| BlackRock, Inc. |
$192,307,120 |
5,877,357 |
7.77% |
주식
|
| RTW INVESTMENTS, LP |
$184,001,738 |
5,623,525 |
7.44% |
주식
|
| FMR LLC |
$173,844,632 |
5,313,100 |
7.03% |
주식
|
| Lynx1 Capital Management LP |
$132,136,579 |
4,038,404 |
5.34% |
주식
|
| Redmile Group, LLC |
$129,110,502 |
3,945,920 |
5.22% |
주식
|
| WELLINGTON MANAGEMENT GROUP LLP |
$115,151,528 |
3,519,301 |
4.65% |
주식
|
| MORGAN STANLEY |
$112,975,453 |
3,452,795 |
4.57% |
주식
|
| BAKER BROS. ADVISORS LP |
$109,176,726 |
3,336,697 |
4.41% |
주식
|
| TORONTO DOMINION BANK |
$103,829,002 |
3,173,258 |
4.20% |
주식
|
| VANGUARD GROUP INC |
$99,956,846 |
3,149,239 |
4.04% |
주식
|
| STATE STREET CORP |
$93,325,293 |
2,852,240 |
3.77% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$84,644,579 |
2,586,937 |
3.42% |
주식
|
| BVF INC/IL |
$83,356,065 |
2,547,557 |
3.37% |
주식
|
| Siren, L.L.C. |
$65,287,754 |
1,995,347 |
2.64% |
주식
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$59,664,920 |
1,823,500 |
2.41% |
주식
|
| Skorpios Trust |
$53,020,254 |
2,256,181 |
2.14% |
주식
|
| JANUS HENDERSON GROUP PLC |
$52,455,703 |
1,612,781 |
2.12% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$49,884,057 |
1,524,309 |
2.02% |
주식
|
| Assenagon Asset Management S.A. |
$36,920,855 |
1,128,388 |
1.49% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$33,173,608 |
1,013,911 |
1.34% |
주식
|
| Polar Capital Holdings Plc |
$27,279,188 |
833,716 |
1.10% |
주식
|
| EcoR1 Capital, LLC |
$24,049,200 |
735,000 |
0.97% |
주식
|
| MPM BIOIMPACT LLC |
$23,666,834 |
723,314 |
0.96% |
주식
|
| Opaleye Management Inc. |
$22,904,000 |
700,000 |
0.93% |
주식
|
| GOLDMAN SACHS GROUP INC |
$18,825,256 |
575,344 |
0.76% |
주식
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$18,552,011 |
566,993 |
0.75% |
주식
|
| BAILLIE GIFFORD & CO |
$16,925,238 |
517,275 |
0.68% |
주식
|
| NORTHERN TRUST CORP |
$16,364,057 |
500,124 |
0.66% |
주식
|
| Troluce Capital Advisors LLC |
$16,242,732 |
496,416 |
0.66% |
주식
|
| FIRST TRUST ADVISORS LP |
$16,062,673 |
490,913 |
0.65% |
주식
|
| CITADEL ADVISORS LLC |
$16,009,929 |
489,301 |
0.65% |
주식
|
| Candriam S.C.A. |
$15,694,935 |
480,136 |
0.63% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$15,280,633 |
467,012 |
0.62% |
주식
|
| Granahan Investment Management, LLC |
$15,103,814 |
461,608 |
0.61% |
주식
|
| Erste Asset Management GmbH |
$13,875,261 |
428,381 |
0.56% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$13,169,898 |
402,503 |
0.53% |
주식
|
| Parkman Healthcare Partners LLC |
$11,630,095 |
355,443 |
0.47% |
주식
|
| Artisan Partners Limited Partnership |
$11,620,606 |
355,153 |
0.47% |
주식
|
| JANE STREET GROUP, LLC |
$10,853,257 |
331,701 |
0.44% |
주식
|
| TANG CAPITAL MANAGEMENT LLC |
$9,816,000 |
300,000 |
0.40% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$8,540,836 |
261,028 |
0.35% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$8,497,646 |
259,708 |
0.34% |
주식
|
| JPMORGAN CHASE & CO |
$8,480,802 |
259,352 |
0.34% |
주식
|
| UBS Group AG |
$6,776,705 |
207,112 |
0.27% |
주식
|
| Birchview Capital, LP |
$5,827,759 |
178,110 |
0.24% |
주식
|
| Bank of New York Mellon Corp |
$5,375,002 |
164,273 |
0.22% |
주식
|
| NORGES BANK |
$5,339,904 |
163,200 |
0.22% |
주식
|
| FRANKLIN RESOURCES INC |
$4,790,044 |
146,395 |
0.19% |
주식
|
| DAFNA Capital Management LLC |
$4,282,230 |
130,875 |
0.17% |
주식
|
| ExodusPoint Capital Management, LP |
$4,242,475 |
129,660 |
0.17% |
주식
|
| Nuveen, LLC |
$4,020,535 |
122,877 |
0.16% |
주식
|
| GILDER GAGNON HOWE & CO LLC |
$3,699,487 |
113,065 |
0.15% |
주식
|
| Jump Financial, LLC |
$3,414,332 |
104,350 |
0.14% |
주식
|
| Schonfeld Strategic Advisors LLC |
$3,344,932 |
102,229 |
0.14% |
주식
|
| Palo Alto Investors LP |
$2,769,126 |
84,631 |
0.11% |
주식
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2,649,273 |
80,968 |
0.11% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$2,633,004 |
80,522 |
0.11% |
주식
|
| XTX Topco Ltd |
$2,604,937 |
79,613 |
0.11% |
주식
|
| RHUMBLINE ADVISERS |
$2,484,451 |
75,931 |
0.10% |
주식
|
| Swiss National Bank |
$2,427,824 |
74,200 |
0.10% |
주식
|
| Trexquant Investment LP |
$2,404,102 |
73,475 |
0.10% |
주식
|
| PRINCIPAL FINANCIAL GROUP INC |
$2,286,474 |
69,880 |
0.09% |
주식
|
| CITIGROUP INC |
$2,268,347 |
69,326 |
0.09% |
주식
|
| Invesco Ltd. |
$2,213,836 |
67,660 |
0.09% |
주식
|
| TD Asset Management Inc |
$2,198,784 |
67,200 |
0.09% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2,164,755 |
66,160 |
0.09% |
주식
|
| Rhenman & Partners Asset Management AB |
$2,110,440 |
64,500 |
0.09% |
주식
|
| ALPS ADVISORS INC |
$2,061,687 |
63,010 |
0.08% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$2,040,779 |
62,371 |
0.08% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$2,031,418 |
62,390 |
0.08% |
주식
|
| HighVista Strategies LLC |
$2,006,260 |
61,316 |
0.08% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1,968,664 |
60,167 |
0.08% |
주식
|
| PANAGORA ASSET MANAGEMENT INC |
$1,925,343 |
58,843 |
0.08% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1,894,503 |
58,185 |
0.08% |
주식
|
| D. E. Shaw & Co., Inc. |
$1,892,754 |
57,847 |
0.08% |
주식
|
| DEUTSCHE BANK AG\ |
$1,890,692 |
57,784 |
0.08% |
주식
|
| WELLS FARGO & COMPANY/MN |
$1,663,322 |
50,835 |
0.07% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1,640,515 |
50,138 |
0.07% |
주식
|
| Woodline Partners LP |
$1,639,926 |
50,120 |
0.07% |
주식
|
| Quantinno Capital Management LP |
$1,633,644 |
49,928 |
0.07% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1,623,272 |
49,611 |
0.07% |
주식
|
| Moran Wealth Management, LLC |
$1,569,807 |
47,977 |
0.06% |
주식
|
| VICTORY CAPITAL MANAGEMENT INC |
$1,469,128 |
44,900 |
0.06% |
주식
|
| Creative Planning |
$1,451,721 |
44,368 |
0.06% |
주식
|
| Rafferty Asset Management, LLC |
$1,431,238 |
43,742 |
0.06% |
주식
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$1,374,240 |
42,000 |
0.06% |
주식
|
| Quadrature Capital Ltd |
$1,348,882 |
41,225 |
0.05% |
주식
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$1,335,467 |
40,815 |
0.05% |
주식
|
| Legal & General Group Plc |
$1,168,268 |
35,705 |
0.05% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1,164,766 |
35,598 |
0.05% |
주식
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1,104,564 |
34,102 |
0.04% |
주식
|
| MetLife Investment Management, LLC |
$1,051,359 |
32,132 |
0.04% |
주식
|
| Corient Private Wealth LP |
$1,008,529 |
30,823 |
0.04% |
주식
|
| OMERS ADMINISTRATION Corp |
$981,600 |
30,000 |
0.04% |
주식
|
| Squarepoint Ops LLC |
$959,023 |
29,310 |
0.04% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$883,833 |
27,012 |
0.04% |
주식
|
| Vanguard Global Advisers, LLC |
$871,628 |
26,639 |
0.04% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$865,411 |
26,449 |
0.03% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$821,730 |
25,114 |
0.03% |
주식
|
| Cresset Asset Management, LLC |
$798,728 |
24,411 |
0.03% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$736,200 |
22,500 |
0.03% |
콜 옵션
|
| PROFUND ADVISORS LLC |
$733,452 |
22,416 |
0.03% |
주식
|
| Allspring Global Investments Holdings, LLC |
$711,083 |
21,739 |
0.03% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$687,120 |
21,000 |
0.03% |
풋 옵션
|
| LPL Financial LLC |
$675,504 |
20,645 |
0.03% |
주식
|
| AMERIPRISE FINANCIAL INC |
$668,240 |
20,423 |
0.03% |
주식
|
| Balyasny Asset Management L.P. |
$652,404 |
19,939 |
0.03% |
주식
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$558,432 |
17,067 |
0.02% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$531,536 |
16,245 |
0.02% |
주식
|
| Aquatic Capital Management LLC |
$506,211 |
15,471 |
0.02% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$498,587 |
15,238 |
0.02% |
주식
|
| Russell Investments Group, Ltd. |
$480,362 |
14,681 |
0.02% |
주식
|
| BARCLAYS PLC |
$477,909 |
14,606 |
0.02% |
주식
|
| AlphaQuest LLC |
$477,243 |
15,036 |
0.02% |
주식
|
| CIM, LLC |
$476,272 |
14,556 |
0.02% |
주식
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$443,356 |
13,550 |
0.02% |
주식
|
| OSAIC HOLDINGS, INC. |
$406,119 |
12,412 |
0.02% |
주식
|
| INTECH INVESTMENT MANAGEMENT LLC |
$400,395 |
12,237 |
0.02% |
주식
|
| Advantage Alpha Capital Partners LP |
$398,114 |
16,941 |
0.02% |
주식
|
| PSP Research LLC |
$392,640 |
12,000 |
0.02% |
주식
|
| State of New Jersey Common Pension Fund D |
$391,135 |
11,954 |
0.02% |
주식
|
| Virtus Investment Advisers, LLC |
$359,037 |
10,973 |
0.01% |
주식
|
| Jain Global LLC |
$356,092 |
10,883 |
0.01% |
주식
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$354,325 |
10,829 |
0.01% |
주식
|
| Dorsey & Whitney Trust CO LLC |
$353,900 |
10,816 |
0.01% |
주식
|
| VOYA INVESTMENT MANAGEMENT LLC |
$349,253 |
10,674 |
0.01% |
주식
|
| ARIZONA STATE RETIREMENT SYSTEM |
$333,777 |
10,201 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$333,286 |
10,186 |
0.01% |
주식
|
| China Universal Asset Management Co., Ltd. |
$330,865 |
10,112 |
0.01% |
주식
|
| CITADEL ADVISORS LLC |
$327,200 |
10,000 |
0.01% |
풋 옵션
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$313,588 |
9,584 |
0.01% |
주식
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$309,826 |
9,469 |
0.01% |
주식
|
| ProShare Advisors LLC |
$302,758 |
9,253 |
0.01% |
주식
|
| Yorktown Management & Research Co Inc |
$299,388 |
9,150 |
0.01% |
주식
|
| PRUDENTIAL FINANCIAL INC |
$294,480 |
9,000 |
0.01% |
주식
|
| SEI INVESTMENTS CO |
$288,067 |
8,804 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$287,936 |
8,800 |
0.01% |
주식
|
| Susquehanna Portfolio Strategies, LLC |
$287,118 |
8,775 |
0.01% |
주식
|
| Inspire Advisors, LLC |
$275,601 |
8,423 |
0.01% |
주식
|
| Toroso Investments, LLC |
$265,188 |
8,355 |
0.01% |
주식
|
| Seven Fleet Capital Management LP |
$255,353 |
7,745 |
0.01% |
주식
|
| Entropy Technologies, LP |
$251,290 |
7,680 |
0.01% |
주식
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$248,410 |
7,592 |
0.01% |
주식
|
| Pictet Asset Management Holding SA |
$248,050 |
7,581 |
0.01% |
주식
|
| Generali Investments, Management Co LLC |
$225,055 |
6,912 |
0.01% |
주식
|
| State of Wyoming |
$218,897 |
6,690 |
0.01% |
주식
|
| Magnetar Financial LLC |
$205,154 |
6,270 |
0.01% |
주식
|
| E Fund Management Co., Ltd. |
$201,817 |
6,168 |
0.01% |
주식
|
| Ameritas Investment Partners, Inc. |
$163,567 |
4,999 |
0.01% |
주식
|
| HARBOUR INVESTMENTS, INC. |
$144,393 |
4,413 |
0.01% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$96,884 |
2,961 |
0.00% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$91,125 |
2,785 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$87,093 |
2,661,739 |
0.00% |
주식
|
| T. Rowe Price Investment Management, Inc. |
$79,024 |
2,415,139 |
0.00% |
주식
|
| Tower Research Capital LLC (TRC) |
$74,929 |
2,290 |
0.00% |
주식
|
| ROYAL BANK OF CANADA |
$68,000 |
2,092 |
0.00% |
주식
|
| JONES FINANCIAL COMPANIES LLLP |
$67,840 |
2,120 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$63,837 |
1,951 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$39,657 |
1,212 |
0.00% |
주식
|
| Quantbot Technologies LP |
$34,160 |
1,044 |
0.00% |
주식
|
| GAMMA Investing LLC |
$28,892 |
883 |
0.00% |
주식
|
| Optiver Holding B.V. |
$21,857 |
668 |
0.00% |
주식
|
| CWM, LLC |
$20,155 |
619 |
0.00% |
주식
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$18,127 |
554 |
0.00% |
주식
|
| Kemnay Advisory Services Inc. |
$17,767 |
543 |
0.00% |
주식
|
| Stone House Investment Management, LLC |
$16,360 |
500 |
0.00% |
주식
|
| Rockefeller Capital Management L.P. |
$15,739 |
481 |
0.00% |
주식
|
| Quarry LP |
$15,640 |
478 |
0.00% |
주식
|
| Wilmington Savings Fund Society, FSB |
$13,088 |
400 |
0.00% |
주식
|
| Arax Advisory Partners |
$12,205 |
373 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$9,489 |
290 |
0.00% |
주식
|
| J.Safra Asset Management Corp |
$8,082 |
247 |
0.00% |
주식
|
| US BANCORP \DE\ |
$7,984 |
244 |
0.00% |
주식
|
| Prestige Wealth Management Group LLC |
$6,544 |
200 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$6,315 |
193 |
0.00% |
주식
|
| Smartleaf Asset Management LLC |
$5,020 |
155 |
0.00% |
주식
|
| Owl Creek Wealth Partners LLC |
$4,908 |
150 |
0.00% |
주식
|
| Financial Life Planners |
$4,712 |
144 |
0.00% |
주식
|
| Larson Financial Group LLC |
$4,057 |
124 |
0.00% |
주식
|
| SIGNATUREFD, LLC |
$2,716 |
83 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$2,160 |
66 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$1,440 |
44 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$1,145 |
35 |
0.00% |
주식
|
| CANADA LIFE ASSURANCE Co |
$824 |
25,197 |
0.00% |
주식
|
| Dogwood Wealth Management LLC |
$785 |
24 |
0.00% |
주식
|
| Strengthening Families & Communities, LLC |
$654 |
20 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$589 |
18 |
0.00% |
주식
|
| Farther Finance Advisors, LLC |
$556 |
17 |
0.00% |
주식
|
| HARBOR CAPITAL ADVISORS, INC. |
$526 |
16,073 |
0.00% |
주식
|
| Vestcor Inc |
$333 |
10,171 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$328 |
10 |
0.00% |
주식
|
| Ameritas Advisory Services, LLC |
$294 |
9 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$262 |
8 |
0.00% |
주식
|
| Allworth Financial LP |
$197 |
6 |
0.00% |
주식
|
| SG Americas Securities, LLC |
$184 |
5,625 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$164 |
5 |
0.00% |
주식
|
| IFP Advisors, Inc |
$164 |
5 |
0.00% |
주식
|
| True Wealth Design, LLC |
$131 |
4 |
0.00% |
주식
|
| Clearstead Advisors, LLC |
$99 |
3 |
0.00% |
주식
|
| KBC Group NV |
$36 |
1,096 |
0.00% |
주식
|
| Pacer Advisors, Inc. |
$24 |
731 |
0.00% |
주식
|
| Covestor Ltd |
$1 |
16 |
0.00% |
주식
|