| VANGUARD GROUP INC |
$43219768 |
8048374 |
10.67% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$39399813 |
17990782 |
9.73% |
股份
|
| ORBIMED ADVISORS LLC |
$33331787 |
15219994 |
8.23% |
股份
|
| MONTANOVA CAPITAL, LLC |
$30881538 |
14101159 |
7.63% |
股份
|
| BlackRock, Inc. |
$24707100 |
11281781 |
6.10% |
股份
|
| STATE STREET CORP |
$21798500 |
9953653 |
5.38% |
股份
|
| ENAVATE SCIENCES GP, LLC |
$17056049 |
7788150 |
4.21% |
股份
|
| Vivo Capital, LLC |
$16987961 |
7757060 |
4.20% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$13400133 |
6118782 |
3.31% |
股份
|
| Palo Alto Investors LP |
$12771670 |
5831813 |
3.15% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$10322011 |
4713247 |
2.55% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$8357450 |
3815189 |
2.06% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$8258560 |
3771032 |
2.04% |
股份
|
| Qube Research & Technologies Ltd |
$8075601 |
3687489 |
1.99% |
股份
|
| Blue Owl Capital Holdings LP |
$7936726 |
3624076 |
1.96% |
股份
|
| CITADEL ADVISORS LLC |
$7819776 |
3570674 |
1.93% |
股份
|
| GOLDMAN SACHS GROUP INC |
$7732890 |
3531000 |
1.91% |
股份
|
| Rock Springs Capital Management LP |
$7719595 |
3524929 |
1.91% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$7685011 |
3509137 |
1.90% |
股份
|
| Birchview Capital, LP |
$3668250 |
1675000 |
0.91% |
股份
|
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
$3066000 |
1400000 |
0.76% |
股份
|
| Fisher Asset Management, LLC |
$3048238 |
1391890 |
0.75% |
股份
|
| ROYCE & ASSOCIATES LP |
$2927548 |
1336780 |
0.72% |
股份
|
| FMR LLC |
$2654709 |
1212196 |
0.66% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$2598435 |
1186500 |
0.64% |
股份
|
| NORTHERN TRUST CORP |
$2498603 |
1140914 |
0.62% |
股份
|
| Atle Fund Management AB |
$2296418 |
1048593 |
0.57% |
股份
|
| Nuveen, LLC |
$2213130 |
1010562 |
0.55% |
股份
|
| Squarepoint Ops LLC |
$2206440 |
1007507 |
0.54% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2192054 |
1000938 |
0.54% |
股份
|
| Blackstone Inc. |
$1970860 |
899936 |
0.49% |
股份
|
| FIRST TRUST ADVISORS LP |
$1767338 |
807004 |
0.44% |
股份
|
| JPMORGAN CHASE & CO |
$1705102 |
789399 |
0.42% |
股份
|
| KVP Capital Advisors, LP |
$1688490 |
771000 |
0.42% |
股份
|
| MORGAN STANLEY |
$1610058 |
735186 |
0.40% |
股份
|
| CITIGROUP INC |
$1563457 |
713907 |
0.39% |
股份
|
| UBS Group AG |
$1560951 |
712763 |
0.39% |
股份
|
| Burkehill Global Management, LP |
$1533000 |
700000 |
0.38% |
股份
|
| Point72 Asset Management, L.P. |
$1503604 |
686577 |
0.37% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$1303516 |
595213 |
0.32% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1241553 |
566919 |
0.31% |
股份
|
| CM Management, LLC |
$1204500 |
550000 |
0.30% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1184772 |
541178 |
0.29% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$1147072 |
523777 |
0.28% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$856345 |
161880 |
0.21% |
股份
|
| Artia Global Partners LP |
$839208 |
383200 |
0.21% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$829324 |
378687 |
0.20% |
股份
|
| ArrowMark Colorado Holdings LLC |
$798785 |
364742 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$768760 |
351032 |
0.19% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$738706 |
139642 |
0.18% |
股份
|
| MARSHALL WACE, LLP |
$733364 |
334869 |
0.18% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$701483 |
320312 |
0.17% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$675166 |
308295 |
0.17% |
股份
|
| ALGERT GLOBAL LLC |
$674761 |
308110 |
0.17% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$663874 |
303139 |
0.16% |
股份
|
| NATIXIS |
$651996 |
297715 |
0.16% |
股份
|
| Exome Asset Management LLC |
$604801 |
276165 |
0.15% |
股份
|
| Caption Management, LLC |
$577234 |
263577 |
0.14% |
股份
|
| TEMA ETFS LLC |
$537945 |
100176 |
0.13% |
股份
|
| Seven Fleet Capital Management LP |
$510415 |
233066 |
0.13% |
股份
|
| DV EQUITIES, LLC |
$510415 |
233066 |
0.13% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$486572 |
222179 |
0.12% |
股份
|
| XTX Topco Ltd |
$476292 |
217485 |
0.12% |
股份
|
| Orion Porfolio Solutions, LLC |
$468360 |
213863 |
0.12% |
股份
|
| D. E. Shaw & Co., Inc. |
$447827 |
204487 |
0.11% |
股份
|
| Rafferty Asset Management, LLC |
$416376 |
190126 |
0.10% |
股份
|
| Creative Planning |
$400421 |
182841 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$400282 |
182777 |
0.10% |
股份
|
| Mariner, LLC |
$378432 |
172821 |
0.09% |
股份
|
| Swiss National Bank |
$376023 |
171700 |
0.09% |
股份
|
| JANE STREET GROUP, LLC |
$372300 |
170000 |
0.09% |
买入期权
|
| Virtus Investment Advisers, LLC |
$352986 |
161181 |
0.09% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$352371 |
160900 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$346984 |
158444 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$294226 |
134350 |
0.07% |
股份
|
| JANUS HENDERSON GROUP PLC |
$293846 |
55600 |
0.07% |
股份
|
| IEQ CAPITAL, LLC |
$269256 |
122948 |
0.07% |
股份
|
| ADAR1 Capital Management, LLC |
$267469 |
122132 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$240447 |
109793 |
0.06% |
股份
|
| Quadrature Capital Ltd |
$237068 |
108250 |
0.06% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$233388 |
106570 |
0.06% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$230198 |
105113 |
0.06% |
股份
|
| PROFUND ADVISORS LLC |
$208508 |
95209 |
0.05% |
股份
|
| Schonfeld Strategic Advisors LLC |
$201975 |
92227 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$197196 |
90044 |
0.05% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$194711 |
83567 |
0.05% |
股份
|
| Jain Global LLC |
$193381 |
88302 |
0.05% |
股份
|
| SmartHarvest Portfolios, LLC |
$189453 |
86508 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$179923 |
82459 |
0.04% |
股份
|
| GROUP ONE TRADING LLC |
$178610 |
81557 |
0.04% |
股份
|
| Cerity Partners LLC |
$177332 |
80973 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$175550 |
80160 |
0.04% |
股份
|
| Legal & General Group Plc |
$164474 |
75103 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$163569 |
74689 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$161622 |
73800 |
0.04% |
买入期权
|
| MetLife Investment Management, LLC |
$156412 |
71421 |
0.04% |
股份
|
| Invesco Ltd. |
$152901 |
69818 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$149395 |
68217 |
0.04% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$148291 |
67713 |
0.04% |
股份
|
| ExodusPoint Capital Management, LP |
$147777 |
67478 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$143445 |
65500 |
0.04% |
卖出期权
|
| Vanguard Global Advisers, LLC |
$133936 |
61158 |
0.03% |
股份
|
| Wealthcare Advisory Partners LLC |
$133507 |
60962 |
0.03% |
股份
|
| Quantbot Technologies LP |
$133209 |
60826 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$131301 |
59955 |
0.03% |
股份
|
| SIMPLEX TRADING, LLC |
$126560 |
57790 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$123078 |
56200 |
0.03% |
卖出期权
|
| Focus Partners Wealth |
$116335 |
53121 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$110606 |
50505 |
0.03% |
股份
|
| BARCLAYS PLC |
$110368 |
50397 |
0.03% |
股份
|
| Sequoia Financial Advisors, LLC |
$98507 |
44980 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$96172 |
43914 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$95438 |
43579 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$92238 |
42118 |
0.02% |
股份
|
| OSAIC HOLDINGS, INC. |
$91904 |
41965 |
0.02% |
股份
|
| TWO SIGMA ADVISERS, LP |
$81624 |
15200 |
0.02% |
股份
|
| Simplicity Wealth,LLC |
$79891 |
36480 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$78032 |
35631 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$77752 |
35503 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$73194 |
33422 |
0.02% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$71414 |
32609 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$71394 |
32600 |
0.02% |
买入期权
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$70737 |
32300 |
0.02% |
股份
|
| Independent Advisor Alliance |
$69176 |
31587 |
0.02% |
股份
|
| LPL Financial LLC |
$68919 |
31470 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$66591 |
30407 |
0.02% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$64498 |
29451 |
0.02% |
股份
|
| FLORIDA FINANCIAL ADVISORS, LLC |
$62604 |
28586 |
0.02% |
股份
|
| Strategic Wealth Partners, Ltd. |
$62579 |
28575 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$61123 |
27910 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$60573 |
27659 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$59281 |
27069 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$58710 |
26808 |
0.01% |
股份
|
| Engineers Gate Manager LP |
$57674 |
26335 |
0.01% |
股份
|
| Walleye Trading LLC |
$54750 |
25000 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$54531 |
24900 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$53874 |
24600 |
0.01% |
股份
|
| Merit Financial Group, LLC |
$51846 |
23674 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$51693 |
23604 |
0.01% |
股份
|
| nVerses Capital, LLC |
$51092 |
23330 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$50057 |
22857 |
0.01% |
股份
|
| INDEPENDENT FINANCIAL GROUP, LLC |
$49886 |
22779 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$47567 |
21720 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$47201 |
21552 |
0.01% |
股份
|
| Arkadios Wealth Advisors |
$47006 |
21464 |
0.01% |
股份
|
| ACT Advisors, LLC. |
$45142 |
20613 |
0.01% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$43344 |
19792 |
0.01% |
股份
|
| Apollon Wealth Management, LLC |
$43115 |
19687 |
0.01% |
股份
|
| Wealthcare Capital Partners, LLC |
$43042 |
19654 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$42269 |
19301 |
0.01% |
股份
|
| Welch & Forbes LLC |
$41610 |
19000 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$40115 |
18317 |
0.01% |
股份
|
| M&T Bank Corp |
$39853 |
18198 |
0.01% |
股份
|
| Ikarian Capital, LLC |
$39419 |
18000 |
0.01% |
股份
|
| ProShare Advisors LLC |
$37596 |
17167 |
0.01% |
股份
|
| McAdam, LLC |
$36122 |
16494 |
0.01% |
股份
|
| JUPITER ASSET MANAGEMENT LTD |
$35631 |
16270 |
0.01% |
股份
|
| Chicago Partners Investment Group LLC |
$34465 |
16257 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$32425 |
14806 |
0.01% |
股份
|
| SIG BROKERAGE, LP |
$31746 |
14496 |
0.01% |
股份
|
| Centiva Capital, LP |
$31606 |
14432 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$31606 |
14432 |
0.01% |
股份
|
| STIFEL FINANCIAL CORP |
$31122 |
14211 |
0.01% |
股份
|
| MAI Capital Management |
$31074 |
14189 |
0.01% |
股份
|
| StoneX Group Inc. |
$31043 |
15000 |
0.01% |
股份
|
| State of Wyoming |
$30802 |
14065 |
0.01% |
股份
|
| HB Wealth Management, LLC |
$28597 |
13058 |
0.01% |
股份
|
| Fortis Capital Advisors, LLC |
$28525 |
13025 |
0.01% |
股份
|
| Belpointe Asset Management LLC |
$28525 |
13025 |
0.01% |
股份
|
| XPONANCE LLC |
$27485 |
12550 |
0.01% |
股份
|
| North Star Investment Management Corp. |
$27375 |
12500 |
0.01% |
股份
|
| BLAIR WILLIAM & CO/IL |
$26687 |
12186 |
0.01% |
股份
|
| SummitTX Capital, L.P. |
$26280 |
12000 |
0.01% |
股份
|
| Crewe Advisors LLC |
$25615 |
11696 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$23956 |
10939 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$23260 |
10621 |
0.01% |
股份
|
| CWM, LLC |
$22837 |
4317 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$22342 |
10202 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$22266 |
10167 |
0.01% |
股份
|
| Allworth Financial LP |
$22084 |
10084 |
0.01% |
股份
|
| Prestige Wealth Management Group LLC |
$16973 |
7750 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$16473 |
7522 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$16368 |
7474 |
0.00% |
股份
|
| Operose Advisors LLC |
$13740 |
6274 |
0.00% |
股份
|
| VSM Wealth Advisory, LLC |
$13359 |
6100 |
0.00% |
股份
|
| Arax Advisory Partners |
$12538 |
5725 |
0.00% |
股份
|
| MCF Advisors LLC |
$12134 |
5540 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$11949 |
5456 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$10543 |
4814 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$9000 |
4048 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$8760 |
4000 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$6579 |
3004 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5786 |
2642 |
0.00% |
股份
|
| True Wealth Design, LLC |
$3410 |
1557 |
0.00% |
股份
|
| Essential Partners LLC |
$3320 |
1516 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$3243 |
1481 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2755 |
1264 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2537 |
1161231 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2440 |
1114 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1779 |
812 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$1716 |
783 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1675 |
765 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$1621 |
740 |
0.00% |
股份
|
| Truvestments Capital LLC |
$1345 |
614 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1244 |
568 |
0.00% |
股份
|
| PICTON MAHONEY ASSET MANAGEMENT |
$1023 |
467 |
0.00% |
股份
|
| GAMMA Investing LLC |
$968 |
442 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$654 |
300 |
0.00% |
股份
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$631 |
288 |
0.00% |
股份
|
| Marshall & Sterling Wealth Advisors Inc. |
$438 |
200 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$394 |
180 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$372 |
170102 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$229 |
104251 |
0.00% |
股份
|
| Larson Financial Group LLC |
$204 |
93 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$195 |
89 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$167 |
76355 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$154 |
70179 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$149 |
69 |
0.00% |
股份
|
| FINANCIAL ADVISORY CORP /UT/ /ADV |
$72 |
13495 |
0.00% |
股份
|
| Betterment LLC |
$66 |
30143 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$42 |
8 |
0.00% |
股份
|
| Virtu Financial LLC |
$36 |
16394 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$7 |
3175 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$4 |
2 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$2 |
1 |
0.00% |
股份
|