | · | · | · | · | · | · | · | · | · | $123.0K | $57.0K | $30.0K | |
| Stock-based Comp | $4M | $4M | $6M | $7M | $10M | $10M | $424.0K | $3M | $3M | $3M | $2M | $459.0K | |
| Deferred Tax | $-11M | $-20M | $-14M | $-9M | $-5M | $-9M | · | · | · | · | · | · | |
| Restructuring | · | · | · | · | · | · | $3M | · | · | · | · | · | |
| Other Non-cash | · | · | · | · | · | · | · | · | · | $1M | $2M | $-7M | |
| Operating Cash Flow | $-56M | $-36M | $-38M | $-26M | $-35M | $-23M | $-5M | $-23M | $-22M | $-24M | $-18M | $-10M | |
| CapEx | $94.0K | $63.0K | $45.0K | $120.0K | $596.0K | $884.0K | $475.0K | $119.0K | $35.0K | $271.0K | $198.0K | $51.0K | |
| Investing Cash Flow | $-139M | $19M | $53M | $15M | $-98M | $3M | $-475.0K | $18M | $-16M | $20M | $-11M | · | |
| Stock Issued | · | · | · | · | · | $74M | · | · | · | · | · | $62M | |
| Stock Repurchased | · | · | $91.0K | $90.0K | $228.0K | · | · | · | · | · | · | · | |
| Net Stock Activity | · | · | $-91.0K | $-90.0K | $-228.0K | $66M | · | · | · | · | · | $62M | |
| Financing Cash Flow | $83M | $140M | $-91.0K | $-90.0K | $-228.0K | $189M | $500.0K | $3M | $23M | $208.0K | $163.0K | · | |
| Net Change in Cash | · | · | · | · | · | · | $-13M | $-2M | $-15M | $-4M | $-29M | $66M | |
| Free Cash Flow | $-56M | $-36M | $-38M | $-27M | $-35M | $-24M | $-16M | · | · | $-24M | $-18M | $-10M |
Profitability 5
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | · | · | · | · | · | -7391.4% | · | · | · | · | · | -257.1% | |
| Net Margin | · | · | · | · | · | -7291.4% | · | · | · | · | · | -113.4% | |
| EBITDA Margin | · | · | · | · | · | -7391.4% | · | · | · | · | · | -256.1% | |
| ROA | -29.4% | -34.2% | -42.0% | -46.1% | -25.1% | -33.2% | -98.3% | · | · | -51.4% | -28.1% | -7.4% | |
| ROE | -33.7% | -35.8% | -55.6% | -54.7% | -28.4% | -17.2% | -449.1% | · | · | -56.0% | -29.3% | 37.0% |
Liquidity & Solvency 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 14.6 | 15.7 | 11.2 | 15.0 | 21.7 | 58.1 | 12.0 | · | · | 8.4 | 16.1 | 36.2 | |
| Quick Ratio | 14.2 | 15.5 | 10.7 | 14.7 | 21.2 | 57.8 | 10.6 | · | · | 8.1 | 15.8 | 35.8 | |
| Interest Coverage | · | · | · | · | · | -1013.1 | · | · | · | · | · | -8.8 |
Efficiency 1
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | · | · | · | · | · | 0.0 | · | · | · | · | · | 0.1 |
Valuation (TTM) 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | · | · | · | · | · | · | · | · | · | · | · | $3M | |
| Net Income TTM | $-57M | $-45M | $-40M | $-66M | $-47M | $-34M | $-8M | $-21M | $-30M | $-29M | $-21M | $-3M | |
| Market Cap | $286M | $185M | $21M | $30M | $76M | $271M | $9M | · | · | $1.26B | $10.24B | $6.84B | |
| P/E | -4.0 | -2.4 | -0.5 | -0.5 | -1.6 | · | · | · | · | · | · | · | |
| P/S | · | · | · | · | · | · | · | · | · | · | · | 2321.1 | |
| P/B | 1.5 | 1.1 | 0.3 | 0.3 | 0.5 | 1.4 | 1.4 | · | · | 32.8 | 161.5 | 83.0 | |
| P / Tangible Book | 1.5 | 1.1 | 0.3 | 0.3 | 0.6 | 1.6 | · | · | · | · | · | · | |
| P / Cash Flow | -5.1 | -5.2 | -0.6 | -1.1 | -2.2 | -11.6 | -0.6 | · | · | -53.3 | -582.8 | -684.9 | |
| P / FCF | -5.1 | -5.2 | -0.6 | -1.1 | -2.2 | -11.2 | -0.6 | · | · | -52.7 | -576.3 | -681.5 | |
| Earnings Yield | -25.1% | -41.1% | -190.4% | -218.7% | -62.4% | · | · | · | · | · | · | · |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $17M | $14M | $13M | $10M | $11M | $9M | $9M | $8M | $6M | $8M | $6M | $6M | $7M | $5M | $5M | $3M | |
| SG&A Expense | $6M | $6M | $6M | $5M | $6M | $5M | $5M | $4M | $4M | $4M | $5M | $4M | $5M | $5M | $5M | $5M | |
| Operating Expenses | $23M | $20M | $19M | $15M | $17M | $14M | $14M | $12M | $11M | $12M | $11M | $11M | $12M | $10M | $40M | $8M | |
| Operating Income | $-23M | $-20M | $-19M | $-15M | $-17M | $-14M | $-14M | $-12M | $-11M | $-12M | $-11M | $-11M | $-12M | $-10M | $-40M | $-8M | |
| Interest Income | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $1M | $756.0K | $820.0K | $840.0K | $846.0K | $687.0K | $542.0K | $283.0K | |
| Other Non-op | $2M | $2M | $2M | $2M | $2M | $2M | $2M | $1M | $1M | $756.0K | $820.0K | $840.0K | $846.0K | $687.0K | $542.0K | $283.0K | |
| Net Income | $-22M | $-18M | $-17M | $-13M | $-15M | $-12M | $-13M | $-11M | $-10M | $-11M | $-10M | $-10M | $-11M | $-9M | $-39M | $-8M | |
| EPS (Basic) | $-0.36 | $-0.31 | $-0.39 | $-0.31 | $-0.35 | $-0.29 | $-0.25 | $-0.50 | $-0.45 | $-0.97 | $-0.90 | $-0.87 | $-1.00 | $-0.80 | $-3.46 | $-0.68 | |
| EPS (Diluted) | $-0.36 | $-0.31 | $-0.39 | $-0.31 | $-0.35 | $-0.29 | $-0.25 | $-0.50 | $-0.45 | $-0.97 | $-0.90 | $-0.87 | $-1.00 | $-0.80 | $-3.46 | $-0.68 | |
| Shares (Basic) | 61,006,766 | 57,538,833 | -82,414,767 | 42,272,104 | 42,270,855 | 40,707,937 | -34,391,036 | 22,329,772 | 21,233,163 | 11,420,948 | -22,628,260 | 11,347,887 | 11,307,842 | 11,303,869 | -22,511,202 | 11,265,475 | |
| Shares (Diluted) | 61,006,766 | 57,538,833 | -82,414,767 | 42,272,104 | 42,270,855 | 40,707,937 | -34,391,036 | 22,329,772 | 21,233,163 | 11,420,948 | -22,628,260 | 11,347,887 | 11,307,842 | 11,303,869 | -22,511,202 | 11,265,475 | |
| EBITDA | $-23M | $-20M | · | $-15M | $-17M | $-14M | · | $-12M | $-11M | $-12M | · | $-11M | $-12M | $-10M | · | $-8M |
Balance Sheet 23
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $17M | $15M | $50M | $13M | $31M | $91M | $163M | $52M | $90M | $52M | $40M | $34M | $34M | $21M | $24M | $47M | |
| Short-term Investments | $125M | $121M | $106M | $120M | $91M | $33M | $7M | $30M | · | $3M | $26M | $40M | $46M | $66M | $60M | $49M | |
| Prepaid Expense | $4M | $4M | $4M | $3M | $3M | $2M | $2M | $4M | $3M | $3M | $3M | $4M | $4M | $8M | $2M | $2M | |
| Other Current Assets | $230.0K | $17.0K | $65.0K | $218.0K | $78.0K | $16.0K | $2.0K | $3.0K | $4.0K | $3.0K | $37.0K | $2.0K | $1.0K | $127.0K | $127.0K | · | |
| Current Assets | $146M | $140M | $160M | $136M | $125M | $127M | $172M | $85M | $92M | $58M | $69M | $78M | $84M | $95M | $86M | $99M | |
| PP&E (Net) | $1M | $669.0K | $759.0K | $828.0K | $912.0K | $988.0K | $1M | $1M | $1M | $1M | $1M | $1M | $1M | $2M | $2M | $2M | |
| PP&E (Gross) | · | · | $2M | · | · | · | $2M | · | · | · | $2M | · | · | · | $2M | · | |
| Accum. Depreciation | · | · | $1M | · | · | · | $1M | · | · | · | $824.0K | · | · | · | $483.0K | · | |
| Goodwill | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $30M | |
| Other Non-current Assets | $74.0K | $76.0K | $20.0K | $21.0K | $29.0K | $35.0K | $27.0K | $33.0K | $19.0K | $31.0K | $11.0K | $3M | $3M | $586.0K | $16.0K | $734.0K | |
| Total Assets | $176M | $192M | $209M | $145M | $157M | $169M | $181M | $94M | $102M | $68M | $79M | $88M | $95M | $106M | $113M | $149M | |
| Accounts Payable | $5M | $4M | $3M | $5M | $5M | $2M | $4M | $2M | $1M | $972.0K | $2M | $3M | $2M | $4M | $2M | $456.0K | |
| Accrued Liabilities | $7M | $4M | $6M | $4M | $3M | $4M | $5M | $5M | $3M | $4M | $3M | $3M | $2M | $1M | $3M | $2M | |
| Current Liabilities | $13M | $9M | $11M | $10M | $10M | $7M | $11M | $9M | $6M | $6M | $6M | $7M | $5M | $6M | $6M | $4M | |
| Capital Leases | $1M | $2M | $2M | $2M | $3M | $3M | $3M | $4M | $4M | $4M | $4M | $5M | $5M | $5M | $5M | $6M | |
| Total Liabilities | $15M | $11M | $13M | $12M | $13M | $10M | $14M | $12M | $10M | $10M | $11M | $12M | $10M | $12M | $11M | $9M | |
| Common Stock | $59.0K | $55.0K | $54.0K | $39.0K | $39.0K | $39.0K | $35.0K | $21.0K | $21.0K | $11.0K | $11.0K | $11.0K | $11.0K | $11.0K | $11.0K | $11.0K | |
| Paid-in Capital | $503M | $502M | $499M | $417M | $416M | $415M | $412M | $314M | $313M | $270M | $269M | $267M | $266M | $264M | $263M | $261M | |
| Retained Earnings | $-342M | $-320M | $-302M | $-285M | $-272M | $-257M | $-245M | $-232M | $-221M | $-211M | $-200M | $-190M | $-180M | $-169M | $-160M | $-121M | |
| AOCI | $-363.0K | $-364.0K | $90.0K | $143.0K | $77.0K | $89.0K | $2.0K | $29.0K | · | $-1.0K | $-31.0K | $-165.0K | $-336.0K | $-469.0K | $-688.0K | $-1M | |
| Stockholders' Equity | $161M | $181M | $196M | $132M | $144M | $158M | $167M | $82M | $92M | $58M | $68M | $77M | $85M | $95M | $102M | $139M | |
| Liabilities + Equity | $176M | $192M | $209M | $145M | $157M | $169M | $181M | $94M | $102M | $68M | $79M | $88M | $95M | $106M | $113M | $149M | |
| Shares Outstanding | 59,083,935 | 55,055,582 | 53,587,260 | 38,587,260 | 38,581,863 | 38,577,813 | 35,044,772 | 20,629,772 | 11,364,903 | 11,433,837 | 11,364,903 | 11,364,903 | 11,307,962 | 11,306,753 | 11,267,389 | 11,267,389 |
Cash Flow 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stock-based Comp | $1M | $1M | $1M | $1M | $903.0K | $833.0K | $904.0K | $931.0K | $1M | $1M | $1M | $1M | $2M | $2M | $1M | $1M | |
| Operating Cash Flow | $-15M | $-21M | $-17M | $-12M | $-12M | $-15M | $-9M | $-8M | $-8M | $-10M | $-9M | $-7M | $-9M | $-13M | $-5M | $-5M | |
| CapEx | · | · | $24.0K | $4.0K | $22.0K | $44.0K | $0 | $8.0K | · | · | $0 | $37.0K | $2.0K | $6.0K | $6.0K | $83.0K | |
| Investing Cash Flow | $18M | $-15M | $-27M | $-7M | $-48M | $-58M | $22M | $-29M | $3M | $23M | $15M | $6M | $22M | $10M | $-18M | $19M | |
| Stock Repurchased | · | · | · | · | · | · | · | · | · | $76.0K | · | $27.0K | $0 | $64.0K | $0 | $18.0K | |
| Net Stock Activity | · | · | · | · | · | · | · | · | · | $-76.0K | · | · | · | $-64.0K | · | · | |
| Financing Cash Flow | $-26.0K | $1M | $81M | $13.0K | $8.0K | $2M | $98M | $0 | $42M | $-76.0K | $0 | $-27.0K | $0 | $-64.0K | $0 | $-18.0K | |
| Free Cash Flow | · | · | · | · | · | $-15M | · | · | · | · | · | · | · | $-13M | · | · |
Profitability 5
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -1575.9% | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Net Margin | -1464.0% | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| EBITDA Margin | -1575.9% | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| ROA | -13.0% | -9.9% | · | -11.1% | -11.6% | -10.1% | · | -12.3% | -9.7% | -12.7% | · | -8.3% | -9.0% | -6.8% | · | -4.7% | |
| ROE | -14.2% | -10.5% | · | -12.4% | -12.7% | -11.0% | · | -14.1% | -10.7% | -14.5% | · | -9.1% | -9.8% | -7.3% | · | -5.0% |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 11.0 | 15.7 | · | 13.7 | 12.8 | 18.0 | · | 9.8 | 16.3 | 10.5 | · | 11.5 | 17.1 | 14.8 | · | 26.6 | |
| Quick Ratio | 10.7 | 15.2 | · | 13.4 | 12.5 | 17.7 | · | 9.4 | 15.9 | 10.0 | · | 10.9 | 16.3 | 13.5 | · | 26.0 |
Efficiency 1
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-68M | $-58M | · | $-51M | $-48M | $-44M | · | $-42M | $-42M | $-41M | · | $-38M | $-37M | $-36M | · | $-38M | |
| Market Cap | $226M | $287M | · | $168M | $117M | $164M | · | $38M | $24M | $46M | · | $19M | $27M | $35M | · | $33M | |
| P/E | -2.9 | -4.1 | · | -3.0 | -1.9 | -1.9 | · | -0.7 | -0.6 | -1.1 | · | -0.5 | -0.7 | -1.0 | · | -0.9 | |
| P/B | 1.4 | 1.6 | · | 1.3 | 0.8 | 1.0 | · | 0.5 | 0.3 | 0.8 | · | 0.2 | 0.3 | 0.4 | · | 0.2 | |
| P / Tangible Book | 1.4 | 1.6 | · | 1.3 | 0.8 | 1.0 | · | 0.5 | 0.3 | 0.8 | · | 0.2 | 0.3 | 0.4 | · | 0.3 | |
| P / Cash Flow | · | -13.4 | · | · | · | -11.2 | · | · | · | -4.4 | · | · | · | -2.7 | · | · | |
| P / FCF | · | · | · | · | · | -11.1 | · | · | · | · | · | · | · | -2.7 | · | · | |
| Earnings Yield | -34.8% | -24.2% | · | -33.3% | -52.5% | -51.9% | · | -152.5% | -158.2% | -90.8% | · | -200.6% | -135.6% | -102.2% | · | -113.5% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Net Income | $-57M | $-45M | $-40M | $-66M | $-47M |
| Diluted EPS | $-1.34 | $-2.17 | $-3.57 | $-5.86 | $-4.21 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 14.6 | 15.7 | 11.2 | 15.0 | 21.7 |
| Quick Ratio | 14.2 | 15.5 | 10.7 | 14.7 | 21.2 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | $-56M | $-36M | $-38M | $-27M | $-35M |
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Institutional owners (13F) 127 filers · $162.3M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 31 (+4 vs prior Q) | 16 (-5 vs prior Q) | 39 (-8 vs prior Q) | 33 (+10 vs prior Q) | +760K |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | $27,154,562 | 5,207,011 | 16.73% | Shares |
| MILLENNIUM MANAGEMENT LLC | $11,846,454 | 3,101,166 | 7.30% | Shares |
| Velan Capital Investment Management LP | $10,866,571 | 2,844,652 | 6.70% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $8,786,508 | 2,300,133 | 5.41% | Shares |
| Blackstone Inc. | $8,654,263 | 2,265,514 | 5.33% | Shares |
| ORBIMED ADVISORS LLC | $8,480,400 | 2,220,000 | 5.23% | Shares |
| Sio Capital Management, LLC | $7,341,551 | 1,921,872 | 4.52% | Shares |
| ACORN CAPITAL ADVISORS, LLC | $6,693,079 | 1,752,115 | 4.12% | Shares |
| Integral Health Asset Management, LLC | $5,730,000 | 1,500,000 | 3.53% | Shares |
| 5AM Venture Management, LLC | $5,232,567 | 1,369,782 | 3.22% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $4,362,540 | 1,141,710 | 2.69% | Shares |
| STATE STREET CORP | $4,080,887 | 1,068,295 | 2.51% | Shares |
| Qube Research & Technologies Ltd | $3,993,871 | 1,045,516 | 2.46% | Shares |
| Balyasny Asset Management L.P. | $3,921,960 | 1,026,691 | 2.42% | Shares |
| BAKER BROS. ADVISORS LP | $3,711,565 | 971,614 | 2.29% | Shares |
| ADAR1 Capital Management, LLC | $3,592,756 | 940,512 | 2.21% | Shares |
| CITADEL ADVISORS LLC | $3,414,045 | 893,729 | 2.10% | Shares |
| BANK OF AMERICA CORP /DE/ | $3,287,679 | 860,649 | 2.03% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $2,389,918 | 625,633 | 1.47% | Shares |
| Point72 Asset Management, L.P. | $2,096,920 | 548,932 | 1.29% | Shares |
| Catalio Capital Management, LP | $1,986,965 | 520,148 | 1.22% | Shares |
| GOLDMAN SACHS GROUP INC | $1,936,106 | 506,834 | 1.19% | Shares |
| Walleye Capital LLC | $1,930,750 | 505,432 | 1.19% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1,878,130 | 491,657 | 1.16% | Shares |
| MORGAN STANLEY | $1,833,917 | 480,083 | 1.13% | Shares |
| UBS Group AG | $1,723,538 | 451,188 | 1.06% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $1,278,489 | 334,683 | 0.79% | Shares |
| Verdad Advisers, LP | $1,192,791 | 312,249 | 0.73% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1,129,058 | 295,565 | 0.70% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $960,730 | 251,500 | 0.59% | Shares |
| OPPENHEIMER & CO INC | $910,543 | 238,362 | 0.56% | Shares |
| Jump Financial, LLC | $775,842 | 203,100 | 0.48% | Shares |
| CIBC WORLD MARKET INC. | $636,011 | 166,495 | 0.39% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $603,449 | 157,971 | 0.37% | Shares |
| J. Goldman & Co LP | $515,700 | 135,000 | 0.32% | Shares |
| SUPERSTRING CAPITAL MANAGEMENT LP | $463,966 | 121,457 | 0.29% | Shares |
| Fisher Asset Management, LLC | $380,342 | 99,566 | 0.23% | Shares |
| AMERICAN CENTURY COMPANIES INC | $376,220 | 98,487 | 0.23% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $325,961 | 85,330 | 0.20% | Shares |
| TWO SIGMA INVESTMENTS, LP | $266,071 | 69,652 | 0.16% | Shares |
| FMR LLC | $260,012 | 68,066 | 0.16% | Shares |
| XTX Topco Ltd | $244,281 | 63,948 | 0.15% | Shares |
| RHUMBLINE ADVISERS | $241,589 | 63,245 | 0.15% | Shares |
| TRUIST FINANCIAL CORP | $229,200 | 60,000 | 0.14% | Shares |
| Assenagon Asset Management S.A. | $229,024 | 59,954 | 0.14% | Shares |
| Trexquant Investment LP | $227,733 | 59,616 | 0.14% | Shares |
| DEUTSCHE BANK AG\ | $220,464 | 57,713 | 0.14% | Shares |
| ALPS ADVISORS INC | $217,897 | 57,041 | 0.13% | Shares |
| AMERIPRISE FINANCIAL INC | $214,863 | 56,247 | 0.13% | Shares |
| PRUDENTIAL FINANCIAL INC | $193,789 | 50,730 | 0.12% | Shares |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $191,000 | 50,000 | 0.12% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $154,252 | 40,380 | 0.10% | Shares |
| Alyeska Investment Group, L.P. | $151,753 | 39,726 | 0.09% | Shares |
| Quadrature Capital Ltd | $150,199 | 39,319 | 0.09% | Shares |
| Marex Group Ltd | $134,655 | 35,250 | 0.08% | Shares |
| WINTON GROUP Ltd | $125,296 | 32,800 | 0.08% | Shares |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $113,454 | 29,700 | 0.07% | Shares |
| MetLife Investment Management, LLC | $108,404 | 28,378 | 0.07% | Shares |
| MARSHALL WACE, LLP | $106,995 | 28,009 | 0.07% | Shares |
| ALLIANCEBERNSTEIN L.P. | $93,988 | 18,040 | 0.06% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $92,043 | 24,095 | 0.06% | Shares |
| WOLVERINE TRADING, LLC | $88,200 | 20,000 | 0.05% | Put option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $87,478 | 22,900 | 0.05% | Put option |
| CITIGROUP INC | $80,698 | 21,125 | 0.05% | Shares |
| Jain Global LLC | $80,220 | 21,000 | 0.05% | Shares |
| Invesco Ltd. | $78,295 | 20,496 | 0.05% | Shares |
| Vanguard Global Advisers, LLC | $76,885 | 20,127 | 0.05% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $74,922 | 19,613 | 0.05% | Shares |
| EntryPoint Capital, LLC | $73,673 | 19,286 | 0.05% | Shares |
| LPL Financial LLC | $73,077 | 19,130 | 0.05% | Shares |
| VANGUARD GROUP INC | $70,479 | 13,223 | 0.04% | Shares |
| Squarepoint Ops LLC | $69,234 | 18,124 | 0.04% | Shares |
| IEQ CAPITAL, LLC | $68,489 | 17,929 | 0.04% | Shares |
| Police & Firemen's Retirement System of New Jersey | $67,114 | 17,569 | 0.04% | Shares |
| BARCLAYS PLC | $60,665 | 15,881 | 0.04% | Shares |
| BlackRock, Inc. | $58,950 | 15,432 | 0.04% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $56,834 | 14,878 | 0.04% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $51,807 | 13,562 | 0.03% | Shares |
| WOLVERINE TRADING, LLC | $51,315 | 11,636 | 0.03% | Shares |
| Mariner, LLC | $45,441 | 11,899 | 0.03% | Shares |
| Bank of New York Mellon Corp | $43,877 | 11,486 | 0.03% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $43,812 | 11,469 | 0.03% | Shares |
| D. E. Shaw & Co., Inc. | $42,452 | 11,113 | 0.03% | Shares |
| COMMONWEALTH EQUITY SERVICES, LLC | $42,020 | 11,000 | 0.03% | Shares |
| WELLS FARGO & COMPANY/MN | $41,161 | 10,775 | 0.03% | Shares |
| Essential Partners LLC | $37,444 | 9,802 | 0.02% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $34,525 | 9,038 | 0.02% | Shares |
| NORTHERN TRUST CORP | $32,061 | 8,393 | 0.02% | Shares |
| CWM, LLC | $30,458 | 5,846 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $30,178 | 7,900 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $28,788 | 7,536 | 0.02% | Shares |
| Tower Research Capital LLC (TRC) | $19,062 | 4,990 | 0.01% | Shares |
| Legal & General Group Plc | $17,129 | 4,490 | 0.01% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $14,645 | 2,811 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $12,598 | 3,298 | 0.01% | Shares |
| Nuveen, LLC | $9,642 | 2,524 | 0.01% | Shares |
| Integrated Wealth Concepts LLC | $6,684 | 1,750 | 0.00% | Shares |
| Arax Advisory Partners | $6,383 | 1,671 | 0.00% | Shares |
| Russell Investments Group, Ltd. | $6,085 | 1,593 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $6,000 | 1,577 | 0.00% | Shares |
Company insiders 40 insiders · 16 officers · 20 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Jesse Shefferman | CEO and President | June 29, 2026 M | 691,832 | 0 | 1 | $-882,160 |
| Timothy P Noyes | President and CEO | Jan. 31, 2019 A | 0 | 0 | 0 | $0 |
| Patrick Fabbio | Chief Financial Officer | Jan. 26, 2026 F | 64,115 | 0 | 0 | $0 |
| Blaine Davis | Chief Financial Officer | July 15, 2022 F | 20,662 | 0 | 0 | $0 |
| George Arthur Eldridge, | Sr VP, CFO, Treasr, Asst Secy | Jan. 18, 2019 A | 29,132 | 0 | 0 | $0 |
| William Conkling | Chief Commercial Officer | June 2, 2026 F | 69,992 | 0 | 0 | $0 |
| Jacqueline Zummo | Chief R&D Officer | April 8, 2026 S | 94,827 | 0 | 2 | $-124,989 |
| Hannah Fry | VP, Controller | Jan. 26, 2026 F | 42,723 | 0 | 0 | $0 |
| Leonardo Viana Nicacio | Chief Medical Officer | Jan. 16, 2026 A | 78,181 | 0 | 0 | $0 |
| Jathin Bandari | Chief Medical Officer | Jan. 19, 2024 A | 56,704 | 0 | 0 | $0 |
| Julio Casoy | Chief Medical Officer | Jan. 9, 2020 A | 45,500 | 0 | 0 | $0 |
| Steven Keith Burke | SVP and Chief Medical Officer | March 15, 2019 G | 26,332 | 0 | 0 | $0 |
| Bradley J Hartman | VP, People | Jan. 18, 2019 A | — | 0 | 0 | $0 |
| Matthew Paul Kowalsky | VP, Legal and Secretary | Jan. 18, 2019 A | 29,479 | 0 | 0 | $0 |
| Scott E. Toner | Senior VP of Commercial | Jan. 18, 2019 A | 23,357 | 0 | 0 | $0 |
| Gottlieb Daniel Philip | VP Corporate Development | Jan. 18, 2019 A | 244 | 0 | 0 | $0 |
| Michael Edward Solomon | Director | June 15, 2026 A | 26,500 | 0 | 0 | $0 |
| Jane Huang | Director | June 15, 2026 A | — | 0 | 0 | $0 |
| Barry P Flannelly | Director | June 15, 2026 A | — | 0 | 0 | $0 |
| Cynthia Smith | Director | June 15, 2026 A | — | 0 | 0 | $0 |
| Richard S Levy | Director | June 15, 2026 A | 51,000 | 0 | 0 | $0 |
| Roger Garceau | Director | June 15, 2026 A | 33,000 | 0 | 0 | $0 |
| Gregory Sargen | Director | June 15, 2026 A | 31,000 | 0 | 0 | $0 |
| Luke M Beshar | Director | June 15, 2026 A | 198,000 | 0 | 0 | $0 |
| Scott Braunstein | Director | June 9, 2020 A | 26,500 | 0 | 0 | $0 |
| John Gordon Freund | Director | Nov. 8, 2019 C | 2,175,882 | 0 | 0 | $0 |
| Hubert Birner | Director | June 8, 2018 A | 1,943,059 | 0 | 0 | $0 |
| Paul J Hastings | Director | June 8, 2018 A | — | 0 | 0 | $0 |
| Scott A Canute | Director | June 8, 2018 A | — | 0 | 0 | $0 |
| Garen G Bohlin | Director | June 8, 2018 A | 53,312 | 0 | 0 | $0 |
| Jonathan S Leff | Director | June 8, 2018 A | — | 0 | 0 | $0 |
| Brendan O'Leary | Director | June 9, 2016 A | 1,387,198 | 0 | 0 | $0 |
| Dmitry Kobyzev | Director | June 2, 2015 A | 1,165,344 | 0 | 0 | $0 |
| Gregory D Phelps | Director | June 2, 2015 A | — | 0 | 0 | $0 |
| Opaleye, L.P. | 10% owner | Jan. 9, 2020 A | 2,208,472 | 0 | 0 | $0 |
| Martin Sebastian Olivo | — | June 10, 2021 P | 14,344 | 0 | 0 | $0 |
| Randall Marshall | — | Sept. 14, 2020 S | 585,600 | 0 | 0 | $0 |
| Timothy Haines | — | Nov. 12, 2019 C | 2,144,517 | 0 | 0 | $0 |
| Abingworth LLP | — | Nov. 12, 2019 C | 2,144,517 | 0 | 0 | $0 |
| Stuart A Kingsley | — | June 8, 2018 A | — | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 8 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Deerfield Partners, L.P., Deerfield Private Design Fund III, L.P., Deerfield Private Design Fund IV, L.P., Deerfield Mgmt, L.P., Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Management Company, L.P., James E. Flynn | Jan. 8, 2021 | — | Initial filing | — | SEC |
| Opaleye Management Inc., Opaleye, L.P., James Silverman ×3 filings | Sept. 25, 2020 | — | Initial filing | — | SEC |
| Deerfield Special Situations Fund, L.P., Deerfield Partners, L.P., Deerfield Private Design Fund III, L.P., Deerfield Private Design Fund IV, L.P., Deerfield Mgmt, L.P., Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Management Company, L.P., James E. Flynn ×6 filings | Jan. 17, 2020 | — | Initial filing | — | SEC |
| Abingworth LLP, Abingworth Bioventures VI, LP | Jan. 17, 2020 | — | Initial filing | M&A / sale | SEC |
| Abingworth LLP 98-051-8585, Abingworth Bioventures VI, LP 98-040-3543 ×3 filings | Nov. 14, 2019 | — | Initial filing | Board campaign | SEC |
| TVM Life Science Ventures VI L.P., TVM Life Science Ventures VI GmbH & Co. KG, TVM Life Science Ventures Management VI L.P., Hubert Birner, Stefan Fischer, Helmut Schuehsler ×2 filings | Aug. 2, 2017 | — | Initial filing | Passive investment | SEC |
| Deerfield Mgmt, L.P., Deerfield Management Company, L.P., Deerfield Mgmt III, L.P., Deerfield Special Situations Fund, L.P., Deerfield Partners, L.P., Deerfield International Master Fund, L.P., Deerfield Private Design Fund III, L.P., James E. Flynn | June 29, 2017 | — | Initial filing | — | SEC |
| Skyline Venture Partners Qualified Purchaser Fund IV, L.P., Skyline Venture Management IV, LLC, John G. Freund, Yasunori Kaneko | Nov. 3, 2014 | — | Initial filing | Passive investment | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 22 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 0.16% | 55,748 NS | May 31, 2026 | N-PORT |
| IWC · iShares Trust | 0.05% | 175,831 SH | Aug. 8, 2026 | Daily |
| VFMO · VANGUARD WELLINGTON FUND | 0.03% | 141,979 SH | Aug. 8, 2026 | Daily |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.02% | 91,844 NS | May 31, 2026 | N-PORT |
| IWN · iShares Trust | 0.01% | 470,658 SH | Aug. 8, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.01% | 300,912 SH | Aug. 8, 2026 | Daily |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.01% | 45,581 SH | Aug. 8, 2026 | Daily |
| RSSL · Global X Funds | 0.01% | 22,265 NS | April 30, 2026 | N-PORT |
| IWM · iShares Trust | 0.01% | 1,336,607 SH | Aug. 8, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.01% | 179,929 NS | April 30, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.01% | 2,419 NS | May 31, 2026 | N-PORT |
| DXUV · Dimensional ETF Trust | 0.01% | 3,715 NS | April 30, 2026 | N-PORT |
| UWM · ProShares Trust | 0.00% | 1,891 NS | May 31, 2026 | N-PORT |
| URTY · ProShares Trust | 0.00% | 1,912 NS | May 31, 2026 | N-PORT |
| HDG · ProShares Trust | 0.00% | 48 NS | May 31, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 5,791 NS | April 30, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 18,477 NS | April 30, 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0.00% | 7,914 NS | April 30, 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0.00% | 20,174 NS | April 30, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.00% | 586,965 SH | Aug. 8, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,657,879 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 3,185 SH | Aug. 8, 2026 | Daily |