| TCG Crossover Management, LLC |
$36000000 |
11111111 |
8.86% |
股份
|
| BlackRock, Inc. |
$34311568 |
10589990 |
8.44% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$28800360 |
8889000 |
7.09% |
股份
|
| Commodore Capital LP |
$28800360 |
8889000 |
7.09% |
股份
|
| ADAR1 Capital Management, LLC |
$28800360 |
8889000 |
7.09% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$19897929 |
6141336 |
4.90% |
股份
|
| Paradigm Biocapital Advisors LP |
$18100665 |
5586625 |
4.45% |
股份
|
| VANGUARD GROUP INC |
$16826539 |
8208068 |
4.14% |
股份
|
| Opaleye Management Inc. |
$12512653 |
3861930 |
3.08% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$11658618 |
3598339 |
2.87% |
股份
|
| Woodline Partners LP |
$11519810 |
3555497 |
2.84% |
股份
|
| Vivo Capital, LLC |
$11519010 |
3555250 |
2.83% |
股份
|
| GordonMD Global Investments LP |
$10131480 |
3127000 |
2.49% |
股份
|
| GOLDMAN SACHS GROUP INC |
$8469476 |
2614036 |
2.08% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$8325643 |
2569072 |
2.05% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$7999298 |
2468919 |
1.97% |
股份
|
| Logos Global Management LP |
$7199280 |
2222000 |
1.77% |
股份
|
| STATE STREET CORP |
$7101442 |
2191803 |
1.75% |
股份
|
| MARSHALL WACE, LLP |
$6600808 |
2037287 |
1.62% |
股份
|
| D. E. Shaw & Co., Inc. |
$6159246 |
1901002 |
1.52% |
股份
|
| JPMORGAN CHASE & CO |
$5959980 |
1862494 |
1.47% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$5094065 |
1572242 |
1.25% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4318842 |
1332976 |
1.06% |
股份
|
| Seven Fleet Capital Management LP |
$4310820 |
1330500 |
1.06% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$4273389 |
1318947 |
1.05% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$3344111 |
1032133 |
0.82% |
股份
|
| MACKENZIE FINANCIAL CORP |
$2844856 |
878042 |
0.70% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2812424 |
868032 |
0.69% |
股份
|
| Nantahala Capital Management, LLC |
$2762748 |
852700 |
0.68% |
股份
|
| NORTHERN TRUST CORP |
$2655806 |
819693 |
0.65% |
股份
|
| TWO SIGMA ADVISERS, LP |
$2509405 |
1224100 |
0.62% |
股份
|
| UBS Group AG |
$2432472 |
750763 |
0.60% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2407158 |
742950 |
0.59% |
股份
|
| Nuveen, LLC |
$1688730 |
521213 |
0.42% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1616750 |
498997 |
0.40% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1545801 |
477099 |
0.38% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1521180 |
469500 |
0.37% |
买入期权
|
| Eversept Partners, LP |
$1486541 |
458809 |
0.37% |
股份
|
| Casdin Capital, LLC |
$1441800 |
445000 |
0.35% |
股份
|
| PEAK6 LLC |
$1346029 |
415441 |
0.33% |
股份
|
| DIADEMA PARTNERS LP |
$1296000 |
400000 |
0.32% |
买入期权
|
| MORGAN STANLEY |
$1108616 |
342165 |
0.27% |
股份
|
| BIT Capital GmbH |
$1056240 |
326000 |
0.26% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1002440 |
309395 |
0.25% |
股份
|
| Cubist Systematic Strategies, LLC |
$994094 |
286482 |
0.24% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$878642 |
271186 |
0.22% |
股份
|
| Bank of New York Mellon Corp |
$850907 |
262625 |
0.21% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$751119 |
231827 |
0.18% |
股份
|
| LPL Financial LLC |
$748813 |
231115 |
0.18% |
股份
|
| Erste Asset Management GmbH |
$736000 |
230000 |
0.18% |
股份
|
| IEQ CAPITAL, LLC |
$705623 |
217785 |
0.17% |
股份
|
| CITADEL ADVISORS LLC |
$689345 |
212761 |
0.17% |
股份
|
| Invesco Ltd. |
$686492 |
211880 |
0.17% |
股份
|
| Walleye Capital LLC |
$595703 |
183859 |
0.15% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$558900 |
172500 |
0.14% |
卖出期权
|
| CITADEL ADVISORS LLC |
$557604 |
172100 |
0.14% |
卖出期权
|
| DAFNA Capital Management LLC |
$552323 |
170470 |
0.14% |
股份
|
| Mariner, LLC |
$548500 |
169291 |
0.13% |
股份
|
| Green Alpha Advisors, LLC |
$505589 |
156046 |
0.12% |
股份
|
| PEAK6 LLC |
$497340 |
153500 |
0.12% |
买入期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$490555 |
151406 |
0.12% |
股份
|
| Russell Investments Group, Ltd. |
$485558 |
149864 |
0.12% |
股份
|
| BARCLAYS PLC |
$483615 |
149264 |
0.12% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$464187 |
187930 |
0.11% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$445030 |
137355 |
0.11% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$408240 |
126000 |
0.10% |
股份
|
| Point72 Asset Management, L.P. |
$405758 |
125234 |
0.10% |
股份
|
| WELLS FARGO & COMPANY/MN |
$391240 |
120753 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$380421 |
117417 |
0.09% |
股份
|
| JANE STREET GROUP, LLC |
$374473 |
115578 |
0.09% |
股份
|
| FMR LLC |
$360281 |
111198 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$321942 |
99365 |
0.08% |
股份
|
| HSBC HOLDINGS PLC |
$314481 |
97062 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$300818 |
92845 |
0.07% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$300226 |
92094 |
0.07% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$300011 |
92596 |
0.07% |
股份
|
| CWM, LLC |
$259352 |
105001 |
0.06% |
股份
|
| STIFEL FINANCIAL CORP |
$242293 |
74782 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$229392 |
70800 |
0.06% |
买入期权
|
| OSAIC HOLDINGS, INC. |
$227198 |
70124 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$221188 |
68268 |
0.05% |
股份
|
| Joel Isaacson & Co., LLC |
$220787 |
68144 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$218376 |
67400 |
0.05% |
卖出期权
|
| SIMPLEX TRADING, LLC |
$207275 |
63974 |
0.05% |
股份
|
| CITIGROUP INC |
$200763 |
61964 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$182140 |
56216 |
0.04% |
股份
|
| Cerity Partners LLC |
$181867 |
56132 |
0.04% |
股份
|
| MML INVESTORS SERVICES, LLC |
$168765 |
52088 |
0.04% |
股份
|
| GROUP ONE TRADING LLC |
$163131 |
50349 |
0.04% |
股份
|
| Creative Planning |
$147653 |
45572 |
0.04% |
股份
|
| China Universal Asset Management Co., Ltd. |
$143934 |
44424 |
0.04% |
股份
|
| WINTON GROUP Ltd |
$141588 |
43700 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$138876 |
42863 |
0.03% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$137376 |
42400 |
0.03% |
股份
|
| Graham Capital Management, L.P. |
$134369 |
41472 |
0.03% |
股份
|
| Quinn Opportunity Partners LLC |
$129600 |
40000 |
0.03% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$124108 |
38305 |
0.03% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$121967 |
37644 |
0.03% |
股份
|
| Balyasny Asset Management L.P. |
$121947 |
37638 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$118104 |
36452 |
0.03% |
股份
|
| SCS Capital Management LLC |
$113400 |
35000 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$109749 |
33873 |
0.03% |
股份
|
| Thrive Wealth Management, LLC |
$108540 |
33500 |
0.03% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$107367 |
33138 |
0.03% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$102359 |
31207 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$98159 |
30296 |
0.02% |
股份
|
| HORIZON KINETICS ASSET MANAGEMENT LLC |
$89683 |
27680 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$88339 |
27265 |
0.02% |
股份
|
| Focus Partners Wealth |
$88336 |
27264 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$87299 |
26944 |
0.02% |
股份
|
| Prime Capital Investment Advisors, LLC |
$85766 |
26471 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$85536 |
26400 |
0.02% |
买入期权
|
| Vise Technologies, Inc. |
$83573 |
25794 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$83148 |
25663 |
0.02% |
股份
|
| DLK Investment Management, LLC |
$82668 |
17702 |
0.02% |
股份
|
| Corient Private Wealth LP |
$79854 |
24646 |
0.02% |
股份
|
| XTX Topco Ltd |
$77656 |
23968 |
0.02% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$74370 |
22954 |
0.02% |
股份
|
| Rockefeller Capital Management L.P. |
$72787 |
22465 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$71231 |
21985 |
0.02% |
股份
|
| State of Wyoming |
$69790 |
21540 |
0.02% |
股份
|
| HighTower Advisors, LLC |
$69718 |
21518 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$66537 |
20536 |
0.02% |
股份
|
| INDEPENDENT FINANCIAL GROUP, LLC |
$66128 |
20410 |
0.02% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$61884 |
19100 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$60718 |
18740 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$59000 |
18103 |
0.01% |
股份
|
| ProShare Advisors LLC |
$58765 |
18137 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$57515 |
17751 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$57160 |
17642 |
0.01% |
股份
|
| Cetera Investment Advisers |
$52336 |
16153 |
0.01% |
股份
|
| StoneX Group Inc. |
$51085 |
16213 |
0.01% |
股份
|
| STRATEGIC ADVISORY PARTNERS, LLC |
$48691 |
15028 |
0.01% |
股份
|
| Abel Hall, LLC |
$47638 |
14703 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$47303 |
1023 |
0.01% |
买入期权
|
| Callan Family Office, LLC |
$46860 |
14463 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$46523 |
14359 |
0.01% |
股份
|
| Keystone Financial Group |
$45522 |
14050 |
0.01% |
股份
|
| Aries Wealth Management |
$40500 |
12500 |
0.01% |
股份
|
| Pallas Capital Advisors LLC |
$37944 |
11711 |
0.01% |
股份
|
| Merit Financial Group, LLC |
$37474 |
11566 |
0.01% |
股份
|
| Gibbs Wealth Management |
$35769 |
10308 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$35731 |
11028 |
0.01% |
股份
|
| Point72 (DIFC) Ltd |
$34276 |
9878 |
0.01% |
股份
|
| Valeo Financial Advisors, LLC |
$32536 |
10042 |
0.01% |
股份
|
| Kera Capital Partners, Inc. |
$32462 |
10019 |
0.01% |
股份
|
| Raiffeisen Bank International AG |
$32400 |
10000 |
0.01% |
买入期权
|
| Legal & General Group Plc |
$31454 |
9708 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$29166 |
9002 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$26714 |
8245 |
0.01% |
股份
|
| CIBC Private Wealth Group LLC |
$25331 |
7300 |
0.01% |
股份
|
| Arax Advisory Partners |
$23863 |
7365 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$22236 |
6863 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$14237 |
4394 |
0.00% |
股份
|
| Allworth Financial LP |
$13542 |
4180 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$13300 |
3833 |
0.00% |
股份
|
| Dunhill Financial, LLC |
$12960 |
4000 |
0.00% |
股份
|
| Activest Wealth Management |
$12960 |
4000 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$10744 |
3316 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$9827 |
3033 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$8236 |
2542 |
0.00% |
股份
|
| Owl Creek Wealth Partners LLC |
$7728 |
2385 |
0.00% |
股份
|
| Atlantic Union Bankshares Corp |
$7459 |
2302 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$7452 |
2300 |
0.00% |
股份
|
| Essential Partners LLC |
$5262 |
1624 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$5241 |
1839 |
0.00% |
股份
|
| Leonteq Securities AG |
$4565 |
1409 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4465 |
1378 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4348 |
1342 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$4212 |
1300 |
0.00% |
股份
|
| NewEdge Advisors, LLC |
$4196 |
1295 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4154 |
1282 |
0.00% |
股份
|
| Twin Lakes Capital Management, LLC |
$4050 |
1250 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$3726 |
1150 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$3364 |
1039001 |
0.00% |
股份
|
| Wilmington Savings Fund Society, FSB |
$3240 |
1000 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$3240 |
1000 |
0.00% |
股份
|
| Costello Asset Management, INC |
$3240 |
1000 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$3020 |
932 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2961 |
914 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$2686 |
829 |
0.00% |
股份
|
| Tradewinds Capital Management, LLC |
$2268 |
700 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2108 |
653 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$2103 |
649 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1944 |
600 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$1717 |
530 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1691 |
522 |
0.00% |
股份
|
| AllSquare Wealth Management LLC |
$1648 |
475 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1639 |
506 |
0.00% |
股份
|
| TRUST CO OF TOLEDO NA /OH/ |
$1620 |
500 |
0.00% |
股份
|
| GILL CAPITAL PARTNERS, LLC |
$1377 |
425 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1335 |
412 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1331 |
410 |
0.00% |
股份
|
| HOLLENCREST CAPITAL MANAGEMENT |
$1296 |
400 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1190 |
367147 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1186 |
480 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1167 |
360 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$1053 |
325 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$1008 |
311 |
0.00% |
股份
|
| Larson Financial Group LLC |
$936 |
289 |
0.00% |
股份
|
| Optiver Holding B.V. |
$839 |
259 |
0.00% |
股份
|
| HM PAYSON & CO |
$681 |
210 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$656 |
200 |
0.00% |
股份
|
| Cambridge Investment Research Advisors, Inc. |
$524 |
161878 |
0.00% |
股份
|
| ISLAY CAPITAL MANAGEMENT, LLC |
$486 |
150 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$399 |
123 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$387 |
119429 |
0.00% |
股份
|
| Quarry LP |
$363 |
112 |
0.00% |
股份
|
| Plante Moran Financial Advisors, LLC |
$324 |
100 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$324 |
100 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$320 |
100 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$306 |
124 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$305 |
94 |
0.00% |
股份
|
| SHP Wealth Management |
$292 |
90 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$257 |
100 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$255 |
78602 |
0.00% |
股份
|
| Key Financial Inc |
$243 |
75 |
0.00% |
股份
|
| Truvestments Capital LLC |
$198 |
61 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$194 |
60 |
0.00% |
股份
|
| MCF Advisors LLC |
$175 |
54 |
0.00% |
股份
|
| DT Investment Partners, LLC |
$175 |
54 |
0.00% |
股份
|
| Gen-Wealth Partners Inc |
$172 |
53 |
0.00% |
股份
|
| Center for Financial Planning, Inc. |
$162 |
50 |
0.00% |
股份
|
| EVOLUTION WEALTH MANAGEMENT INC. |
$162 |
50 |
0.00% |
股份
|
| North Star Investment Management Corp. |
$123 |
38 |
0.00% |
股份
|
| COMERICA BANK |
$111 |
54 |
0.00% |
股份
|
| Colonial Trust Advisors |
$97 |
30 |
0.00% |
股份
|
| Hilton Head Capital Partners, LLC |
$87 |
27 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$49 |
15 |
0.00% |
股份
|
| Abich Financial Wealth Management LLC |
$42 |
12 |
0.00% |
股份
|
| Financial Perspectives, Inc |
$19 |
6 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$13 |
4 |
0.00% |
股份
|
| Forum Finance Group S.A. |
$7 |
2500 |
0.00% |
股份
|
| Sandy Spring Bank |
$3 |
2 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
108 |
0.00% |
股份
|
| HANTZ FINANCIAL SERVICES, INC. |
$0 |
100 |
0.00% |
股份
|