ZNTL Zentalis Pharmaceuticals, Inc. - common stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$3.75
Price · Aug 19, 2026
Fundamentals as of Aug 6, 2026

ZNTL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$3.75
Market Cap
$267M
P/E (TTM)
-2.0
EPS (TTM)
$-1.91
Revenue (TTM)
$0
Div Yield
ROE
-49.5%
Debt/Equity
52W Range
$1 – $7

ZNTL Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
4-point trend, +0.00
2022-12-31 2025-12-31
EPS $-1.91
7-point trend, +76.6%
2019-12-31 2025-12-31
Free Cash Flow $-125M
5-point trend, -43.0%
2020-12-31 2025-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ZNTL
Peer Median
P/E (TTM)
5-point trend, +96.9%
-2.0
6.1
P/B
5-point trend, -93.3%
1.2
2.2
Price / FCF
5-point trend, +96.9%
-2.1

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ZNTL
Peer Median
ROA
5-point trend, +26.7%
-38.1%
-50.0%
ROE
5-point trend, -20.1%
-49.5%
-44.8%
ROIC
5-point trend, -98.2%
-70.9%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ZNTL
Peer Median
Current Ratio
5-point trend, -42.6%
6.9
5.9
Quick Ratio
5-point trend, -49.1%
1.0

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ZNTL
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ZNTL
Peer Median
EPS (Diluted)
5-point trend, +48.7%
$-1.91

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ZNTL
Peer Median

ZNTL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 16 analysts
  • Strong Buy 4 25.0%
  • Buy 6 37.5%
  • Hold 6 37.5%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

9 analysts · 2026-08-18
Median target $6.00 +60.0%
Mean target $6.89 +83.7%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.08%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.59 $-0.50 -0.09%
March 31, 2026 $-0.50 $-0.49 -0.01%
Dec. 31, 2025 $-0.50 $-0.59 0.09%
Sept. 30, 2025 $-0.37 $-0.54 0.17%
June 30, 2025 $-0.37 $-0.59 0.22%
March 31, 2025 $-0.56 $-0.65 0.09%
Dec. 31, 2024 $-0.62 $-0.72 0.10%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ZNTL $93M -0.7 -49.5%
ENTA $256M -3.1 -3.4% -125.4% -103.5%
DMAC $428M -78.7%
GALT $271M -8.7 25.0%
STRO $99M -0.5 65.2% -186.5% 232.2%
IPSC $87M -7.1 1556.8% -8.8% -5.2%
SABS
ABEO $290M 5.2 147.5% 1223.1% 44.1%
IMRX -5.2 -45.3%
TLSI

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 13
Annual Income Statement data for ZNTL
Metric Trend 2025202420232022
Revenue 4-point trend, +0.00 $0 $67M $0 $0
R&D Expense 4-point trend, -37.9% $107M $168M $190M $173M
SG&A Expense 4-point trend, -30.9% $38M $87M $64M $55M
Operating Expenses 4-point trend, -32.8% $153M $259M $300M $227M
Operating Income 4-point trend, +32.8% $-153M $-191M $-300M $-227M
Pretax Income 4-point trend, +42.5% $-137M $-166M $-293M $-238M
Income Tax 4-point trend, +194.2% $442.0K $177.0K $-601.0K $-469.0K
Net Income 4-point trend, +42.1% $-137M $-166M $-292M $-237M
EPS (Basic) 4-point trend, +57.4% $-1.91 $-2.33 $-4.47 $-4.48
EPS (Diluted) 4-point trend, +57.4% $-1.91 $-2.33 $-4.47 $-4.48
Shares (Basic) 4-point trend, +36.0% 71,869,000 71,080,000 65,409,000 52,857,000
Shares (Diluted) 4-point trend, +36.0% 71,869,000 71,080,000 65,409,000 52,857,000
EBITDA 4-point trend, +32.7% $-152M $-190M $-298M $-226M
Balance Sheet 23
Annual Balance Sheet data for ZNTL
Metric Trend 2025202420232022
Cash & Equivalents 4-point trend, -16.4% $36M $34M $28M $43M
Receivables 3-point trend, +0.00 $0 $5M $0 ·
Prepaid Expense 4-point trend, -49.9% $7M $10M $14M $15M
Current Assets 4-point trend, -44.0% $253M $386M $497M $452M
PP&E (Net) 4-point trend, -64.0% $3M $5M $6M $8M
PP&E (Gross) 4-point trend, -43.2% $6M $9M $9M $10M
Accum. Depreciation 4-point trend, +34.7% $3M $4M $3M $2M
Goodwill 3-point trend, -100.0% · $0 $4M $4M
Total Assets 4-point trend, -46.4% $289M $430M $552M $539M
Accounts Payable 4-point trend, -35.9% $7M $7M $15M $11M
Accrued Liabilities 4-point trend, -35.4% $29M $45M $54M $45M
Current Liabilities 4-point trend, -35.5% $37M $53M $69M $57M
Capital Leases 4-point trend, -20.9% $36M $40M $43M $45M
Deferred Tax 2-point trend, -100.0% · · $0 $853.0K
Other Non-current Liabilities 4-point trend, -80.9% $500.0K $849.0K $2M $3M
Total Liabilities 4-point trend, -30.9% $73M $93M $114M $105M
Common Stock 4-point trend, +16.9% $69.0K $71.0K $70.0K $59.0K
Paid-in Capital 4-point trend, +36.4% $1.41B $1.39B $1.32B $1.03B
Retained Earnings 4-point trend, -99.8% $-1.19B $-1.05B $-889M $-596M
AOCI 4-point trend, +114.5% $196.0K $558.0K $2M $-1M
Stockholders' Equity 4-point trend, -50.2% $216M $337M $437M $434M
Liabilities + Equity 4-point trend, -46.4% $289M $430M $552M $539M
Shares Outstanding 4-point trend, +16.5% 69,085,980 71,282,000 70,767,000 59,280,000
Cash Flow 15
Annual Cash Flow data for ZNTL
Metric Trend 2025202420232022
D&A 4-point trend, -48.2% $739.0K $1M $1M $1M
Stock-based Comp 4-point trend, -55.8% $21M $67M $55M $47M
Deferred Tax 4-point trend, +106.6% $51.0K $-63.0K $-891.0K $-778.0K
Restructuring 3-point trend, +7796000.00 $8M $0 $0 ·
Other Non-cash 4-point trend, -137.9% $-10M $-74M $29M $26M
Operating Cash Flow 4-point trend, +23.5% $-125M $-171M $-208M $-164M
CapEx 4-point trend, -100.0% $0 $221.0K $583.0K $3M
Investing Cash Flow 4-point trend, +215.3% $132M $177M $-44M $-114M
Stock Issued 4-point trend, -97.9% $5M $0 $236M $258M
Stock Repurchased 3-point trend, +9976000.00 $10M $0 $0 ·
Net Stock Activity 4-point trend, -101.8% $-5M $0 $236M $258M
Financing Cash Flow 4-point trend, -101.6% $-4M $108.0K $237M $261M
Net Change in Cash 4-point trend, +112.4% $2M $6M $-15M $-17M
Taxes Paid $85.0K · · ·
Free Cash Flow 4-point trend, +24.7% $-125M $-171M $-208M $-166M
Profitability 7
Annual Profitability data for ZNTL
Metric Trend 2025202420232022
Operating Margin · -283.6% · ·
Net Margin · -246.0% · ·
Pretax Margin · -245.7% · ·
EBITDA Margin · -281.6% · ·
ROA 4-point trend, +20.0% -38.1% -33.8% -53.6% -47.7%
ROE 4-point trend, +16.5% -49.5% -42.8% -67.1% -59.3%
ROIC 4-point trend, -35.7% -70.9% -56.8% -68.3% -52.3%
Liquidity & Solvency 2
Annual Liquidity & Solvency data for ZNTL
Metric Trend 2025202420232022
Current Ratio 4-point trend, -13.2% 6.9 7.3 7.2 8.0
Quick Ratio 4-point trend, +29.5% 1.0 0.7 0.4 0.8
Efficiency 2
Annual Efficiency data for ZNTL
Metric Trend 2025202420232022
Asset Turnover 2-point trend, -100.0% 0.0 0.1 · ·
Receivables Turnover 2-point trend, -100.0% 0.0 27.0 · ·
Per Share 5
Annual Per Share data for ZNTL
Metric Trend 2025202420232022
Book Value / Share 4-point trend, -57.3% $3.13 $4.73 $6.18 $7.32
Revenue / Share 2-point trend, -100.0% $0.00 $0.95 · ·
Cash Flow / Share 4-point trend, +43.7% $-1.74 $-2.40 $-3.18 $-3.10
Cash / Share 4-point trend, -28.3% $0.52 $0.48 $0.40 $0.73
EPS (TTM) 4-point trend, +57.4% $-1.91 $-2.33 $-4.47 $-4.48
Valuation (TTM) 10
Annual Valuation (TTM) data for ZNTL
Metric Trend 2025202420232022
Revenue TTM 4-point trend, +0.00 $0 $67M $0 $0
Net Income TTM 4-point trend, +42.1% $-137M $-166M $-292M $-237M
Market Cap 4-point trend, -92.2% $93M $216M $1.07B $1.19B
P/E 4-point trend, +84.3% -0.7 -1.3 -3.4 -4.5
P/S · 3.2 · ·
P/B 4-point trend, -84.3% 0.4 0.6 2.5 2.8
P / Tangible Book 4-point trend, -84.5% 0.4 0.6 2.5 2.8
P / Cash Flow 4-point trend, +89.8% -0.7 -1.3 -5.2 -7.3
P / FCF 4-point trend, +89.6% -0.7 -1.3 -5.1 -7.2
Earnings Yield 4-point trend, -536.2% -141.5% -76.9% -29.5% -22.2%

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $0$67M$0$0
Operating Margin % -283.6%
Net Income $-137M$-166M$-292M$-237M$-159M
Diluted EPS $-1.91$-2.33$-4.47$-4.48$-3.72
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 6.97.37.28.0
Quick Ratio 1.00.70.40.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-125M$-171M$-208M$-166M

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Institutional owners (13F) 129 filers · $188.0M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
41 (+13 vs prior Q) 19 (+9 vs prior Q) 26 (-6 vs prior Q) 35 (+13 vs prior Q) +4.0M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
5AM Venture Management, LLC $19,147,378 3,947,913 10.19% Shares
Squadron Capital Management LLC $17,945,000 3,700,000 9.55% Shares
TWO SIGMA INVESTMENTS, LP $14,670,940 3,024,936 7.80% Shares
VANGUARD CAPITAL MANAGEMENT LLC $13,752,995 2,835,669 7.32% Shares
CITADEL ADVISORS LLC $10,666,687 2,199,317 5.67% Shares
RENAISSANCE TECHNOLOGIES LLC $7,804,028 1,609,078 4.15% Shares
Opaleye Management Inc. $6,851,382 1,412,656 3.64% Shares
ORBIMED ADVISORS LLC $6,744,294 1,390,576 3.59% Shares
Decheng Capital LLC $6,418,136 1,323,327 3.41% Shares
GEODE CAPITAL MANAGEMENT, LLC $5,306,560 1,093,779 2.82% Shares
Ishara Investments LP $4,971,250 1,025,000 2.64% Shares
PRIMECAP MANAGEMENT CO/CA/ $4,643,487 957,420 2.47% Shares
Soleus Capital Management, L.P. $4,607,500 950,000 2.45% Shares
STATE STREET CORP $4,303,968 887,416 2.29% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $3,921,458 808,548 2.09% Shares
Pfizer Inc $3,853,489 953,834 2.05% Shares
Connor, Clark & Lunn Investment Management Ltd. $3,676,460 758,033 1.96% Shares
MILLENNIUM MANAGEMENT LLC $3,221,763 664,281 1.71% Shares
ADAR1 Capital Management, LLC $3,165,838 652,750 1.68% Shares
Qube Research & Technologies Ltd $2,787,809 574,806 1.48% Shares
D. E. Shaw & Co., Inc. $2,650,845 546,566 1.41% Shares
DIMENSIONAL FUND ADVISORS LP $2,228,114 459,405 1.19% Shares
Squadron Capital Management LLC $2,066,100 426,000 1.10% Call option
TWO SIGMA ADVISERS, LP $2,002,725 1,483,500 1.07% Shares
VANGUARD FIDUCIARY TRUST CO $1,634,159 336,940 0.87% Shares
FMR LLC $1,504,780 310,264 0.80% Shares
GOLDMAN SACHS GROUP INC $1,469,458 302,981 0.78% Shares
TYBOURNE CAPITAL MANAGEMENT (HK) LTD $1,451,844 961,486 0.77% Shares
Seven Fleet Capital Management LP $1,451,432 317,600 0.77% Shares
UBS Group AG $1,442,283 297,378 0.77% Shares
XTX Topco Ltd $1,405,011 289,693 0.75% Shares
Creative Planning $1,382,250 285,000 0.74% Shares
SEI INVESTMENTS CO $1,241,983 256,079 0.66% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,043,298 215,113 0.56% Shares
Peapod Lane Capital LLC $983,890 202,864 0.52% Shares
CDC Financial, Inc. $862,146 177,762 0.46% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $833,768 171,911 0.44% Shares
Stonepine Capital Management, LLC $783,678 161,583 0.42% Shares
BARCLAYS PLC $747,090 154,039 0.40% Shares
Anfield Capital Management, LLC $642,367 274,516 0.34% Shares
Informed Momentum Co LLC $615,286 126,863 0.33% Shares
Quarry LP $606,803 125,114 0.32% Shares
MARSHALL WACE, LLP $584,682 120,553 0.31% Shares
Susquehanna Portfolio Strategies, LLC $543,792 112,122 0.29% Shares
BARR E S & CO $533,500 110,000 0.28% Shares
JANE STREET GROUP, LLC $481,120 99,200 0.26% Call option
AMERICAN CENTURY COMPANIES INC $474,121 97,757 0.25% Shares
FEDERATED HERMES, INC. $409,204 84,372 0.22% Shares
SIMPLEX TRADING, LLC $382,684 78,904 0.20% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $374,905 77,300 0.20% Shares
ExodusPoint Capital Management, LP $363,585 74,966 0.19% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $335,824 68,816 0.18% Shares
Nuveen, LLC $323,369 66,674 0.17% Shares
COMMONWEALTH EQUITY SERVICES, LLC $297,850 61,412 0.16% Shares
RHUMBLINE ADVISERS $270,430 55,760 0.14% Shares
DEUTSCHE BANK AG\ $236,709 48,806 0.13% Shares
Bank of New York Mellon Corp $210,345 43,370 0.11% Shares
WELLS FARGO & COMPANY/MN $203,200 41,897 0.11% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $200,305 41,300 0.11% Call option
Verdad Advisers, LP $192,099 39,608 0.10% Shares
Quadrature Capital Ltd $182,423 37,613 0.10% Shares
Private Advisor Group, LLC $176,889 36,472 0.09% Shares
BlackRock, Inc. $153,852 31,722 0.08% Shares
MetLife Investment Management, LLC $145,961 30,095 0.08% Shares
RBF Capital, LLC $145,500 30,000 0.08% Shares
Regency Capital Management Inc.\DE $143,075 29,500 0.08% Shares
Marquette Asset Management, LLC $140,520 28,973 0.07% Shares
BANK OF AMERICA CORP /DE/ $140,175 28,902 0.07% Shares
CITADEL ADVISORS LLC $128,525 26,500 0.07% Call option
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC $125,916 25,962 0.07% Shares
TORONTO DOMINION BANK $114,295 23,566 0.06% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $111,729 23,037 0.06% Shares
Graham Capital Management, L.P. $108,436 22,358 0.06% Shares
Nuveen Asset Management, LLC $107,020 35,320 0.06% Shares
Cubist Systematic Strategies, LLC $106,619 70,609 0.06% Shares
Vanguard Global Advisers, LLC $105,366 21,725 0.06% Shares
Carson Advisory Inc. $102,675 21,170 0.05% Shares
CITIGROUP INC $98,091 20,225 0.05% Shares
Sivia Capital Partners, LLC $97,000 20,000 0.05% Shares
Invesco Ltd. $96,753 19,949 0.05% Shares
State of Wyoming $90,967 18,756 0.05% Shares
RAYMOND JAMES FINANCIAL INC $86,257 17,785 0.05% Shares
NEW YORK STATE COMMON RETIREMENT FUND $75,175 15,500 0.04% Shares
Police & Firemen's Retirement System of New Jersey $71,562 14,755 0.04% Shares
JANE STREET GROUP, LLC $69,816 14,395 0.04% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $69,302 14,289 0.04% Shares
PRELUDE CAPITAL MANAGEMENT, LLC $67,139 13,843 0.04% Shares
Scientech Research LLC $66,023 13,613 0.04% Shares
Squarepoint Ops LLC $65,412 13,487 0.03% Shares
CITADEL ADVISORS LLC $62,565 12,900 0.03% Put option
OPPENHEIMER & CO INC $61,382 12,656 0.03% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $61,110 12,600 0.03% Put option
Spark Investment Management LLC $60,625 12,500 0.03% Shares
BNP PARIBAS FINANCIAL MARKETS $60,523 12,479 0.03% Shares
nVerses Capital, LLC $53,146 10,958 0.03% Shares
INTECH INVESTMENT MANAGEMENT LLC $50,731 10,460 0.03% Shares
Cornerstone Wealth Management, LLC $49,402 10,186 0.03% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $48,966 10,096 0.03% Shares
ALLIANCEBERNSTEIN L.P. $40,014 17,100 0.02% Shares
NORTHERN TRUST CORP $37,976 7,830 0.02% Shares

Company insiders 10 insiders · 3 officers · 7 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Anthony Y Sun President & CEO April 7, 2020 A 2,145,680 0 0 $0
Melissa B, Epperly Chief Financial Officer April 7, 2020 A 277,529 0 0 $0
Kevin D. Bunker Chief Operating Officer April 7, 2020 A 544,650 0 0 $0
Enoch Kariuki Director June 16, 2026 A 194,465 0 0 $0
Jan Skvarka Director June 16, 2026 A 264,254 0 0 $0
David Michael Johnson Director June 16, 2026 A 307,521 0 0 $0
Luke Nathaniel Walker Director June 16, 2026 A 201,384 0 0 $0
Scott Dunseth Myers Director June 16, 2026 A 395,895 0 0 $0
Kimberly Blackwell Director July 1, 2020 A 0 0 $0
Cam Gallagher April 7, 2020 A 489,143 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Matrix Capital Management Company, LP, David E. Goel ×2 filings Jan. 2, 2026 0.00% Amendment SEC
Matrix Capital Management Company LP, David E. Goel ×2 filings June 20, 2023 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 15 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
FSCC · Federated Hermes ETF Trust 0.11% 79,362 NS May 31, 2026 N-PORT
IWC · iShares Trust 0.06% 171,328 SH Aug. 8, 2026 Daily
OMFS · Invesco Exchange-Traded Self-Indexe… 0.03% 21,464 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.02% 43,495 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.02% 481,349 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.02% 113,589 SH Aug. 8, 2026 Daily
AVSC · AMERICAN CENTURY ETF TRUST 0.01% 78,150 NS May 31, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 289,218 SH Aug. 8, 2026 Daily
IWM · iShares Trust 0.01% 1,213,598 SH Aug. 8, 2026 Daily
DFAS · Dimensional ETF Trust 0.00% 112,118 NS April 30, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.00% 10,252 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 575,846 SH Aug. 8, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 2,187,299 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 4,227 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.00% 151,148 SH Aug. 8, 2026 Daily